Editorial:

JBC Electronic Submission Required (Starting September 1, 2000)
J. Biol. Chem. 2000 275: 25055. [Full Text] [PDF]  

Minireviews:

Thomas V. O'Halloran and Valeria Cizewski Culotta

Metallochaperones, an Intracellular Shuttle Service for Metal Ions
J. Biol. Chem. 2000 275: 25057-25060. [Full Text] [PDF]  

Accelerated Publications:

Stefan Strack, A. J. Robison, Martha A. Bass, and Roger J. Colbran

Association of Calcium/Calmodulin-dependent Kinase II with Developmentally Regulated Splice Variants of the Postsynaptic Density Protein Densin-180
J. Biol. Chem. 2000 275: 25061-25064. [Abstract] [Full Text] [PDF]  

Anna A. Kuang, Gretchen E. Diehl, Jianke Zhang, and Astar Winoto

FADD Is Required for DR4- and DR5-mediated Apoptosis. LACK OF TRAIL-INDUCED APOPTOSIS IN FADD-DEFICIENT MOUSE EMBRYONIC FIBROBLASTS
J. Biol. Chem. 2000 275: 25065-25068. [Abstract] [Full Text] [PDF]  

George A. Mackie

Stabilization of Circular rpsT mRNA Demonstrates the 5'-End Dependence of RNase E Action in Vivo
J. Biol. Chem. 2000 275: 25069-25072. [Abstract] [Full Text] [PDF]  

DNA: Replication Repair and Recombination:

Mamuka Kvaratskhelia, Benjamin N. Wardleworth, David G. Norman, and Malcolm F. White

A Conserved Nuclease Domain in the Archaeal Holliday Junction Resolving Enzyme Hjc
J. Biol. Chem. 2000 275: 25540-25546. [Abstract] [Full Text] [PDF]  

Violetta Skalski, Kevin R. Brown, Bo Yon Choi, Zhen-Yuan Lin, and Shali Chen

A 3'-5' Exonuclease in Human Leukemia Cells. IMPLICATIONS FOR RESISTANCE TO 1--D-ARABINOFURANOSYLCYTOSINE AND 9--D-ARABINOFURANOSYL-2-FLUOROADENINE 5'-MONOPHOSPHATE
J. Biol. Chem. 2000 275: 25814-25819. [Abstract] [Full Text] [PDF]  

Genes: Structure and Regulation:

Kannan Thirunavukkarasu, David L. Halladay, Rebecca R. Miles, Xuhao Yang, Rachelle J. S. Galvin, S. Chandrasekhar, T. John Martin, and Jude E. Onyia

The Osteoblast-specific Transcription Factor Cbfa1 Contributes to the Expression of Osteoprotegerin, a Potent Inhibitor of Osteoclast Differentiation and Function
J. Biol. Chem. 2000 275: 25163-25172. [Abstract] [Full Text] [PDF]  

Stephen R. Biggar and Gerald R. Crabtree

Chemically Regulated Transcription Factors Reveal the Persistence of Repressor-resistant Transcription after Disrupting Activator Function
J. Biol. Chem. 2000 275: 25381-25390. [Abstract] [Full Text] [PDF]  

Cynthia Cheryl Smith, Yan Xing Yu, Michael Kulka, and Laure Aurelian

A Novel Human Gene Similar to the Protein Kinase (PK) Coding Domain of the Large Subunit of Herpes Simplex Virus Type 2 Ribonucleotide Reductase (ICP10) Codes for a Serine-Threonine PK and Is Expressed in Melanoma Cells
J. Biol. Chem. 2000 275: 25690-25699. [Abstract] [Full Text] [PDF]  

Mark W. Feinberg, Mukesh K. Jain, Frank Werner, Nicholas E. S. Sibinga, Philippe Wiesel, Hong Wang, James N. Topper, Mark A. Perrella, and Mu-En Lee

Transforming Growth Factor-1 Inhibits Cytokine-mediated Induction of Human Metalloelastase in Macrophages
J. Biol. Chem. 2000 275: 25766-25773. [Abstract] [Full Text] [PDF]  

Nobushige Tanaka, Hideto Yonekura, Sho-ichi Yamagishi, Hideki Fujimori, Yasuhiko Yamamoto, and Hiroshi Yamamoto

The Receptor for Advanced Glycation End Products Is Induced by the Glycation Products Themselves and Tumor Necrosis Factor- through Nuclear Factor-B, and by 17-Estradiol through Sp-1 in Human Vascular Endothelial Cells
J. Biol. Chem. 2000 275: 25781-25790. [Abstract] [Full Text] [PDF]  

Mohamed Ragaa Mohamed and Edward G. Niles

Interaction between Nucleoside Triphosphate Phosphohydrolase I and the H4L Subunit of the Viral RNA Polymerase Is Required for Vaccinia Virus Early Gene Transcript Release
J. Biol. Chem. 2000 275: 25798-25804. [Abstract] [Full Text] [PDF]  

Corinne Espéret, Sandrine Sabatier, Marie-Alice Deville, Roland Ouazana, Eric E. Bouhassira, Jacqueline Godet, François Morlé, and Agnès Bernet

Non-erythroid Genes Inserted on Either Side of Human HS-40 Impair the Activation of Its Natural -Globin Gene Targets without Being Themselves Preferentially Activated
J. Biol. Chem. 2000 275: 25831-25839. [Abstract] [Full Text] [PDF]  

