Minireviews:

Murray P. Deutscher

Degradation of Stable RNA in Bacteria
J. Biol. Chem. 2003 278: 45041-45044. First Published on August 26, 2003; doi:10.1074/jbc.R300031200 [Full Text] [PDF]  

Accelerated Publications:

Hanne Hastrup, Namita Sen, and Jonathan A. Javitch

The Human Dopamine Transporter Forms a Tetramer in the Plasma Membrane: CROSS-LINKING OF A CYSTEINE IN THE FOURTH TRANSMEMBRANE SEGMENT IS SENSITIVE TO COCAINE ANALOGS
J. Biol. Chem. 2003 278: 45045-45048. First Published on September 30, 2003; doi:10.1074/jbc.C300349200 [Abstract] [Full Text] [PDF]  

DNA: Replication, Repair, and Recombination:

Joanna S. Bell and Richard McCulloch

Mismatch Repair Regulates Homologous Recombination, but Has Little Influence on Antigenic Variation, in Trypanosoma brucei
J. Biol. Chem. 2003 278: 45182-45188. First Published on August 21, 2003; doi:10.1074/jbc.M308123200 [Abstract] [Full Text] [PDF]  

Zhenping Zhong, Donald Helinski, and Aresa Toukdarian

A Specific Region in the N Terminus of a Replication Initiation Protein of Plasmid RK2 Is Required for Recruitment of Pseudomonas aeruginosa DnaB Helicase to the Plasmid Origin
J. Biol. Chem. 2003 278: 45305-45310. First Published on September 2, 2003; doi:10.1074/jbc.M306058200 [Abstract] [Full Text] [PDF]  

Catherine A. French, Cathryn E. Tambini, and John Thacker

Identification of Functional Domains in the RAD51L2 (RAD51C) Protein and Its Requirement for Gene Conversion
J. Biol. Chem. 2003 278: 45445-45450. First Published on September 8, 2003; doi:10.1074/jbc.M308621200 [Abstract] [Full Text] [PDF]  

YoungHo Kwon and Michael J. Smerdon

Binding of Zinc Finger Protein Transcription Factor IIIA to Its Cognate DNA Sequence with Single UV Photoproducts at Specific Sites and Its Effect on DNA Repair
J. Biol. Chem. 2003 278: 45451-45459. First Published on September 8, 2003; doi:10.1074/jbc.M308645200 [Abstract] [Full Text] [PDF]  

W. Hayes McDonald, Yelena Pavlova, John R. Yates, III, and Michael N. Boddy

Novel Essential DNA Repair Proteins Nse1 and Nse2 Are Subunits of the Fission Yeast Smc5-Smc6 Complex
J. Biol. Chem. 2003 278: 45460-45467. First Published on September 8, 2003; doi:10.1074/jbc.M308828200 [Abstract] [Full Text] [PDF]  

Mayuresh M. Abhyankar, S. Zzaman, and Deepak Bastia

Reconstitution of R6K DNA Replication in Vitro Using 22 Purified Proteins
J. Biol. Chem. 2003 278: 45476-45484. First Published on September 10, 2003; doi:10.1074/jbc.M308516200 [Abstract] [Full Text] [PDF]  

Edgardo R. Parrilla-Castellar and Larry M. Karnitz

Cut5 Is Required for the Binding of Atr and DNA Polymerase to Genotoxin-damaged Chromatin
J. Biol. Chem. 2003 278: 45507-45511. First Published on October 2, 2003; doi:10.1074/jbc.C300418200 [Abstract] [Full Text] [PDF]  

Sung-Hun Bae, Hae-Kap Cheong, Chaejoon Cheong, Sukhyun Kang, Deog Su Hwang, and Byong-Seok Choi

Structure and Dynamics of Hemimethylated GATC Sites: IMPLICATIONS FOR DNA-SeqA RECOGNITION
J. Biol. Chem. 2003 278: 45987-45993. First Published on August 27, 2003; doi:10.1074/jbc.M306038200 [Abstract] [Full Text] [PDF]  

Genes: Structure and Regulation:

Hye Sook Jeong, Myoung Hee Lee, Kyu-Ho Lee, Soon-Jung Park, and Sang Ho Choi

SmcR and Cyclic AMP Receptor Protein Coactivate Vibrio vulnificus vvpE Encoding Elastase through the RpoS-dependent Promoter in a Synergistic Manner
J. Biol. Chem. 2003 278: 45072-45081. First Published on August 28, 2003; doi:10.1074/jbc.M308184200 [Abstract] [Full Text] [PDF]  

Paul O. Hassa, Christine Buerki, Cornelia Lombardi, Ralph Imhof, and Michael O. Hottiger

Transcriptional Coactivation of Nuclear Factor-B-dependent Gene Expression by p300 Is Regulated by Poly(ADP)-ribose Polymerase-1
J. Biol. Chem. 2003 278: 45145-45153. First Published on September 5, 2003; doi:10.1074/jbc.M307957200 [Abstract] [Full Text] [PDF]  

Cornelia Brunner, Helmut Laumen, Peter J. Nielsen, Norbert Kraut, and Thomas Wirth

Expression of the Aldehyde Dehydrogenase 2-like Gene Is Controlled by BOB.1/OBF.1 in B Lymphocytes
J. Biol. Chem. 2003 278: 45231-45239. First Published on August 28, 2003; doi:10.1074/jbc.M302539200 [Abstract] [Full Text] [PDF]  

Susan Ruone, Alison R. Rhoades, and Tim Formosa

Multiple Nhp6 Molecules Are Required to Recruit Spt16-Pob3 to Form yFACT Complexes and to Reorganize Nucleosomes
J. Biol. Chem. 2003 278: 45288-45295. First Published on September 1, 2003; doi:10.1074/jbc.M307291200 [Abstract] [Full Text] [PDF]  

Claudia M. Litterst, Stefanie Kliem, Dominique Marilley, and Edith Pfitzner

NCoA-1/SRC-1 Is an Essential Coactivator of STAT5 That Binds to the FDL Motif in the -Helical Region of the STAT5 Transactivation Domain
J. Biol. Chem. 2003 278: 45340-45351. First Published on September 3, 2003; doi:10.1074/jbc.M303644200 [Abstract] [Full Text] [PDF]  

Mahesh B. Chandrasekharan, Guofu Li, Kenneth J. Bishop, and Timothy C. Hall

S Phase Progression Is Required for Transcriptional Activation of the -Phaseolin Promoter
J. Biol. Chem. 2003 278: 45397-45405. First Published on September 5, 2003; doi:10.1074/jbc.M307787200 [Abstract] [Full Text] [PDF] Supplemental Data  

Joy X. S. Jiang, Roy C. Y. Choi, Nina L. Siow, Henry H. C. Lee, David C. C. Wan, and Karl W. K. Tsim

Muscle Induces Neuronal Expression of Acetylcholinesterase in Neuron-Muscle Co-culture: TRANSCRIPTIONAL REGULATION MEDIATED BY cAMP-DEPENDENT SIGNALING
J. Biol. Chem. 2003 278: 45435-45444. First Published on September 8, 2003; doi:10.1074/jbc.M306320200 [Abstract] [Full Text] [PDF]  

Juan Jurado, María-José Prieto-Álamo, José Madrid-Rísquez, and Carmen Pueyo

Absolute Gene Expression Patterns of Thioredoxin and Glutaredoxin Redox Systems in Mouse
J. Biol. Chem. 2003 278: 45546-45554. First Published on September 3, 2003; doi:10.1074/jbc.M307866200 [Abstract] [Full Text] [PDF]  

SangYoon Han, Wensheng Xie, Stephen R. Hammes, and Jeff DeJong

Expression of the Germ Cell-specific Transcription Factor ALF in Xenopus Oocytes Compensates for Translational Inactivation of the Somatic Factor TFIIA
J. Biol. Chem. 2003 278: 45586-45593. First Published on August 14, 2003; doi:10.1074/jbc.M302884200 [Abstract] [Full Text] [PDF]  

