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J. Biol. Chem., Vol. 281, Issue 44, 99934, November 3, 2006

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Building a Plant Signaling Molecule

Jasmonic acid is a signaling molecule that regulates a wide range of developmental and defense-related processes in higher plants. It is synthesized from linolenic acid via an enzymatic pathway that begins in the plastid and terminates in peroxisomes. The jasmonic acid precursor 12-oxo-phytodienoic acid is converted in the peroxisome to 3-oxo-2-(2'-[Z]-pentenyl)-cyclopentane-1-octanoic acid (OPC-8:0), which subsequently undergoes three rounds of -oxidation to yield jasmonic acid. Although most jasmonic acid biosynthetic enzymes have been identified, several key steps in the pathway are unknown.

OPC-8:0 CoA Ligase1 is targeted to peroxisomes.

In this Paper of the Week, Abraham J. K. Koo and colleagues use co-expression analysis to identify genes that are coordinately regulated with known jasmonic acid biosynthetic components in Arabidopsis. Among the candidate genes uncovered by this approach is a 4-coumarate:CoA ligase-like member of the acyl-activating enzyme gene family that the authors named OPC-8:0 CoA Ligase1. Using a combination of genetic, biochemical, and cellular evidence, Koo et al. show that OPC-8:0 CoA Ligase1 is involved in peroxisomal jasmonic acid biosynthesis. These findings establish a clear physiological role for OPC-8:0 CoA Ligase1 in the activation of jasmonic acid biosynthetic precursors and indicate that OPC-8:0 is a physiological substrate for the activation step. As a result, this study provides a further understanding of the biosynthetic pathway of this important plant signaling molecule.

FOOTNOTES

See referenced article, J. Biol. Chem. 2006, 281, 33511-33520

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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Related Collections Papers Of The Week Social Bookmarking                      What's this?