HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Goodman, I. Articles by Weiss, R. L. Search for Related Content PubMed PubMed Citation Articles by Goodman, I. Articles by Weiss, R. L. Social Bookmarking                      What's this?

J. Biol. Chem., Vol. 261, Issue 22, 10264-10270, Aug, 1986

Control of arginine metabolism in Neurospora crassa. Role of feedback inhibition

I Goodman and RL Weiss

Flux through the arginine biosynthetic pathway of Neurospora crassa was measured under a variety of physiological conditions. Flux persisted, although at a reduced rate, in mutant strains resistant to feedback inhibition even after prolonged growth in the presence of exogenous arginine. Flux reverted to the uninhibited rate more quickly in feedback-resistant strains than in wild type strains upon removal of exogenous arginine. These results rule out enzyme repression as a major factor in controlling arginine biosynthesis. Feedback inhibition was shown to be independent of the size of the mycelial arginine pool or of the cytosolic arginine concentration, suggesting a role for the mitochondrial membrane in controlling the concentration of arginine at the site of inhibition--the mitochondrial matrix. The implications of these results are discussed.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				I. Semenov, B. Wang, J. T. Herlihy, and R. Brenner BK channel beta1-subunit regulation of calcium handling and constriction in tracheal smooth muscle Am J Physiol Lung Cell Mol Physiol, October 1, 2006; 291(4): L802 - L810. [Abstract] [Full Text] [PDF]