Manfred Kunz, Steffen Moeller, Dirk Koczan, Peter Lorenz, Roland H. Wenger, Michael O. Glocker, Hans-Juergen Thiesen, Gerd Gross, and Saleh M. Ibrahim

Mechanisms of Hypoxic Gene Regulation of Angiogenesis Factor Cyr61 in Melanoma Cells
J. Biol. Chem. 2003 278: 45651-45660. First Published on August 25, 2003; doi:10.1074/jbc.M301373200 [Abstract] [Full Text] [PDF]  

Ying-Nai Wang and Wen-Chang Chang

Induction of Disease-associated Keratin 16 Gene Expression by Epidermal Growth Factor Is Regulated through Cooperation of Transcription Factors Sp1 and c-Jun
J. Biol. Chem. 2003 278: 45848-45857. First Published on September 3, 2003; doi:10.1074/jbc.M302630200 [Abstract] [Full Text] [PDF]  

Nicoletta Guaragnella and Ronald A. Butow

ATO3 Encoding a Putative Outward Ammonium Transporter Is an RTG-independent Retrograde Responsive Gene Regulated by GCN4 and the Ssy1-Ptr3-Ssy5 Amino Acid Sensor System
J. Biol. Chem. 2003 278: 45882-45887. First Published on September 9, 2003; doi:10.1074/jbc.M309301200 [Abstract] [Full Text] [PDF]  

Shinya Takahata, Hidei Ryu, Kazushige Ohtsuki, Koji Kasahara, Masashi Kawaichi, and Tetsuro Kokubo

Identification of a Novel TATA Element-binding Protein Binding Region at the N Terminus of the Saccharomyces cerevisiae TAF1 Protein
J. Biol. Chem. 2003 278: 45888-45902. First Published on August 25, 2003; doi:10.1074/jbc.M306886200 [Abstract] [Full Text] [PDF]  

RNA: Structure, Metabolism, and Catalysis:

Kirk Beebe, Eve Merriman, and Paul Schimmel

Structure-specific tRNA Determinants for Editing a Mischarged Amino Acid
J. Biol. Chem. 2003 278: 45056-45061. First Published on August 28, 2003; doi:10.1074/jbc.M307080200 [Abstract] [Full Text] [PDF]  

Muralikrishna Vemula, Pitchaimani Kandasamy, Chan-Seok Oh, Ramesh Chellappa, Carlos I. Gonzalez, and Charles E. Martin

Maintenance and Regulation of mRNA Stability of the Saccharomyces cerevisiae OLE1 Gene Requires Multiple Elements within the Transcript That Act through Translation-independent Mechanisms
J. Biol. Chem. 2003 278: 45269-45279. First Published on August 28, 2003; doi:10.1074/jbc.M308812200 [Abstract] [Full Text] [PDF]  

Protein Synthesis, Post-Translation Modification, and Degradation:

Mohamed Benderdour, Guy Charron, Denis deBlois, Blandine Comte, and Christine Des Rosiers

Cardiac Mitochondrial NADP⁺-isocitrate Dehydrogenase Is Inactivated through 4-Hydroxynonenal Adduct Formation: AN EVENT THAT PRECEDES HYPERTROPHY DEVELOPMENT
J. Biol. Chem. 2003 278: 45154-45159. First Published on September 6, 2003; doi:10.1074/jbc.M306285200 [Abstract] [Full Text] [PDF]  

Nono Takeuchi and Takuya Ueda

Down-regulation of the Mitochondrial Translation System during Terminal Differentiation of HL-60 cells by 12-O-Tetradecanoyl-1-phorbol-13-acetate: COMPARISON WITH THE CYTOPLASMIC TRANSLATION SYSTEM
J. Biol. Chem. 2003 278: 45318-45324. First Published on September 2, 2003; doi:10.1074/jbc.M307620200 [Abstract] [Full Text] [PDF]  

Steeve Boulant, Michel Becchi, François Penin, and Jean-Pierre Lavergne

Unusual Multiple Recoding Events Leading to Alternative Forms of Hepatitis C Virus Core Protein from Genotype 1b
J. Biol. Chem. 2003 278: 45785-45792. First Published on September 2, 2003; doi:10.1074/jbc.M307174200 [Abstract] [Full Text] [PDF]  

Hidehiko Kawai, Dmitri Wiederschain, Hiroyuki Kitao, Jeremy Stuart, Kelvin K. C. Tsai, and Zhi-Min Yuan

DNA Damage-induced MDMX Degradation Is Mediated by MDM2
J. Biol. Chem. 2003 278: 45946-45953. First Published on September 8, 2003; doi:10.1074/jbc.M308295200 [Abstract] [Full Text] [PDF]  

Giuseppina Tesco, Young Ho Koh, and Rudolph E. Tanzi

Caspase Activation Increases -Amyloid Generation Independently of Caspase Cleavage of the -Amyloid Precursor Protein (APP)
J. Biol. Chem. 2003 278: 46074-46080. First Published on September 5, 2003; doi:10.1074/jbc.M307809200 [Abstract] [Full Text] [PDF]  

Genomics, Proteomics, and Bioinformatics:

Nicole M. Verrills, Bradley J. Walsh, Gary S. Cobon, Peter G. Hains, and Maria Kavallaris

Proteome Analysis of Vinca Alkaloid Response and Resistance in Acute Lymphoblastic Leukemia Reveals Novel Cytoskeletal Alterations
J. Biol. Chem. 2003 278: 45082-45093. First Published on August 29, 2003; doi:10.1074/jbc.M303378200 [Abstract] [Full Text] [PDF] Supplemental Data  

Weimin Zhong, Pedro A. Reche, Char-Chang Lai, Bruce Reinhold, and Ellis L. Reinherz

Genome-wide Characterization of a Viral Cytotoxic T Lymphocyte Epitope Repertoire
J. Biol. Chem. 2003 278: 45135-45144. First Published on September 5, 2003; doi:10.1074/jbc.M307417200 [Abstract] [Full Text] [PDF] Supplemental Data  

George H. Searfoss, William H. Jordan, David O. Calligaro, Elizabeth J. Galbreath, Linda M. Schirtzinger, Brian R. Berridge, Hong Gao, Marnie A. Higgins, Patrick C. May, and Timothy P. Ryan

Adipsin, a Biomarker of Gastrointestinal Toxicity Mediated by a Functional -Secretase Inhibitor
J. Biol. Chem. 2003 278: 46107-46116. First Published on August 29, 2003; doi:10.1074/jbc.M307757200 [Abstract] [Full Text] [PDF]  

Richard Vernell, Kristian Helin, and Heiko Müller

Identification of Target Genes of the p16^INK4A-pRB-E2F Pathway
J. Biol. Chem. 2003 278: 46124-46137. First Published on August 15, 2003; doi:10.1074/jbc.M304930200 [Abstract] [Full Text] [PDF] Supplemental Data  

Protein Structure and Folding:

Jean-Francois Collet, Jonathan Conrad D'Souza, Ursula Jakob, and James C. A. Bardwell

Thioredoxin 2, an Oxidative Stress-induced Protein, Contains a High Affinity Zinc Binding Site
J. Biol. Chem. 2003 278: 45325-45332. First Published on September 2, 2003; doi:10.1074/jbc.M307818200 [Abstract] [Full Text] [PDF]  

Triantafyllos Chavakis, Sentot Santoso, Kenneth J. Clemetson, Ulrich J. H. Sachs, Irma Isordia-Salas, Robin A. Pixley, Peter P. Nawroth, Robert W. Colman, and Klaus T. Preissner

High Molecular Weight Kininogen Regulates Platelet-Leukocyte Interactions by Bridging Mac-1 and Glycoprotein Ib
J. Biol. Chem. 2003 278: 45375-45381. First Published on September 2, 2003; doi:10.1074/jbc.M304344200 [Abstract] [Full Text] [PDF]  

