JBC -- Table of Contents (Dec 5 2003, 278, (49))

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Classics:

Robert D. Simoni, Robert L. Hill, Martha Vaughan, and Herbert Tabor: A Classic Instrument: The Beckman DU Spectrophotometer and Its Inventor, Arnold O. Beckman
J. Biol. Chem. 2003 278: e1. [Full Text]

Accelerated Publications:

Vera Kozjak, Nils Wiedemann, Dusanka Milenkovic, Christiane Lohaus, Helmut E. Meyer, Bernard Guiard, Chris Meisinger, and Nikolaus Pfanner: An Essential Role of Sam50 in the Protein Sorting and Assembly Machinery of the Mitochondrial Outer Membrane
J. Biol. Chem. 2003 278: 48520-48523. First Published on October 21, 2003; doi:10.1074/jbc.C300442200 [Abstract] [Full Text] [PDF]

DNA: Replication, Repair, and Recombination:

Kevin J. Harvey and John Newport: Metazoan Origin Selection: ORIGIN RECOGNITION COMPLEX CHROMATIN BINDING IS REGULATED BY CDC6 RECRUITMENT AND ATP HYDROLYSIS
J. Biol. Chem. 2003 278: 48524-48528. First Published on September 23, 2003; doi:10.1074/jbc.M307661200 [Abstract] [Full Text] [PDF]

Jenny A. Korhonen, Martina Gaspari, and Maria Falkenberg: TWINKLE Has 5' $->$ 3' DNA Helicase Activity and Is Specifically Stimulated by Mitochondrial Single-stranded DNA-binding Protein
J. Biol. Chem. 2003 278: 48627-48632. First Published on September 15, 2003; doi:10.1074/jbc.M306981200 [Abstract] [Full Text] [PDF]

Vanessa C. Csitkovits and Ellen L. Zechner: Extent of Single-stranded DNA Required for Efficient TraI Helicase Activity in Vitro
J. Biol. Chem. 2003 278: 48696-48703. First Published on September 23, 2003; doi:10.1074/jbc.M310025200 [Abstract] [Full Text] [PDF]

Sukhyun Kang, Joo Seok Han, Jong Hoon Park, Kirsten Skarstad, and Deog Su Hwang: SeqA Protein Stimulates the Relaxing and Decatenating Activities of Topoisomerase IV
J. Biol. Chem. 2003 278: 48779-48785. First Published on September 25, 2003; doi:10.1074/jbc.M308843200 [Abstract] [Full Text] [PDF]

Kelly M. Trujillo, Dong Hyun Roh, Ling Chen, Stephen Van Komen, Alan Tomkinson, and Patrick Sung: Yeast Xrs2 Binds DNA and Helps Target Rad50 and Mre11 to DNA Ends
J. Biol. Chem. 2003 278: 48957-48964. First Published on September 30, 2003; doi:10.1074/jbc.M309877200 [Abstract] [Full Text] [PDF]

Jae-Ho Shin, Yun Jiang, Beatrice Grabowski, Jerard Hurwitz, and Zvi Kelman: Substrate Requirements for Duplex DNA Translocation by the Eukaryal and Archaeal Minichromosome Maintenance Helicases
J. Biol. Chem. 2003 278: 49053-49062. First Published on September 15, 2003; doi:10.1074/jbc.M308599200 [Abstract] [Full Text] [PDF]

Tina T. Saxowsky, Gunjan Choudhary, Michele M. Klingbeil, and Paul T. Englund: Trypanosoma brucei Has Two Distinct Mitochondrial DNA Polymerase ${beta}$ Enzymes
J. Biol. Chem. 2003 278: 49095-49101. First Published on September 8, 2003; doi:10.1074/jbc.M308565200 [Abstract] [Full Text] [PDF]

Daniel L. Kaplan, Megan J. Davey, and Mike O'Donnell: Mcm4,6,7 Uses a "Pump in Ring" Mechanism to Unwind DNA by Steric Exclusion and Actively Translocate along a Duplex
J. Biol. Chem. 2003 278: 49171-49182. First Published on September 17, 2003; doi:10.1074/jbc.M308074200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Celia Baitinger, Vickers Burdett, and Paul Modrich: Hydrolytically Deficient MutS E694A Is Defective in the MutL-dependent Activation of MutH and in the Mismatch-dependent Assembly of the MutS · MutL · Heteroduplex Complex
J. Biol. Chem. 2003 278: 49505-49511. First Published on September 23, 2003; doi:10.1074/jbc.M308738200 [Abstract] [Full Text] [PDF]

Genes: Structure and Regulation:

John R. Lynch, Wen Tang, Haichen Wang, Michael P. Vitek, Ellen R. Bennett, Patrick M. Sullivan, David S. Warner, and Daniel T. Laskowitz: APOE Genotype and an ApoE-mimetic Peptide Modify the Systemic and Central Nervous System Inflammatory Response
J. Biol. Chem. 2003 278: 48529-48533. First Published on September 24, 2003; doi:10.1074/jbc.M306923200 [Abstract] [Full Text] [PDF]

Aruna Ramachandran, Mahera Omar, Peter Cheslock, and Gavin R. Schnitzler: Linker Histone H1 Modulates Nucleosome Remodeling by Human SWI/SNF
J. Biol. Chem. 2003 278: 48590-48601. First Published on September 25, 2003; doi:10.1074/jbc.M309033200 [Abstract] [Full Text] [PDF]

Claire K. Inman and Paul Shore: The Osteoblast Transcription Factor Runx2 Is Expressed in Mammary Epithelial Cells and Mediates osteopontin Expression
J. Biol. Chem. 2003 278: 48684-48689. First Published on September 23, 2003; doi:10.1074/jbc.M308001200 [Abstract] [Full Text] [PDF]

Malkhey Verma, Paike Jayadeva Bhat, and K. V. Venkatesh: Quantitative Analysis of GAL Genetic Switch of Saccharomyces cerevisiae Reveals That Nucleocytoplasmic Shuttling of Gal80p Results in a Highly Sensitive Response to Galactose
J. Biol. Chem. 2003 278: 48764-48769. First Published on September 25, 2003; doi:10.1074/jbc.M303526200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Stéphanie Papin, Cécile Cazeneuve, Philippe Duquesnoy, Isabelle Jéru, Djillali Sahali, and Serge Amselem: The Tumor Necrosis Factor ${alpha}$ -dependent Activation of the Human Mediterranean Fever (MEFV) Promoter Is Mediated by a Synergistic Interaction between C/EBP ${beta}$ and NF ${kappa}$ B p65
J. Biol. Chem. 2003 278: 48839-48847. First Published on September 26, 2003; doi:10.1074/jbc.M305166200 [Abstract] [Full Text] [PDF]

Julie L. Bronder and Richard G. Moran: A Defect in the p53 Response Pathway Induced by de Novo Purine Synthesis Inhibition
J. Biol. Chem. 2003 278: 48861-48871. First Published on September 29, 2003; doi:10.1074/jbc.M304844200 [Abstract] [Full Text] [PDF]

Lynn M. Ziegler, Denys A. Khaperskyy, Michelle L. Ammerman, and Alfred S. Ponticelli: Yeast RNA Polymerase II Lacking the Rpb9 Subunit Is Impaired for Interaction with Transcription Factor IIF
J. Biol. Chem. 2003 278: 48950-48956. First Published on September 30, 2003; doi:10.1074/jbc.M309656200 [Abstract] [Full Text] [PDF]

Yong Xu, Lin Wang, Giovanna Butticè, Pritam K. Sengupta, and Barbara D. Smith: Interferon ${gamma}$ Repression of Collagen (COL1A2) Transcription Is Mediated by the RFX5 Complex
J. Biol. Chem. 2003 278: 49134-49144. First Published on September 10, 2003; doi:10.1074/jbc.M309003200 [Abstract] [Full Text] [PDF]

Hiroshi Suzuki, Satoshi Tashiro, Jiying Sun, Hideyuki Doi, Susumu Satomi, and Kazuhiko Igarashi: Cadmium Induces Nuclear Export of Bach1, a Transcriptional Repressor of Heme Oxygenase-1 Gene
J. Biol. Chem. 2003 278: 49246-49253. First Published on September 22, 2003; doi:10.1074/jbc.M306764200 [Abstract] [Full Text] [PDF]

