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Table of Contents: Aug 5 1989; 264 (22)   [Index by Author]       Other Issues:  
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Minireviews:

JD Capra and PW Tucker
Human immunoglobulin heavy chain genes
J. Biol. Chem. 1989 264: 12745-12748. [PDF]  


Articles:

S Olsnes, H Stenmark, S McGill, E Hovig, RJ Collier, and K Sandvig
Formation of active diphtheria toxin in vitro based on ligated fragments of cloned mutant genes
J. Biol. Chem. 1989 264: 12749-12751. [Abstract] [PDF]  

J Kuriyan, L Wong, M Russel, and P Model
Crystallization and preliminary x-ray characterization of thioredoxin reductase from Escherichia coli
J. Biol. Chem. 1989 264: 12752-12753. [Abstract] [PDF]  

KL Kelly, JT Deeney, and BE Corkey
Cytosolic free calcium in adipocytes. Distinct mechanisms of regulation and effects on insulin action
J. Biol. Chem. 1989 264: 12754-12757. [Abstract] [PDF]  

WJ Hong and D Doyle
Cloning and analysis of cDNA clones for rat kidney alpha-spectrin
J. Biol. Chem. 1989 264: 12758-12764. [Abstract] [PDF]  

PN McFadden, A Mandpe, and DE Koshland, Jr
Calcium- and lipid-independent protein kinase C autophosphorylation. Activation by low pH
J. Biol. Chem. 1989 264: 12765-12771. [Abstract] [PDF]  

KD Sharma, LA Andersson, TM Loehr, J Terner, and HM Goff
Comparative spectral analysis of mammalian, fungal, and bacterial catalases. Resonance Raman evidence for iron-tyrosinate coordination
J. Biol. Chem. 1989 264: 12772-12779. [Abstract] [PDF]  

S Jain and M Sundaralingam
Effect of crystal packing environment on conformation of the DNA duplex. Molecular structure of the A-DNA octamer d(G-T-G-T-A-C-A-C) in two crystal forms
J. Biol. Chem. 1989 264: 12780-12784. [Abstract] [PDF]  

M Chiba, H Shimizu, A Fujimoto, H Nashimoto, and H Ikeda
Common sites for recombination and cleavage mediated by bacteriophage T4 DNA topoisomerase in vitro
J. Biol. Chem. 1989 264: 12785-12790. [Abstract] [PDF]  

JY Bradfield and LL Keeley
Adipokinetic hormone gene sequence from Manduca sexta
J. Biol. Chem. 1989 264: 12791-12793. [Abstract] [PDF]  

Y Sharma, CM Rao, ML Narasu, SC Rao, T Somasundaram, A Gopalakrishna, and D Balasubramanian
Calcium ion binding to delta- and to beta-crystallins. The presence of the "EF-hand" motif in delta-crystallin that aids in calcium ion binding
J. Biol. Chem. 1989 264: 12794-12799. [Abstract] [PDF]  

YC Liu and DR Storm
Dephosphorylation of neuromodulin by calcineurin
J. Biol. Chem. 1989 264: 12800-12804. [Abstract] [PDF]  

B Schobert and JK Lanyi
Hysteretic behavior of an ATPase from the archaebacterium, Halobacterium saccharovorum
J. Biol. Chem. 1989 264: 12805-12812. [Abstract] [PDF]  

MM Smith, JP Merlie, and JC Lawrence, Jr
Ca2+-dependent and cAMP-dependent control of nicotinic acetylcholine receptor phosphorylation in muscle cells
J. Biol. Chem. 1989 264: 12813-12819. [Abstract] [PDF]  

RS Thies, A Ullrich, and DA McClain
Augmented mitogenesis and impaired metabolic signaling mediated by a truncated insulin receptor
J. Biol. Chem. 1989 264: 12820-12825. [Abstract] [PDF]  

C Orskov, M Bersani, AH Johnsen, P Hojrup, and JJ Holst
Complete sequences of glucagon-like peptide-1 from human and pig small intestine
J. Biol. Chem. 1989 264: 12826-12829. [Abstract] [PDF]  

BA Dawson, T Herman, and J Lough
Affinity isolation of transcriptionally active murine erythroleukemia cell DNA using a cleavable biotinylated nucleotide analog
J. Biol. Chem. 1989 264: 12830-12837. [Abstract] [PDF]  