Daniel Monleón, M. Paz Moreno-Murciano, Helena Kovacs, Cezary Marcinkiewicz, Juan J. Calvete, and Bernardo Celda

Concerted Motions of the Integrin-binding Loop and the C-terminal Tail of the Non-RGD Disintegrin Obtustatin
J. Biol. Chem. 2003 278: 45570-45576. First Published on August 28, 2003; doi:10.1074/jbc.M307030200 [Abstract] [Full Text] [PDF]  

Rodolfo Ghirlando and Cecelia D. Trainor

Determinants of GATA-1 Binding to DNA: THE ROLE OF NON-FINGER RESIDUES
J. Biol. Chem. 2003 278: 45620-45628. First Published on August 26, 2003; doi:10.1074/jbc.M306410200 [Abstract] [Full Text] [PDF]  

Zhen Zhang and Timothy Palzkill

Determinants of Binding Affinity and Specificity for the Interaction of TEM-1 and SME-1 -Lactamase with -Lactamase Inhibitory Protein
J. Biol. Chem. 2003 278: 45706-45712. First Published on August 21, 2003; doi:10.1074/jbc.M308572200 [Abstract] [Full Text] [PDF]  

Klaas A. E. van't Slot, Harrold A. van den Burg, Cathelijne P. A. M. Kloks, Cornelis W. Hilbers, Wolfgang Knogge, and Christina H. M. Papavoine

Solution Structure of the Plant Disease Resistance-triggering Protein NIP1 from the Fungus Rhynchosporium secalis Shows a Novel -Sheet Fold
J. Biol. Chem. 2003 278: 45730-45736. First Published on August 27, 2003; doi:10.1074/jbc.M308304200 [Abstract] [Full Text] [PDF]  

Kevin H. Mayo, Ruud P. M. Dings, Carolee Flader, Irina Nesmelova, Balasz Hargittai, Daisy W. J. van der Schaft, Loes I. van Eijk, Dinesha Walek, Judy Haseman, Thomas R. Hoye, and Arjan W. Griffioen

Design of a Partial Peptide Mimetic of Anginex with Antiangiogenic and Anticancer Activity
J. Biol. Chem. 2003 278: 45746-45752. First Published on August 28, 2003; doi:10.1074/jbc.M308608200 [Abstract] [Full Text] [PDF]  

Fabio Arnesano, Lucia Banci, Manuela Benvenuti, Ivano Bertini, Vito Calderone, Stefano Mangani, and Maria Silvia Viezzoli

The Evolutionarily Conserved Trimeric Structure of CutA1 Proteins Suggests a Role in Signal Transduction
J. Biol. Chem. 2003 278: 45999-46006. First Published on August 29, 2003; doi:10.1074/jbc.M304398200 [Abstract] [Full Text] [PDF] Supplemental Data  

Kuen-Phon Wu, Chih-Wei Wu, Ya-Ping Tsao, Ting-Wei Kuo, Yuan-Chao Lou, Cheng-Wen Lin, Suh-Chin Wu, and Jya-Wei Cheng

Structural Basis of a Flavivirus Recognized by Its Neutralizing Antibody: SOLUTION STRUCTURE OF THE DOMAIN III OF THE JAPANESE ENCEPHALITIS VIRUS ENVELOPE PROTEIN
J. Biol. Chem. 2003 278: 46007-46013. First Published on September 2, 2003; doi:10.1074/jbc.M307776200 [Abstract] [Full Text] [PDF]  

Guennadi Kozlov, John Lee, Demetra Elias, Michel Gravel, Pablo Gutierrez, Irena Ekiel, Peter E. Braun, and Kalle Gehring

Structural Evidence That Brain Cyclic Nucleotide Phosphodiesterase Is a Member of the 2H Phosphodiesterase Superfamily
J. Biol. Chem. 2003 278: 46021-46028. First Published on August 28, 2003; doi:10.1074/jbc.M305176200 [Abstract] [Full Text] [PDF]  

Rie Omi, Masaru Goto, Ikuko Miyahara, Hiroyuki Mizuguchi, Hideyuki Hayashi, Hiroyuki Kagamiyama, and Ken Hirotsu

Crystal Structures of Threonine Synthase from Thermus thermophilus HB8: CONFORMATIONAL CHANGE, SUBSTRATE RECOGNITION, AND MECHANISM
J. Biol. Chem. 2003 278: 46035-46045. First Published on September 2, 2003; doi:10.1074/jbc.M308065200 [Abstract] [Full Text] [PDF]  

Toshiyuki Shimizu, Kentaro Ihara, Ryoko Maesaki, Mutsuki Amano, Kozo Kaibuchi, and Toshio Hakoshima

Parallel Coiled-coil Association of the RhoA-binding Domain in Rho-kinase
J. Biol. Chem. 2003 278: 46046-46051. First Published on September 3, 2003; doi:10.1074/jbc.M306458200 [Abstract] [Full Text] [PDF]  

Christine E. Foster, Marco Colonna, and Peter D. Sun

Crystal Structure of the Human Natural Killer (NK) Cell Activating Receptor NKp46 Reveals Structural Relationship to Other Leukocyte Receptor Complex Immunoreceptors
J. Biol. Chem. 2003 278: 46081-46086. First Published on September 4, 2003; doi:10.1074/jbc.M308491200 [Abstract] [Full Text] [PDF]  

Jia Huang, Regina Valluzzi, Elisabetta Bini, Brian Vernaglia, and David L. Kaplan

Cloning, Expression, and Assembly of Sericin-like Protein
J. Biol. Chem. 2003 278: 46117-46123. First Published on September 8, 2003; doi:10.1074/jbc.M307792200 [Abstract] [Full Text] [PDF]  

Sonia Huecas and José Manuel Andreu

Energetics of the Cooperative Assembly of Cell Division Protein FtsZ and the Nucleotide Hydrolysis Switch
J. Biol. Chem. 2003 278: 46146-46154. First Published on August 21, 2003; doi:10.1074/jbc.M307128200 [Abstract] [Full Text] [PDF]  

Kazuma Murakami, Kazuhiro Irie, Akira Morimoto, Hajime Ohigashi, Mayumi Shindo, Masaya Nagao, Takahiko Shimizu, and Takuji Shirasawa

Neurotoxicity and Physicochemical Properties of A Mutant Peptides from Cerebral Amyloid Angiopathy: IMPLICATION FOR THE PATHOGENESIS OF CEREBRAL AMYLOID ANGIOPATHY AND ALZHEIMER'S DISEASE
J. Biol. Chem. 2003 278: 46179-46187. First Published on August 27, 2003; doi:10.1074/jbc.M301874200 [Abstract] [Full Text] [PDF]  

Enzyme Catalysis and Regulation:

Zbynek Prokop, Marta Monincová, Radka Chaloupková, Martin Klvana, Yuji Nagata, Dick B. Janssen, and Jirí Damborsky

Catalytic Mechanism of the Haloalkane Dehalogenase LinB from Sphingomonas paucimobilis UT26
J. Biol. Chem. 2003 278: 45094-45100. First Published on September 1, 2003; doi:10.1074/jbc.M307056200 [Abstract] [Full Text] [PDF]  

Kiyonari Masumoto, Yasuhisa Sakata, Kazuhiko Arima, Isao Nakao, and Kenji Izuhara

Inhibitory Mechanism of a Cross-class Serpin, the Squamous Cell Carcinoma Antigen 1
J. Biol. Chem. 2003 278: 45296-45304. First Published on August 29, 2003; doi:10.1074/jbc.M307741200 [Abstract] [Full Text] [PDF]  

Mathias Antoine, Sandrine Boschi-Muller, and Guy Branlant

Kinetic Characterization of the Chemical Steps Involved in the Catalytic Mechanism of Methionine Sulfoxide Reductase A from Neisseria meningitidis
J. Biol. Chem. 2003 278: 45352-45357. First Published on September 3, 2003; doi:10.1074/jbc.M307471200 [Abstract] [Full Text] [PDF]  