Nenad Petrovic, Shripad V. Bhagwat, William J. Ratzan, Michael C. Ostrowski, and Linda H. Shapiro: CD13/APN Transcription Is Induced by RAS/MAPK-mediated Phosphorylation of Ets-2 in Activated Endothelial Cells
J. Biol. Chem. 2003 278: 49358-49368. First Published on September 24, 2003; doi:10.1074/jbc.M308071200 [Abstract] [Full Text] [PDF]

Xiangyang Dong, Theodore Craig, Nianzeng Xing, Lori A. Bachman, Carlos V. Paya, Falk Weih, David J. McKean, Rajiv Kumar, and Matthew D. Griffin: Direct Transcriptional Regulation of RelB by 1 ${alpha}$ ,25-Dihydroxyvitamin D₃ and Its Analogs: PHYSIOLOGIC AND THERAPEUTIC IMPLICATIONS FOR DENDRITIC CELL FUNCTION
J. Biol. Chem. 2003 278: 49378-49385. First Published on September 24, 2003; doi:10.1074/jbc.M308448200 [Abstract] [Full Text] [PDF]

Lihui Wang, Bow Ho, and Jeak Ling Ding: Transcriptional Regulation of Limulus Factor C: REPRESSION OF AN NF ${kappa}$ B MOTIF MODULATES ITS RESPONSIVENESS TO BACTERIAL LIPOPOLYSACCHARIDE
J. Biol. Chem. 2003 278: 49428-49437. First Published on August 29, 2003; doi:10.1074/jbc.M306641200 [Abstract] [Full Text] [PDF]

James R. Gum, Jr., James W. Hicks, Suzanne C. Crawley, Christine M. Dahl, Stacey C. Yang, Anthony M. Roberton, and Young S. Kim: Initiation of Transcription of the MUC3A Human Intestinal Mucin from a TATA-less Promoter and Comparison with the MUC3B Amino Terminus
J. Biol. Chem. 2003 278: 49600-49609. First Published on September 4, 2003; doi:10.1074/jbc.M305769200 [Abstract] [Full Text] [PDF]

Kaoru Tominaga, James K. Leung, Paul Rookard, Johanna Echigo, James R. Smith, and Olivia M. Pereira-Smith: MRGX Is a Novel Transcriptional Regulator That Exhibits Activation or Repression of the B-myb Promoter in a Cell Type-dependent Manner
J. Biol. Chem. 2003 278: 49618-49624. First Published on September 23, 2003; doi:10.1074/jbc.M309192200 [Abstract] [Full Text] [PDF]

Jennifer L. Rychlik, Vincent Gerbasi, and Elaine J. Lewis: The Interaction between dHAND and Arix at the Dopamine ${beta}$ -Hydroxylase Promoter Region Is Independent of Direct dHAND Binding to DNA
J. Biol. Chem. 2003 278: 49652-49660. First Published on September 23, 2003; doi:10.1074/jbc.M308577200 [Abstract] [Full Text] [PDF]

Protein Synthesis, Post-Translation Modification, and Degradation:

Atsunori Furuhata, Takeshi Ishii, Shigenori Kumazawa, Tomoe Yamada, Tsutomu Nakayama, and Koji Uchida: N ${epsilon}$ -(3-Methylpyridinium)lysine, a Major Antigenic Adduct Generated in Acrolein-modified Protein
J. Biol. Chem. 2003 278: 48658-48665. First Published on September 22, 2003; doi:10.1074/jbc.M309401200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Nathalie Allaman-Pillet, Joachim Størling, Anne Oberson, Raphael Roduit, Stéphanie Negri, Christelle Sauser, Pascal Nicod, Jacques S. Beckmann, Daniel F. Schorderet, Thomas Mandrup-Poulsen, and Christophe Bonny: Calcium- and Proteasome-dependent Degradation of the JNK Scaffold Protein Islet-brain 1
J. Biol. Chem. 2003 278: 48720-48726. First Published on September 24, 2003; doi:10.1074/jbc.M306745200 [Abstract] [Full Text] [PDF]

Ludmila Kaplun, Yelena Ivantsiv, Anna Bakhrat, and Dina Raveh: DNA Damage Response-mediated Degradation of Ho Endonuclease via the Ubiquitin System Involves Its Nuclear Export
J. Biol. Chem. 2003 278: 48727-48734. First Published on September 23, 2003; doi:10.1074/jbc.M308671200 [Abstract] [Full Text] [PDF]

Mamoru Matsubara, Koiti Titani, Hisaaki Taniguchi, and Nobuihiro Hayashi: Direct Involvement of Protein Myristoylation in Myristoylated Alanine-rich C Kinase Substrate (MARCKS)-Calmodulin Interaction
J. Biol. Chem. 2003 278: 48898-48902. First Published on September 23, 2003; doi:10.1074/jbc.M305488200 [Abstract] [Full Text] [PDF]

Frank Brasch, Matthias Ochs, Thilo Kähne, Susan Guttentag, Vesna Schauer-Vukasinovic, Matthew Derrick, Georg Johnen, Nadine Kapp, Klaus-Michael Müller, Joachim Richter, Thomas Giller, Samuel Hawgood, and Frank Bühling: Involvement of Napsin A in the C- and N-terminal Processing of Surfactant Protein B in Type-II Pneumocytes of the Human Lung
J. Biol. Chem. 2003 278: 49006-49014. First Published on September 16, 2003; doi:10.1074/jbc.M306844200 [Abstract] [Full Text] [PDF]

Boris Shor, Jimmy Calaycay, Julie Rushbrook, and Maureen McLeod: Cpc2/RACK1 Is a Ribosome-associated Protein That Promotes Efficient Translation in Schizosaccharomyces pombe
J. Biol. Chem. 2003 278: 49119-49128. First Published on September 12, 2003; doi:10.1074/jbc.M303968200 [Abstract] [Full Text] [PDF]

Marcella Fulco, Antonio Costanzo, Paola Merlo, Rosamaria Mangiacasale, Sabrina Strano, Giovanni Blandino, Clara Balsano, Patrizia Lavia, and Massimo Levrero: p73 Is Regulated by Phosphorylation at the G₂/M Transition
J. Biol. Chem. 2003 278: 49196-49202. First Published on August 13, 2003; doi:10.1074/jbc.M304921200 [Abstract] [Full Text] [PDF]

Masayasu Kawasaki, Toshinaga Maeda, Kazuyoshi Hanasawa, Iwao Ohkubo, and Tohru Tani: Effect of His-Gly-Lys Motif Derived from Domain 5 of High Molecular Weight Kininogen on Suppression of Cancer Metastasis Both in Vitro and in Vivo
J. Biol. Chem. 2003 278: 49301-49307. First Published on September 23, 2003; doi:10.1074/jbc.M308790200 [Abstract] [Full Text] [PDF]

Takashi Hirakawa, Colette Galet, Mikiko Kishi, and Mario Ascoli: GIPC Binds to the Human Lutropin Receptor (hLHR) through an Unusual PDZ Domain Binding Motif, and It Regulates the Sorting of the Internalized Human Choriogonadotropin and the Density of Cell Surface hLHR
J. Biol. Chem. 2003 278: 49348-49357. First Published on September 24, 2003; doi:10.1074/jbc.M306557200 [Abstract] [Full Text] [PDF]

Yoichi Araki, Susumu Tomita, Haruyasu Yamaguchi, Naomi Miyagi, Akio Sumioka, Yutaka Kirino, and Toshiharu Suzuki: Novel Cadherin-related Membrane Proteins, Alcadeins, Enhance the X11-like Protein-mediated Stabilization of Amyloid ${beta}$ -Protein Precursor Metabolism
J. Biol. Chem. 2003 278: 49448-49458. First Published on September 12, 2003; doi:10.1074/jbc.M306024200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Genomics, Proteomics, and Bioinformatics:

Takeshi Yamagami, Atsunari Tsuchisaka, Kayoko Yamada, William F. Haddon, Leslie A. Harden, and Athanasios Theologis: Biochemical Diversity among the 1-Amino-cyclopropane-1-Carboxylate Synthase Isozymes Encoded by the Arabidopsis Gene Family
J. Biol. Chem. 2003 278: 49102-49112. First Published on September 10, 2003; doi:10.1074/jbc.M308297200 [Abstract] [Full Text] [PDF]