WP Schilling, L Rajan, and E Strobl-Jager
Characterization of the bradykinin-stimulated calcium influx pathway of cultured vascular endothelial cells. Saturability, selectivity, and kinetics
J. Biol. Chem. 1989 264: 12838-12848. [Abstract] [PDF]  

DW Christianson, S Mangani, G Shoham, and WN Lipscomb
Binding of D-phenylalanine and D-tyrosine to carboxypeptidase A
J. Biol. Chem. 1989 264: 12849-12853. [Abstract] [PDF]  

VE Reyes, L Phillips, RE Humphreys, and RA Lew
Prediction of protein helices with a derivative of the strip-of-helix hydrophobicity algorithm
J. Biol. Chem. 1989 264: 12854-12858. [Abstract] [PDF]  

T Kawanishi, LM Blank, AT Harootunian, MT Smith, and RY Tsien
Ca2+ oscillations induced by hormonal stimulation of individual fura-2- loaded hepatocytes
J. Biol. Chem. 1989 264: 12859-12866. [Abstract] [PDF]  

M Wong, DA Rice, KL Parker, and BP Schimmer
The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells
J. Biol. Chem. 1989 264: 12867-12871. [Abstract] [PDF]  

C Baron, JF Gonzalez, PL Mateo, and M Cortijo
Thermodynamic analysis of the activation of glycogen phosphorylase b over a range of temperatures
J. Biol. Chem. 1989 264: 12872-12878. [Abstract] [PDF]  

IM Ota and S Clarke
Enzymatic methylation of 23-29-kDa bovine retinal rod outer segment membrane proteins. Evidence for methyl ester formation at carboxyl- terminal cysteinyl residues
J. Biol. Chem. 1989 264: 12879-12884. [Abstract] [PDF]  

BK Lam, WF Owen, Jr, KF Austen, and RJ Soberman
The identification of a distinct export step following the biosynthesis of leukotriene C4 by human eosinophils
J. Biol. Chem. 1989 264: 12885-12889. [Abstract] [PDF]  

DA Grahame
Different isozymes of methylcobalamin:2-mercaptoethanesulfonate methyltransferase predominate in methanol- versus acetate-grown Methanosarcina barkeri
J. Biol. Chem. 1989 264: 12890-12894. [Abstract] [PDF]  

FS Mickel, F Weidenbach, B Swarovsky, KS LaForge, and GA Scheele
Structure of the canine pancreatic lipase gene
J. Biol. Chem. 1989 264: 12895-12901. [Abstract] [PDF]  

TD Elich and JC Lagarias
Formation of a photoreversible phycocyanobilin-apophytochrome adduct in vitro
J. Biol. Chem. 1989 264: 12902-12908. [Abstract] [PDF]  

M Nakamura, I Yamazaki, T Kotani, and S Ohtaki
Thyroglobulin-mediated one- and two-electron oxidations of glutathione and ascorbate in thyroid peroxidase systems
J. Biol. Chem. 1989 264: 12909-12913. [Abstract] [PDF]  

A Pandiella, M Magni, D Lovisolo, and J Meldolesi
The effect of epidermal growth factor on membrane potential. Rapid hyperpolarization followed by persistent fluctuations
J. Biol. Chem. 1989 264: 12914-12921. [Abstract] [PDF]  

TK Alexandrides and RJ Smith
A novel fetal insulin-like growth factor (IGF) I receptor. Mechanism for increased IGF I- and insulin-stimulated tyrosine kinase activity in fetal muscle
J. Biol. Chem. 1989 264: 12922-12930. [Abstract] [PDF]  

MN Khan, G Baquiran, C Brule, J Burgess, B Foster, JJ Bergeron, and BI Posner
Internalization and activation of the rat liver insulin receptor kinase in vivo
J. Biol. Chem. 1989 264: 12931-12940. [Abstract] [PDF]  

JH Nuijens, CC Huijbregts, AJ Eerenberg-Belmer, JC Meijers, BN Bouma, and CE Hack
Activation of the contact system of coagulation by a monoclonal antibody directed against a neodeterminant in the heavy chain region of human coagulation factor XII (Hageman factor)
J. Biol. Chem. 1989 264: 12941-12949. [Abstract] [PDF]  

