HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Henriksen, E. J. Articles by Johnson, D. G. Search for Related Content PubMed PubMed Citation Articles by Henriksen, E. J. Articles by Johnson, D. G. Social Bookmarking                      What's this?

J. Biol. Chem., Vol. 261, Issue 23, 10707-10712, 08, 1986

Increased response to insulin of glucose metabolism in the 6-day unloaded rat soleus muscle

EJ Henriksen, ME Tischler and DG Johnson

Hind leg muscles of female rats (85-99 g) were unloaded by tail cast suspension for 6 days. In the fresh-frozen unloaded soleus, the significantly greater concentration of glycogen correlated with a lower activity ratio of glycogen phosphorylase (p less than 0.02). The activity ratio of glycogen synthase also was lower (p less than 0.001), possibly due to the higher concentration of glycogen. In isolated unloaded soleus, insulin (0.1 milliunit/ml) increased the oxidation of D-[U-14C]glucose, release of lactate and pyruvate, incorporation of D- [U-14C]glucose into glycogen, and the concentration of glucose 6- phosphate more (p less than 0.05) than in the weight-bearing soleus. At physiological doses of insulin, the percent of maximal uptake of 2- deoxy-D-[1,2-3H]glucose/muscle also was greater in the unloaded soleus. Unloading of the soleus increased by 50% the concentration of insulin receptors, due to no decrease in total receptor number during muscle atrophy. This increase may account for the greater response of glucose metabolism to insulin in this muscle. The extensor digitorum longus, which generally shows little response to unloading, displayed no differential response of glucose metabolism to insulin.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				B. B. Dokken, V. Saengsirisuwan, J. S. Kim, M. K. Teachey, and E. J. Henriksen Oxidative stress-induced insulin resistance in rat skeletal muscle: role of glycogen synthase kinase-3 Am J Physiol Endocrinol Metab, March 1, 2008; 294(3): E615 - E621. [Abstract] [Full Text] [PDF]

				T. P. Stein and C. E. Wade Metabolic Consequences of Muscle Disuse Atrophy J. Nutr., July 1, 2005; 135(7): 1824S - 1828S. [Abstract] [Full Text] [PDF]

				J. A. Sloniger, V. Saengsirisuwan, C. J. Diehl, B. B. Dokken, N. Lailerd, A. M. Lemieux, J. S. Kim, and E. J. Henriksen Defective insulin signaling in skeletal muscle of the hypertensive TG(mREN2)27 rat Am J Physiol Endocrinol Metab, June 1, 2005; 288(6): E1074 - E1081. [Abstract] [Full Text] [PDF]

				B. B. Dokken, J. A. Sloniger, and E. J. Henriksen Acute selective glycogen synthase kinase-3 inhibition enhances insulin signaling in prediabetic insulin-resistant rat skeletal muscle Am J Physiol Endocrinol Metab, June 1, 2005; 288(6): E1188 - E1194. [Abstract] [Full Text] [PDF]

				M. P. O'Keefe, F. R. Perez, J. A. Sloniger, M. E. Tischler, and E. J. Henriksen Enhanced insulin action on glucose transport and insulin signaling in 7-day unweighted rat soleus muscle J Appl Physiol, July 1, 2004; 97(1): 63 - 71. [Abstract] [Full Text] [PDF]

				E. J. Henriksen, T. R. Kinnick, M. K. Teachey, M. P. O'Keefe, D. Ring, K. W. Johnson, and S. D. Harrison Modulation of muscle insulin resistance by selective inhibition of GSK-3 in Zucker diabetic fatty rats Am J Physiol Endocrinol Metab, May 1, 2003; 284(5): E892 - E900. [Abstract] [Full Text] [PDF]

				C. S. Stump, C. M. Tipton, and E. J. Henriksen Muscle adaptations to hindlimb suspension in mature and old Fischer 344 rats J Appl Physiol, June 1, 1997; 82(6): 1875 - 1881. [Abstract] [Full Text] [PDF]