Jian-Ke Tie, Vasantha P. Mutucumarana, David L. Straight, Kevin L. Carrick, R. Marshall Pope, and Darrel W. Stafford

Determination of Disulfide Bond Assignment of Human Vitamin K-dependent -Glutamyl Carboxylase by Matrix-assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
J. Biol. Chem. 2003 278: 45468-45475. First Published on September 8, 2003; doi:10.1074/jbc.M309164200 [Abstract] [Full Text] [PDF]  

Kathleen M. George, Travis Schule, Lisa E. Sandoval, Lori L. Jennings, Palmer Taylor, and Charles M. Thompson

Differentiation between Acetylcholinesterase and the Organophosphate-inhibited Form Using Antibodies and the Correlation of Antibody Recognition with Reactivation Mechanism and Rate
J. Biol. Chem. 2003 278: 45512-45518. First Published on August 21, 2003; doi:10.1074/jbc.M304781200 [Abstract] [Full Text] [PDF]  

Shailendra Kumar Sharma, Mili Kapoor, T. N. C. Ramya, Sanjay Kumar, Gyanendra Kumar, Rahul Modak, Shilpi Sharma, Namita Surolia, and Avadhesha Surolia

Identification, Characterization, and Inhibition of Plasmodium falciparum -Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)
J. Biol. Chem. 2003 278: 45661-45671. First Published on August 20, 2003; doi:10.1074/jbc.M304283200 [Abstract] [Full Text] [PDF]  

F. Wayne Outten, Matthew J. Wood, F. Michael Muñoz, and Gisela Storz

The SufE Protein and the SufBCD Complex Enhance SufS Cysteine Desulfurase Activity as Part of a Sulfur Transfer Pathway for Fe-S Cluster Assembly in Escherichia coli
J. Biol. Chem. 2003 278: 45713-45719. First Published on August 26, 2003; doi:10.1074/jbc.M308004200 [Abstract] [Full Text] [PDF] Supplemental Data  

Scott W. Rowlinson, James R. Kiefer, Jeffery J. Prusakiewicz, Jennifer L. Pawlitz, Kevin R. Kozak, Amit S. Kalgutkar, William C. Stallings, Ravi G. Kurumbail, and Lawrence J. Marnett

A Novel Mechanism of Cyclooxygenase-2 Inhibition Involving Interactions with Ser-530 and Tyr-385
J. Biol. Chem. 2003 278: 45763-45769. First Published on August 18, 2003; doi:10.1074/jbc.M305481200 [Abstract] [Full Text] [PDF]  

Roman Fedorov, Elisabeth Hartmann, Dipak K. Ghosh, and Ilme Schlichting

Structural Basis for the Specificity of the Nitric-oxide Synthase Inhibitors W1400 and N-Propyl-L-Arg for the Inducible and Neuronal Isoforms
J. Biol. Chem. 2003 278: 45818-45825. First Published on September 3, 2003; doi:10.1074/jbc.M306030200 [Abstract] [Full Text] [PDF]  

Jing-Hua Yang, Yongzhan Nie, Qingchuan Zhao, Yingjun Su, Marc Pypaert, Haili Su, and Reuven Rabinovici

Intracellular Localization of Differentially Regulated RNA-specific Adenosine Deaminase Isoforms in Inflammation
J. Biol. Chem. 2003 278: 45833-45842. First Published on September 3, 2003; doi:10.1074/jbc.M308612200 [Abstract] [Full Text] [PDF]  

Eric L. Wise, David E. Graham, Robert H. White, and Ivan Rayment

The Structural Determination of Phosphosulfolactate Synthase from Methanococcus jannaschii at 1.7-Å Resolution: AN ENOLASE THAT IS NOT AN ENOLASE
J. Biol. Chem. 2003 278: 45858-45863. First Published on September 2, 2003; doi:10.1074/jbc.M307486200 [Abstract] [Full Text] [PDF]  

Hazel R. Evans, J. Mark Sutton, Daniel E. Holloway, Joanne Ayriss, Clifford C. Shone, and K. Ravi Acharya

The Crystal Structure of C3stau2 from Staphylococcus aureus and Its Complex with NAD
J. Biol. Chem. 2003 278: 45924-45930. First Published on August 21, 2003; doi:10.1074/jbc.M307719200 [Abstract] [Full Text] [PDF]  

Steve A. Seibold, Terry Ball, Linda C. Hsi, Denise A. Mills, Rajeewa D. Abeysinghe, Renee Micielli, Caroline Jill Rieke, Robert I. Cukier, and William L. Smith

Histidine 386 and Its Role in Cyclooxygenase and Peroxidase Catalysis by Prostaglandin-endoperoxide H Synthases
J. Biol. Chem. 2003 278: 46163-46170. First Published on September 2, 2003; doi:10.1074/jbc.M306319200 [Abstract] [Full Text] [PDF]  

Metabolism and Bioenergetics:

Grace L. Guo, Gilles Lambert, Masahiko Negishi, Jerrold M. Ward, H. Bryan Brewer, Jr., Steven A. Kliewer, Frank J. Gonzalez, and Christopher J. Sinal

Complementary Roles of Farnesoid X Receptor, Pregnane X Receptor, and Constitutive Androstane Receptor in Protection against Bile Acid Toxicity
J. Biol. Chem. 2003 278: 45062-45071. First Published on August 15, 2003; doi:10.1074/jbc.M307145200 [Abstract] [Full Text] [PDF]  

Michal Pravenec, Ludmila Kazdová, Vladimír Landa, Václav Zídek, Petr Mlejnek, Petr Jansa, Jiaming Wang, Nianning Qi, and Theodore W. Kurtz

Transgenic and Recombinant Resistin Impair Skeletal Muscle Glucose Metabolism in the Spontaneously Hypertensive Rat
J. Biol. Chem. 2003 278: 45209-45215. First Published on August 27, 2003; doi:10.1074/jbc.M304869200 [Abstract] [Full Text] [PDF]  

Mutsuo Yamaguchi and C. David Stout

Essential Glycine in the Proton Channel of Escherichia coli Transhydrogenase
J. Biol. Chem. 2003 278: 45333-45339. First Published on September 2, 2003; doi:10.1074/jbc.M308236200 [Abstract] [Full Text] [PDF]  

Valérie Haurie, Hélian Boucherie, and Francis Sagliocco

The Snf1 Protein Kinase Controls the Induction of Genes of the Iron Uptake Pathway at the Diauxic Shift in Saccharomyces cerevisiae
J. Biol. Chem. 2003 278: 45391-45396. First Published on September 5, 2003; doi:10.1074/jbc.M307447200 [Abstract] [Full Text] [PDF]  

Robert J. Crisp, Annette Pollington, Charles Galea, Shulamit Jaron, Yuko Yamaguchi-Iwai, and Jerry Kaplan

Inhibition of Heme Biosynthesis Prevents Transcription of Iron Uptake Genes in Yeast
J. Biol. Chem. 2003 278: 45499-45506. First Published on August 19, 2003; doi:10.1074/jbc.M307229200 [Abstract] [Full Text] [PDF]  

M. Kalim Akhtar, Naheed N. Kaderbhai, David J. Hopper, Steven L. Kelly, and Mustak A. Kaderbhai

Export of a Heterologous Cytochrome P450 (CYP105D1) in Escherichia coli Is Associated with Periplasmic Accumulation of Uroporphyrin
J. Biol. Chem. 2003 278: 45555-45562. First Published on August 20, 2003; doi:10.1074/jbc.M212685200 [Abstract] [Full Text] [PDF]  

Jing-Ning Huan, Ji Li, Yiping Han, Ke Chen, Nancy Wu, and Allan Z. Zhao

Adipocyte-selective Reduction of the Leptin Receptors Induced by Antisense RNA Leads to Increased Adiposity, Dyslipidemia, and Insulin Resistance
J. Biol. Chem. 2003 278: 45638-45650. First Published on August 18, 2003; doi:10.1074/jbc.M304165200 [Abstract] [Full Text] [PDF] Supplemental Data  