Protein Structure and Folding:

Ming Miao, Catherine M. Bellingham, Richard J. Stahl, Eva E. Sitarz, Christopher J. Lane, and Fred W. Keeley: Sequence and Structure Determinants for the Self-aggregation of Recombinant Polypeptides Modeled after Human Elastin
J. Biol. Chem. 2003 278: 48553-48562. First Published on September 18, 2003; doi:10.1074/jbc.M308465200 [Abstract] [Full Text] [PDF]

Glyn L. Devlin, John A. Carver, and Stephen P. Bottomley: The Selective Inhibition of Serpin Aggregation by the Molecular Chaperone, ${alpha}$ -Crystallin, Indicates a Nucleation-dependent Specificity
J. Biol. Chem. 2003 278: 48644-48650. First Published on September 18, 2003; doi:10.1074/jbc.M308376200 [Abstract] [Full Text] [PDF]

Deborah A. Fraser, Claire L. Harris, Anwen S. Williams, Masashi Mizuno, Sean Gallagher, Richard A. G. Smith, and B. Paul Morgan: Generation of a Recombinant, Membrane-targeted Form of the Complement Regulator CD59: ACTIVITY IN VITRO AND IN VIVO
J. Biol. Chem. 2003 278: 48921-48927. First Published on September 30, 2003; doi:10.1074/jbc.M302598200 [Abstract] [Full Text] [PDF]

Urszula A. Wojtyra, Guillaume Thibault, Ashleigh Tuite, and Walid A. Houry: The N-terminal Zinc Binding Domain of ClpX Is a Dimerization Domain That Modulates the Chaperone Function
J. Biol. Chem. 2003 278: 48981-48990. First Published on August 23, 2003; doi:10.1074/jbc.M307825200 [Abstract] [Full Text] [PDF]

Logan W. Donaldson, Urszula Wojtyra, and Walid A. Houry: Solution Structure of the Dimeric Zinc Binding Domain of the Chaperone ClpX
J. Biol. Chem. 2003 278: 48991-48996. First Published on October 1, 2003; doi:10.1074/jbc.M307826200 [Abstract] [Full Text] [PDF]

Qiaofang Chen, Kevin L. Behar, Tian Xu, Chenhao Fan, and Gabriel G. Haddad: Expression of Drosophila Trehalose-Phosphate Synthase in HEK-293 Cells Increases Hypoxia Tolerance
J. Biol. Chem. 2003 278: 49113-49118. First Published on September 16, 2003; doi:10.1074/jbc.M308652200 [Abstract] [Full Text] [PDF]

Keisuke Hamada, Hideo Ago, Mitsuaki Sugahara, Yuichi Nodake, Seiki Kuramitsu, and Masashi Miyano: Oxyanion Hole-stabilized Stereospecific Isomerization in Ribose-5-phosphate Isomerase (Rpi)
J. Biol. Chem. 2003 278: 49183-49190. First Published on September 17, 2003; doi:10.1074/jbc.M309272200 [Abstract] [Full Text] [PDF]

Hoa P. Nguyen, Nina O. L. Seto, Ye Cai, Eeva K. Leinala, Svetlana N. Borisova, Monica M. Palcic, and Stephen V. Evans: The Influence of an Intramolecular Hydrogen Bond in Differential Recognition of Inhibitory Acceptor Analogs by Human ABO(H) Blood Group A and B Glycosyltransferases
J. Biol. Chem. 2003 278: 49191-49195. First Published on September 11, 2003; doi:10.1074/jbc.M308770200 [Abstract] [Full Text] [PDF]

Eduard Bitto and David B. McKay: The Periplasmic Molecular Chaperone Protein SurA Binds a Peptide Motif That Is Characteristic of Integral Outer Membrane Proteins
J. Biol. Chem. 2003 278: 49316-49322. First Published on September 23, 2003; doi:10.1074/jbc.M308853200 [Abstract] [Full Text] [PDF]

Kenneth A. Bradley, Jeremy Mogridge, G. Jonah, A. Rainey, Sarah Batty, and John A. T. Young: Binding of Anthrax Toxin to Its Receptor Is Similar to ${alpha}$ Integrin-Ligand Interactions
J. Biol. Chem. 2003 278: 49342-49347. First Published on September 24, 2003; doi:10.1074/jbc.M307900200 [Abstract] [Full Text] [PDF]

Jongkeun Choi, Soonwoong Choi, Jungwon Choi, Mee-Kyung Cha, Il-Han Kim, and Whanchul Shin: Crystal Structure of Escherichia coli Thiol Peroxidase in the Oxidized State: INSIGHTS INTO INTRAMOLECULAR DISULFIDE FORMATION AND SUBSTRATE BINDING IN ATYPICAL 2-CYS PEROXIREDOXINS
J. Biol. Chem. 2003 278: 49478-49486. First Published on September 23, 2003; doi:10.1074/jbc.M309015200 [Abstract] [Full Text] [PDF]

Dmitry S. Kryndushkin, Ilya M. Alexandrov, Michael D. Ter-Avanesyan, and Vitaly V. Kushnirov: Yeast [PSI⁺] Prion Aggregates Are Formed by Small Sup35 Polymers Fragmented by Hsp104
J. Biol. Chem. 2003 278: 49636-49643. First Published on September 24, 2003; doi:10.1074/jbc.M307996200 [Abstract] [Full Text] [PDF]

Bi-Hung Peng, J. Ching Lee, and Gerald A. Campbell: In Vitro Protein Complex Formation with Cytoskeleton-anchoring Domain of Occludin Identified by Limited Proteolysis
J. Biol. Chem. 2003 278: 49644-49651. First Published on September 25, 2003; doi:10.1074/jbc.M302782200 [Abstract] [Full Text] [PDF]

Enzyme Catalysis and Regulation:

Daniel P. Sherbet, Dov Tiosano, Kerri M. Kwist, Zeev Hochberg, and Richard J. Auchus: CYP17 Mutation E305G Causes Isolated 17,20-Lyase Deficiency by Selectively Altering Substrate Binding
J. Biol. Chem. 2003 278: 48563-48569. First Published on September 22, 2003; doi:10.1074/jbc.M307586200 [Abstract] [Full Text] [PDF]

Richárd Szmola, Zoltán Kukor, and Miklós Sahin-Tóth: Human Mesotrypsin Is a Unique Digestive Protease Specialized for the Degradation of Trypsin Inhibitors
J. Biol. Chem. 2003 278: 48580-48589. First Published on September 24, 2003; doi:10.1074/jbc.M310301200 [Abstract] [Full Text] [PDF]

Morten Sørlie, Antonius C. F. Gorren, Stéphane Marchal, Toru Shimizu, Reinhard Lange, Kristoffer K. Andersson, and Bernd Mayer: Single-turnover of Nitric-oxide Synthase in the Presence of 4-Amino-tetrahydrobiopterin: PROPOSED ROLE FOR TETRAHYDROBIOPTERIN AS A PROTON DONOR
J. Biol. Chem. 2003 278: 48602-48610. First Published on September 26, 2003; doi:10.1074/jbc.M305682200 [Abstract] [Full Text] [PDF]

Gerrit J. Poelarends, William H. Johnson, Jr., Alexey G. Murzin, and Christian P. Whitman: Mechanistic Characterization of a Bacterial Malonate Semialdehyde Decarboxylase: IDENTIFICATION OF A NEW ACTIVITY IN THE TAUTOMERASE SUPERFAMILY
J. Biol. Chem. 2003 278: 48674-48683. First Published on September 23, 2003; doi:10.1074/jbc.M306706200 [Abstract] [Full Text] [PDF]

Stefan F. Lichtenthaler, Diana-ines Dominguez, Gil G. Westmeyer, Karina Reiss, Christian Haass, Paul Saftig, Bart De Strooper, and Brian Seed: The Cell Adhesion Protein P-selectin Glycoprotein Ligand-1 Is a Substrate for the Aspartyl Protease BACE1
J. Biol. Chem. 2003 278: 48713-48719. First Published on September 24, 2003; doi:10.1074/jbc.M303861200 [Abstract] [Full Text] [PDF]