Protein Synthesis Post-Translation Modification and Degradation:

Noriko Ishida, Masatoshi Kitagawa, Shigetsugu Hatakeyama, and Kei-ichi Nakayama

Phosphorylation at Serine 10, a Major Phosphorylation Site of p27^Kip1, Increases Its Protein Stability
J. Biol. Chem. 2000 275: 25146-25154. [Abstract] [Full Text] [PDF]  

Linda S. Musil, Anh-Chi N. Le, Judy K. VanSlyke, and Lori M. Roberts

Regulation of Connexin Degradation as a Mechanism to Increase Gap Junction Assembly and Function
J. Biol. Chem. 2000 275: 25207-25215. [Abstract] [Full Text] [PDF]  

Tomoko Kadowaki, Takayuki Tsukuba, Greg P. Bertenshaw, and Judith S. Bond

N-Linked Oligosaccharides on the Meprin A Metalloprotease Are Important for Secretion and Enzymatic Activity, but Not for Apical Targeting
J. Biol. Chem. 2000 275: 25577-25584. [Abstract] [Full Text] [PDF]  

Matthew E. Cockman, Norma Masson, David R. Mole, Panu Jaakkola, Gin-Wen Chang, Steven C. Clifford, Eamonn R. Maher, Christopher W. Pugh, Peter J. Ratcliffe, and Patrick H. Maxwell

Hypoxia Inducible Factor- Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein
J. Biol. Chem. 2000 275: 25733-25741. [Abstract] [Full Text] [PDF]  

Genomics Proteomics and Bioinformatics:

Sabine Zimmer, Achim Stocker, Mohammad N. Sarbolouki, Stefan E. Spycher, Judyth Sassoon, and Angelo Azzi

A Novel Human Tocopherol-associated Protein. CLONING, IN VITRO EXPRESSION, AND CHARACTERIZATION
J. Biol. Chem. 2000 275: 25672-25680. [Abstract] [Full Text] [PDF]  

Protein Structure and Folding:

Harold Tjalsma, Axel G. Stöver, Adam Driks, Gerard Venema, Sierd Bron, and Jan Maarten van Dijl

Conserved Serine and Histidine Residues Are Critical for Activity of the ER-type Signal Peptidase SipW of Bacillus subtilis
J. Biol. Chem. 2000 275: 25102-25108. [Abstract] [Full Text] [PDF]  

Eleri Hughes, Ron M. Burke, and Andrew J. Doig

Inhibition of Toxicity in the -Amyloid Peptide Fragment -(25-35) Using N-Methylated Derivatives. A GENERAL STRATEGY TO PREVENT AMYLOID FORMATION
J. Biol. Chem. 2000 275: 25109-25115. [Abstract] [Full Text] [PDF]  

David H. Ho, Karen Badellino, Frank A. Baglia, Mao-Fu Sun, Ming-Ming Zhao, David Gailani, and Peter N. Walsh

The Role of High Molecular Weight Kininogen and Prothrombin as Cofactors in the Binding of Factor XI A3 Domain to the Platelet Surface
J. Biol. Chem. 2000 275: 25139-25145. [Abstract] [Full Text] [PDF]  

Yuji Hidaka, Chisei Shimono, Megumu Ohno, Nobuaki Okumura, Knut Adermann, Wolf-Georg Forssmann, and Yasutsugu Shimonishi

Dual Function of the Propeptide of Prouroguanylin in the Folding of the Mature Peptide. DISULFIDE-COUPLED FOLDING AND DIMERIZATION
J. Biol. Chem. 2000 275: 25155-25162. [Abstract] [Full Text] [PDF]  

Toshio Iwasaki, Eiji Watanabe, Daijiro Ohmori, Takeo Imai, Akio Urushiyama, Minoru Akiyama, Yoko Hayashi-Iwasaki, Nathaniel J. Cosper, and Robert A. Scott

Spectroscopic Investigation of Selective Cluster Conversion of Archaeal Zinc-containing Ferredoxin from Sulfolobus sp. Strain 7
J. Biol. Chem. 2000 275: 25391-25401. [Abstract] [Full Text] [PDF]  

Thomas J. Podor, Stephen G. Shaughnessy, Michael N. Blackburn, and Cynthia B. Peterson

New Insights into the Size and Stoichiometry of the Plasminogen Activator Inhibitor Type-1·Vitronectin Complex
J. Biol. Chem. 2000 275: 25402-25410. [Abstract] [Full Text] [PDF]  

Yakov Paz, Zvulun Elazar, and Deborah Fass

Structure of GATE-16, Membrane Transport Modulator and Mammalian Ortholog of Autophagocytosis Factor Aut7p
J. Biol. Chem. 2000 275: 25445-25450. [Abstract] [Full Text] [PDF]  

Maurizio Mongiat, Gabriella Mungiguerra, Simonetta Bot, Maria Teresa Mucignat, Emiliana Giacomello, Roberto Doliana, and Alfonso Colombatti

Self-assembly and Supramolecular Organization of EMILIN
J. Biol. Chem. 2000 275: 25471-25480. [Abstract] [Full Text] [PDF]  

Elisabeth Busch, Erhard Hohenester, Rupert Timpl, Mats Paulsson, and Patrik Maurer