J Fujii, K Maruyama, M Tada, and DH MacLennan
Expression and site-specific mutagenesis of phospholamban. Studies of residues involved in phosphorylation and pentamer formation
J. Biol. Chem. 1989 264: 12950-12955. [Abstract] [PDF]  

RL Lu, NL Esmon, CT Esmon, and AE Johnson
The active site of the thrombin-thrombomodulin complex. A fluorescence energy transfer measurement of its distance above the membrane surface
J. Biol. Chem. 1989 264: 12956-12962. [Abstract] [PDF]  

SN Gacheru, PC Trackman, SD Calaman, FT Greenaway, and HM Kagan
Vicinal diamines as pyrroloquinoline quinone-directed irreversible inhibitors of lysyl oxidase
J. Biol. Chem. 1989 264: 12963-12969. [Abstract] [PDF]  

SF Wood, EZ Szuts, and A Fein
Inositol trisphosphate production in squid photoreceptors. Activation by light, aluminum fluoride, and guanine nucleotides
J. Biol. Chem. 1989 264: 12970-12976. [Abstract] [PDF]  

SR Tyagi, DN Burnham, and JD Lambeth
On the biological occurrence and regulation of 1-acyl and 1-O-alkyl- diradylglycerols in human neutrophils. Selective destruction of diacyl species using Rhizopus lipase
J. Biol. Chem. 1989 264: 12977-12982. [Abstract] [PDF]  

AK Ho, CL Chik, JL Weller, EJ Cragoe, Jr, and DC Klein
Evidence of alpha 1-adrenergic----protein kinase C----Na+/H+ antiporter- dependent increase in pinealocyte intracellular pH. Role in the adrenergic stimulation of cGMP accumulation
J. Biol. Chem. 1989 264: 12983-12988. [Abstract] [PDF]  

HU Marschall, B Egestad, H Matern, S Matern, and J Sjovall
N-acetylglucosaminides. A new type of bile acid conjugate in man
J. Biol. Chem. 1989 264: 12989-12993. [Abstract] [PDF]  

J Katz, WN Lee, PA Wals, and EA Bergner
Studies of glycogen synthesis and the Krebs cycle by mass isotopomer analysis with [U-13C]glucose in rats
J. Biol. Chem. 1989 264: 12994-13004. [Abstract] [PDF]  

Y Kumazawa, T Yokogawa, E Hasegawa, K Miura, and K Watanabe
The aminoacylation of structurally variant phenylalanine tRNAs from mitochondria and various nonmitochondrial sources by bovine mitochondrial phenylalanyl-tRNA synthetase
J. Biol. Chem. 1989 264: 13005-13011. [Abstract] [PDF]  

E Vijgenboom and L Bosch
Translational frameshifts induced by mutant species of the polypeptide chain elongation factor Tu of Escherichia coli
J. Biol. Chem. 1989 264: 13012-13017. [Abstract] [PDF]  

L Ng, SJ Weiss, and PA Fisher
Recognition and binding of template-primers containing defined abasic sites by Drosophila DNA polymerase alpha holoenzyme
J. Biol. Chem. 1989 264: 13018-13023. [Abstract] [PDF]  

OI Aruoma, B Halliwell, and M Dizdaroglu
Iron ion-dependent modification of bases in DNA by the superoxide radical-generating system hypoxanthine/xanthine oxidase
J. Biol. Chem. 1989 264: 13024-13028. [Abstract] [PDF]  

F Okajima, K Sato, M Nazarea, K Sho, and Y Kondo
A permissive role of pertussis toxin substrate G-protein in P2- purinergic stimulation of phosphoinositide turnover and arachidonate release in FRTL-5 thyroid cells. Cooperative mechanism of signal transduction systems
J. Biol. Chem. 1989 264: 13029-13037. [Abstract] [PDF]  

K Maruyama, DM Clarke, J Fujii, G Inesi, TW Loo, and DH MacLennan
Functional consequences of alterations to amino acids located in the catalytic center (isoleucine 348 to threonine 357) and nucleotide- binding domain of the Ca2+-ATPase of sarcoplasmic reticulum
J. Biol. Chem. 1989 264: 13038-13042. [Abstract] [PDF]  