Jui Pandhare, Chandravanu Dash, Mala Rao, and Vasanti Deshpande: Slow Tight Binding Inhibition of Proteinase K by a Proteinaceous Inhibitor: CONFORMATIONAL ALTERATIONS RESPONSIBLE FOR CONFERRING IRREVERSIBILITY TO THE ENZYME-INHIBITOR COMPLEX
J. Biol. Chem. 2003 278: 48735-48744. First Published on September 24, 2003; doi:10.1074/jbc.M308976200 [Abstract] [Full Text] [PDF]

Zoltán Szeltner, Dean Rea, Veronika Renner, Luiz Juliano, Vilmos Fülöp, and László Polgár: Electrostatic Environment at the Active Site of Prolyl Oligopeptidase Is Highly Influential during Substrate Binding
J. Biol. Chem. 2003 278: 48786-48793. First Published on September 25, 2003; doi:10.1074/jbc.M309555200 [Abstract] [Full Text] [PDF]

Gareth A. Roberts, Ayhan Çelik, Dominic J. B. Hunter, Tobias W. B. Ost, John H. White, Stephen K. Chapman, Nicholas J. Turner, and Sabine L. Flitsch: A Self-sufficient Cytochrome P450 with a Primary Structural Organization That Includes a Flavin Domain and a [2Fe-2S] Redox Center
J. Biol. Chem. 2003 278: 48914-48920. First Published on September 27, 2003; doi:10.1074/jbc.M309630200 [Abstract] [Full Text] [PDF]

Jesús Tejero, Marta Martínez-Júlvez, Tomás Mayoral, Alejandra Luquita, Julia Sanz-Aparicio, Juan A. Hermoso, John K. Hurley, Gordon Tollin, Carlos Gómez-Moreno, and Milagros Medina: Involvement of the Pyrophosphate and the 2'-Phosphate Binding Regions of Ferredoxin-NADP⁺ Reductase in Coenzyme Specificity
J. Biol. Chem. 2003 278: 49203-49214. First Published on September 18, 2003; doi:10.1074/jbc.M307934200 [Abstract] [Full Text] [PDF]

Susanne Eschenburg, Wolfgang Kabsch, Martha L. Healy, and Ernst Schönbrunn: A New View of the Mechanisms of UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA) and 5-Enolpyruvylshikimate-3-phosphate Synthase (AroA) Derived from X-ray Structures of Their Tetrahedral Reaction Intermediate States
J. Biol. Chem. 2003 278: 49215-49222. First Published on September 16, 2003; doi:10.1074/jbc.M309741200 [Abstract] [Full Text] [PDF]

Tae-Kang Kim, Peychii Lee, and Roberta F. Colman: Critical Role of Lys²¹² and Tyr¹⁴⁰ in Porcine NADP-dependent Isocitrate Dehydrogenase
J. Biol. Chem. 2003 278: 49323-49331. First Published on September 25, 2003; doi:10.1074/jbc.M303781200 [Abstract] [Full Text] [PDF]

Yu-Chun Du, Srinivasa R. Peddi, and Robert J. Spreitzer: Assessment of Structural and Functional Divergence Far from the Large Subunit Active Site of Ribulose-1,5-bisphosphate Carboxylase/Oxygenase
J. Biol. Chem. 2003 278: 49401-49405. First Published on September 23, 2003; doi:10.1074/jbc.M309993200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Yihua Huang, Rebecca L. Rich, David G. Myszka, and Hao Wu: Requirement of Both the Second and Third BIR Domains for the Relief of X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Caspase Inhibition by Smac
J. Biol. Chem. 2003 278: 49517-49522. First Published on September 25, 2003; doi:10.1074/jbc.M310061200 [Abstract] [Full Text] [PDF]

Metabolism and Bioenergetics:

Michael P. Murphy, Karim S. Echtay, Frances H. Blaikie, Jordi Asin-Cayuela, Helena M. Cochemé, Katherine Green, Julie A. Buckingham, Ellen R. Taylor, Fiona Hurrell, Gillian Hughes, Satomi Miwa, Christopher E. Cooper, Dimitri A. Svistunenko, Robin A. J. Smith, and Martin D. Brand: Superoxide Activates Uncoupling Proteins by Generating Carbon-centered Radicals and Initiating Lipid Peroxidation: STUDIES USING A MITOCHONDRIA-TARGETED SPIN TRAP DERIVED FROM ${alpha}$ -PHENYL-N-tert-BUTYLNITRONE
J. Biol. Chem. 2003 278: 48534-48545. First Published on September 12, 2003; doi:10.1074/jbc.M308529200 [Abstract] [Full Text] [PDF]

Tomas Morosinotto, Jacques Breton, Roberto Bassi, and Roberta Croce: The Nature of a Chlorophyll Ligand in Lhca Proteins Determines the Far Red Fluorescence Emission Typical of Photosystem I
J. Biol. Chem. 2003 278: 49223-49229. First Published on September 22, 2003; doi:10.1074/jbc.M309203200 [Abstract] [Full Text] [PDF]

Ruth E. Gimeno, David J. Hirsch, Sandhya Punreddy, Ying Sun, Angelica M. Ortegon, Hui Wu, Tom Daniels, Alain Stricker-Krongrad, Harvey F. Lodish, and Andreas Stahl: Targeted Deletion of Fatty Acid Transport Protein-4 Results in Early Embryonic Lethality
J. Biol. Chem. 2003 278: 49512-49516. First Published on September 24, 2003; doi:10.1074/jbc.M309759200 [Abstract] [Full Text] [PDF]

Virginie Coustou, Sébastien Besteiro, Marc Biran, Philippe Diolez, Véronique Bouchaud, Pierre Voisin, Paul A. M. Michels, Paul Canioni, Théo Baltz, and Frédéric Bringaud: ATP Generation in the Trypanosoma brucei Procyclic Form: CYTOSOLIC SUBSTRATE LEVEL PHOSPHORYLATION IS ESSENTIAL, BUT NOT OXIDATIVE PHOSPHORYLATION
J. Biol. Chem. 2003 278: 49625-49635. First Published on September 23, 2003; doi:10.1074/jbc.M307872200 [Abstract] [Full Text] [PDF]

Glycobiology and Extracellular Matrices:

Zhonglin Xie, Mahipal Singh, Deborah A. Siwik, William L. Joyner, and Krishna Singh: Osteopontin Inhibits Interleukin-1 ${beta}$ -stimulated Increases in Matrix Metalloproteinase Activity in Adult Rat Cardiac Fibroblasts: ROLE OF PROTEIN KINASE C- ${zeta}$
J. Biol. Chem. 2003 278: 48546-48552. First Published on September 18, 2003; doi:10.1074/jbc.M302727200 [Abstract] [Full Text] [PDF]

Xiao-Qi Wang, Ping Sun, and Amy S. Paller: Ganglioside GM3 Blocks the Activation of Epidermal Growth Factor Receptor Induced by Integrin at Specific Tyrosine Sites
J. Biol. Chem. 2003 278: 48770-48778. First Published on September 25, 2003; doi:10.1074/jbc.M308818200 [Abstract] [Full Text] [PDF]

Charles D. Blundell, David J. Mahoney, Andrew Almond, Paul L. DeAngelis, Jan D. Kahmann, Peter Teriete, Andrew R. Pickford, Iain D. Campbell, and Anthony J. Day: The Link Module from Ovulation- and Inflammation-associated Protein TSG-6 Changes Conformation on Hyaluronan Binding
J. Biol. Chem. 2003 278: 49261-49270. First Published on September 11, 2003; doi:10.1074/jbc.M309623200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Misa Suzuki, Kiyohiko Angata, Jun Nakayama, and Minoru Fukuda: Polysialic Acid and Mucin Type O-Glycans on the Neural Cell Adhesion Molecule Differentially Regulate Myoblast Fusion
J. Biol. Chem. 2003 278: 49459-49468. First Published on September 17, 2003; doi:10.1074/jbc.M308316200 [Abstract] [Full Text] [PDF]