Calcium Affinity, Cooperativity, and Domain Interactions of Extracellular EF-hands Present in BM-40
J. Biol. Chem. 2000 275: 25508-25515. [Abstract] [Full Text] [PDF]  

Akira Katsumi, Elodee A. Tuley, Imre Bodó, and J. Evan Sadler

Localization of Disulfide Bonds in the Cystine Knot Domain of Human von Willebrand Factor
J. Biol. Chem. 2000 275: 25585-25594. [Abstract] [Full Text] [PDF]  

Tomohiro Mizobata, Masashi Kawagoe, Kunihiro Hongo, Jun Nagai, and Yasushi Kawata

Refolding of Target Proteins from a "Rigid" Mutant Chaperonin Demonstrates a Minimal Mechanism of Chaperonin Binding and Release
J. Biol. Chem. 2000 275: 25600-25607. [Abstract] [Full Text] [PDF]  

Sophie Michalet, Fatima Teixeira, Bernard Gilquin, Gilles Mourier, Denis Servent, Pascal Drevet, Patrice Binder, Socrates Tzartos, André Ménez, and Pascal Kessler

Relative Spatial Position of a Snake Neurotoxin and the Reduced Disulfide Bond (Cys¹⁹²-Cys¹⁹³) at the Interface of the Nicotinic Acetylcholine Receptor
J. Biol. Chem. 2000 275: 25608-25615. [Abstract] [Full Text] [PDF]  

Jonathan M. G. Higgins, Manuela Cernadas, Kemin Tan, Atsushi Irie, Jia-huai Wang, Yoshikazu Takada, and Michael B. Brenner

The Role of  and  Chains in Ligand Recognition by ₇ Integrins
J. Biol. Chem. 2000 275: 25652-25664. [Abstract] [Full Text] [PDF]  

Keiji Nogami, Midori Shima, Kazuya Hosokawa, Masanori Nagata, Takehiko Koide, Evgueni L. Saenko, Ichiro Tanaka, Masaru Shibata, and Akira Yoshioka

Factor VIII C2 Domain Contains the Thrombin-binding Site Responsible for Thrombin-catalyzed Cleavage at Arg¹⁶⁸⁹
J. Biol. Chem. 2000 275: 25774-25780. [Abstract] [Full Text] [PDF]  

Gregory C. Ireton, Lance Stewart, Leon H. Parker, and James J. Champoux

Expression of Human Topoisomerase I with a Partial Deletion of the Linker Region Yields Monomeric and Dimeric Enzymes That Respond Differently to Camptothecin
J. Biol. Chem. 2000 275: 25820-25830. [Abstract] [Full Text] [PDF]  

Enzyme Catalysis and Regulation:

Arif Jafferji, James W. A. Allen, Stuart J. Ferguson, and Vilmos Fülöp

X-ray Crystallographic Study of Cyanide Binding Provides Insights into the Structure-Function Relationship for Cytochrome cd₁ Nitrite Reductase from Paracoccus pantotrophus
J. Biol. Chem. 2000 275: 25089-25094. [Abstract] [Full Text] [PDF]  

Anna Cozzi, Barbara Corsi, Sonia Levi, Paolo Santambrogio, Alberto Albertini, and Paolo Arosio

Overexpression of Wild Type and Mutated Human Ferritin H-chain in HeLa Cells. IN VIVO ROLE OF FERRITIN FERROXIDASE ACTIVITY
J. Biol. Chem. 2000 275: 25122-25129. [Abstract] [Full Text] [PDF]  

Kazumi Hiraga, Takashi Suzuki, and Kohei Oda

A Novel Double-headed Proteinaceous Inhibitor for Metalloproteinase and Serine Proteinase
J. Biol. Chem. 2000 275: 25173-25179. [Abstract] [Full Text] [PDF]  

Bernat Crosas, Abdellah Allali-Hassani, Susana Eva Martínez, Sílvia Martras, Bengt Persson, Hans Jörnvall, Xavier Parés, and Jaume Farrés

Molecular Basis for Differential Substrate Specificity in Class IV Alcohol Dehydrogenases. A CONSERVED FUNCTION IN RETINOID METABOLISM BUT NOT IN ETHANOL OXIDATION
J. Biol. Chem. 2000 275: 25180-25187. [Abstract] [Full Text] [PDF]  

Deborah M. Leonard, Stanley J. Stachelek, Marjorie Safran, Alan P. Farwell, Timothy F. Kowalik, and Jack L. Leonard

Cloning, Expression, and Functional Characterization of the Substrate Binding Subunit of Rat Type II Iodothyronine 5'-Deiodinase
J. Biol. Chem. 2000 275: 25194-25201. [Abstract] [Full Text] [PDF]  

Alanna M. Hurne, Christina L. L. Chai, and Paul Waring

Inactivation of Rabbit Muscle Creatine Kinase by Reversible Formation of an Internal Disulfide Bond Induced by the Fungal Toxin Gliotoxin
J. Biol. Chem. 2000 275: 25202-25206. [Abstract] [Full Text] [PDF]  

Jennifer L. Mullin, Oleg V. Gorkun, Cameron G. Binnie, and Susan T. Lord

Recombinant Fibrinogen Studies Reveal That Thrombin Specificity Dictates Order of Fibrinopeptide Release
J. Biol. Chem. 2000 275: 25239-25246. [Abstract] [Full Text] [PDF]  

