J. Biol. Chem., Vol. 261, Issue 27, 12441-12443, 09, 1986
10-Thiastearic acid inhibits both dihydrosterculic acid biosynthesis and growth of the protozoan Crithidia fasciculata
RA Pascal Jr, SJ Mannarelli and DL Ziering
10-Thiastearic acid is a specific inhibitor of the biosynthesis of
dihydrosterculic acid (9,10-methyleneoctadecanoic acid) in the
trypanosomatid protozoan Crithidia fasciculata. A 50% inhibition of the
biosynthesis of dihydrosterculate is observed in the presence of 4 microM
10-thiastearate in the protozoan growth medium, but little effect is seen
on the distribution of the other fatty acids. In addition, the growth of
the protozoa is slowed by the presence of 10- thiastearate, with 50% growth
inhibition produced at about 10 microM. A possible mechanism of this
inhibition and the implication of this result with regard to the design of
antiprotozoal agents are discussed.
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