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J. Biol. Chem., Vol. 283, Issue 26, 99929, June 27, 2008

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Stressful Decay Is Okay

When confronted by different external stresses such as temperature shifts or nutritional depletion, cells must quickly react in order to adapt to the new environment and prevent damage. Most of these adaptations occur at the transcriptional and post-transcriptional levels, and in this Paper of the Week María Micaela Molina-Navarro and colleagues have taken a global analysis of one such stress response in yeast. Through an approach known as genomic run-on (GRO) methodology, they determined in parallel the mRNA levels and gene transcription rates of Saccharomyces cerevisiae in response to oxidative stress. Most of the 4700 genes analyzed exhibited a change in at least one of these two parameters during the course of the stress response, and about one-quarter of these genes experienced induced transcription without a parallel increase in mRNA levels, indicating altered mRNA stability. Among the destabilized genes are many ribosomal proteins and RNA processing enzymes. This study highlights the importance of mRNA decay dynamics as an important regulatory mechanism that acts together with RNA transcription to respond to physiological and environmental changes.

The S. cerevisiae genome can be clustered into 25 groups based on the kinetics of transcription rate (TR) and total mRNA levels (RA) in response to oxidative stress.

FOOTNOTES

See referenced article, J. Biol. Chem. 2008, 283, 17908-17918

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This Article Full Text (PDF) Author Profile Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Related Collections Papers Of The Week Social Bookmarking                      What's this?