J Soppa and D Oesterhelt
Bacteriorhodopsin mutants of Halobacterium sp. GRB. I. The 5-bromo-2'- deoxyuridine selection as a method to isolate point mutants in halobacteria
J. Biol. Chem. 1989 264: 13043-13048. [Abstract] [PDF]  

J Soppa, J Otomo, J Straub, J Tittor, S Meessen, and D Oesterhelt
Bacteriorhodopsin mutants of Halobacterium sp. GRB. II. Characterization of mutants
J. Biol. Chem. 1989 264: 13049-13056. [Abstract] [PDF]  

TJ Dunn, AJ Koleske, R Lindahl, and HC Pitot
Phenobarbital-inducible aldehyde dehydrogenase in the rat. cDNA sequence and regulation of the mRNA by phenobarbital in responsive rats
J. Biol. Chem. 1989 264: 13057-13065. [Abstract] [PDF]  

JA Bernstein and CC Richardson
Characterization of the helicase and primase activities of the 63-kDa component of the bacteriophage T7 gene 4 protein
J. Biol. Chem. 1989 264: 13066-13073. [Abstract] [PDF]  

ET Ben-Ari, KR Lynch, and JC Garrison
Glucocorticoids induce the accumulation of novel angiotensinogen gene transcripts
J. Biol. Chem. 1989 264: 13074-13079. [Abstract] [PDF]  

CW Distelhorst and KJ Howard
Kinetic pulse-chase labeling study of the glucocorticoid receptor in mouse lymphoma cells. Effect of glucocorticoid and antiglucocorticoid hormones on intracellular receptor half-life
J. Biol. Chem. 1989 264: 13080-13085. [Abstract] [PDF]  

J John, I Schlichting, E Schiltz, P Rosch, and A Wittinghofer
C-terminal truncation of p21H preserves crucial kinetic and structural properties
J. Biol. Chem. 1989 264: 13086-13092. [Abstract] [PDF]  

MJ Fraser, Z Hatahet, and XT Huang
The actions of Neurospora endo-exonuclease on double strand DNAs
J. Biol. Chem. 1989 264: 13093-13101. [Abstract] [PDF]  

B Steiner, D Cousot, A Trzeciak, D Gillessen, and P Hadvary
Ca2+-dependent binding of a synthetic Arg-Gly-Asp (RGD) peptide to a single site on the purified platelet glycoprotein IIb-IIIa complex
J. Biol. Chem. 1989 264: 13102-13108. [Abstract] [PDF]  

GE Bartley and PA Scolnik
Carotenoid biosynthesis in photosynthetic bacteria. Genetic characterization of the Rhodobacter capsulatus CrtI protein [published erratum appears in J Biol Chem 1989 Oct 25;264(30):18260]
J. Biol. Chem. 1989 264: 13109-13113. [Abstract] [PDF]  

UK Pati and SM Weissman
Isolation and molecular characterization of a cDNA encoding the 23-kDa subunit of human RNA polymerase II [published erratum appears in J Biol Chem 1991 Jul 15;266(20):13468]
J. Biol. Chem. 1989 264: 13114-13121. [Abstract] [PDF]  

JB Miller, SB Teal, and FE Stockdale
Evolutionarily conserved sequences of striated muscle myosin heavy chain isoforms. Epitope mapping by cDNA expression
J. Biol. Chem. 1989 264: 13122-13130. [Abstract] [PDF]  

K Matter, W McDowell, RT Schwartz, and HP Hauri
Asynchronous transport to the cell surface of intestinal brush border hydrolases is not due to differential trimming of N-linked oligosaccharides
J. Biol. Chem. 1989 264: 13131-13139. [Abstract] [PDF]  

DM Haverstick and MJ Bannon
Evidence for dual mechanisms involved in methamphetamine-induced increases in striatal preprotachykinin mRNA
J. Biol. Chem. 1989 264: 13140-13144. [Abstract] [PDF]  

LS Marton, JR Gulcher, and K Stefansson
Binding of hexabrachions to heparin and DNA
J. Biol. Chem. 1989 264: 13145-13149. [Abstract] [PDF]  

