Reflections:

Bruce N. Ames

An Enthusiasm for Metabolism
J. Biol. Chem. 2003 278: 4369-4380. First Published on December 20, 2002; doi:10.1074/jbc.X200010200 [Full Text] [PDF]  

Accelerated Publications:

Tiziana Mordasini, Alessandro Curioni, and Wanda Andreoni

Why Do Divalent Metal Ions Either Promote or Inhibit Enzymatic Reactions? THE CASE OF BamHI RESTRICTION ENDONUCLEASE FROM COMBINED QUANTUM-CLASSICAL SIMULATIONS
J. Biol. Chem. 2003 278: 4381-4384. First Published on December 19, 2002; doi:10.1074/jbc.C200664200 [Abstract] [Full Text] [PDF]  

Wen Guo, Lei Shi, and Jonathan A. Javitch

The Fourth Transmembrane Segment Forms the Interface of the Dopamine D2 Receptor Homodimer
J. Biol. Chem. 2003 278: 4385-4388. First Published on December 19, 2002; doi:10.1074/jbc.C200679200 [Abstract] [Full Text] [PDF]  

Alexandra M. Gouveia, Carla P. Guimarães, Márcia E. Oliveira, Clara Sá-Miranda, and Jorge E. Azevedo

Insertion of Pex5p into the Peroxisomal Membrane Is Cargo Protein-dependent
J. Biol. Chem. 2003 278: 4389-4392. First Published on December 26, 2002; doi:10.1074/jbc.C200650200 [Abstract] [Full Text] [PDF]  

Saumendra N. Sarkar, Heather L. Smith, Theresa M. Rowe, and Ganes C. Sen

Double-stranded RNA Signaling by Toll-like Receptor 3 Requires Specific Tyrosine Residues in Its Cytoplasmic Domain
J. Biol. Chem. 2003 278: 4393-4396. First Published on December 30, 2002; doi:10.1074/jbc.C200655200 [Abstract] [Full Text] [PDF]  

DNA: Replication, Repair, and Recombination:

Ryushin Mizuta, Kousuke Iwai, Masatsugu Shigeno, Midori Mizuta, Takeshi Uemura, Tatsuo Ushiki, and Daisuke Kitamura

Molecular Visualization of Immunoglobulin Switch Region RNA/DNA Complex by Atomic Force Microscope
J. Biol. Chem. 2003 278: 4431-4434. First Published on December 9, 2002; doi:10.1074/jbc.M209262200 [Abstract] [Full Text] [PDF]  

Megan J. Davey, Chiara Indiani, and Mike O'Donnell

Reconstitution of the Mcm2-7p Heterohexamer, Subunit Arrangement, and ATP Site Architecture
J. Biol. Chem. 2003 278: 4491-4499. First Published on December 11, 2002; doi:10.1074/jbc.M210511200 [Abstract] [Full Text] [PDF]  

Stéphane Priet, Jean-Marc Navarro, Nathalie Gros, Gilles Quérat, and Joséphine Sire

Functional Role of HIV-1 Virion-associated Uracil DNA Glycosylase 2 in the Correction of G:U Mispairs to G:C Pairs
J. Biol. Chem. 2003 278: 4566-4571. First Published on November 27, 2002; doi:10.1074/jbc.M209311200 [Abstract] [Full Text] [PDF]  

Richard G. Baumann and Lindsay W. Black

Isolation and Characterization of T4 Bacteriophage gp17 Terminase, a Large Subunit Multimer with Enhanced ATPase Activity
J. Biol. Chem. 2003 278: 4618-4627. First Published on December 3, 2002; doi:10.1074/jbc.M208574200 [Abstract] [Full Text] [PDF]  

Hiromichi Kimura and Kunio Shiota

Methyl-CpG-binding Protein, MeCP2, Is a Target Molecule for Maintenance DNA Methyltransferase, Dnmt1
J. Biol. Chem. 2003 278: 4806-4812. First Published on December 6, 2002; doi:10.1074/jbc.M209923200 [Abstract] [Full Text] [PDF]  

Paola Crucitti, Ana M. Abril, and Margarita Salas

Bacteriophage 29 Early Protein p17. SELF-ASSOCIATION AND HETERO-ASSOCIATION WITH THE VIRAL HISTONE-LIKE PROTEIN p6
J. Biol. Chem. 2003 278: 4906-4911. First Published on December 11, 2002; doi:10.1074/jbc.M210289200 [Abstract] [Full Text] [PDF]  

Miran Yoon-Robarts and R. Michael Linden

Identification of Active Site Residues of the Adeno-associated Virus Type 2 Rep Endonuclease
J. Biol. Chem. 2003 278: 4912-4918. First Published on December 11, 2002; doi:10.1074/jbc.M209750200 [Abstract] [Full Text] [PDF]  

Soon-Jong Kim, William A. Beard, John Harvey, David D. Shock, Jay R. Knutson, and Samuel H. Wilson

Rapid Segmental and Subdomain Motions of DNA Polymerase
J. Biol. Chem. 2003 278: 5072-5081. First Published on November 27, 2002; doi:10.1074/jbc.M208472200 [Abstract] [Full Text] [PDF]  

Tadayoshi Bessho

Induction of DNA Replication-mediated Double Strand Breaks by Psoralen DNA Interstrand Cross-links
J. Biol. Chem. 2003 278: 5250-5254. First Published on December 8, 2002; doi:10.1074/jbc.M212323200 [Abstract] [Full Text] [PDF]  

Peiying Wu, Chen Qiu, Anjum Sohail, Xing Zhang, Ashok S. Bhagwat, and Xiaodong Cheng

Mismatch Repair in Methylated DNA. STRUCTURE AND ACTIVITY OF THE MISMATCH-SPECIFIC THYMINE GLYCOSYLASE DOMAIN OF METHYL-CpG-BINDING PROTEIN MBD4
J. Biol. Chem. 2003 278: 5285-5291. First Published on November 26, 2002; doi:10.1074/jbc.M210884200 [Abstract] [Full Text] [PDF]  

Rachelle J. Bienstock, Milan Skorvaga, Bhaskar S. Mandavilli, and Bennett Van Houten

Structural and Functional Characterization of the Human DNA Repair Helicase XPD by Comparative Molecular Modeling and Site-directed Mutagenesis of the Bacterial Repair Protein UvrB
J. Biol. Chem. 2003 278: 5309-5316. First Published on November 27, 2002; doi:10.1074/jbc.M210159200 [Abstract] [Full Text] [PDF]  

Genes: Structure and Regulation:

Carol A. Gilchrist, Megan Leo, C. Genghis Line, Barbara J. Mann, and William A. Petri, Jr.

