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J. Biol. Chem., Vol. 283, Issue 21, 14177-14181, May 23, 2008

This Article Full Text Full Text (PDF) Supplemental Data All Versions of this Article: 283/21/14177    most recent R700052200v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Levine, S. J. Search for Related Content PubMed PubMed Citation Articles by Levine, S. J. Social Bookmarking                      What's this?

Minireview

Molecular Mechanisms of Soluble Cytokine Receptor Generation^*

From the Pulmonary and Vascular Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-1590

Soluble cytokine receptors play key roles in regulating cytokine-mediated biological events by binding and modulating the activity of target ligands in either an antagonistic or agonistic fashion. This Minireview will provide an overview of the molecular mechanisms mediating the generation of soluble cytokine receptors, which include sheddase-mediated proteolytic cleavage of cell-surface receptors, generation of soluble receptors by alternative gene splicing, transcription and translation of cytokine-binding genes, and extracellular release of membrane-bound receptors within vesicles such as exosomes.

^* This minireview will be reprinted in the 2008 Minireview Compendium, which will be available in January, 2009. This work was supported, in whole or in part, by the National Institutes of Health NHLBI Intramural Research Program.

The on-line version of this article (available at http://www.jbc.org) contains supplemental Table 1 and Refs. 72–76.

¹ To whom correspondence should be addressed. E-mail: levines{at}nhlbi.nih.gov.

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