B Dublet, S Oh, SP Sugrue, MK Gordon, DR Gerecke, BR Olsen, and M van der Rest
The structure of avian type XII collagen. Alpha 1 (XII) chains contain 190-kDa non-triple helical amino-terminal domains and form homotrimeric molecules (published erratum appears in J Biol Chem 1990 Jan 15;265(2):1231]
J. Biol. Chem. 1989 264: 13150-13156. [Abstract] [PDF]  

WW Barrington, KA Jacobson, and GL Stiles
Demonstration of distinct agonist and antagonist conformations of the A1 adenosine receptor
J. Biol. Chem. 1989 264: 13157-13164. [Abstract] [PDF]  

F Tan, SJ Chan, DF Steiner, JW Schilling, and RA Skidgel
Molecular cloning and sequencing of the cDNA for human membrane-bound carboxypeptidase M. Comparison with carboxypeptidases A, B, H, and N
J. Biol. Chem. 1989 264: 13165-13170. [Abstract] [PDF]  

R Diaz, LS Mayorga, LE Mayorga, and P Stahl
In vitro clustering and multiple fusion among macrophage endosomes
J. Biol. Chem. 1989 264: 13171-13180. [Abstract] [PDF]  

U Testa, M Petrini, MT Quaranta, E Pelosi-Testa, G Mastroberardino, A Camagna, G Boccoli, M Sargiacomo, G Isacchi, and A Cozzi
Iron up-modulates the expression of transferrin receptors during monocyte-macrophage maturation
J. Biol. Chem. 1989 264: 13181-13187. [Abstract] [PDF]  

K Kamitani, K Narita, and F Sakiyama
Purification and characterization of hen oviduct N alpha- acetyltransferase
J. Biol. Chem. 1989 264: 13188-13193. [Abstract] [PDF]  

K Kamitani and F Sakiyama
Hen oviduct N alpha-acetyltransferase is a ribonucleoprotein having 7 S RNA
J. Biol. Chem. 1989 264: 13194-13198. [Abstract] [PDF]  

C Vannier, S Deslex, A Pradines-Figueres, and G Ailhaud
Biosynthesis of lipoprotein lipase in cultured mouse adipocytes. I. Characterization of a specific antibody and relationships between the intracellular and secreted pools of the enzyme
J. Biol. Chem. 1989 264: 13199-13205. [Abstract] [PDF]  

C Vannier and G Ailhaud
Biosynthesis of lipoprotein lipase in cultured mouse adipocytes. II. Processing, subunit assembly, and intracellular transport
J. Biol. Chem. 1989 264: 13206-13216. [Abstract] [PDF]  

MS Parmacek and JM Leiden
Structure and expression of the murine slow/cardiac troponin C gene
J. Biol. Chem. 1989 264: 13217-13225. [Abstract] [PDF]  

K Marien, K Mathews, K van Holde, and G Bailey
Replication blocks and sequence interaction specificities in the codon 12 region of the c-Ha-ras proto-oncogene induced by four carcinogens in vitro
J. Biol. Chem. 1989 264: 13226-13232. [Abstract] [PDF]  

CL Schengrund and NJ Ringler
Binding of Vibrio cholera toxin and the heat-labile enterotoxin of Escherichia coli to GM1, derivatives of GM1, and nonlipid oligosaccharide polyvalent ligands [published erratum appears in J Biol Chem 1989 Nov 5;264(31):18853]
J. Biol. Chem. 1989 264: 13233-13237. [Abstract] [PDF]  

CP Moxham, V Duronio, and S Jacobs
Insulin-like growth factor I receptor beta-subunit heterogeneity. Evidence for hybrid tetramers composed of insulin-like growth factor I and insulin receptor heterodimers
J. Biol. Chem. 1989 264: 13238-13244. [Abstract] [PDF]  

DJ McQuillan, M Yanagishita, VC Hascall, and M Bickel
Proteoglycan biosynthesis in murine monocytic leukemic (M1) cells before and after differentiation
J. Biol. Chem. 1989 264: 13245-13251. [Abstract] [PDF]  

M Baniyash, VW Hsu, MF Seldin, and RD Klausner
The isolation and characterization of the murine T cell antigen receptor zeta chain gene
J. Biol. Chem. 1989 264: 13252-13257. [Abstract] [PDF]  

