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J. Biol. Chem., Vol. 261, Issue 26, 12179-12183, 09, 1986
KL Tobey and GA Grant
The nucleotide sequence of serA, the structural gene of Escherichia coli
which codes for D-3-phosphoglycerate dehydrogenase, has been determined.
The structural gene contains 1233 nucleotides which code for the 409 amino
acids of the subunit of the tetrameric enzyme, as well as the initiator
methionine, which is cleaved from the mature protein, and the termination
codon. The majority of the primary structure of the enzyme has been
confirmed by automated Edman degradation of peptide fragments produced by a
variety of cleavage agents. Comparison of the amino acid sequence of
phosphoglycerate dehydrogenase with other NAD-dependent oxidoreductases
reveals less than 20% homology, although conservation of certain specific
residues in the coenzyme binding domain appears to be evident.
The nucleotide sequence of the serA gene of Escherichia coli and the amino acid sequence of the encoded protein, D-3-phosphoglycerate dehydrogenase
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