Calcium Modulates Promoter Occupancy by the Entamoeba histolytica Ca²⁺-binding Transcription Factor URE3-BP
J. Biol. Chem. 2003 278: 4646-4653. First Published on December 3, 2002; doi:10.1074/jbc.M211271200 [Abstract] [Full Text] [PDF]  

Yue Xie, Rong Zhong, Changmin Chen, and Stuart K. Calderwood

Heat Shock Factor 1 Contains Two Functional Domains That Mediate Transcriptional Repression of the c-fos and c-fms Genes
J. Biol. Chem. 2003 278: 4687-4698. First Published on December 4, 2002; doi:10.1074/jbc.M210189200 [Abstract] [Full Text] [PDF]  

Claudie Lemercier, Gaëlle Legube, Cécile Caron, Mathilde Louwagie, Jérôme Garin, Didier Trouche, and Saadi Khochbin

Tip60 Acetyltransferase Activity Is Controlled by Phosphorylation
J. Biol. Chem. 2003 278: 4713-4718. First Published on December 4, 2002; doi:10.1074/jbc.M211811200 [Abstract] [Full Text] [PDF]  

Kezhong Zhang, Sumiko Kurachi, and Kotoku Kurachi

Limitation in Use of Heterologous Reporter Genes for Gene Promoter Analysis. SILENCER ACTIVITY ASSOCIATED WITH THE CHLORAMPHENICOL ACETYLTRANSFERASE REPORTER GENE
J. Biol. Chem. 2003 278: 4826-4830. First Published on December 6, 2002; doi:10.1074/jbc.M211361200 [Abstract] [Full Text] [PDF]  

Helen Rizos, Eve Diefenbach, Prerna Badhwar, Sarah Woodruff, Therese M. Becker, Robert J. Rooney, and Richard F. Kefford

Association of p14^ARF with the p120^E4F Transcriptional Repressor Enhances Cell Cycle Inhibition
J. Biol. Chem. 2003 278: 4981-4989. First Published on November 21, 2002; doi:10.1074/jbc.M210978200 [Abstract] [Full Text] [PDF]  

Guoqing Liao, Liuh-Yow Chen, Aihua Zhang, Aparna Godavarthy, Fang Xia, Jagadish Chandra Ghosh, Hui Li, and J. Don Chen

Regulation of Androgen Receptor Activity by the Nuclear Receptor Corepressor SMRT
J. Biol. Chem. 2003 278: 5052-5061. First Published on November 18, 2002; doi:10.1074/jbc.M206374200 [Abstract] [Full Text] [PDF]  

Kiyoshi Higashi, Yutaka Inagaki, Noriyuki Suzuki, Shinichi Mitsui, Alain Mauviel, Hideo Kaneko, and Iwao Nakatsuka

Y-box-binding Protein YB-1 Mediates Transcriptional Repression of Human 2(I) Collagen Gene Expression by Interferon-
J. Biol. Chem. 2003 278: 5156-5162. First Published on November 20, 2002; doi:10.1074/jbc.M208724200 [Abstract] [Full Text] [PDF]  

Rossen Donev, Roger Horton, Stephan Beck, Teodora Doneva, Radost Vatcheva, W. Richard Bowen, and Denise Sheer

Recruitment of Heterogeneous Nuclear Ribonucleoprotein A1 in Vivo to the LMP/TAP Region of the Major Histocompatibility Complex
J. Biol. Chem. 2003 278: 5214-5226. First Published on November 14, 2002; doi:10.1074/jbc.M206621200 [Abstract] [Full Text] [PDF]  

Christophe Beloin, Josette Jeusset, Bernard Révet, Gilles Mirambeau, Françoise Le Hégarat, and Eric Le Cam

Contribution of DNA Conformation and Topology in Right-handed DNA Wrapping by the Bacillus subtilis LrpC Protein
J. Biol. Chem. 2003 278: 5333-5342. First Published on November 27, 2002; doi:10.1074/jbc.M207489200 [Abstract] [Full Text] [PDF]  

Natsumi Araya, Keiko Hirota, Yoko Shimamoto, Makoto Miyagishi, Eisaku Yoshida, Junji Ishida, Setsuko Kaneko, Michio Kaneko, Toshihiro Nakajima, and Akiyoshi Fukamizu

Cooperative Interaction of EWS with CREB-binding Protein Selectively Activates Hepatocyte Nuclear Factor 4-mediated Transcription
J. Biol. Chem. 2003 278: 5427-5432. First Published on November 28, 2002; doi:10.1074/jbc.M210234200 [Abstract] [Full Text] [PDF]  

RNA: Structure, Metabolism, and Catalysis:

Shveta Bagga, Divya Seth, and Janendra K. Batra

The Cytotoxic Activity of Ribosome-inactivating Protein Saporin-6 Is Attributed to Its rRNA N-Glycosidase and Internucleosomal DNA Fragmentation Activities
J. Biol. Chem. 2003 278: 4813-4820. First Published on December 3, 2002; doi:10.1074/jbc.M207389200 [Abstract] [Full Text] [PDF]  

Masaaki Hirano, Shuichi Kaneko, Tatsuya Yamashita, Hong Luo, Weiping Qin, Yukihiro Shirota, Takahiro Nomura, Kenichi Kobayashi, and Seishi Murakami

Direct Interaction between Nucleolin and Hepatitis C Virus NS5B
J. Biol. Chem. 2003 278: 5109-5115. First Published on November 9, 2002; doi:10.1074/jbc.M207629200 [Abstract] [Full Text] [PDF]  

Protein Synthesis, Post-Translation Modification, and Degradation:

