HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Vrijsen, R. Articles by Boeye, A. Search for Related Content PubMed PubMed Citation Articles by Vrijsen, R. Articles by Boeye, A. Social Bookmarking                      What's this?

J. Biol. Chem., Vol. 261, Issue 2, 505-507, Jan, 1986

Lycorine: a eukaryotic termination inhibitor?

R Vrijsen, DA Vanden Berghe, AJ Vlietinck and A Boeye

The effect of the alkaloid lycorine on viral protein synthesis was studied in poliovirus-infected HeLa cells. The incorporation of [3H]leucine was inhibited by lycorine in a dose-dependent way, although lycorine never completely abolished translation. Using polyacrylamide gel electrophoresis, the viral proteins were identified as derived from the P1 (5' terminal), P2 (middle), or P3 (3' terminal) region of the poliovirus translation unit. The residual labeling of viral proteins in the presence of lycorine was mainly due to synthesis of P1 proteins and slightly less to P2 proteins, while virtually no P3-derived proteins were made. It is suggested that lycorine may act at the level of termination.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				L. Deng, P. Dai, A. Ciro, D. F. Smee, H. Djaballah, and S. Shuman Identification of Novel Antipoxviral Agents: Mitoxantrone Inhibits Vaccinia Virus Replication by Blocking Virion Assembly J. Virol., December 15, 2007; 81(24): 13392 - 13402. [Abstract] [Full Text] [PDF]

				Y. Ando, T. Tateishi, Y. Sekido, T. Yamamoto, T. Satoh, Y. Hasegawa, S. Kobayashi, Y. Katsumata, K. Shimokata, and H. Saito Re: Modification of Clinical Presentation of Prostate Tumors by a Novel Genetic Variant in CYP3A4 J Natl Cancer Inst, September 15, 1999; 91(18): 1587 - 1588. [Full Text] [PDF]