BE Symington, FW Symington, and LR Rohrschneider
Phorbol ester induces increased expression, altered glycosylation, and reduced adhesion of K562 erythroleukemia cell fibronectin receptors
J. Biol. Chem. 1989 264: 13258-13266. [Abstract] [PDF]  

NH Guo, GR Her, VN Reinhold, MJ Brennan, RP Siraganian, and V Ginsburg
Monoclonal antibody AA4, which inhibits binding of IgE to high affinity receptors on rat basophilic leukemia cells, binds to novel alpha- galactosyl derivatives of ganglioside GD1b
J. Biol. Chem. 1989 264: 13267-13272. [Abstract] [PDF]  

S Kraner, J Yang, and R Barchi
Structural inferences for the native skeletal muscle sodium channel as derived from patterns of endogenous proteolysis
J. Biol. Chem. 1989 264: 13273-13280. [Abstract] [PDF]  

CW Dieffenbach, DN SenGupta, D Krause, D Sawzak, and RH Silverman
Cloning of murine gelsolin and its regulation during differentiation of embryonal carcinoma cells
J. Biol. Chem. 1989 264: 13281-13288. [Abstract] [PDF]  

S Chwetzoff, S Tsunasawa, F Sakiyama, and A Menez
Nigexine, a phospholipase A2 from cobra venom with cytotoxic properties not related to esterase activity. Purification, amino acid sequence, and biological properties
J. Biol. Chem. 1989 264: 13289-13297. [Abstract] [PDF]  

KE Carlson, LF Brass, and DR Manning
Thrombin and phorbol esters cause the selective phosphorylation of a G protein other than Gi in human platelets
J. Biol. Chem. 1989 264: 13298-13305. [Abstract] [PDF]  

SV Cannon-Carlson, H Gokhale, and GW Teebor
Purification and characterization of 5-hydroxymethyluracil-DNA glycosylase from calf thymus. Its possible role in the maintenance of methylated cytosine residues
J. Biol. Chem. 1989 264: 13306-13312. [Abstract] [PDF]  

S Kargman and CA Rouzer
Studies on the regulation, biosynthesis, and activation of 5- lipoxygenase in differentiated HL60 cells
J. Biol. Chem. 1989 264: 13313-13320. [Abstract] [PDF]  

TA Woodford, LA Correll, GS McKnight, and JD Corbin
Expression and characterization of mutant forms of the type I regulatory subunit of cAMP-dependent protein kinase. The effect of defective cAMP binding on holoenzyme activation
J. Biol. Chem. 1989 264: 13321-13328. [Abstract] [PDF]  

DR Hampson, KD Wheaton, CJ Dechesne, and RJ Wenthold
Identification and characterization of the ligand binding subunit of a kainic acid receptor using monoclonal antibodies and peptide mapping
J. Biol. Chem. 1989 264: 13329-13335. [Abstract] [PDF]  

RK Hamatake, CC Dykstra, and A Sugino
Presynapsis and synapsis of DNA promoted by the STP alpha and single- stranded DNA-binding proteins from Saccharomyces cerevisiae
J. Biol. Chem. 1989 264: 13336-13342. [Abstract] [PDF]  

ST Sawyer
The two proteins of the erythropoietin receptor are structurally similar
J. Biol. Chem. 1989 264: 13343-13347. [Abstract] [PDF]  

RM Breyer and RT Sauer
Production and characterization of monoclonal antibodies to the N- terminal domain of lambda repressor
J. Biol. Chem. 1989 264: 13348-13354. [Abstract] [PDF]  

RM Breyer and RT Sauer
Mutational analysis of the fine specificity of binding of monoclonal antibody 51F to lambda repressor
J. Biol. Chem. 1989 264: 13355-13360. [Abstract] [PDF]  

H Takahara, M Tsuchida, M Kusubata, K Akutsu, S Tagami, and K Sugawara
Peptidylarginine deiminase of the mouse. Distribution, properties, and immunocytochemical localization
J. Biol. Chem. 1989 264: 13361-13368. [Abstract] [PDF]  


To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by the American Society for Biochemistry and Molecular Biology.