Anirban Roy and William F. Wonderlin

The Permeability of the Endoplasmic Reticulum Is Dynamically Coupled to Protein Synthesis
J. Biol. Chem. 2003 278: 4397-4403. First Published on November 27, 2002; doi:10.1074/jbc.M207295200 [Abstract] [Full Text] [PDF]  

Dominique Dorin, Marion C. Bonnet, Sylvie Bannwarth, Anne Gatignol, Eliane F. Meurs, and Catherine Vaquero

The TAR RNA-binding Protein, TRBP, Stimulates the Expression of TAR-containing RNAs in Vitro and in Vivo Independently of Its Ability to Inhibit the dsRNA-dependent Kinase PKR
J. Biol. Chem. 2003 278: 4440-4448. First Published on December 9, 2002; doi:10.1074/jbc.M208954200 [Abstract] [Full Text] [PDF]  

Xiaohong Zhao, Barry J. Lamphear, Dingding Xiong, Kirk Knowlton, and Robert E. Rhoads

Protection of Cap-dependent Protein Synthesis in Vivo and in Vitro with an eIF4G-1 Variant Highly Resistant to Cleavage by Coxsackievirus 2A Protease
J. Biol. Chem. 2003 278: 4449-4457. First Published on December 9, 2002; doi:10.1074/jbc.M212393200 [Abstract] [Full Text] [PDF]  

Edward B. Lee, Daniel M. Skovronsky, Farhad Abtahian, Robert W. Doms, and Virginia M.-Y. Lee

Secretion and Intracellular Generation of Truncated A in -Site Amyloid- Precursor Protein-cleaving Enzyme Expressing Human Neurons
J. Biol. Chem. 2003 278: 4458-4466. First Published on December 11, 2002; doi:10.1074/jbc.M210105200 [Abstract] [Full Text] [PDF]  

Jingxiang Bai and Arthur I. Cederbaum

Catalase Protects HepG2 Cells from Apoptosis Induced by DNA-damaging Agents by Accelerating the Degradation of p53
J. Biol. Chem. 2003 278: 4660-4667. First Published on December 4, 2002; doi:10.1074/jbc.M206273200 [Abstract] [Full Text] [PDF]  

John den Engelsman, Vivian Keijsers, Wilfried W. de Jong, and Wilbert C. Boelens

The Small Heat-shock Protein B-Crystallin Promotes FBX4-dependent Ubiquitination
J. Biol. Chem. 2003 278: 4699-4704. First Published on December 4, 2002; doi:10.1074/jbc.M211403200 [Abstract] [Full Text] [PDF]  

Karen Bollan, Dale King, Laura A. Robertson, Kenneth Brown, Pamela M. Taylor, Stephen J. Moss, and Christopher N. Connolly

GABA_A Receptor Composition Is Determined by Distinct Assembly Signals within and Subunits
J. Biol. Chem. 2003 278: 4747-4755. First Published on December 5, 2002; doi:10.1074/jbc.M210229200 [Abstract] [Full Text] [PDF]  

Mika Hashimoto, Takahiro Sibata, Hiroaki Wasada, Shinya Toyokuni, and Koji Uchida

Structural Basis of Protein-bound Endogenous Aldehydes. CHEMICAL AND IMMUNOCHEMICAL CHARACTERIZATIONS OF CONFIGURATIONAL ISOMERS OF A 4-HYDROXY-2-NONENAL-HISTIDINE ADDUCT
J. Biol. Chem. 2003 278: 5044-5051. First Published on December 6, 2002; doi:10.1074/jbc.M210129200 [Abstract] [Full Text] [PDF] Supplemental Data  

Yan Xia, Gerald M. Pao, Hong-Wu Chen, Inder M. Verma, and Tony Hunter

Enhancement of BRCA1 E3 Ubiquitin Ligase Activity through Direct Interaction with the BARD1 Protein
J. Biol. Chem. 2003 278: 5255-5263. First Published on November 12, 2002; doi:10.1074/jbc.M204591200 [Abstract] [Full Text] [PDF]  

Genomics, Proteomics, and Bioinformatics:

Yuan Yao, Eric A. Berg, Catherine E. Costello, Robert F. Troxler, and Frank G. Oppenheim

Identification of Protein Components in Human Acquired Enamel Pellicle and Whole Saliva Using Novel Proteomics Approaches
J. Biol. Chem. 2003 278: 5300-5308. First Published on November 19, 2002; doi:10.1074/jbc.M206333200 [Abstract] [Full Text] [PDF]  

Man-Hee Suh, Lakshmi Pulakat, and Nara Gavini

Functional Expression of a Fusion-dimeric MoFe Protein of Nitrogenase in Azotobacter vinelandii
J. Biol. Chem. 2003 278: 5353-5360. First Published on December 4, 2002; doi:10.1074/jbc.M208969200 [Abstract] [Full Text] [PDF]  

Protein Structure and Folding:

Oliver Daltrop and Stuart J. Ferguson

Cytochrome c Maturation. THE IN VITRO REACTIONS OF HORSE HEART APOCYTOCHROME c AND PARACOCCUS DENITRIFICANS APOCYTOCHROME c₅₅₀ WITH HEME
J. Biol. Chem. 2003 278: 4404-4409. First Published on November 27, 2002; doi:10.1074/jbc.M211124200 [Abstract] [Full Text] [PDF]  

Florence Vignols, Nabil Mouaheb, Dominique Thomas, and Yves Meyer

Redox Control of Hsp70-Co-chaperone Interaction Revealed by Expression of a Thioredoxin-like Arabidopsis Protein
J. Biol. Chem. 2003 278: 4516-4523. First Published on November 13, 2002; doi:10.1074/jbc.M210080200 [Abstract] [Full Text] [PDF]  

John F. Andersen, Ivo M. B. Francischetti, Jesus G. Valenzuela, Peter Schuck, and José M. C. Ribeiro

Inhibition of Hemostasis by a High Affinity Biogenic Amine-binding Protein from the Saliva of a Blood-feeding Insect
J. Biol. Chem. 2003 278: 4611-4617. First Published on December 2, 2002; doi:10.1074/jbc.M211438200 [Abstract] [Full Text] [PDF]  