Susanna Karvinen, Sanna Pasonen-Seppänen, Juha M. T. Hyttinen, Juha-Pekka Pienimäki, Kari Törrönen, Tiina A. Jokela, Markku I. Tammi, and Raija Tammi: Keratinocyte Growth Factor Stimulates Migration and Hyaluronan Synthesis in the Epidermis by Activation of Keratinocyte Hyaluronan Synthases 2 and 3
J. Biol. Chem. 2003 278: 49495-49504. First Published on September 23, 2003; doi:10.1074/jbc.M310445200 [Abstract] [Full Text] [PDF]

Lipids and Lipoproteins:

Xian-Cheng Jiang, Thomas P. Beyer, Zhiqiang Li, Jin Liu, Wei Quan, Robert J. Schmidt, Youyan Zhang, William R. Bensch, Patrick I. Eacho, and Guoqing Cao: Enlargement of High Density Lipoprotein in Mice via Liver X Receptor Activation Requires Apolipoprotein E and Is Abolished by Cholesteryl Ester Transfer Protein Expression
J. Biol. Chem. 2003 278: 49072-49078. First Published on August 28, 2003; doi:10.1074/jbc.M304274200 [Abstract] [Full Text] [PDF]

Tatsufumi Hiramatsu, Hirofumi Sonoda, Yasukazu Takanezawa, Rei Morikawa, Mayuko Ishida, Kohji Kasahara, Yutaka Sanai, Ryo Taguchi, Junken Aoki, and Hiroyuki Arai: Biochemical and Molecular Characterization of Two Phosphatidic Acid-selective Phospholipase A₁s, mPA-PLA₁ ${alpha}$ and mPA-PLA₁ ${beta}$
J. Biol. Chem. 2003 278: 49438-49447. First Published on September 8, 2003; doi:10.1074/jbc.M213018200 [Abstract] [Full Text] [PDF]

Membrane Transport, Structure, Function, and Biogenesis:

Julien Mamet, Michel Lazdunski, and Nicolas Voilley: How Nerve Growth Factor Drives Physiological and Inflammatory Expressions of Acid-sensing Ion Channel 3 in Sensory Neurons
J. Biol. Chem. 2003 278: 48907-48913. First Published on September 30, 2003; doi:10.1074/jbc.M309468200 [Abstract] [Full Text] [PDF]

Fenglei Jiang, Minyong Chen, Liang Yi, Jan-Willem de Gier, Andreas Kuhn, and Ross E. Dalbey: Defining the Regions of Escherichia coli YidC That Contribute to Activity
J. Biol. Chem. 2003 278: 48965-48972. First Published on September 22, 2003; doi:10.1074/jbc.M307362200 [Abstract] [Full Text] [PDF]

Noriko Kondo-Okamoto, Janet M. Shaw, and Koji Okamoto: Mmm1p Spans Both the Outer and Inner Mitochondrial Membranes and Contains Distinct Domains for Targeting and Foci Formation
J. Biol. Chem. 2003 278: 48997-49005. First Published on September 12, 2003; doi:10.1074/jbc.M308436200 [Abstract] [Full Text] [PDF]

Dong Wang, Juan M. Pascual, Pavel Iserovich, Hong Yang, Li Ma, Kunyan Kuang, Felipe A. Zuniga, Ruo Peng Sun, Kavita M. Swaroop, Jorge Fischbarg, and Darryl C. De Vivo: Functional Studies of Threonine 310 Mutations in Glut1: T310I IS PATHOGENIC, CAUSING Glut1 DEFICIENCY
J. Biol. Chem. 2003 278: 49015-49021. First Published on September 16, 2003; doi:10.1074/jbc.M308765200 [Abstract] [Full Text] [PDF]

Marco A. Salazar, Adam V. Kwiatkowski, Lorenzo Pellegrini, Gianluca Cestra, Margaret H. Butler, Kent L. Rossman, Daniel M. Serna, John Sondek, Frank B. Gertler, and Pietro De Camilli: Tuba, a Novel Protein Containing Bin/Amphiphysin/Rvs and Dbl Homology Domains, Links Dynamin to Regulation of the Actin Cytoskeleton
J. Biol. Chem. 2003 278: 49031-49043. First Published on September 22, 2003; doi:10.1074/jbc.M308104200 [Abstract] [Full Text] [PDF]

Peng-Peng Zhu, Andrew Patterson, Brigitte Lavoie, Julia Stadler, Marwa Shoeb, Rakesh Patel, and Craig Blackstone: Cellular Localization, Oligomerization, and Membrane Association of the Hereditary Spastic Paraplegia 3A (SPG3A) Protein Atlastin
J. Biol. Chem. 2003 278: 49063-49071. First Published on September 23, 2003; doi:10.1074/jbc.M306702200 [Abstract] [Full Text] [PDF]

Yanfang Xu, Dipika Tuteja, Zhao Zhang, Danyan Xu, Yi Zhang, Jennifer Rodriguez, Liping Nie, Holly R. Tuxson, J. Nilas Young, Kathryn A. Glatter, Ana E. Vázquez, Ebenezer N. Yamoah, and Nipavan Chiamvimonvat: Molecular Identification and Functional Roles of a Ca²⁺-activated K⁺ Channel in Human and Mouse Hearts
J. Biol. Chem. 2003 278: 49085-49094. First Published on September 17, 2003; doi:10.1074/jbc.M307508200 [Abstract] [Full Text] [PDF]

M. Mobeen Raja, Navneet K. Tyagi, and Rolf K. H. Kinne: Phlorizin Recognition in a C-terminal Fragment of SGLT1 Studied by Tryptophan Scanning and Affinity Labeling
J. Biol. Chem. 2003 278: 49154-49163. First Published on September 3, 2003; doi:10.1074/jbc.M306881200 [Abstract] [Full Text] [PDF]

Morris F. Manolson, Hesheng Yu, Weimin Chen, Yeqi Yao, Keying Li, Rita L. Lees, and Johan N. M. Heersche: The a3 Isoform of the 100-kDa V-ATPase Subunit Is Highly but Differentially Expressed in Large ( $>=$ 10 Nuclei) and Small ( $<=$ 5 Nuclei) Osteoclasts
J. Biol. Chem. 2003 278: 49271-49278. First Published on September 22, 2003; doi:10.1074/jbc.M309914200 [Abstract] [Full Text] [PDF]

Lidija Ivic, Tristan T. J. Sands, Nathan Fishkin, Koji Nakanishi, Arnold R. Kriegstein, and Kristian Strømgaard: Terpene Trilactones from Ginkgo biloba Are Antagonists of Cortical Glycine and GABA_A Receptors
J. Biol. Chem. 2003 278: 49279-49285. First Published on September 22, 2003; doi:10.1074/jbc.M304034200 [Abstract] [Full Text] [PDF]

Hélène Réglier-Poupet, Claude Frehel, Iharilalao Dubail, Jean-Luc Beretti, Patrick Berche, Alain Charbit, and Catherine Raynaud: Maturation of Lipoproteins by Type II Signal Peptidase Is Required for Phagosomal Escape of Listeria monocytogenes
J. Biol. Chem. 2003 278: 49469-49477. First Published on September 15, 2003; doi:10.1074/jbc.M307953200 [Abstract] [Full Text] [PDF]

Nuria Pastor-Soler, Valérie Beaulieu, Tatiana N. Litvin, Nicolas Da Silva, Yanqiu Chen, Dennis Brown, Jochen Buck, Lonny R. Levin, and Sylvie Breton: Bicarbonate-regulated Adenylyl Cyclase (sAC) Is a Sensor That Regulates pH-dependent V-ATPase Recycling
J. Biol. Chem. 2003 278: 49523-49529. First Published on September 25, 2003; doi:10.1074/jbc.M309543200 [Abstract] [Full Text] [PDF]

Katherine M. Dibb, Thierry Rose, Samy Y. Makary, Thomas W. Claydon, Decha Enkvetchakul, Robert Leach, Colin G. Nichols, and Mark R. Boyett: Molecular Basis of Ion Selectivity, Block, and Rectification of the Inward Rectifier Kir3.1/Kir3.4 K⁺ Channel
J. Biol. Chem. 2003 278: 49537-49548. First Published on September 22, 2003; doi:10.1074/jbc.M307723200 [Abstract] [Full Text] [PDF]

