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J. Biol. Chem., Vol. 261, Issue 15, 6712-6718, 05, 1986
HS Kim and N Maeda
Two members of the human salivary proline-rich protein (PRP) multigene
family have been isolated and completely sequenced. These PRP genes, PRH1
and PRH2, are of the HaeIII-type subfamily and code for acidic PRP
proteins. Both genes are approximately 3.5 kilobase pairs (kb) in length
and contain four exons. Exon 3 encodes the proline-rich part of the protein
and includes five 63-base pair (bp) repeats. CAT and ATA boxes and several
possible enhancer sequences occur in a 1-kb region 5' to exon 1. Two sets
of repeats occur in the sequenced region in addition to the 63-bp repeats:
one pair of about 140 bp flanks 500 bp of DNA in the first intervening
sequence, and the other pair of 72 bp is tandemly repeated 1.4 kb 5' to the
PRH1 gene. The 4-kb region of sequenced DNA from PRH1 differs by an average
of 8.7% from the same region in PRH2, but the nucleotide sequences of the
exon 3 of the two genes differ by only 0.2%. This result suggests the
occurrence of a recent gene conversion event. The regions containing the
5-fold repeated sequences of 63 bp are identical in the two genes, PRH1 and
PRH2. A comparison of the human HaeIII and BstNI subfamily repeats and a
comparison of the human, mouse, and rat repeats suggest that the individual
repeats have evolved in a concerted fashion within each gene and within the
PRP gene family as a whole.
Structures of two HaeIII-type genes in the human salivary proline-rich protein multigene family
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