Luis J. del Valle, Eva Ramon, Xavier Cañavate, Paulo Dias, and Pere Garriga

Zinc-induced Decrease of the Thermal Stability and Regeneration of Rhodopsin
J. Biol. Chem. 2003 278: 4719-4724. First Published on December 12, 2002; doi:10.1074/jbc.M210760200 [Abstract] [Full Text] [PDF]  

Sabine Van Doorslaer, Sylvia Dewilde, Laurent Kiger, Sergiu V. Nistor, Etienne Goovaerts, Michael C. Marden, and Luc Moens

Nitric Oxide Binding Properties of Neuroglobin. A CHARACTERIZATION BY EPR AND FLASH PHOTOLYSIS
J. Biol. Chem. 2003 278: 4919-4925. First Published on December 11, 2002; doi:10.1074/jbc.M210617200 [Abstract] [Full Text] [PDF] Supplemental Data  

Ulrike Schmidt, Gabriela M. Wochnik, Marcus C. Rosenhagen, Jason C. Young, F. Ulrich Hartl, Florian Holsboer, and Theo Rein

Essential Role of the Unusual DNA-binding Motif of BAG-1 for Inhibition of the Glucocorticoid Receptor
J. Biol. Chem. 2003 278: 4926-4931. First Published on December 12, 2002; doi:10.1074/jbc.M212000200 [Abstract] [Full Text] [PDF] Supplemental Data  

William James Smith, Nicolas Nassar, Anthony Bretscher, Richard A. Cerione, and P. Andrew Karplus

Structure of the Active N-terminal Domain of Ezrin. CONFORMATIONAL AND MOBILITY CHANGES IDENTIFY KEYSTONE INTERACTIONS
J. Biol. Chem. 2003 278: 4949-4956. First Published on November 11, 2002; doi:10.1074/jbc.M210601200 [Abstract] [Full Text] [PDF]  

Shwu-Huey Liaw, Shen-Jia Chen, Tzu-Ping Ko, Cheng-Sheng Hsu, Chun-Jung Chen, Andrew H.-J. Wang, and Ying-Chieh Tsai

Crystal Structure of D-Aminoacylase from Alcaligenes faecalis DA1. A NOVEL SUBSET OF AMIDOHYDROLASES AND INSIGHTS INTO THE ENZYME MECHANISM
J. Biol. Chem. 2003 278: 4957-4962. First Published on November 25, 2002; doi:10.1074/jbc.M210795200 [Abstract] [Full Text] [PDF]  

Takuji Shirasawa, Masahiko Izumizaki, Yo-ichi Suzuki, Akihiko Ishihara, Takahiko Shimizu, Masakatsu Tamaki, Fei Huang, Ken-ichi Koizumi, Michiko Iwase, Hiromi Sakai, Eishun Tsuchida, Kenji Ueshima, Hiroshi Inoue, Haruhiko Koseki, Toshiya Senda, Takayuki Kuriyama, and Ikuo Homma

Oxygen Affinity of Hemoglobin Regulates O₂ Consumption, Metabolism, and Physical Activity
J. Biol. Chem. 2003 278: 5035-5043. First Published on November 27, 2002; doi:10.1074/jbc.M211110200 [Abstract] [Full Text] [PDF]  

Roland K. Strong, Margaret A. Holmes, Pingwei Li, Laura Braun, Ni Lee, and Daniel E. Geraghty

HLA-E Allelic Variants. CORRELATING DIFFERENTIAL EXPRESSION, PEPTIDE AFFINITIES, CRYSTAL STRUCTURES, AND THERMAL STABILITIES
J. Biol. Chem. 2003 278: 5082-5090. First Published on October 30, 2002; doi:10.1074/jbc.M208268200 [Abstract] [Full Text] [PDF]  

Jan L. Wahlstrom, M. Allen Randall, Jr., J. David Lawson, Derek E. Lyons, William F. Siems, Greg J. Crouch, Regina Barr, Kevin C. Facemyer, and Christine R. Cremo

Structural Model of the Regulatory Domain of Smooth Muscle Heavy Meromyosin
J. Biol. Chem. 2003 278: 5123-5131. First Published on November 21, 2002; doi:10.1074/jbc.M206963200 [Abstract] [Full Text] [PDF]  

David Leys, Christopher G. Mowat, Kirsty J. McLean, Alison Richmond, Stephen K. Chapman, Malcolm D. Walkinshaw, and Andrew W. Munro

Atomic Structure of Mycobacterium tuberculosis CYP121 to 1.06 Å Reveals Novel Features of Cytochrome P450
J. Biol. Chem. 2003 278: 5141-5147. First Published on November 14, 2002; doi:10.1074/jbc.M209928200 [Abstract] [Full Text] [PDF]  

Cédric Blanpain, Benjamin J. Doranz, Antoine Bondue, Cédric Govaerts, Anne De Leener, Gilbert Vassart, Robert W. Doms, Amanda Proudfoot, and Marc Parmentier

The Core Domain of Chemokines Binds CCR5 Extracellular Domains while Their Amino Terminus Interacts with the Transmembrane Helix Bundle
J. Biol. Chem. 2003 278: 5179-5187. First Published on December 3, 2002; doi:10.1074/jbc.M205684200 [Abstract] [Full Text] [PDF]  

Surbhi Gupta and Dipankar Chatterji

Bimodal Protection of DNA by Mycobacterium smegmatis DNA-binding Protein from Stationary Phase Cells
J. Biol. Chem. 2003 278: 5235-5241. First Published on December 3, 2002; doi:10.1074/jbc.M208825200 [Abstract] [Full Text] [PDF]  

Akiko Yokota, Kouhei Tsumoto, Mitsunori Shiroishi, Hidemasa Kondo, and Izumi Kumagai

The Role of Hydrogen Bonding via Interfacial Water Molecules in Antigen-Antibody Complexation. THE HyHEL-10-HEL INTERACTION
J. Biol. Chem. 2003 278: 5410-5418. First Published on November 19, 2002; doi:10.1074/jbc.M210182200 [Abstract] [Full Text] [PDF]  

Enzyme Catalysis and Regulation:

Patricia A. Ellison, Zachary S. DePew, and Christine R. Cremo

Both Heads of Tissue-derived Smooth Muscle Heavy Meromyosin Bind to Actin in the Presence of ADP
J. Biol. Chem. 2003 278: 4410-4415. First Published on December 2, 2002; doi:10.1074/jbc.M211016200 [Abstract] [Full Text] [PDF]  