Zhiqiang Qu, Raymond W. Wei, Wesley Mann, and H. Criss Hartzell: Two Bestrophins Cloned from Xenopus laevis Oocytes Express Ca²⁺-activated Cl^- Currents
J. Biol. Chem. 2003 278: 49563-49572. First Published on August 25, 2003; doi:10.1074/jbc.M308414200 [Abstract] [Full Text] [PDF]

Mechanisms Of Signal Transduction:

Hui Qin, Brian Raught, Nahum Sonenberg, Elaine G. Goldstein, and Arthur M. Edelman: Phosphorylation Screening Identifies Translational Initiation Factor 4GII as an Intracellular Target of Ca²⁺/Calmodulin-dependent Protein Kinase I
J. Biol. Chem. 2003 278: 48570-48579. First Published on September 24, 2003; doi:10.1074/jbc.M308781200 [Abstract] [Full Text] [PDF]

Hendrik Szurmant, Michael W. Bunn, Vincent J. Cannistraro, and George W. Ordal: Bacillus subtilis Hydrolyzes CheY-P at the Location of Its Action, the Flagellar Switch
J. Biol. Chem. 2003 278: 48611-48616. First Published on August 14, 2003; doi:10.1074/jbc.M306180200 [Abstract] [Full Text] [PDF]

Coralie Sengenès, Anne Bouloumié, Hans Hauner, Michel Berlan, Rudi Busse, Max Lafontan, and Jean Galitzky: Involvement of a cGMP-dependent Pathway in the Natriuretic Peptide-mediated Hormone-sensitive Lipase Phosphorylation in Human Adipocytes
J. Biol. Chem. 2003 278: 48617-48626. First Published on September 10, 2003; doi:10.1074/jbc.M303713200 [Abstract] [Full Text] [PDF]

Steve Gendron, Julie Couture, and Fawzi Aoudjit: Integrin ${alpha}$ ₂ ${beta}$ ₁ Inhibits Fas-mediated Apoptosis in T Lymphocytes by Protein Phosphatase 2A-dependent Activation of the MAPK/ERK Pathway
J. Biol. Chem. 2003 278: 48633-48643. First Published on September 17, 2003; doi:10.1074/jbc.M305169200 [Abstract] [Full Text] [PDF]

Joachim G. Schulz, Wim Annaert, Joël Vandekerckhove, Pascale Zimmermann, Bart De Strooper, and Guido David: Syndecan 3 Intramembrane Proteolysis Is Presenilin/ ${gamma}$ -Secretase-dependent and Modulates Cytosolic Signaling
J. Biol. Chem. 2003 278: 48651-48657. First Published on September 22, 2003; doi:10.1074/jbc.M308424200 [Abstract] [Full Text] [PDF]

Patrick Tarnow, Torsten Schöneberg, Heiko Krude, Annette Grüters, and Heike Biebermann: Mutationally Induced Disulfide Bond Formation within the Third Extracellular Loop Causes Melanocortin 4 Receptor Inactivation in Patients with Obesity
J. Biol. Chem. 2003 278: 48666-48673. First Published on September 22, 2003; doi:10.1074/jbc.M309941200 [Abstract] [Full Text] [PDF]

Luis del Peso, María C. Castellanos, Elisa Temes, Silvia Martín-Puig, Yolanda Cuevas, Gemma Olmos, and Manuel O. Landázuri: The von Hippel Lindau/Hypoxia-inducible Factor (HIF) Pathway Regulates the Transcription of the HIF-Proline Hydroxylase Genes in Response to Low Oxygen
J. Biol. Chem. 2003 278: 48690-48695. First Published on September 23, 2003; doi:10.1074/jbc.M308862200 [Abstract] [Full Text] [PDF]

Kim Henriksen, Morten Karsdal, Jean-Marie Delaissé, and Michael T. Engsig: RANKL and Vascular Endothelial Growth Factor (VEGF) Induce Osteoclast Chemotaxis through an ERK1/2-dependent Mechanism
J. Biol. Chem. 2003 278: 48745-48753. First Published on September 23, 2003; doi:10.1074/jbc.M309193200 [Abstract] [Full Text] [PDF]

Yoshihiro Morishima, Kimon C. Kanelakis, Patrick J. M. Murphy, Ezra R. Lowe, Gary J. Jenkins, Yoichi Osawa, Roger K. Sunahara, and William B. Pratt: The Hsp90 Cochaperone p23 Is the Limiting Component of the Multiprotein Hsp90/Hsp70-based Chaperone System in Vivo Where It Acts to Stabilize the Client Protein·Hsp90 Complex
J. Biol. Chem. 2003 278: 48754-48763. First Published on September 24, 2003; doi:10.1074/jbc.M309814200 [Abstract] [Full Text] [PDF]

Takashi Ohama, Masatoshi Hori, Koichi Sato, Hiroshi Ozaki, and Hideaki Karaki: Chronic Treatment with Interleukin-1 ${beta}$ Attenuates Contractions by Decreasing the Activities of CPI-17 and MYPT-1 in Intestinal Smooth Muscle
J. Biol. Chem. 2003 278: 48794-48804. First Published on September 25, 2003; doi:10.1074/jbc.M310166200 [Abstract] [Full Text] [PDF]

Samer M. Hussein, Eleanor K. Duff, and Christian Sirard: Smad4 and ${beta}$ -Catenin Co-activators Functionally Interact with Lymphoid-enhancing Factor to Regulate Graded Expression of Msx2
J. Biol. Chem. 2003 278: 48805-48814. First Published on October 9, 2003; doi:10.1074/jbc.M305472200 [Abstract] [Full Text] [PDF]

Hong Ren, Yumiko Honse, and Robert W. Peoples: A Site of Alcohol Action in the Fourth Membrane-associated Domain of the N-Methyl-D-aspartate Receptor
J. Biol. Chem. 2003 278: 48815-48820. First Published on September 23, 2003; doi:10.1074/jbc.M302097200 [Abstract] [Full Text] [PDF]

Peirong Yang, Yibing Qyang, Geoffrey Bartholomeusz, Xiao Zhou, and Stevan Marcus: The Novel Rho GTPase-activating Protein Family Protein, Rga8, Provides a Potential Link between Cdc42/p21-activated Kinase and Rho Signaling Pathways in the Fission Yeast, Schizosaccharomyces pombe
J. Biol. Chem. 2003 278: 48821-48830. First Published on September 23, 2003; doi:10.1074/jbc.M306819200 [Abstract] [Full Text] [PDF]

Ling Wang, Huiyan Zeng, Ping Wang, Shay Soker, and Debabrata Mukhopadhyay: Neuropilin-1-mediated Vascular Permeability Factor/Vascular Endothelial Growth Factor-dependent Endothelial Cell Migration
J. Biol. Chem. 2003 278: 48848-48860. First Published on September 26, 2003; doi:10.1074/jbc.M310047200 [Abstract] [Full Text] [PDF]

Piyajit Watcharasit, Gautam N. Bijur, Ling Song, Jianhui Zhu, Xinbin Chen, and Richard S. Jope: Glycogen Synthase Kinase-3 ${beta}$ (GSK3 ${beta}$ ) Binds to and Promotes the Actions of p53
J. Biol. Chem. 2003 278: 48872-48879. First Published on September 30, 2003; doi:10.1074/jbc.M305870200 [Abstract] [Full Text] [PDF]

Naohisa Tamura and David L. Garbers: Regulation of the Guanylyl Cyclase-B Receptor by Alternative Splicing
J. Biol. Chem. 2003 278: 48880-48889. First Published on September 26, 2003; doi:10.1074/jbc.M308680200 [Abstract] [Full Text] [PDF]

Isabel D. Alves, Zdzislaw Salamon, Eva Varga, Henry I. Yamamura, Gordon Tollin, and Victor J. Hruby: Direct Observation of G-protein Binding to the Human ${delta}$ -Opioid Receptor Using Plasmon-Waveguide Resonance Spectroscopy
J. Biol. Chem. 2003 278: 48890-48897. First Published on September 30, 2003; doi:10.1074/jbc.M306866200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Robert S. Carter, Kevin N. Pennington, Bradley J. Ungurait, Pia Arrate, and Dean W. Ballard: Signal-induced Ubiquitination of I ${kappa}$ B Kinase- ${beta}$
J. Biol. Chem. 2003 278: 48903-48906. First Published on September 26, 2003; doi:10.1074/jbc.M310686200 [Abstract] [Full Text] [PDF]