Yasmin Huque, Franck Fieschi, Eduard Torrents, Isidre Gibert, Rolf Eliasson, Peter Reichard, Margareta Sahlin, and Britt-Marie Sjöberg

The Active Form of the R2F Protein of Class Ib Ribonucleotide Reductase from Corynebacterium ammoniagenes Is a Diferric Protein
J. Biol. Chem. 2000 275: 25365-25371. [Abstract] [Full Text] [PDF]  

Elena Cabezon, P. Jonathan G. Butler, Michael J. Runswick, and John E. Walker

Modulation of the Oligomerization State of the Bovine F₁-ATPase Inhibitor Protein, IF₁, by pH
J. Biol. Chem. 2000 275: 25460-25464. [Abstract] [Full Text] [PDF]  

Christopher M. Yengo, Lyun R. Chrin, Arthur S. Rovner, and Christopher L. Berger

Tryptophan 512 Is Sensitive to Conformational Changes in the Rigid Relay Loop of Smooth Muscle Myosin during the MgATPase Cycle
J. Biol. Chem. 2000 275: 25481-25487. [Abstract] [Full Text] [PDF]  

Sergei Nechaev, Mark Chlenov, and Konstantin Severinov

Dissection of Two Hallmarks of the Open Promoter Complex by Mutation in an RNA Polymerase Core Subunit
J. Biol. Chem. 2000 275: 25516-25522. [Abstract] [Full Text] [PDF]  

David W. Gohara, Shane Crotty, Jamie J. Arnold, Joshua D. Yoder, Raul Andino, and Craig E. Cameron

Poliovirus RNA-dependent RNA Polymerase (3D^pol). STRUCTURAL, BIOCHEMICAL, AND BIOLOGICAL ANALYSIS OF CONSERVED STRUCTURAL MOTIFS A AND B
J. Biol. Chem. 2000 275: 25523-25532. [Abstract] [Full Text] [PDF]  

Jonathan M. Caruthers, Ilgu Kang, Michael J. Rynkiewicz, David E. Cane, and David W. Christianson

Crystal Structure Determination of Aristolochene Synthase from the Blue Cheese Mold, Penicillium roqueforti^*
J. Biol. Chem. 2000 275: 25533-25539. [Abstract] [Full Text] [PDF]  

Tamo Fukamizo, André H. Juffer, Hans J. Vogel, Yuji Honda, Hugo Tremblay, Isabelle Boucher, Witold A. Neugebauer, and Ryszard Brzezinski

Theoretical Calculation of pK_a Reveals an Important Role of Arg²⁰⁵ in the Activity and Stability of Streptomyces sp. N174 Chitosanase
J. Biol. Chem. 2000 275: 25633-25640. [Abstract] [Full Text] [PDF]  

Micky Tortorella, Michael Pratta, Rui-Qin Liu, Ilgar Abbaszade, Harold Ross, Timothy Burn, and Elizabeth Arner

The Thrombospondin Motif of Aggrecanase-1 (ADAMTS-4) Is Critical for Aggrecan Substrate Recognition and Cleavage
J. Biol. Chem. 2000 275: 25791-25797. [Abstract] [Full Text] [PDF]  

Metabolism and Bioenergetics:

Anita Matthias, Kerstin B. E. Ohlson, J. Magnus Fredriksson, Anders Jacobsson, Jan Nedergaard, and Barbara Cannon

Thermogenic Responses in Brown Fat Cells Are Fully UCP1-dependent. UCP2 OR UCP3 DO NOT SUBSTITUTE FOR UCP1 IN ADRENERGICALLY OR FATTY ACID-INDUCED THERMOGENESIS
J. Biol. Chem. 2000 275: 25073-25081. [Abstract] [Full Text] [PDF]  

Clary B. Clish, Bruce D. Levy, Nan Chiang, Hsin-Hsiung Tai, and Charles N. Serhan

Oxidoreductases in Lipoxin A₄ Metabolic Inactivation. A NOVEL ROLE FOR 15-OXOPROSTAGLANDIN 13-REDUCTASE/LEUKOTRIENE B₄ 12-HYDROXYDEHYDROGENASE IN INFLAMMATION
J. Biol. Chem. 2000 275: 25372-25380. [Abstract] [Full Text] [PDF]  

Glycobiology and Extracellular Matrices:

Jeremy J. Keusch, Stephen M. Manzella, Kwame A. Nyame, Richard D. Cummings, and Jacques U. Baenziger

Expression Cloning of a New Member of the ABO Blood Group Glycosyltransferases, iGb₃ Synthase, That Directs the Synthesis of Isoglobo-glycosphingolipids
J. Biol. Chem. 2000 275: 25308-25314. [Abstract] [Full Text] [PDF]  

Jeremy J. Keusch, Stephen M. Manzella, Kwame A. Nyame, Richard D. Cummings, and Jacques U. Baenziger

Cloning of Gb₃ Synthase, the Key Enzyme in Globo-series Glycosphingolipid Synthesis, Predicts a Family of 1,4-Glycosyltransferases Conserved in Plants, Insects, and Mammals
J. Biol. Chem. 2000 275: 25315-25321. [Abstract] [Full Text] [PDF]  