Sophie Rousset, Marie-Clotilde Alves-Guerra, Salma Ouadghiri-Bencherif, Leslie P. Kozak, Bruno Miroux, Denis Richard, Frédéric Bouillaud, Daniel Ricquier, and Anne-Marie Cassard-Doulcier

Uncoupling Protein 2, but Not Uncoupling Protein 1, Is Expressed in the Female Mouse Reproductive Tract
J. Biol. Chem. 2003 278: 45843-45847. First Published on August 26, 2003; doi:10.1074/jbc.M306980200 [Abstract] [Full Text] [PDF]  

Kimmo K. Lehtimäki, Piia K. Valonen, Julian L. Griffin, Tuula H. Väisänen, Olli H. J. Gröhn, Mikko I. Kettunen, Jouko Vepsäläinen, Seppo Ylä-Herttuala, Jeremy Nicholson, and Risto A. Kauppinen

Metabolite Changes in BT4C Rat Gliomas Undergoing Ganciclovir-Thymidine Kinase Gene Therapy-induced Programmed Cell Death as Studied by ¹H NMR Spectroscopy in Vivo, ex Vivo, and in Vitro
J. Biol. Chem. 2003 278: 45915-45923. First Published on September 3, 2003; doi:10.1074/jbc.M306209200 [Abstract] [Full Text] [PDF]  

Glycobiology and Extracellular Matrices:

Cécile Tétaud, Thomas Falguières, Karine Carlier, Yann Lécluse, Julie Garibal, Dominique Coulaud, Pierre Busson, Rudi Steffensen, Henrik Clausen, Ludger Johannes, and Joëlle Wiels

Two Distinct Gb3/CD77 Signaling Pathways Leading to Apoptosis Are Triggered by Anti-Gb3/CD77 mAb and Verotoxin-1
J. Biol. Chem. 2003 278: 45200-45208. First Published on August 27, 2003; doi:10.1074/jbc.M303868200 [Abstract] [Full Text] [PDF]  

Magali M. Le Goff, Vincent J. Hindson, Thomas A. Jowitt, Paul G. Scott, and Paul N. Bishop

Characterization of Opticin and Evidence of Stable Dimerization in Solution
J. Biol. Chem. 2003 278: 45280-45287. First Published on September 1, 2003; doi:10.1074/jbc.M303117200 [Abstract] [Full Text] [PDF]  

Shingo Nakayamada, Yosuke Okada, Kazuyoshi Saito, Masahito Tamura, and Yoshiya Tanaka

₁ Integrin/Focal Adhesion Kinase-mediated Signaling Induces Intercellular Adhesion Molecule 1 and Receptor Activator of Nuclear Factor B Ligand on Osteoblasts and Osteoclast Maturation
J. Biol. Chem. 2003 278: 45368-45374. First Published on September 3, 2003; doi:10.1074/jbc.M308786200 [Abstract] [Full Text] [PDF]  

Michael A. Pratta, Wenqing Yao, Carl Decicco, Micky D. Tortorella, Riu-Qin Liu, Robert A. Copeland, Ronald Magolda, Robert C. Newton, James M. Trzaskos, and Elizabeth C. Arner

Aggrecan Protects Cartilage Collagen from Proteolytic Cleavage
J. Biol. Chem. 2003 278: 45539-45545. First Published on July 30, 2003; doi:10.1074/jbc.M303737200 [Abstract] [Full Text] [PDF]  

James L. Funderburgh, Mary M. Mann, and Martha L. Funderburgh

Keratocyte Phenotype Mediates Proteoglycan Structure: A ROLE FOR FIBROBLASTS IN CORNEAL FIBROSIS
J. Biol. Chem. 2003 278: 45629-45637. First Published on August 20, 2003; doi:10.1074/jbc.M303292200 [Abstract] [Full Text] [PDF]  

Nobuharu Suzuki, Hiroko Nakatsuka, Mayumi Mochizuki, Norio Nishi, Yuichi Kadoya, Atsushi Utani, Shinya Oishi, Nobutaka Fujii, Hynda K. Kleinman, and Motoyoshi Nomizu

Biological Activities of Homologous Loop Regions in the Laminin Chain G Domains
J. Biol. Chem. 2003 278: 45697-45705. First Published on August 20, 2003; doi:10.1074/jbc.M304667200 [Abstract] [Full Text] [PDF]  

Alexandra Zoltan-Jones, Lei Huang, Shibnath Ghatak, and Bryan P. Toole

Elevated Hyaluronan Production Induces Mesenchymal and Transformed Properties in Epithelial Cells
J. Biol. Chem. 2003 278: 45801-45810. First Published on September 3, 2003; doi:10.1074/jbc.M308168200 [Abstract] [Full Text] [PDF]  

Ten-Yang Yen, Bruce A. Macher, Steve Bryson, Xiaoqing Chang, Igor Tvaroska, Roderick Tse, Sawako Takeshita, April M. Lew, and Alessandro Datti

Highly Conserved Cysteines of Mouse Core 2 1,6-N-Acetylglucosaminyltransferase I Form a Network of Disulfide Bonds and Include a Thiol That Affects Enzyme Activity
J. Biol. Chem. 2003 278: 45864-45881. First Published on September 3, 2003; doi:10.1074/jbc.M303851200 [Abstract] [Full Text] [PDF]  

Lipids and Lipoproteins:

Satoshi Uemura, Akio Kihara, Jin-ichi Inokuchi, and Yasuyuki Igarashi

Csg1p and Newly Identified Csh1p Function in Mannosylinositol Phosphorylceramide Synthesis by Interacting with Csg2p
J. Biol. Chem. 2003 278: 45049-45055. First Published on September 3, 2003; doi:10.1074/jbc.M305498200 [Abstract] [Full Text] [PDF]  

Sujoy Ghosh, Sean Moore, Robert M. Bell, and Michael Dush

Functional Analysis of a Phosphatidic Acid Binding Domain in Human Raf-1 Kinase: MUTATIONS IN THE PHOSPHATIDATE BINDING DOMAIN LEAD TO TAIL AND TRUNK ABNORMALITIES IN DEVELOPING ZEBRAFISH EMBRYOS
J. Biol. Chem. 2003 278: 45690-45696. First Published on August 18, 2003; doi:10.1074/jbc.M302933200 [Abstract] [Full Text] [PDF]  

Youchun Zeng, Nengbing Tao, Koong-Nah Chung, John E. Heuser, and Douglas M. Lublin

Endocytosis of Oxidized Low Density Lipoprotein through Scavenger Receptor CD36 Utilizes a Lipid Raft Pathway That Does Not Require Caveolin-1
J. Biol. Chem. 2003 278: 45931-45936. First Published on August 28, 2003; doi:10.1074/jbc.M307722200 [Abstract] [Full Text] [PDF]  

Membrane Transport, Structure, Function, and Biogenesis:

Ehud Sass, Sharon Karniely, and Ophry Pines

Folding of Fumarase during Mitochondrial Import Determines its Dual Targeting in Yeast
J. Biol. Chem. 2003 278: 45109-45116. First Published on September 5, 2003; doi:10.1074/jbc.M302344200 [Abstract] [Full Text] [PDF]  

Lars Hinrichsen, Jens Harborth, Lars Andrees, Klaus Weber, and Ernst J. Ungewickell

Effect of Clathrin Heavy Chain- and -Adaptin-specific Small Inhibitory RNAs on Endocytic Accessory Proteins and Receptor Trafficking in HeLa Cells
J. Biol. Chem. 2003 278: 45160-45170. First Published on September 6, 2003; doi:10.1074/jbc.M307290200 [Abstract] [Full Text] [PDF]  

Ji-Hoon Lee, Rodolfo Ghirlando, Venugopal Bhaskara, Michaela R. Hoffmeyer, Jian Gu, and Tanya T. Paull

