HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Maekawa, T. Articles by Ishii, S. Search for Related Content PubMed PubMed Citation Articles by Maekawa, T. Articles by Ishii, S. Social Bookmarking                      What's this?

J. Biol. Chem., Vol. 264, Issue 10, 5488-5494, Apr, 1989

Cooperative function of two separate enhancers of the human epidermal growth factor receptor proto-oncogene

T Maekawa, F Imamoto, GT Merlino, I Pastan and S Ishii
Tsukuba Life Science Center, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan.

Two separate enhancers were identified both upstream and downstream of the promoter of the human epidermal growth factor receptor gene. Transcriptional enhancer activity was found to be associated with a region 1172 and 852 base pairs upstream of the most upstream RNA start site, and within a 530-base pair fragment located in the first intron about 2000 base pairs downstream of the most upstream RNA start site. These two separate enhancers stimulated promoter activity cooperatively in HeLa cells synthesizing the epidermal growth factor receptor. The enhancer downstream of the promoter functioned only in the presence of the other upstream enhancer. Several areas of sequences homology with viral and cellular enhancers were noted in both the upstream and downstream enhancers. The region essential for the downstream enhancer activity has 10 nuclear factor-binding sites.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				B. Brandt, S. Meyer-Staeckling, H. Schmidt, K. Agelopoulos, and H. Buerger Mechanisms of egfr Gene Transcription Modulation: Relationship to Cancer Risk and Therapy Response Clin. Cancer Res., December 15, 2006; 12(24): 7252 - 7260. [Abstract] [Full Text] [PDF]

				W. Liu, F. Innocenti, M. H. Wu, A. A. Desai, M. E. Dolan, E. H. Cook Jr., and M. J. Ratain A Functional Common Polymorphism in a Sp1 Recognition Site of the Epidermal Growth Factor Receptor Gene Promoter Cancer Res., January 1, 2005; 65(1): 46 - 53. [Abstract] [Full Text] [PDF]

				O. V. Skabkina, M. A. Skabkin, N. V. Popova, D. N. Lyabin, L. O. Penalva, and L. P. Ovchinnikov Poly(A)-binding Protein Positively Affects YB-1 mRNA Translation through Specific Interaction with YB-1 mRNA J. Biol. Chem., May 9, 2003; 278(20): 18191 - 18198. [Abstract] [Full Text] [PDF]

				N. Tidow, A. Boecker, H. Schmidt, K. Agelopoulos, W. Boecker, H. Buerger, and B. Brandt Distinct Amplification of an Untranslated Regulatory Sequence in the egfr Gene Contributes to Early Steps in Breast Cancer Development Cancer Res., March 15, 2003; 63(6): 1172 - 1178. [Abstract] [Full Text] [PDF]

				F. Vasseur, N. Helbecque, C. Dina, S. Lobbens, V. Delannoy, S. Gaget, P. Boutin, M. Vaxillaire, F. Lepretre, S. Dupont, et al. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians Hum. Mol. Genet., October 2, 2002; 11(21): 2607 - 2614. [Abstract] [Full Text] [PDF]

				F. Gebhardt, K. S. Zanker, and B. Brandt Modulation of Epidermal Growth Factor Receptor Gene Transcription by a Polymorphic Dinucleotide Repeat in Intron 1 J. Biol. Chem., May 7, 1999; 274(19): 13176 - 13180. [Abstract] [Full Text] [PDF]

				A. S. Takaoka, T. Yamada, M. Gotoh, Y. Kanai, K. Imai, and S. Hirohashi Cloning and Characterization of the Human beta 4-Integrin Gene Promoter and Enhancers J. Biol. Chem., December 11, 1998; 273(50): 33848 - 33855. [Abstract] [Full Text] [PDF]

				D Fornzler, J Altschmied, I Nanda, R Kolb, M Baudler, M Schmid, and M Schartl The Xmrk oncogene promoter is derived from a novel amplified locus of unusual organization. Genome Res., February 1, 1996; 6(2): 102 - 113. [Abstract] [PDF]