Ilia V. Fuki, Renato V. Iozzo, and Kevin Jon Williams

Perlecan Heparan Sulfate Proteoglycan. A NOVEL RECEPTOR THAT MEDIATES A DISTINCT PATHWAY FOR LIGAND CATABOLISM
J. Biol. Chem. 2000 275: 25742-25750. [Abstract] [Full Text] [PDF]  

Kaori Sato, Tetsuya Ebihara, Eijiro Adachi, Seiichi Kawashima, Shunji Hattori, and Shinkichi Irie

Possible Involvement of Aminotelopeptide in Self-assembly and Thermal Stability of Collagen I as Revealed by Its Removal with Proteases
J. Biol. Chem. 2000 275: 25870-25875. [Abstract] [Full Text] [PDF]  

Lipids and Lipoproteins:

Friedhelm Schroeder, Andrey Frolov, Olga Starodub, Barbara B. Atshaves, William Russell, Anca Petrescu, Huan Huang, Adalberto M. Gallegos, Avery McIntosh, Dana Tahotna, David H. Russell, Jeffrey T. Billheimer, Charles L. Baum, and Ann B. Kier

Pro-sterol Carrier Protein-2. ROLE OF THE N-TERMINAL PRESEQUENCE IN STRUCTURE, FUNCTION, AND PEROXISOMAL TARGETING
J. Biol. Chem. 2000 275: 25547-25555. [Abstract] [Full Text] [PDF]  

Annette Uittenbogaard and Eric J. Smart

Palmitoylation of Caveolin-1 Is Required for Cholesterol Binding, Chaperone Complex Formation, and Rapid Transport of Cholesterol to Caveolae
J. Biol. Chem. 2000 275: 25595-25599. [Abstract] [Full Text] [PDF]  

Membrane Transport Structure Function and Biogenesis:

Pierre Escoubas, Jan R. De Weille, Alain Lecoq, Sylvie Diochot, Rainer Waldmann, Guy Champigny, Danielle Moinier, André Ménez, and Michel Lazdunski

Isolation of a Tarantula Toxin Specific for a Class of Proton-gated Na⁺ Channels
J. Biol. Chem. 2000 275: 25116-25121. [Abstract] [Full Text] [PDF]  

Sul-Hee Chung, János Polgár, and Guy L. Reed

Protein Kinase C Phosphorylation of Syntaxin 4 in Thrombin-activated Human Platelets
J. Biol. Chem. 2000 275: 25286-25291. [Abstract] [Full Text] [PDF]  

Tianyan Gao, Moritz Bünemann, Brian L. Gerhardstein, Hong Ma, and M. Marlene Hosey

Role of the C terminus of the _1C (Ca_V1.2) Subunit in Membrane Targeting of Cardiac L-type Calcium Channels
J. Biol. Chem. 2000 275: 25436-25444. [Abstract] [Full Text] [PDF]  

Zhi Liu, Ying Chen, Rong Mo, Chi-chung Hui, Jan-Fang Cheng, Narla Mohandas, and Cheng-Han Huang

Characterization of Human RhCG and Mouse Rhcg as Novel Nonerythroid Rh Glycoprotein Homologues Predominantly Expressed in Kidney and Testis
J. Biol. Chem. 2000 275: 25641-25651. [Abstract] [Full Text] [PDF]  

Eric Turk, Olivia Kim, Johannes le Coutre, Julian P. Whitelegge, Sepehr Eskandari, Jason T. Lam, Michael Kreman, Guido Zampighi, Kym F. Faull, and Ernest M. Wright

Molecular Characterization of Vibrio parahaemolyticus vSGLT. A MODEL FOR SODIUM-COUPLED SUGAR COTRANSPORTERS
J. Biol. Chem. 2000 275: 25711-25716. [Abstract] [Full Text] [PDF]  

Sidney V. Scott, Daniel C. Nice, III, Johnathan J. Nau, Lois S. Weisman, Yoshiaki Kamada, Ineke Keizer-Gunnink, Tomoko Funakoshi, Marten Veenhuis, Yoshinori Ohsumi, and Daniel J. Klionsky

Apg13p and Vac8p Are Part of a Complex of Phosphoproteins That Are Required for Cytoplasm to Vacuole Targeting
J. Biol. Chem. 2000 275: 25840-25849. [Abstract] [Full Text] [PDF]  

Mechanisms Of Signal Transduction:

Sherri L. Rogalski, Suzanne M. Appleyard, Aaron Pattillo, Gregory W. Terman, and Charles Chavkin

TrkB Activation by Brain-derived Neurotrophic Factor Inhibits the G Protein-gated Inward Rectifier Kir3 by Tyrosine Phosphorylation of the Channel
J. Biol. Chem. 2000 275: 25082-25088. [Abstract] [Full Text] [PDF]  

Navdeep S. Chandel, David S. McClintock, Carlos E. Feliciano, Teresa M. Wood, J. Andres Melendez, Ana M. Rodriguez, and Paul T. Schumacker

Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1 during Hypoxia. A MECHANISM OF O₂ SENSING
J. Biol. Chem. 2000 275: 25130-25138. [Abstract] [Full Text] [PDF]  

Michael J. Shapiro, Ethan J. Weiss, Tatjana R. Faruqi, and Shaun R. Coughlin

Protease-activated Receptors 1 and 4 Are Shut Off with Distinct Kinetics after Activation by Thrombin
J. Biol. Chem. 2000 275: 25216-25221. [Abstract] [Full Text] [PDF]  