Regulation of Mre11/Rad50 by Nbs1: EFFECTS ON NUCLEOTIDE-DEPENDENT DNA BINDING AND ASSOCIATION WITH ATAXIA-TELANGIECTASIA-LIKE DISORDER MUTANT COMPLEXES
J. Biol. Chem. 2003 278: 45171-45181. First Published on September 8, 2003; doi:10.1074/jbc.M308705200 [Abstract] [Full Text] [PDF]  

Gregor Anderluh, Mauro Dalla Serra, Gabriella Viero, Graziano Guella, Peter Macek, and Gianfranco Menestrina

Pore Formation by Equinatoxin II, a Eukaryotic Protein Toxin, Occurs by Induction of Nonlamellar Lipid Structures
J. Biol. Chem. 2003 278: 45216-45223. First Published on August 27, 2003; doi:10.1074/jbc.M305916200 [Abstract] [Full Text] [PDF]  

Tatjana Coric, Ping Zhang, Natasa Todorovic, and Cecilia M. Canessa

The Extracellular Domain Determines the Kinetics of Desensitization in Acid-sensitive Ion Channel 1
J. Biol. Chem. 2003 278: 45240-45247. First Published on August 28, 2003; doi:10.1074/jbc.M304441200 [Abstract] [Full Text] [PDF]  

Mansoureh Eghbali, Ligia Toro, and Enrico Stefani

Diminished Surface Clustering and Increased Perinuclear Accumulation of Large Conductance Ca²⁺-activated K⁺ Channel in Mouse Myometrium with Pregnancy
J. Biol. Chem. 2003 278: 45311-45317. First Published on September 2, 2003; doi:10.1074/jbc.M306564200 [Abstract] [Full Text] [PDF]  

Holger A. Scheidt, Peter Müller, Andreas Herrmann, and Daniel Huster

The Potential of Fluorescent and Spin-labeled Steroid Analogs to Mimic Natural Cholesterol
J. Biol. Chem. 2003 278: 45563-45569. First Published on August 28, 2003; doi:10.1074/jbc.M303567200 [Abstract] [Full Text] [PDF]  

Uwe Ludewig, Stephanie Wilken, Binghua Wu, Wolfgang Jost, Petr Obrdlik, Mohamed El Bakkoury, Anne-Marie Marini, Bruno André, Tanja Hamacher, Eckhard Boles, Nicolaus von Wirén, and Wolf B. Frommer

Homo- and Hetero-oligomerization of Ammonium Transporter-1 NH4 Uniporters
J. Biol. Chem. 2003 278: 45603-45610. First Published on September 2, 2003; doi:10.1074/jbc.M307424200 [Abstract] [Full Text] [PDF] Supplemental Data  

Junichiro Nishi, Jalaluddin Sheikh, Kenji Mizuguchi, Ben Luisi, Valerie Burland, Adam Boutin, Debra J. Rose, Frederick R. Blattner, and James P. Nataro

The Export of Coat Protein from Enteroaggregative Escherichia coli by a Specific ATP-binding Cassette Transporter System
J. Biol. Chem. 2003 278: 45680-45689. First Published on August 21, 2003; doi:10.1074/jbc.M306413200 [Abstract] [Full Text] [PDF]  

Michael Tanowitz and Mark von Zastrow

A Novel Endocytic Recycling Signal That Distinguishes the Membrane Trafficking of Naturally Occurring Opioid Receptors
J. Biol. Chem. 2003 278: 45978-45986. First Published on August 25, 2003; doi:10.1074/jbc.M304504200 [Abstract] [Full Text] [PDF]  

Da-Wei Zhang, Hong-Mei Gu, Donna Situ, Anass Haimeur, Susan P. C. Cole, and Roger G. Deeley

Functional Importance of Polar and Charged Amino Acid Residues in Transmembrane Helix 14 of Multidrug Resistance Protein 1 (MRP1/ABCC1): IDENTIFICATION OF AN ASPARTATE RESIDUE CRITICAL FOR CONVERSION FROM A HIGH TO LOW AFFINITY SUBSTRATE BINDING STATE
J. Biol. Chem. 2003 278: 46052-46063. First Published on September 3, 2003; doi:10.1074/jbc.M308403200 [Abstract] [Full Text] [PDF]  

David Strugatsky, Kay-Eberhard Gottschalk, Rivka Goldshleger, Eitan Bibi, and Steven J. D. Karlish

Expression of Na⁺,K⁺-ATPase in Pichia pastoris: ANALYSIS OF WILD TYPE AND D369N MUTANT PROTEINS BY FE²⁺-CATALYZED OXIDATIVE CLEAVAGE AND MOLECULAR MODELING
J. Biol. Chem. 2003 278: 46064-46073. First Published on August 29, 2003; doi:10.1074/jbc.M308303200 [Abstract] [Full Text] [PDF]  

Yu Chen, Norio Takizawa, Jessica L. Crowley, Sang W. Oh, Cheryl L. Gatto, Taketoshi Kambara, Osamu Sato, Xiang-dong Li, Mitsuo Ikebe, and Elizabeth J. Luna

F-actin and Myosin II Binding Domains in Supervillin
J. Biol. Chem. 2003 278: 46094-46106. First Published on August 12, 2003; doi:10.1074/jbc.M305311200 [Abstract] [Full Text] [PDF] Supplemental Data  

Janine H. Peterson, Cheryl A. Woolhead, and Harris D. Bernstein

Basic Amino Acids in a Distinct Subset of Signal Peptides Promote Interaction with the Signal Recognition Particle
J. Biol. Chem. 2003 278: 46155-46162. First Published on August 29, 2003; doi:10.1074/jbc.M309082200 [Abstract] [Full Text] [PDF]  

Mechanisms Of Signal Transduction:

Maddalena Illario, Anna Lina Cavallo, K. Ulrich Bayer, Tiziana Di Matola, Gianfranco Fenzi, Guido Rossi, and Mario Vitale

Calcium/Calmodulin-dependent Protein Kinase II Binds to Raf-1 and Modulates Integrin-stimulated ERK Activation
J. Biol. Chem. 2003 278: 45101-45108. First Published on September 3, 2003; doi:10.1074/jbc.M305355200 [Abstract] [Full Text] [PDF]  

Hyung-Kyu Lim, Young-Ae Choi, Wan Park, Taehoon Lee, Sung Ho Ryu, Seong-Yong Kim, Jae-Ryong Kim, Jung-Hye Kim, and Suk-Hwan Baek

Phosphatidic Acid Regulates Systemic Inflammatory Responses by Modulating the Akt-Mammalian Target of Rapamycin-p70 S6 Kinase 1 Pathway
J. Biol. Chem. 2003 278: 45117-45127. First Published on September 5, 2003; doi:10.1074/jbc.M303789200 [Abstract] [Full Text] [PDF]  

Tiffani A. Greene, Penda Powell, Chima Nzerem, Michael J. Shapiro, and Virginia Smith Shapiro

Cloning and Characterization of ALX, an Adaptor Downstream of CD28
J. Biol. Chem. 2003 278: 45128-45134. First Published on September 5, 2003; doi:10.1074/jbc.M306283200 [Abstract] [Full Text] [PDF]  

Mónica Arribas, Angela M. Valverde, and Manuel Benito

Role of IRS-3 in the Insulin Signaling of IRS-1-deficient Brown Adipocytes
J. Biol. Chem. 2003 278: 45189-45199. First Published on August 27, 2003; doi:10.1074/jbc.M301185200 [Abstract] [Full Text] [PDF]  

Thomas S. Nühse, Thomas Boller, and Scott C. Peck

A Plasma Membrane Syntaxin Is Phosphorylated in Response to the Bacterial Elicitor Flagellin
J. Biol. Chem. 2003 278: 45248-45254. First Published on August 28, 2003; doi:10.1074/jbc.M307443200 [Abstract] [Full Text] [PDF]  