Hend M. Abdelghany, Scott Bailey, G. Michael Blackburn, John B. Rafferty, and Alexander G. McLennan

Analysis of the Catalytic and Binding Residues of the Diadenosine Tetraphosphate Pyrophosphohydrolase from Caenorhabditis elegans by Site-directed Mutagenesis
J. Biol. Chem. 2003 278: 4435-4439. First Published on December 9, 2002; doi:10.1074/jbc.M211983200 [Abstract] [Full Text] [PDF]  

Daniel Pilloff, Kristina Dabovic, Michael J. Romanowski, Jeffrey B. Bonanno, Mary Doherty, Stephen K. Burley, and Thomas S. Leyh

The Kinetic Mechanism of Phosphomevalonate Kinase
J. Biol. Chem. 2003 278: 4510-4515. First Published on November 6, 2002; doi:10.1074/jbc.M210551200 [Abstract] [Full Text] [PDF]  

Larisa Toulokhonova, William J. Metzler, Mark R. Witmer, Robert A. Copeland, and Jovita Marcinkeviciene

Kinetic Studies on -Site Amyloid Precursor Protein-cleaving Enzyme (BACE). CONFIRMATION OF AN ISO-MECHANISM
J. Biol. Chem. 2003 278: 4582-4589. First Published on November 27, 2002; doi:10.1074/jbc.M210471200 [Abstract] [Full Text] [PDF]  

Zhongsen Zhang, Kui Shen, Wei Lu, and Philip A. Cole

The Role of C-terminal Tyrosine Phosphorylation in the Regulation of SHP-1 Explored via Expressed Protein Ligation
J. Biol. Chem. 2003 278: 4668-4674. First Published on December 4, 2002; doi:10.1074/jbc.M210028200 [Abstract] [Full Text] [PDF]  

Rungaroon Waditee, Yoshito Tanaka, Kenji Aoki, Takashi Hibino, Hiroshi Jikuya, Jun Takano, Tetsuko Takabe, and Teruhiro Takabe

Isolation and Functional Characterization of N-Methyltransferases That Catalyze Betaine Synthesis from Glycine in a Halotolerant Photosynthetic Organism Aphanothece halophytica
J. Biol. Chem. 2003 278: 4932-4942. First Published on December 3, 2002; doi:10.1074/jbc.M210970200 [Abstract] [Full Text] [PDF]  

Wentian Luo, Xuemin Chen, Hong Fang, and Neil Green

Factors Governing Nonoverlapping Substrate Specificity by Mitochondrial Inner Membrane Peptidase
J. Biol. Chem. 2003 278: 4943-4948. First Published on December 13, 2002; doi:10.1074/jbc.M210916200 [Abstract] [Full Text] [PDF]  

Ahmed Haouz, Veerle Vanheusden, Hélène Munier-Lehmann, Mattheus Froeyen, Piet Herdewijn, Serge Van Calenbergh, and Marc Delarue

Enzymatic and Structural Analysis of Inhibitors Designed against Mycobacterium tuberculosis Thymidylate Kinase. NEW INSIGHTS INTO THE PHOSPHORYL TRANSFER MECHANISM
J. Biol. Chem. 2003 278: 4963-4971. First Published on November 25, 2002; doi:10.1074/jbc.M209630200 [Abstract] [Full Text] [PDF]  

Kathleen M. Holtz, Sara Rockwell, Maria Tomasz, and Alan C. Sartorelli

Nuclear Overexpression of NADH:Cytochrome b₅ Reductase Activity Increases the Cytotoxicity of Mitomycin C (MC) and the Total Number of MC-DNA Adducts in Chinese Hamster Ovary Cells
J. Biol. Chem. 2003 278: 5029-5034. First Published on November 6, 2002; doi:10.1074/jbc.M209722200 [Abstract] [Full Text] [PDF]  

Manuela Cervelli, Fabio Polticelli, Rodolfo Federico, and Paolo Mariottini

Heterologous Expression and Characterization of Mouse Spermine Oxidase
J. Biol. Chem. 2003 278: 5271-5276. First Published on November 27, 2002; doi:10.1074/jbc.M207888200 [Abstract] [Full Text] [PDF]  

Stéphane Paris, Claire Viemon, Gilles Curien, and Renaud Dumas

Mechanism of Control of Arabidopsis thaliana Aspartate Kinase-Homoserine Dehydrogenase by Threonine
J. Biol. Chem. 2003 278: 5361-5366. First Published on November 14, 2002; doi:10.1074/jbc.M207379200 [Abstract] [Full Text] [PDF]  

Robert C. Lee, Maria Hrmova, Rachel A. Burton, Jelle Lahnstein, and Geoffrey B. Fincher

Bifunctional Family 3 Glycoside Hydrolases from Barley with -L-Arabinofuranosidase and -D-Xylosidase Activity. CHARACTERIZATION, PRIMARY STRUCTURES, AND COOH-TERMINAL PROCESSING
J. Biol. Chem. 2003 278: 5377-5387. First Published on December 2, 2002; doi:10.1074/jbc.M210627200 [Abstract] [Full Text] [PDF]  

Guozhou Xu, Rebecca L. Rich, Clemens Steegborn, Tongpil Min, Yihua Huang, David G. Myszka, and Hao Wu

Mutational Analyses of the p35-Caspase Interaction. A BOWSTRING KINETIC MODEL OF CASPASE INHIBITION BY p35
J. Biol. Chem. 2003 278: 5455-5461. First Published on November 27, 2002; doi:10.1074/jbc.M211607200 [Abstract] [Full Text] [PDF]  

Akira Inoue and Mitsuo Ikebe

Characterization of the Motor Activity of Mammalian Myosin VIIA
J. Biol. Chem. 2003 278: 5478-5487. First Published on December 3, 2002; doi:10.1074/jbc.M210489200 [Abstract] [Full Text] [PDF]  

Metabolism and Bioenergetics:

