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J. Biol. Chem., Vol. 281, Issue 29, 99922, July 21, 2006

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Interfer-ing with Myelin

Inflammatory reactions in the central nervous system play important roles in the pathogenesis of white matter diseases such as multiple sclerosis and periventricular leukomalacia. These reactions result in the exposure of oligodendrocytes to various cytokines that affect oligodendroglial survival, proliferation, and differentiation. One of these cytokines, interferon- (IFNG), has been reported to have both a deleterious and protective role on myelin synthesis. These conflicting observations prompted Makoto Horiuchi and colleagues to investigate the effects of interferon- on rat oligodendroglial cultures at different developmental stages.

IFNG induces cell death in oligodendroglial progenitor cells.

In this Paper of the Week, the researchers show that simultaneous activation of the signal transducers and activator of transcription (STAT) pathway by interferon- and of the extracellular signal-regulated kinase (ERK) pathway by exogenous trophic factors plays a role in interferon-induced cytotoxicity in proliferating oligodendroglial progenitors. The effect is developmental stage-specific in that non-proliferating immature and mature oligodendrocytes are protected from interferon-induced cell death. This comprehensive study is of considerable importance and relevance to inflammation-induced demyelinating disease.

FOOTNOTES

See referenced article, J. Biol. Chem. 2006, 281, 20095-20106

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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Related Collections Papers Of The Week Social Bookmarking                      What's this?