Sylvain M. Le Gall, Rodolphe Auger, Catherine Dreux, and Philippe Mauduit

Regulated Cell Surface Pro-EGF Ectodomain Shedding Is a Zinc Metalloprotease-dependent Process
J. Biol. Chem. 2003 278: 45255-45268. First Published on August 28, 2003; doi:10.1074/jbc.M307745200 [Abstract] [Full Text] [PDF]  

Bin Yan, Marina Zemskova, Sheldon Holder, Vernon Chin, Andrew Kraft, Paivi J. Koskinen, and Michael Lilly

The PIM-2 Kinase Phosphorylates BAD on Serine 112 and Reverses BAD-induced Cell Death
J. Biol. Chem. 2003 278: 45358-45367. First Published on September 3, 2003; doi:10.1074/jbc.M307933200 [Abstract] [Full Text] [PDF]  

Bruce S. Hostager, Sokol A. Haxhinasto, Sarah L. Rowland, and Gail A. Bishop

Tumor Necrosis Factor Receptor-associated Factor 2 (TRAF2)-deficient B Lymphocytes Reveal Novel Roles for TRAF2 in CD40 Signaling
J. Biol. Chem. 2003 278: 45382-45390. First Published on September 4, 2003; doi:10.1074/jbc.M306708200 [Abstract] [Full Text] [PDF]  

Min Zhou, Yahong Zhang, Jeanette A. Ardans, and Larry M. Wahl

Interferon- Differentially Regulates Monocyte Matrix Metalloproteinase-1 and -9 through Tumor Necrosis Factor- and Caspase 8
J. Biol. Chem. 2003 278: 45406-45413. First Published on September 5, 2003; doi:10.1074/jbc.M309075200 [Abstract] [Full Text] [PDF]  

Li-Fan Lu, W. James Cook, Ling-Li Lin, and Randolph J. Noelle

CD40 Signaling through a Newly Identified Tumor Necrosis Factor Receptor-associated Factor 2 (TRAF2) Binding Site
J. Biol. Chem. 2003 278: 45414-45418. First Published on September 5, 2003; doi:10.1074/jbc.M309601200 [Abstract] [Full Text] [PDF]  

Alexander Hess, Nastiti Wijayanti, Andrea Pathe Neuschäfer-Rube, Norbert Katz, Thomas Kietzmann, and Stephan Immenschuh

Phorbol Ester-dependent Activation of Peroxiredoxin I Gene Expression via a Protein Kinase C, Ras, p38 Mitogen-activated Protein Kinase Signaling Pathway
J. Biol. Chem. 2003 278: 45419-45434. First Published on September 5, 2003; doi:10.1074/jbc.M307871200 [Abstract] [Full Text] [PDF]  

Paul Dowell, Tamara C. Otto, Saleh Adi, and M. Daniel Lane

Convergence of Peroxisome Proliferator-activated Receptor and Foxo1 Signaling Pathways
J. Biol. Chem. 2003 278: 45485-45491. First Published on September 9, 2003; doi:10.1074/jbc.M309069200 [Abstract] [Full Text] [PDF]  

Yue-xin Shan, Tung-Lin Yang, Ruben Mestril, and Ping H. Wang

Hsp10 and Hsp60 Suppress Ubiquitination of Insulin-like Growth Factor-1 Receptor and Augment Insulin-like Growth Factor-1 Receptor Signaling in Cardiac Muscle: IMPLICATIONS ON DECREASED MYOCARDIAL PROTECTION IN DIABETIC CARDIOMYOPATHY
J. Biol. Chem. 2003 278: 45492-45498. First Published on September 11, 2003; doi:10.1074/jbc.M304498200 [Abstract] [Full Text] [PDF]  

Angus Harding, Virginia Hsu, Kerry Kornfeld, and John F. Hancock

Identification of Residues and Domains of Raf Important for Function in Vivo and in Vitro
J. Biol. Chem. 2003 278: 45519-45527. First Published on September 3, 2003; doi:10.1074/jbc.M303106200 [Abstract] [Full Text] [PDF]  

Georgia I. Anyatonwu, Edmond D. Buck, and Barbara E. Ehrlich

Methanethiosulfonate Ethylammonium Block of Amine Currents through the Ryanodine Receptor Reveals Single Pore Architecture
J. Biol. Chem. 2003 278: 45528-45538. First Published on September 8, 2003; doi:10.1074/jbc.M307863200 [Abstract] [Full Text] [PDF]  

Sailaja Paruchuri and Anita Sjölander

Leukotriene D₄ Mediates Survival and Proliferation via Separate but Parallel Pathways in the Human Intestinal Epithelial Cell Line Int 407
J. Biol. Chem. 2003 278: 45577-45585. First Published on August 11, 2003; doi:10.1074/jbc.M302881200 [Abstract] [Full Text] [PDF]  

Junji Sagara, Tsukasa Higuchi, Yukiko Hattori, Mie Moriya, Haritha Sarvotham, Hiroshi Shima, Haruki Shirato, Kunimi Kikuchi, and Shunichiro Taniguchi

Scapinin, a Putative Protein Phosphatase-1 Regulatory Subunit Associated with the Nuclear Nonchromatin Structure
J. Biol. Chem. 2003 278: 45611-45619. First Published on August 17, 2003; doi:10.1074/jbc.M305227200 [Abstract] [Full Text] [PDF]  

Jenny Jongstra-Bilen, Rene Harrison, and Sergio Grinstein

Fc-receptors Induce Mac-1 (CD11b/CD18) Mobilization and Accumulation in the Phagocytic Cup for Optimal Phagocytosis
J. Biol. Chem. 2003 278: 45720-45729. First Published on August 26, 2003; doi:10.1074/jbc.M303704200 [Abstract] [Full Text] [PDF]  

Sunil K. Sukumaran, George McNamara, and Nemani V. Prasadarao

Escherichia coli K-1 Interaction with Human Brain Micro-vascular Endothelial Cells Triggers Phospholipase C-1 Activation Downstream of Phosphatidylinositol 3-Kinase
J. Biol. Chem. 2003 278: 45753-45762. First Published on September 2, 2003; doi:10.1074/jbc.M307374200 [Abstract] [Full Text] [PDF]  

Victoria Rotter, Ivan Nagaev, and Ulf Smith

Interleukin-6 (IL-6) Induces Insulin Resistance in 3T3-L1 Adipocytes and Is, Like IL-8 and Tumor Necrosis Factor-, Overexpressed in Human Fat Cells from Insulin-resistant Subjects
J. Biol. Chem. 2003 278: 45777-45784. First Published on September 2, 2003; doi:10.1074/jbc.M301977200 [Abstract] [Full Text] [PDF]  

Larry E. Wagner, II, Wen-Hong Li, and David I. Yule

Phosphorylation of Type-1 Inositol 1,4,5-Trisphosphate Receptors by Cyclic Nucleotide-dependent Protein Kinases: A MUTATIONAL ANALYSIS OF THE FUNCTIONALLY IMPORTANT SITES IN THE S2⁺ AND S2^- SPLICE VARIANTS
J. Biol. Chem. 2003 278: 45811-45817. First Published on August 25, 2003; doi:10.1074/jbc.M306270200 [Abstract] [Full Text] [PDF]  

Xun Shang, Yi Ting Zhou, and Boon Chuan Low

Concerted Regulation of Cell Dynamics by BNIP-2 and Cdc42GAP Homology/Sec14p-like, Proline-rich, and GTPase-activating Protein Domains of a Novel Rho GTPase-activating Protein, BPGAP1
J. Biol. Chem. 2003 278: 45903-45914. First Published on August 27, 2003; doi:10.1074/jbc.M304514200 [Abstract] [Full Text] [PDF]  

Ratan Bhat, Yafeng Xue, Stefan Berg, Sven Hellberg, Mats Ormö, Yvonne Nilsson, Ann-Cathrin Radesäter, Eva Jerning, Per-Olof Markgren, Thomas Borgegård, Martin Nylöf, Alfredo Giménez-Cassina, Félix Hernández, Jose J. Lucas, Javier Díaz-Nido, and Jesús Avila