Gholam Reza Tavankar, Dimitris Mossialos, and Huw D. Williams

Mutation or Overexpression of a Terminal Oxidase Leads to a Cell Division Defect and Multiple Antibiotic Sensitivity in Pseudomonas aeruginosa
J. Biol. Chem. 2003 278: 4524-4530. First Published on November 14, 2002; doi:10.1074/jbc.M210355200 [Abstract] [Full Text] [PDF]  

Hassan Jijakli, Philippe Courtois, Hai-Xia Zhang, Abdullah Sener, and Willy J. Malaisse

Anomeric Specificity of the Stimulatory Effect of D-Glucose on D-Fructose Phosphorylation by Human Liver Glucokinase
J. Biol. Chem. 2003 278: 4531-4535. First Published on November 19, 2002; doi:10.1074/jbc.M206730200 [Abstract] [Full Text] [PDF]  

Glycobiology and Extracellular Matrices:

Eric I. Park, Stephen M. Manzella, and Jacques U. Baenziger

Rapid Clearance of Sialylated Glycoproteins by the Asialoglycoprotein Receptor
J. Biol. Chem. 2003 278: 4597-4602. First Published on December 2, 2002; doi:10.1074/jbc.M210612200 [Abstract] [Full Text] [PDF]  

Sai Prasad N. Iyer, Yoshihiro Akimoto, and Gerald W. Hart

Identification and Cloning of a Novel Family of Coiled-coil Domain Proteins That Interact with O-GlcNAc Transferase
J. Biol. Chem. 2003 278: 5399-5409. First Published on November 14, 2002; doi:10.1074/jbc.M209384200 [Abstract] [Full Text] [PDF]  

Lipids and Lipoproteins:

Mari Iwabuchi, Junko Kohno-Murase, and Jun Imamura

12-Oleate Desaturase-related Enzymes Associated with Formation of Conjugated trans-11, cis-13 Double Bonds
J. Biol. Chem. 2003 278: 4603-4610. First Published on December 2, 2002; doi:10.1074/jbc.M210748200 [Abstract] [Full Text] [PDF]  

Cinzia Parolini, Giulia Chiesa, Yiwen Zhu, Trudy Forte, Silvia Caligari, Elisabetta Gianazza, Maria Grazia Sacco, Cesare R. Sirtori, and Edward M. Rubin

Targeted Replacement of Mouse Apolipoprotein A-I with Human ApoA-I or the Mutant ApoA-I_Milano. EVIDENCE OF APOA-I_M IMPAIRED HEPATIC SECRETION
J. Biol. Chem. 2003 278: 4740-4746. First Published on December 5, 2002; doi:10.1074/jbc.M207335200 [Abstract] [Full Text] [PDF]  

Ryan E. Temel, John S. Parks, and David L. Williams

Enhancement of Scavenger Receptor Class B Type I-mediated Selective Cholesteryl Ester Uptake from apoA-I^/ High Density Lipoprotein (HDL) by Apolipoprotein A-I Requires HDL Reorganization by Lecithin Cholesterol Acyltransferase
J. Biol. Chem. 2003 278: 4792-4799. First Published on December 6, 2002; doi:10.1074/jbc.M208160200 [Abstract] [Full Text] [PDF]  

Marisa Viñals, Shangzhe Xu, Eliza Vasile, and Monty Krieger

Identification of the N-Linked Glycosylation Sites on the High Density Lipoprotein (HDL) Receptor SR-BI and Assessment of Their Effects on HDL Binding and Selective Lipid Uptake
J. Biol. Chem. 2003 278: 5325-5332. First Published on November 11, 2002; doi:10.1074/jbc.M211073200 [Abstract] [Full Text] [PDF]  

Membrane Transport, Structure, Function, and Biogenesis:

Robert Sijbrandi, Malene L. Urbanus, Corinne M. ten Hagen-Jongman, Harris D. Bernstein, Bauke Oudega, Ben R. Otto, and Joen Luirink

Signal Recognition Particle (SRP)-mediated Targeting and Sec-dependent Translocation of an Extracellular Escherichia coli Protein
J. Biol. Chem. 2003 278: 4654-4659. First Published on December 3, 2002; doi:10.1074/jbc.M211630200 [Abstract] [Full Text] [PDF]  

Dawei Jiang, Bailong Xiao, Xiaoli Li, and S. R. Wayne Chen

Smooth Muscle Tissues Express a Major Dominant Negative Splice Variant of the Type 3 Ca²⁺ Release Channel (Ryanodine Receptor)
J. Biol. Chem. 2003 278: 4763-4769. First Published on December 5, 2002; doi:10.1074/jbc.M210410200 [Abstract] [Full Text] [PDF]  

Hong Shen, David E. Smith, Richard F. Keep, Jianming Xiang, and Frank C. Brosius, III

Targeted Disruption of the PEPT2 Gene Markedly Reduces Dipeptide Uptake in Choroid Plexus
J. Biol. Chem. 2003 278: 4786-4791. First Published on December 6, 2002; doi:10.1074/jbc.M207397200 [Abstract] [Full Text] [PDF]  

Patricia Hermand, Pierre Gane, Martine Huet, Vincent Jallu, Cécile Kaplan, H. H. Sonneborn, Jean-Pierre Cartron, and Pascal Bailly

Red Cell ICAM-4 Is a Novel Ligand for Platelet-activated _IIb3 Integrin
J. Biol. Chem. 2003 278: 4892-4898. First Published on December 10, 2002; doi:10.1074/jbc.M211282200 [Abstract] [Full Text] [PDF]  

Charlotta Grånäs, Jasmine Ferrer, Claus Juul Loland, Jonathan A. Javitch, and Ulrik Gether

N-terminal Truncation of the Dopamine Transporter Abolishes Phorbol Ester- and Substance P Receptor-stimulated Phosphorylation without Impairing Transporter Internalization
J. Biol. Chem. 2003 278: 4990-5000. First Published on December 2, 2002; doi:10.1074/jbc.M205058200 [Abstract] [Full Text] [PDF]  

Fulvio Reggiori, Chao-Wen Wang, Per E. Stromhaug, Takahiro Shintani, and Daniel J. Klionsky

Vps51 Is Part of the Yeast Vps Fifty-three Tethering Complex Essential for Retrograde Traffic from the Early Endosome and Cvt Vesicle Completion
J. Biol. Chem. 2003 278: 5009-5020. First Published on November 20, 2002; doi:10.1074/jbc.M210436200 [Abstract] [Full Text] [PDF]  