Neal Silverman, Rui Zhou, Rachel L. Erlich, Mike Hunter, Erik Bernstein, David Schneider, and Tom Maniatis: Immune Activation of NF- ${kappa}$ B and JNK Requires Drosophila TAK1
J. Biol. Chem. 2003 278: 48928-48934. First Published on September 30, 2003; doi:10.1074/jbc.M304802200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Weigang Tang, Oleg A. Pavlish, Vladimir S. Spiegelman, Andrey A. Parkhitko, and Serge Y. Fuchs: Interaction of Epstein-Barr Virus Latent Membrane Protein 1 with SCF^HOS/-TrCP E3 Ubiquitin Ligase Regulates Extent of NF- ${kappa}$ B Activation
J. Biol. Chem. 2003 278: 48942-48949. First Published on September 30, 2003; doi:10.1074/jbc.M307962200 [Abstract] [Full Text] [PDF]

Margaret I. Davis, Jennifer Ronesi, and David M. Lovinger: A Predominant Role for Inhibition of the Adenylate Cyclase/Protein Kinase A Pathway in ERK Activation by Cannabinoid Receptor 1 in N1E-115 Neuroblastoma Cells
J. Biol. Chem. 2003 278: 48973-48980. First Published on September 29, 2003; doi:10.1074/jbc.M305697200 [Abstract] [Full Text] [PDF]

Xiaoxiao Chen, Yong Li, Kaihua Wei, Li Li, Wanli Liu, Yunping Zhu, Zongyin Qiu, and Fuchu He: The Potentiation Role of Hepatopoietin on Activator Protein-1 Is Dependent on Its Sulfhydryl Oxidase Activity
J. Biol. Chem. 2003 278: 49022-49030. First Published on September 18, 2003; doi:10.1074/jbc.M304057200 [Abstract] [Full Text] [PDF]

Jeffrey S. Armstrong, Matthew Whiteman, Peter Rose, and Dean P. Jones: The Coenzyme Q₁₀ Analog Decylubiquinone Inhibits the Redox-activated Mitochondrial Permeability Transition: ROLE OF MITOCHONDRIAL RESPIRATORY COMPLEX III
J. Biol. Chem. 2003 278: 49079-49084. First Published on August 29, 2003; doi:10.1074/jbc.M307841200 [Abstract] [Full Text] [PDF]

Shusuke Takahashi, Ryoko Inatome, Azusa Hotta, Qingyu Qin, Renee Hackenmiller, M. Celeste Simon, Hirohei Yamamura, and Shigeru Yanagi: Role for Fes/Fps Tyrosine Kinase in Microtubule Nucleation through Its Fes/CIP4 Homology Domain
J. Biol. Chem. 2003 278: 49129-49133. First Published on October 8, 2003; doi:10.1074/jbc.C300289200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Jürgen Radons, Stefan Dove, Detlef Neumann, Reinhold Altmann, Alexander Botzki, Michael U. Martin, and Werner Falk: The Interleukin 1 (IL-1) Receptor Accessory Protein Toll/IL-1 Receptor Domain: ANALYSIS OF PUTATIVE INTERACTION SITES BY IN VITRO MUTAGENESIS AND MOLECULAR MODELING
J. Biol. Chem. 2003 278: 49145-49153. First Published on September 17, 2003; doi:10.1074/jbc.M306077200 [Abstract] [Full Text] [PDF]

Graeme B. Bolger, Angela McCahill, Elaine Huston, York-Fong Cheung, Theresa McSorley, George S. Baillie, and Miles D. Houslay: The Unique Amino-terminal Region of the PDE4D5 cAMP Phosphodiesterase Isoform Confers Preferential Interaction with ${beta}$ -Arrestins
J. Biol. Chem. 2003 278: 49230-49238. First Published on September 18, 2003; doi:10.1074/jbc.M303772200 [Abstract] [Full Text] [PDF]

Naoya Fujita, Saori Sato, and Takashi Tsuruo: Phosphorylation of p27^Kip1 at Threonine 198 by p90 Ribosomal Protein S6 Kinases Promotes Its Binding to 14-3-3 and Cytoplasmic Localization
J. Biol. Chem. 2003 278: 49254-49260. First Published on September 22, 2003; doi:10.1074/jbc.M306614200 [Abstract] [Full Text] [PDF]

Hongyan Zhu, Liqing Wu, and Carl G. Maki: MDM2 and Promyelocytic Leukemia Antagonize Each Other through Their Direct Interaction with p53
J. Biol. Chem. 2003 278: 49286-49292. First Published on September 24, 2003; doi:10.1074/jbc.M308302200 [Abstract] [Full Text] [PDF]

Shine Tu, Wen Jin Wu, Jiabin Wang, and Richard A. Cerione: Epidermal Growth Factor-dependent Regulation of Cdc42 Is Mediated by the Src Tyrosine Kinase
J. Biol. Chem. 2003 278: 49293-49300. First Published on September 23, 2003; doi:10.1074/jbc.M307021200 [Abstract] [Full Text] [PDF]

Fabio Naro, Vania De Arcangelis, Claudio Sette, Caterina Ambrosio, Hiba Komati, Mario Molinaro, Sergio Adamo, and Georges Nemoz: A Bimodal Modulation of the cAMP Pathway Is Involved in the Control of Myogenic Differentiation in L6 Cells
J. Biol. Chem. 2003 278: 49308-49315. First Published on September 23, 2003; doi:10.1074/jbc.M306941200 [Abstract] [Full Text] [PDF]

Jihong Jiang, Douglas Cyr, Roger W. Babbitt, William C. Sessa, and Cam Patterson: Chaperone-dependent Regulation of Endothelial Nitric-oxide Synthase Intracellular Trafficking by the Co-chaperone/Ubiquitin Ligase CHIP
J. Biol. Chem. 2003 278: 49332-49341. First Published on September 24, 2003; doi:10.1074/jbc.M304738200 [Abstract] [Full Text] [PDF]

Mark C. Overton, Sharon L. Chinault, and Kendall J. Blumer: Oligomerization, Biogenesis, and Signaling Is Promoted by a Glycophorin A-like Dimerization Motif in Transmembrane Domain 1 of a Yeast G Protein-coupled Receptor
J. Biol. Chem. 2003 278: 49369-49377. First Published on September 23, 2003; doi:10.1074/jbc.M308654200 [Abstract] [Full Text] [PDF]

Alexander Hümmer, Oliver Delzeith, Shannon R. Gomez, Rosa L. Moreno, Melanie D. Mark, and Stefan Herlitze: Competitive and Synergistic Interactions of G Protein ${beta}$ ₂ and Ca²⁺ Channel ${beta}$ _1b Subunits with Ca_v2.1 Channels, Revealed by Mammalian Two-hybrid and Fluorescence Resonance Energy Transfer Measurements
J. Biol. Chem. 2003 278: 49386-49400. First Published on September 24, 2003; doi:10.1074/jbc.M306645200 [Abstract] [Full Text] [PDF] [Supplemental Data]

L. Miguel Martins, Benjamin E. Turk, Victoria Cowling, Annabel Borg, Emily T. Jarrell, Lewis C. Cantley, and Julian Downward: Binding Specificity and Regulation of the Serine Protease and PDZ Domains of HtrA2/Omi
J. Biol. Chem. 2003 278: 49417-49427. First Published on September 25, 2003; doi:10.1074/jbc.M308659200 [Abstract] [Full Text] [PDF]

Christophe Petrel, Albane Kessler, Fouzia Maslah, Philippe Dauban, Robert H. Dodd, Didier Rognan, and Martial Ruat: Modeling and Mutagenesis of the Binding Site of Calhex 231, a Novel Negative Allosteric Modulator of the Extracellular Ca²⁺-sensing Receptor
J. Biol. Chem. 2003 278: 49487-49494. First Published on September 23, 2003; doi:10.1074/jbc.M308010200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Sun Sik Bae, Han Cho, James Mu, and Morris J. Birnbaum: Isoform-specific Regulation of Insulin-dependent Glucose Uptake by Akt/Protein Kinase B
J. Biol. Chem. 2003 278: 49530-49536. First Published on September 30, 2003; doi:10.1074/jbc.M306782200 [Abstract] [Full Text] [PDF]