Isis Rivera-Walsh, Mary Ellen Cvijic, Gutian Xiao, and Shao-Cong Sun

The NF-B Signaling Pathway Is Not Required for Fas Ligand Gene Induction but Mediates Protection from Activation-induced Cell Death
J. Biol. Chem. 2000 275: 25222-25230. [Abstract] [Full Text] [PDF]  

Marion P. Boland, Katherine A. Fitzgerald, and Luke A. J. O'Neill

Topoisomerase II Is Required for Mitoxantrone to Signal Nuclear Factor B Activation in HL60 Cells
J. Biol. Chem. 2000 275: 25231-25238. [Abstract] [Full Text] [PDF]  

Mitsuko Hashiguchi, Kazuya Sobue, and Hemant K. Paudel

14-3-3 Is an Effector of Tau Protein Phosphorylation
J. Biol. Chem. 2000 275: 25247-25254. [Abstract] [Full Text] [PDF]  

Jeehyeon Bae, Chandra P. Leo, Sheau Yu Hsu, and Aaron J. W. Hsueh

MCL-1S, a Splicing Variant of the Antiapoptotic BCL-2 Family Member MCL-1, Encodes a Proapoptotic Protein Possessing Only the BH3 Domain
J. Biol. Chem. 2000 275: 25255-25261. [Abstract] [Full Text] [PDF]  

Lisa M. Bell, Meredith L. L. Leong, Brian Kim, Edward Wang, Jongsun Park, Brian A. Hemmings, and Gary L. Firestone

Hyperosmotic Stress Stimulates Promoter Activity and Regulates Cellular Utilization of the Serum- and Glucocorticoid-inducible Protein Kinase (Sgk) by a p38 MAPK-dependent Pathway
J. Biol. Chem. 2000 275: 25262-25272. [Abstract] [Full Text] [PDF]  

Yanping Wang, Olivier Robledo, Erin Kinzie, Frédéric Blanchard, Carl Richards, Atsushi Miyajima, and Heinz Baumann

Receptor Subunit-specific Action of Oncostatin M in Hepatic Cells and Its Modulation by Leukemia Inhibitory Factor
J. Biol. Chem. 2000 275: 25273-25285. [Abstract] [Full Text] [PDF]  

Baolin Zhang, Yaqin Zhang, Zhi-xin Wang, and Yi Zheng

The Role of Mg²⁺ Cofactor in the Guanine Nucleotide Exchange and GTP Hydrolysis Reactions of Rho Family GTP-binding Proteins
J. Biol. Chem. 2000 275: 25299-25307. [Abstract] [Full Text] [PDF]  

Janet E. Valentine, Eric Kalkhoven, Roger White, Sue Hoare, and Malcolm G. Parker

Mutations in the Estrogen Receptor Ligand Binding Domain Discriminate between Hormone-dependent Transactivation and Transrepression
J. Biol. Chem. 2000 275: 25322-25329. [Abstract] [Full Text] [PDF]  

John M. Schmitt and Philip J. S. Stork

₂-Adrenergic Receptor Activates Extracellular Signal-regulated Kinases (ERKs) via the Small G Protein Rap1 and the Serine/Threonine Kinase B-Raf
J. Biol. Chem. 2000 275: 25342-25350. [Abstract] [Full Text] [PDF]  

Michael J. O'Hare, Sheng T. Hou, Erick J. Morris, Sean P. Cregan, Qin Xu, Ruth S. Slack, and David S. Park

Induction and Modulation of Cerebellar Granule Neuron Death by E2F-1
J. Biol. Chem. 2000 275: 25358-25364. [Abstract] [Full Text] [PDF]  

An Boudrez, Monique Beullens, Peter Groenen, Aleyde Van Eynde, Veerle Vulsteke, Izabela Jagiello, Michael Murray, Adrian R. Krainer, Willy Stalmans, and Mathieu Bollen

NIPP1-mediated Interaction of Protein Phosphatase-1 with CDC5L, a Regulator of Pre-mRNA Splicing and Mitotic Entry
J. Biol. Chem. 2000 275: 25411-25417. [Abstract] [Full Text] [PDF]  

Jihong Bai, Cynthia A. Earles, Jessica L. Lewis, and Edwin R. Chapman

Membrane-embedded Synaptotagmin Penetrates cis or trans Target Membranes and Clusters via a Novel Mechanism
J. Biol. Chem. 2000 275: 25427-25435. [Abstract] [Full Text] [PDF]  

Barbara Valentinis, Magali Navarro, Tommaso Zanocco-Marani, Pamela Edmonds, Jason McCormick, Andrea Morrione, Ada Sacchi, Gaetano Romano, Krzysztof Reiss, and Renato Baserga

Insulin Receptor Substrate-1, p70^S6K, and Cell Size in Transformation and Differentiation of Hemopoietic Cells
J. Biol. Chem. 2000 275: 25451-25459. [Abstract] [Full Text] [PDF]  

Edward J. Kaftan, Tao Xu, Ronald F. Abercrombie, and Bertil Hille

Mitochondria Shape Hormonally Induced Cytoplasmic Calcium Oscillations and Modulate Exocytosis
J. Biol. Chem. 2000 275: 25465-25470. [Abstract] [Full Text] [PDF]  