Shihui Liu and Stephen H. Leppla

Cell Surface Tumor Endothelium Marker 8 Cytoplasmic Tail-independent Anthrax Toxin Binding, Proteolytic Processing, Oligomer Formation, and Internalization
J. Biol. Chem. 2003 278: 5227-5234. First Published on December 4, 2002; doi:10.1074/jbc.M210321200 [Abstract] [Full Text] [PDF]  

Amy E. Moseley, Steve P. Lieske, Randall K. Wetzel, Paul F. James, Suiwen He, Daniel A. Shelly, Richard J. Paul, Gregory P. Boivin, David P. Witte, Jan Marino Ramirez, Kathleen J. Sweadner, and Jerry B Lingrel

The Na,K-ATPase 2 Isoform Is Expressed in Neurons, and Its Absence Disrupts Neuronal Activity in Newborn Mice
J. Biol. Chem. 2003 278: 5317-5324. First Published on November 27, 2002; doi:10.1074/jbc.M211315200 [Abstract] [Full Text] [PDF]  

Huân M. Ngô, Mei Yang, Kerstin Paprotka, Marc Pypaert, Heinrich Hoppe, and Keith A. Joiner

AP-1 in Toxoplasma gondii Mediates Biogenesis of the Rhoptry Secretory Organelle from a Post-Golgi Compartment
J. Biol. Chem. 2003 278: 5343-5352. First Published on November 20, 2002; doi:10.1074/jbc.M208291200 [Abstract] [Full Text] [PDF]  

Timothy T. Stedman, A. Ross Sussmann, and Keith A. Joiner

Toxoplasma gondii Rab6 Mediates a Retrograde Pathway for Sorting of Constitutively Secreted Proteins to the Golgi Complex
J. Biol. Chem. 2003 278: 5433-5443. First Published on December 4, 2002; doi:10.1074/jbc.M209390200 [Abstract] [Full Text] [PDF]  

Mechanisms Of Signal Transduction:

Ivana Galetic, Sauveur-Michel Maira, Mirjana Andjelkovic, and Brian A. Hemmings

Negative Regulation of ERK and Elk by Protein Kinase B Modulates c-fos Transcription
J. Biol. Chem. 2003 278: 4416-4423. First Published on December 4, 2002; doi:10.1074/jbc.M210578200 [Abstract] [Full Text] [PDF]  

Malgorzata Czarny, Jun Liu, Phil Oh, and Jan E. Schnitzer

Transient Mechanoactivation of Neutral Sphingomyelinase in Caveolae to Generate Ceramide
J. Biol. Chem. 2003 278: 4424-4430. First Published on December 6, 2002; doi:10.1074/jbc.M210375200 [Abstract] [Full Text] [PDF]  

Wasana K. Sumanasekera, Eric S. Tien, Rex Turpey, John P. Vanden Heuvel, and Gary H. Perdew

Evidence That Peroxisome Proliferator-activated Receptor Is Complexed with the 90-kDa Heat Shock Protein and the Hepatitis Virus B X-associated Protein 2
J. Biol. Chem. 2003 278: 4467-4473. First Published on December 13, 2002; doi:10.1074/jbc.M211261200 [Abstract] [Full Text] [PDF]  

Jan Humrich, Christina Bermel, Tobias Grübel, Ursula Quitterer, and Martin J. Lohse

Regulation of Phosducin-like Protein by Casein Kinase 2 and N-terminal Splicing
J. Biol. Chem. 2003 278: 4474-4481. First Published on December 3, 2002; doi:10.1074/jbc.M206347200 [Abstract] [Full Text] [PDF]  

Philippe Guillaume, Daniel F. Legler, Nicole Boucheron, Marie-Agnès Doucey, Jean-Charles Cerottini, and Immanuel F. Luescher

Soluble Major Histocompatibility Complex-Peptide Octamers with Impaired CD8 Binding Selectively Induce Fas-dependent Apoptosis
J. Biol. Chem. 2003 278: 4500-4509. First Published on October 28, 2002; doi:10.1074/jbc.M208863200 [Abstract] [Full Text] [PDF] Supplemental Data  

Truyen Nguyen, Philip J. Sherratt, H.-C. Huang, Chung S. Yang, and Cecil B. Pickett

Increased Protein Stability as a Mechanism That Enhances Nrf2-mediated Transcriptional Activation of the Antioxidant Response Element. DEGRADATION OF Nrf2 BY THE 26 S PROTEASOME
J. Biol. Chem. 2003 278: 4536-4541. First Published on November 22, 2002; doi:10.1074/jbc.M207293200 [Abstract] [Full Text] [PDF]  

Jia Luo, Yanbo Sun, Hong Lin, Yong Qian, Zheng Li, Stephen S. Leonard, Chuanshu Huang, and Xianglin Shi

Activation of JNK by Vanadate Induces a Fas-associated Death Domain (FADD)-dependent Death of Cerebellar Granule Progenitors in Vitro
J. Biol. Chem. 2003 278: 4542-4551. First Published on November 25, 2002; doi:10.1074/jbc.M208295200 [Abstract] [Full Text] [PDF]  

Eric J. Nelson, Kaisa Hellevuo, Masami Yoshimura, and Boris Tabakoff

Ethanol-induced Phosphorylation and Potentiation of the Activity of Type 7 Adenylyl Cyclase. INVOLVEMENT OF PROTEIN KINASE C
J. Biol. Chem. 2003 278: 4552-4560. First Published on November 25, 2002; doi:10.1074/jbc.M210386200 [Abstract] [Full Text] [PDF]  

Chang-Yuan Ni, Hongping Yuan, and Graham Carpenter

Role of the ErbB-4 Carboxyl Terminus in -Secretase Cleavage
J. Biol. Chem. 2003 278: 4561-4565. First Published on November 25, 2002; doi:10.1074/jbc.M210504200 [Abstract] [Full Text] [PDF]  

David Matallanas, Imanol Arozarena, María T. Berciano, David S. Aaronson, Angel Pellicer, Miguel Lafarga, and Piero Crespo

