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J. Biol. Chem., Vol. 261, Issue 21, 9721-9726, Jul, 1986
JM Short, A Wynshaw-Boris, HP Short and RW Hanson
Hormonal regulatory elements within the phosphoenolpyruvate carboxykinase
(GTP) (EC 4.1.1.32) (PEPCK) promoter region were mapped using a series of
5' deletions linked to the amino-3'-glycosyl phosphotransferase structural
gene. These deletion mutants were stably transfected into the genome of
FTO-2B hepatoma cells. A 47-base pair region of the PEPCK promoter was
identified which was essential for stimulation by dibutyryl cAMP. A 12-base
pair core sequence (CTTACGTCAGAG) within this region shows significant
homology with sequences in four other cAMP-regulated genes. There are two
glucocorticoid regulatory elements within the promoter, as well as an
inhibitory element which depresses the level of basal gene transcription.
The deletion of this inhibitory sequence prevents the induction of the
chimeric gene by dexamethasone. The existence of the hormone regulatory
domains within the PEPCK promoter was confirmed by attaching these elements
upstream of the heterologous Herpes simplex virus thymidine kinase
structural gene, containing its own promoter.
Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains
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