Shigeko Yamashita, Naoki Mochizuki, Yusuke Ohba, Minoru Tobiume, Yuki Okada, Hirofumi Sawa, Kazuo Nagashima, and Michiyuki Matsuda

CalDAG-GEFIII Activation of Ras, R-Ras, and Rap1
J. Biol. Chem. 2000 275: 25488-25493. [Abstract] [Full Text] [PDF]  

Mathias Fasshauer, Johannes Klein, Kohjiro Ueki, Kristina M. Kriauciunas, Manuel Benito, Morris F. White, and C. Ronald Kahn

Essential Role of Insulin Receptor Substrate-2 in Insulin Stimulation of Glut4 Translocation and Glucose Uptake in Brown Adipocytes
J. Biol. Chem. 2000 275: 25494-25501. [Abstract] [Full Text] [PDF]  

Lothar Rössig, Judith Haendeler, Corinna Hermann, Philipp Malchow, Carmen Urbich, Andreas M. Zeiher, and Stefanie Dimmeler

Nitric Oxide Down-regulates MKP-3 mRNA Levels. INVOLVEMENT IN ENDOTHELIAL CELL PROTECTION FROM APOPTOSIS
J. Biol. Chem. 2000 275: 25502-25507. [Abstract] [Full Text] [PDF]  

Tara Mirzadegan, Frank Diehl, Bettina Ebi, Sunil Bhakta, Irene Polsky, Deborah McCarley, Mary Mulkins, Gabe S. Weatherhead, Jean-Marc Lapierre, John Dankwardt, David Morgans, Jr., Robert Wilhelm, and Kurt Jarnagin

Identification of the Binding Site for a Novel Class of CCR2b Chemokine Receptor Antagonists. BINDING TO A COMMON CHEMOKINE RECEPTOR MOTIF WITHIN THE HELICAL BUNDLE
J. Biol. Chem. 2000 275: 25562-25571. [Abstract] [Full Text] [PDF]  

Li-Xin Feng, Neelakanta Ravindranath, and Martin Dym

Stem Cell Factor/c-kit Up-regulates Cyclin D3 and Promotes Cell Cycle Progression via the Phosphoinositide 3-Kinase/p70 S6 Kinase Pathway in Spermatogonia
J. Biol. Chem. 2000 275: 25572-25576. [Abstract] [Full Text] [PDF]  

Michael Gotthardt, Marion Trommsdorff, Matthew F. Nevitt, John Shelton, James A. Richardson, Walter Stockinger, Johannes Nimpf, and Joachim Herz

Interactions of the Low Density Lipoprotein Receptor Gene Family with Cytosolic Adaptor and Scaffold Proteins Suggest Diverse Biological Functions in Cellular Communication and Signal Transduction
J. Biol. Chem. 2000 275: 25616-25624. [Abstract] [Full Text] [PDF]  

Walter Stockinger, Christian Brandes, Daniela Fasching, Marcela Hermann, Michael Gotthardt, Joachim Herz, Wolfgang J. Schneider, and Johannes Nimpf

The Reelin Receptor ApoER2 Recruits JNK-interacting Proteins-1 and -2
J. Biol. Chem. 2000 275: 25625-25632. [Abstract] [Full Text] [PDF]  

Chun-Ying Li, Jae-Seon Lee, Young-Gyu Ko, Jong-Il Kim, and Jeong-Sun Seo

Heat Shock Protein 70 Inhibits Apoptosis Downstream of Cytochrome c Release and Upstream of Caspase-3 Activation
J. Biol. Chem. 2000 275: 25665-25671. [Abstract] [Full Text] [PDF]  

Ernesto Bernal-Mizrachi, Burton Wice, Hiroshi Inoue, and M. Alan Permutt

Activation of Serum Response Factor in the Depolarization Induction of Egr-1 Transcription in Pancreatic Islet -Cells
J. Biol. Chem. 2000 275: 25681-25689. [Abstract] [Full Text] [PDF]  

Helen J. Walter, Thomas McMahon, Jahan Dadgar, Dan Wang, and Robert O. Messing

Ethanol Regulates Calcium Channel Subunits by Protein Kinase C -dependent and -independent Mechanisms
J. Biol. Chem. 2000 275: 25717-25722. [Abstract] [Full Text] [PDF]  

Albert Smolenski, Wolfgang Poller, Ulrich Walter, and Suzanne M. Lohmann

Regulation of Human Endothelial Cell Focal Adhesion Sites and Migration by cGMP-dependent Protein Kinase I
J. Biol. Chem. 2000 275: 25723-25732. [Abstract] [Full Text] [PDF]  

Anne M. Crompton, Louise H. Foley, Alexander Wood, William Roscoe, David Stokoe, Frank McCormick, Marc Symons, and Gideon Bollag

Regulation of Tiam1 Nucleotide Exchange Activity by Pleckstrin Domain Binding Ligands
J. Biol. Chem. 2000 275: 25751-25759. [Abstract] [Full Text] [PDF]  

James D. Stockand, Hui-Fang Bao, Julie Schenck, Bela Malik, Pam Middleton, Lynn E. Schlanger, and Douglas C. Eaton

Differential Effects of Protein Kinase C on the Levels of Epithelial Na⁺ Channel Subunit Proteins
J. Biol. Chem. 2000 275: 25760-25765. [Abstract] [Full Text] [PDF]  