Mark Paciga, Christopher R. McCudden, Constantine Londos, Gabriel E. DiMattia, and Graham F. Wagner: Targeting of Big Stanniocalcin and Its Receptor to Lipid Storage Droplets of Ovarian Steroidogenic Cells
J. Biol. Chem. 2003 278: 49549-49554. First Published on September 25, 2003; doi:10.1074/jbc.M307302200 [Abstract] [Full Text] [PDF]

Yonglong Zou, Seunghwan Lim, Kangmoon Lee, Xiaobing Deng, and Eileen Friedman: Serine/Threonine Kinase Mirk/Dyrk1B Is an Inhibitor of Epithelial Cell Migration and Is Negatively Regulated by the Met Adaptor Ran-binding Protein M
J. Biol. Chem. 2003 278: 49573-49581. First Published on September 18, 2003; doi:10.1074/jbc.M307556200 [Abstract] [Full Text] [PDF]

Jiuhong Yu, Xu-Wen Liu, and Hyeong-Reh Choi Kim: Platelet-derived Growth Factor (PDGF) Receptor- ${alpha}$ -activated c-Jun NH₂-terminal Kinase-1 Is Critical for PDGF-induced p21^WAF1/CIP1 Promoter Activity Independent of p53
J. Biol. Chem. 2003 278: 49582-49588. First Published on September 23, 2003; doi:10.1074/jbc.M309986200 [Abstract] [Full Text] [PDF]

Thomas Strahl, Birgit Grafelmann, Jens Dannenberg, Jeremy Thorner, and Olaf Pongs: Conservation of Regulatory Function in Calcium-binding Proteins: HUMAN FREQUENIN (NEURONAL CALCIUM SENSOR-1) ASSOCIATES PRODUCTIVELY WITH YEAST PHOSPHATIDYLINOSITOL 4-KINASE ISOFORM, Pik1
J. Biol. Chem. 2003 278: 49589-49599. First Published on September 25, 2003; doi:10.1074/jbc.M309017200 [Abstract] [Full Text] [PDF]

Betty Yuet Ye Tam, Kenneth W. Finnson, and Anie Philip: Glycosylphosphatidylinositol-anchored Proteins Regulate Transforming Growth Factor- ${beta}$ Signaling in Human Keratinocytes
J. Biol. Chem. 2003 278: 49610-49617. First Published on September 22, 2003; doi:10.1074/jbc.M308492200 [Abstract] [Full Text] [PDF]

Molecular Basis Of Cell and Developmental Biology:

Patria Castronuevo, Michael A. Thornton, Lois E. McCarthy, Joanne Klimas, and Barbara P. Schick: DNase I Hypersensitivity Patterns of the Serglycin Proteoglycan Gene in Resting and Phorbol 12-Myristate 13-Acetate-stimulated Human Erythroleukemia (HEL), CHRF 288-11, and HL-60 Cells Compared with Neutrophils and Human Umbilical Vein Endothelial Cells
J. Biol. Chem. 2003 278: 48704-48712. First Published on September 23, 2003; doi:10.1074/jbc.M310220200 [Abstract] [Full Text] [PDF]

Susana Solá, Xiaoming Ma, Rui E. Castro, Betsy T. Kren, Clifford J. Steer, and Cecília M. P. Rodrigues: Ursodeoxycholic Acid Modulates E2F-1 and p53 Expression through a Caspase-independent Mechanism in Transforming Growth Factor ${beta}$ 1-induced Apoptosis of Rat Hepatocytes
J. Biol. Chem. 2003 278: 48831-48838. First Published on September 26, 2003; doi:10.1074/jbc.M300468200 [Abstract] [Full Text] [PDF]

Jeremy A. Yethon, Raquel F. Epand, Brian Leber, Richard M. Epand, and David W. Andrews: Interaction with a Membrane Surface Triggers a Reversible Conformational Change in Bax Normally Associated with Induction of Apoptosis
J. Biol. Chem. 2003 278: 48935-48941. First Published on September 30, 2003; doi:10.1074/jbc.M306289200 [Abstract] [Full Text] [PDF]

Zheng-Ming Wang, Xinna Li, Ross R. Cocklin, Minhui Wang, Mu Wang, Koichi Fukase, Seiichi Inamura, Shoichi Kusumoto, Dipika Gupta, and Roman Dziarski: Human Peptidoglycan Recognition Protein-L Is an N-Acetylmuramoyl-L-alanine Amidase
J. Biol. Chem. 2003 278: 49044-49052. First Published on September 23, 2003; doi:10.1074/jbc.M307758200 [Abstract] [Full Text] [PDF]

Giovanni Migliaccio, Joanne E. Tomassini, Steven S. Carroll, Licia Tomei, Sergio Altamura, Balkrishen Bhat, Linda Bartholomew, Michele R. Bosserman, Alessandra Ceccacci, Lawrence F. Colwell, Riccardo Cortese, Raffaele De Francesco, Anne B. Eldrup, Krista L. Getty, Xiaoli S. Hou, Robert L. LaFemina, Steven W. Ludmerer, Malcolm MacCoss, Daniel R. McMasters, Mark W. Stahlhut, David B. Olsen, Daria J. Hazuda, and Osvaldo A. Flores: Characterization of Resistance to Non-obligate Chain-terminating Ribonucleoside Analogs That Inhibit Hepatitis C Virus Replication in Vitro
J. Biol. Chem. 2003 278: 49164-49170. First Published on September 8, 2003; doi:10.1074/jbc.M305041200 [Abstract] [Full Text] [PDF]

Parimal Sheth, Shyamali Basuroy, Chunyang Li, Anjaparavanda P. Naren, and Radnakrishna K. Rao: Role of Phosphatidylinositol 3-Kinase in Oxidative Stress-induced Disruption of Tight Junctions
J. Biol. Chem. 2003 278: 49239-49245. First Published on September 18, 2003; doi:10.1074/jbc.M305654200 [Abstract] [Full Text] [PDF]

Mossaad Abdel-Ghany, Hung-Chi Cheng, Randolph C. Elble, Haiqun Lin, John DiBiasio, and Bendicht U. Pauli: The Interacting Binding Domains of the ${beta}$ ₄ Integrin and Calcium-activated Chloride Channels (CLCAs) in Metastasis
J. Biol. Chem. 2003 278: 49406-49416. First Published on September 25, 2003; doi:10.1074/jbc.M309086200 [Abstract] [Full Text] [PDF]

Jason Burgess, Abdelmadjid K. Hihi, Claire Y. Bénard, Robyn Branicky, and Siegfried Hekimi: Molecular Mechanism of Maternal Rescue in the clk-1 Mutants of Caenorhabditis elegans
J. Biol. Chem. 2003 278: 49555-49562. First Published on September 29, 2003; doi:10.1074/jbc.M308507200 [Abstract] [Full Text] [PDF]

Additions and Corrections:

Eric D. Tang, Naohiro Inohara, Cun-Yu Wang, Gabriel Nuñez, and Kun-Liang Guan: Roles for homotypic interactions and transautophosphorylation in I ${kappa}$ B kinase ${beta}$ (IKK ${beta}$ ) activation. Vol. 278 (2003) 38566–38570
J. Biol. Chem. 2003 278: 49661. [Full Text] [PDF]

Sabine Mütze, Ulrike Hebling, Wolfgang Stremmel, Jian Wang, Jürgen Arnhold, Kostas Pantopoulos, and Sebastian Mueller: Myeloperoxidase-derived hypochlorous acid antagonizes the oxidative stress-mediated activation of iron regulatory protein 1. Vol. 278 (2003) 40542-40549
J. Biol. Chem. 2003 278: 49662. [Full Text] [PDF]

Daisuke Sugiyama, Hiroyuki Kusuhara, Hirokazu Taniguchi, Shumpei Ishikawa, Yoshitane Nozaki, Hiroyuki Aburatani, and Yuichi Sugiyama: Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier. High affinity transporter for thyroxine. Vol. 278 (2003) 43489-43495
J. Biol. Chem. 2003 278: 49662-a. [Full Text] [PDF]