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JBC, Vol. 250, Issue 16, 6304-6314, Aug, 1975
K. Tornheim and J. M. Lowenstein
Linked oscillations of the glycolytic pathway and the purine nucleotide
cycle were studied in particle-free extracts of rat skeletal muscle. Under
the conditions used, an accumulation of about 1 muM fructose diphosphate
can trigger a sudden increase in phosphofructokinase activity. The
activation by fructose diphosphate depends on the presence of AMP. When the
AMP concentration drops, phosphofructokinase becomes inhibited, even though
the fructose disphosphate concentration remains high. It is concluded that
the oscillatory behavior can be of advantage for maintaining a high average
[ATP]/[ADP] ratio.
The purine nucleotide cycle. Control of phosphofructokinase and glycolytic oscillations in muscle extracts
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