Structural Insights and Biological Effects of Glycogen Synthase Kinase 3-specific Inhibitor AR-A014418
J. Biol. Chem. 2003 278: 45937-45945. First Published on August 19, 2003; doi:10.1074/jbc.M306268200 [Abstract] [Full Text] [PDF]  

Negin P. Martin, Robert J. Lefkowitz, and Sudha K. Shenoy

Regulation of V2 Vasopressin Receptor Degradation by Agonist-promoted Ubiquitination
J. Biol. Chem. 2003 278: 45954-45959. First Published on September 5, 2003; doi:10.1074/jbc.M308285200 [Abstract] [Full Text] [PDF]  

Shihe Hou, Hancheng Guan, and Robert P. Ricciardi

Phosphorylation of Serine 337 of NF-B p50 Is Critical for DNA Binding
J. Biol. Chem. 2003 278: 45994-45998. First Published on August 28, 2003; doi:10.1074/jbc.M307971200 [Abstract] [Full Text] [PDF]  

Seiji Mori, Motonari Tanaka, Daisuke Nanba, Eiji Nishiwaki, Hiroshi Ishiguro, Shigeki Higashiyama, and Nariaki Matsuura

PACSIN3 Binds ADAM12/Meltrin and Up-regulates Ectodomain Shedding of Heparin-binding Epidermal Growth Factor-like Growth Factor
J. Biol. Chem. 2003 278: 46029-46034. First Published on September 2, 2003; doi:10.1074/jbc.M306393200 [Abstract] [Full Text] [PDF]  

Anastasia C. Rigas, Daniel M. Ozanne, David E. Neal, and Craig N. Robson

The Scaffolding Protein RACK1 Interacts with Androgen Receptor and Promotes Cross-talk through a Protein Kinase C Signaling Pathway
J. Biol. Chem. 2003 278: 46087-46093. First Published on September 4, 2003; doi:10.1074/jbc.M306219200 [Abstract] [Full Text] [PDF]  

Malcolm Begg, Fong-Ming Mo, László Offertáler, Sándor Bátkai, Pál Pacher, Raj K. Razdan, David M. Lovinger, and George Kunos

G Protein-coupled Endothelial Receptor for Atypical Cannabinoid Ligands Modulates a Ca²⁺-dependent K⁺ Current
J. Biol. Chem. 2003 278: 46188-46194. First Published on September 2, 2003; doi:10.1074/jbc.M307258200 [Abstract] [Full Text] [PDF]  

Molecular Basis Of Cell and Developmental Biology:

Wade E. Huber, E. Roydon Price, Hans R. Widlund, Jinyan Du, Ian J. Davis, Michael Wegner, and David E. Fisher

A Tissue-restricted cAMP Transcriptional Response: SOX10 MODULATES -MELANOCYTE-STIMULATING HORMONE-TRIGGERED EXPRESSION OF MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR IN MELANOCYTES
J. Biol. Chem. 2003 278: 45224-45230. First Published on August 27, 2003; doi:10.1074/jbc.M309036200 [Abstract] [Full Text] [PDF]  

Joel S. Griffitts, Danielle L. Huffman, Johanna L. Whitacre, Brad D. Barrows, Lisa D. Marroquin, Reto Müller, Jillian R. Brown, Thierry Hennet, Jeffrey D. Esko, and Raffi V. Aroian

Resistance to a Bacterial Toxin Is Mediated by Removal of a Conserved Glycosylation Pathway Required for Toxin-Host Interactions
J. Biol. Chem. 2003 278: 45594-45602. First Published on August 27, 2003; doi:10.1074/jbc.M308142200 [Abstract] [Full Text] [PDF]  

Agnes G. S. H. van Rossum, Jos H. de Graaf, Ellen Schuuring-Scholtes, Philip M. Kluin, Ying-xin Fan, Xi Zhan, Wouter H. Moolenaar, and Ed Schuuring

Alternative Splicing of the Actin Binding Domain of Human Cortactin Affects Cell Migration
J. Biol. Chem. 2003 278: 45672-45679. First Published on September 2, 2003; doi:10.1074/jbc.M306688200 [Abstract] [Full Text] [PDF]  

Hui Qin Wang, Taihao Quan, Tianyuan He, Thomas F. Franke, John J. Voorhees, and Gary J. Fisher

Epidermal Growth Factor Receptor-dependent, NF-B-independent Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway Inhibits Ultraviolet Irradiation-induced Caspases-3, -8, and -9 in Human Keratinocytes
J. Biol. Chem. 2003 278: 45737-45745. First Published on September 2, 2003; doi:10.1074/jbc.M300574200 [Abstract] [Full Text] [PDF]  

Peter J. O'Toole, Toshiaki Inoue, Lindsay Emerson, Ian E. G. Morrison, Alan R. Mackie, Richard J. Cherry, and John D. Norton

Id Proteins Negatively Regulate Basic Helix-Loop-Helix Transcription Factor Function by Disrupting Subnuclear Compartmentalization
J. Biol. Chem. 2003 278: 45770-45776. First Published on September 1, 2003; doi:10.1074/jbc.M306056200 [Abstract] [Full Text] [PDF]  

Heather A. Ferguson, Peter M. Marietta, and Carla L. Van Den Berg

UV-induced Apoptosis Is Mediated Independent of Caspase-9 in MCF-7 Cells: A MODEL FOR CYTOCHROME c RESISTANCE
J. Biol. Chem. 2003 278: 45793-45800. First Published on September 3, 2003; doi:10.1074/jbc.M307979200 [Abstract] [Full Text] [PDF]  

Olivier Peyruchaud, Claire-Marie Serre, Roisin NicAmhlaoibh, Pierrick Fournier, and Philippe Clézardin

Angiostatin Inhibits Bone Metastasis Formation in Nude Mice through a Direct Anti-osteoclastic Activity
J. Biol. Chem. 2003 278: 45826-45832. First Published on September 3, 2003; doi:10.1074/jbc.M309024200 [Abstract] [Full Text] [PDF]  

Richard S. Stewart and David A. Harris

Mutational Analysis of Topological Determinants in Prion Protein (PrP) and Measurement of Transmembrane and Cytosolic PrP during Prion Infection
J. Biol. Chem. 2003 278: 45960-45968. First Published on August 21, 2003; doi:10.1074/jbc.M307833200 [Abstract] [Full Text] [PDF]  

Su-Li Cheng, Jian-Su Shao, Nichole Charlton-Kachigian, Arleen P. Loewy, and Dwight A. Towler

Msx2 Promotes Osteogenesis and Suppresses Adipogenic Differentiation of Multipotent Mesenchymal Progenitors
J. Biol. Chem. 2003 278: 45969-45977. First Published on August 18, 2003; doi:10.1074/jbc.M306972200 [Abstract] [Full Text] [PDF]  

Masayuki Ozawa

p120-independent Modulation of E-cadherin Adhesion Activity by the Membrane-proximal Region of the Cytoplasmic Domain
J. Biol. Chem. 2003 278: 46014-46020. First Published on September 2, 2003; doi:10.1074/jbc.M307778200 [Abstract] [Full Text] [PDF]  

Jason C. Mills, Niklas Andersson, Thaddeus S. Stappenbeck, Christopher C. M. Chen, and Jeffrey I. Gordon

Molecular Characterization of Mouse Gastric Zymogenic Cells
J. Biol. Chem. 2003 278: 46138-46145. First Published on September 8, 2003; doi:10.1074/jbc.M308385200 [Abstract] [Full Text] [PDF] Supplemental Data  

Sunil Srivastava, Manabu Matsuda, Zhaoyuan Hou, Jason P. Bailey, Riko Kitazawa, Matthew P. Herbst, and Nelson D. Horseman

Receptor Activator of NF-B Ligand Induction via Jak2 and Stat5a in Mammary Epithelial Cells
J. Biol. Chem. 2003 278: 46171-46178. First Published on September 2, 2003; doi:10.1074/jbc.M308545200 [Abstract] [Full Text] [PDF]  

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