J. Biol. Chem., Vol. 281, Issue 9, 5973-5981, March 3, 2006
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FIGURE 1.
A, structure of ligand-free 2B4. B, structure of 2B4-CPI. The chemical formula of CPI is shown below the protein structure. C, structure of 2B4-bifonazole. The chemical formula of bifonazole is shown below the protein structure. The three structures are shown in the same orientation by aligning the most conserved tertiary structure (residues 61-98 and 306-465). Four regions around the active site (residues 100-140, 203-262, 276-290, and 474-479) are colored green in A, orange in B, and yellow in C, respectively, with the major helices labeled. Other parts of the protein are colored gray in all three structures. Heme, CPI, and bifonazole are shown as red, cyan, and forest green sticks, respectively. Images were generated using PyMol (www.pymol.org) unless otherwise credited.
Copyright © 2008 by the American Society for Biochemistry and Molecular Biology.
