HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Birch, H. E. Articles by Schreiber, G. Search for Related Content PubMed PubMed Citation Articles by Birch, H. E. Articles by Schreiber, G. Social Bookmarking                      What's this?

J. Biol. Chem., Vol. 261, Issue 18, 8077-8080, 06, 1986

Transcriptional regulation of plasma protein synthesis during inflammation

HE Birch and G Schreiber

The regulation of the synthesis of plasma proteins in rat liver during the acute phase response was studied by measuring gene transcription activities in a cell-free nuclear transcription system. The transcription activities for the genes of major acute phase alpha 1- protein, the beta-chain of fibrinogen, transferrin, alpha 1-acid glycoprotein, and alpha 2-macroglobulin increased, reaching a maximum level between 18 and 36 h after inducing an acute inflammation. The transcription activities for the genes of alpha 2u-globulin, albumin, and transthyretin (formerly called prealbumin) decreased, reaching a minimum level after 12 to 24 h. The extent of the relative changes in transcription activities was similar to that of the relative changes in mRNA levels for major acute phase alpha 1-protein, the beta-chain of fibrinogen, transferrin, alpha 2u-globulin, albumin, and transthyretin. This is consistent with the assumption that the principal mechanism of the regulation of the synthesis of these proteins operates at the level of transcription. In contrast, the relative changes in transcription activities for alpha 1-acid glycoprotein and alpha 2-macroglobulin were far smaller than the changes of their mRNA levels, suggesting that, in addition to transcriptional changes, other mechanism(s) are involved in the regulation of the synthesis of these proteins.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				D. M. Wrighting and N. C. Andrews Interleukin-6 induces hepcidin expression through STAT3 Blood, November 1, 2006; 108(9): 3204 - 3209. [Abstract] [Full Text] [PDF]

				C. J. Cifelli and A. C. Ross All-trans-retinoic acid distribution and metabolism in vitamin A-marginal rats. Am J Physiol Gastrointest Liver Physiol, August 1, 2006; 291(2): G195 - G202. [Abstract] [Full Text] [PDF]

				T. Hochepied, W. Van Molle, F. G. Berger, H. Baumann, and C. Libert Involvement of the Acute Phase Protein alpha 1-Acid Glycoprotein in Nonspecific Resistance to a Lethal Gram-negative Infection J. Biol. Chem., May 12, 2000; 275(20): 14903 - 14909. [Abstract] [Full Text] [PDF]

				Y. Han, T. Meng, N. R. Murray, A. P. Fields, and A. R. Brasier Interleukin-1-induced Nuclear Factor-kappa B-Ikappa Balpha Autoregulatory Feedback Loop in Hepatocytes. A ROLE FOR PROTEIN KINASE Calpha IN POST-TRANSCRIPTIONAL REGULATION OF Ikappa Balpha RESYNTHESIS J. Biol. Chem., January 8, 1999; 274(2): 939 - 947. [Abstract] [Full Text] [PDF]

				L. Voisin, D. Breuille, B. Ruot, C. Ralliere, F. Rambourdin, M. Dalle, and C. Obled Cytokine modulation by PX differently affects specific acute phase proteins during sepsis in rats Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1998; 275(5): R1412 - R1419. [Abstract] [Full Text] [PDF]

				J. C. Corton, L.-Q. Fan, S. Brown, S. P. Anderson, C. Bocos, R. C. Cattley, A. Mode, and J.-A. Gustafsson Down-Regulation of Cytochrome P450 2C Family Members and Positive Acute-Phase Response Gene Expression by Peroxisome Proliferator Chemicals Mol. Pharmacol., September 1, 1998; 54(3): 463 - 473. [Abstract] [Full Text]

				F. Citarella, A. Felici, M. Brouwer, J. Wagstaff, A. Fantoni, and C. E. Hack Interleukin-6 Downregulates Factor XII Production by Human Hepatoma Cell Line (HepG2) Blood, August 15, 1997; 90(4): 1501 - 1507. [Abstract] [Full Text] [PDF]

				Y. Han and A. R. Brasier Mechanism for Biphasic Rel A· NF-kappa B1 Nuclear Translocation in Tumor Necrosis Factor alpha -stimulated Hepatocytes J. Biol. Chem., April 11, 1997; 272(15): 9825 - 9832. [Abstract] [Full Text] [PDF]

				M. B. Sewer, D. R. Koop, and E. T. Morgan Differential Inductive and Suppressive Effects of Endotoxin and Particulate Irritants on Hepatic and Renal Cytochrome P-450 Expression J. Pharmacol. Exp. Ther., March 1, 1997; 280(3): 1445 - 1454. [Abstract] [Full Text]

				A. R. Brasier and J. Li Mechanisms for Inducible Control of Angiotensinogen Gene Transcription Hypertension, March 1, 1996; 27(3): 465 - 475. [Abstract] [Full Text]

				J. A. Ripperger, S. Fritz, K. Richter, G. M. Hocke, F. Lottspeich, and G. H. Fey Transcription Factors Stat3 and Stat5b Are Present in Rat Liver Nuclei Late in an Acute Phase Response and Bind Interleukin-6 Response Elements J. Biol. Chem., December 15, 1995; 270(50): 29998 - 30006. [Abstract] [Full Text] [PDF]

				E. Ikeda, M. G. Achen, G. Breier, and W. Risau Hypoxia-induced Transcriptional Activation and Increased mRNA Stability of Vascular Endothelial Growth Factor in C6 Glioma Cells J. Biol. Chem., August 25, 1995; 270(34): 19761 - 19766. [Abstract] [Full Text] [PDF]