Bob van de Water, Ine B. Tijdens, Annelies Verbrugge, Merei Huigsloot, Ashwin A. Dihal, James L. Stevens, Susan Jaken, and Gerard J. Mulder

Cleavage of the Actin-capping Protein -Adducin at Asp-Asp-Ser-Asp⁶³³-Ala by Caspase-3 Is Preceded by Its Phosphorylation on Serine 726 in Cisplatin-induced Apoptosis of Renal Epithelial Cells
J. Biol. Chem. 2000 275: 25805-25813. [Abstract] [Full Text] [PDF]  

Wen-Ling Shih, Min-Liang Kuo, Shuang-En Chuang, Ann-Lii Cheng, and Shin-Lian Doong

Hepatitis B Virus X Protein Inhibits Transforming Growth Factor--induced Apoptosis through the Activation of Phosphatidylinositol 3-Kinase Pathway
J. Biol. Chem. 2000 275: 25858-25864. [Abstract] [Full Text] [PDF]  

Yi Tan, Matthew R. Demeter, Hong Ruan, and Michael J. Comb

BAD Ser-155 Phosphorylation Regulates BAD/Bcl-XL Interaction and Cell Survival
J. Biol. Chem. 2000 275: 25865-25869. [Abstract] [Full Text] [PDF]  

Molecular Basis Of Cell and Developmental Biology:

Helen Petropoulos and Ilona S. Skerjanc

Analysis of the Inhibition of MyoD Activity by ITF-2B and Full-length E12/E47
J. Biol. Chem. 2000 275: 25095-25101. [Abstract] [Full Text] [PDF]  

Jeffrey P. Krise, Paul M. Sincock, Joke G. Orsel, and Suzanne R. Pfeffer

Quantitative Analysis of TIP47-Receptor Cytoplasmic Domain Interactions. IMPLICATIONS FOR ENDOSOME-TO-TRANS GOLGI NETWORK TRAFFICKING
J. Biol. Chem. 2000 275: 25188-25193. [Abstract] [Full Text] [PDF]  

Melissa S. Sayer, Peta A. Tilbrook, Angelo Spadaccini, Evan Ingley, Mohinder K. Sarna, James H. Williams, Nancy C. Andrews, and S. Peter Klinken

Ectopic Expression of Transcription Factor NF-E2 Alters the Phenotype of Erythroid and Monoblastoid Cells
J. Biol. Chem. 2000 275: 25292-25298. [Abstract] [Full Text] [PDF]  

Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto, Tsuyoshi Kakita, Tetsuhiko Yanazume, and Shigetake Sasayama

A p300 Protein as a Coactivator of GATA-6 in the Transcription of the Smooth Muscle-Myosin Heavy Chain Gene
J. Biol. Chem. 2000 275: 25330-25335. [Abstract] [Full Text] [PDF]  

Jaleh Doostzadeh-Cizeron, Shenmin Yin, and David W. Goodrich

Apoptosis Induced by the Nuclear Death Domain Protein p84N5 Is Associated with Caspase-6 and NF-B Activation
J. Biol. Chem. 2000 275: 25336-25341. [Abstract] [Full Text] [PDF]  

Mary A. Bittner and Ronald W. Holz

Latrotoxin Stimulates Secretion in Permeabilized Cells by Regulating an Intracellular Ca²⁺- and ATP-dependent Event. A ROLE FOR PROTEIN KINASE C
J. Biol. Chem. 2000 275: 25351-25357. [Abstract] [Full Text] [PDF]  

Steven S. Rosenfeld, Jun Xing, Michael Whitaker, Herbert C. Cheung, Fred Brown, Amber Wells, Ron A. Milligan, and H. Lee Sweeney

Kinetic and Spectroscopic Evidence for Three Actomyosin:ADP States in Smooth Muscle
J. Biol. Chem. 2000 275: 25418-25426. [Abstract] [Full Text] [PDF]  

Bruno Allard, Marie-Lise Couble, Henry Magloire, and Françoise Bleicher

Characterization and Gene Expression of High Conductance Calcium-activated Potassium Channels Displaying Mechanosensitivity in Human Odontoblasts
J. Biol. Chem. 2000 275: 25556-25561. [Abstract] [Full Text] [PDF]  

Kanji Okumoto, Isao Abe, and Yukio Fujiki

Molecular Anatomy of the Peroxin Pex12p. RING FINGER DOMAIN IS ESSENTIAL FOR Pex12p FUNCTION AND INTERACTS WITH THE PEROXISOME-TARGETING SIGNAL TYPE 1-RECEPTOR Pex5p AND A RING PEROXIN, Pex10p
J. Biol. Chem. 2000 275: 25700-25710. [Abstract] [Full Text] [PDF]  

Hwa-Chain R. Wang and Kellie A. Fecteau

Detection of a Novel Quiescence-dependent Protein Kinase
J. Biol. Chem. 2000 275: 25850-25857. [Abstract] [Full Text] [PDF]  

Additions and Corrections:

Michael J. Orsini, Jean-Luc Parent, Stuart J. Mundell, Adriano Marchese, and Jeffrey L. Benovic

Trafficking of the HIV coreceptor CXCR4: Role of arrestins and identification of residues in the C-terminal tail that mediate receptor internalization.
J. Biol. Chem. 2000 275: 25876. [Full Text] [PDF]  

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