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JBC, Vol. 250, Issue 15, 5967-5975, Aug, 1975
H. G. Lebherz
The intraccellular proteins of animal cells are continuously turning over;
therefore, the concentration of a given protein is regulated both at the
level of protein synthesis and at the level of protein degradation. Studies
on the relative rates of turnover of isoenzymes, such as those of aldolase
and lactate dehydrogenase, may help to clarify the mechanisms involved in
protein turnover. The isoenzymes and subunit types are very similar
proteins, and are located within the same intracellular compartments; yet,
the concentrations of these proteins are independently regulated. The
present paper describes the roles of synthesis and degradation in
regulating aldolase isoenzyme concentrations in avian brain...
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