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J. Biol. Chem., Vol. 261, Issue 22, 10290-10292, 08, 1986
B Dozin, MA Magnuson and VM Nikodem
The regulatory mechanism(s) involved in the tissue-specific induction of
cytosolic malic enzyme (EC 1.1.1.40) by triiodothyronine (T3) have been
investigated in rat liver and heart. In these two tissues, cellular malic
enzyme mRNA accumulates to different extents in response to hormonal
stimulation (11-16- and 3-4-fold above the respective basal levels) (Dozin,
B., Magnuson, M. A., and Nikodem, V. M. (1985) Biochemistry 24, 5581-5586).
To gain further insight into this pretranslational control, nuclear in
vitro run-off transcription assays were performed and correlated with the
levels of malic enzyme RNA sequences in cytoplasm. The data demonstrate
that the rate of transcription of the malic enzyme gene is stimulated by T3
to similar extents in liver and heart (3-4-fold above the basal activity).
In liver, T3 also promotes an additional increase in cellular malic enzyme
mRNA. This additional effect could be due to a tissue-specific change in
the rate of degradation of cytoplasmic mRNA or to an effect on malic enzyme
mRNA in the nucleus.
Thyroid hormone regulation of malic enzyme synthesis. Dual tissue- specific control
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