Current Position: Senior Vice Dean of Research, Duke-NUS Graduate Medical School Singapore; James B. Duke Professor of Pharmacology and Cancer Biology, Duke University Medical Center.

Education: Ph.D. in Biochemistry (1986) at Brandeis University.

Non-scientific Interests: Outdoor activities, exploring southeast Asia with my wife and two children.

I Joined Duke University Medical Center in 1990, then in 2005, I moved to Singapore with my family to help establish a new medical school being jointly developed by Duke University and the National University of Singapore. This laboratory at the Duke-NUS Medical School is a joint venture with my wife, Mei Wang, who is also the first author on the highlighted paper. My research interests are in the areas of lipid modifications of proteins, particularly lipid modifications that are important in oncoprotein activity, and in deciphering novel signaling processes involving GTP-binding regulatory proteins. This particular study was the result of efforts aimed at understanding the mechanisms through which blockade of the Icmt methyltransferase impacts tumor cell growth and survival, and took advantage of a selective small molecule inhibitor of Icmt that we had previously discovered.

Read Dr. Casey's article on page 18678.

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