Differences on the Inhibitory Specificities of H-Ras, K-Ras, and N-Ras (N17) Dominant Negative Mutants Are Related to Their Membrane Microlocalization
J. Biol. Chem. 2003 278: 4572-4581. First Published on November 27, 2002; doi:10.1074/jbc.M209807200 [Abstract] [Full Text] [PDF]  

William H. Loomis, Sachiko Namiki, Rennolds S. Ostrom, Paul A. Insel, and Wolfgang G. Junger

Hypertonic Stress Increases T Cell Interleukin-2 Expression through a Mechanism That Involves ATP Release, P2 Receptor, and p38 MAPK Activation
J. Biol. Chem. 2003 278: 4590-4596. First Published on December 2, 2002; doi:10.1074/jbc.M207868200 [Abstract] [Full Text] [PDF]  

Ramji R. Rajendran, Anne C. Nye, Jonna Frasor, Rashna D. Balsara, Paolo G. V. Martini, and Benita S. Katzenellenbogen

Regulation of Nuclear Receptor Transcriptional Activity by a Novel DEAD Box RNA Helicase (DP97)
J. Biol. Chem. 2003 278: 4628-4638. First Published on December 3, 2002; doi:10.1074/jbc.M210066200 [Abstract] [Full Text] [PDF]  

Qing Lu, Howard K. Surks, Heather Ebling, Wendy E. Baur, Donald Brown, David C. Pallas, and Richard H. Karas

Regulation of Estrogen Receptor -mediated Transcription by a Direct Interaction with Protein Phosphatase 2A
J. Biol. Chem. 2003 278: 4639-4645. First Published on December 3, 2002; doi:10.1074/jbc.M210949200 [Abstract] [Full Text] [PDF]  

Bysani Chandrasekar, Peter C. Melby, Henry M. Sarau, Muthuswamy Raveendran, Rao P. Perla, Federica M. Marelli-Berg, Nickolai O. Dulin, and Ishwar S. Singh

Chemokine-Cytokine Cross-talk. THE ELR⁺ CXC CHEMOKINE LIX (CXCL5) AMPLIFIES A PROINFLAMMATORY CYTOKINE RESPONSE VIA A PHOSPHATIDYLINOSITOL 3-KINASE-NF-B PATHWAY
J. Biol. Chem. 2003 278: 4675-4686. First Published on December 4, 2002; doi:10.1074/jbc.M207006200 [Abstract] [Full Text] [PDF]  

Kazumi Kitta, Regina M. Day, Yuri Kim, Ingrid Torregroza, Todd Evans, and Yuichiro J. Suzuki

Hepatocyte Growth Factor Induces GATA-4 Phosphorylation and Cell Survival in Cardiac Muscle Cells
J. Biol. Chem. 2003 278: 4705-4712. First Published on December 4, 2002; doi:10.1074/jbc.M211616200 [Abstract] [Full Text] [PDF]  

Lixin Li, Yi Yang, and Richard L. Stevens

RasGRP4 Regulates the Expression of Prostaglandin D₂ in Human and Rat Mast Cell Lines
J. Biol. Chem. 2003 278: 4725-4729. First Published on December 18, 2002; doi:10.1074/jbc.C200635200 [Abstract] [Full Text] [PDF]  

Thangiah Geetha and Marie W. Wooten

Association of the Atypical Protein Kinase C-interacting Protein p62/ZIP with Nerve Growth Factor Receptor TrkA Regulates Receptor Trafficking and Erk5 Signaling
J. Biol. Chem. 2003 278: 4730-4739. First Published on December 5, 2002; doi:10.1074/jbc.M208468200 [Abstract] [Full Text] [PDF]  

Karine Robbe, Annie Otto-Bruc, Pierre Chardin, and Bruno Antonny

Dissociation of GDP Dissociation Inhibitor and Membrane Translocation Are Required for Efficient Activation of Rac by the Dbl Homology-Pleckstrin Homology Region of Tiam
J. Biol. Chem. 2003 278: 4756-4762. First Published on December 5, 2002; doi:10.1074/jbc.M210412200 [Abstract] [Full Text] [PDF]  

Wu-Guo Deng, Ying Zhu, and Kenneth K. Wu

Up-regulation of p300 Binding and p50 Acetylation in Tumor Necrosis Factor--induced Cyclooxygenase-2 Promoter Activation
J. Biol. Chem. 2003 278: 4770-4777. First Published on December 5, 2002; doi:10.1074/jbc.M209286200 [Abstract] [Full Text] [PDF]  

Tristan Bouschet, Virgili Perez, Céline Fernandez, Joël Bockaert, Alain Eychene, and Laurent Journot

Stimulation of the ERK Pathway by GTP-loaded Rap1 Requires the Concomitant Activation of Ras, Protein Kinase C, and Protein Kinase A in Neuronal Cells
J. Biol. Chem. 2003 278: 4778-4785. First Published on December 6, 2002; doi:10.1074/jbc.M204652200 [Abstract] [Full Text] [PDF]  

Julie A. Losman, X. Peter Chen, Bao Q. Vuong, Scott Fay, and Paul B. Rothman

Protein Phosphatase 2A Regulates the Stability of Pim Protein Kinases
J. Biol. Chem. 2003 278: 4800-4805. First Published on December 6, 2002; doi:10.1074/jbc.M208246200 [Abstract] [Full Text] [PDF]  

Tomokazu Nagasako, Toshiro Sugiyama, Takuji Mizushima, Yosuke Miura, Mototsugu Kato, and Masahiro Asaka

Up-regulated Smad5 Mediates Apoptosis of Gastric Epithelial Cells Induced by Helicobacter pylori Infection
J. Biol. Chem. 2003 278: 4821-4825. First Published on December 6, 2002; doi:10.1074/jbc.M211143200 [Abstract] [Full Text] [PDF]  

Rocky Pramanik, Xiaomei Qi, Stanley Borowicz, Divaker Choubey, Richard M. Schultz, Jiahuai Han, and Guan Chen

p38 Isoforms Have Opposite Effects on AP-1-dependent Transcription through Regulation of c-Jun. THE DETERMINANT ROLE OF THE ISOFORMS IN THE p38 MAPK SIGNAL SPECIFICITY
J. Biol. Chem. 2003 278: 4831-4839. First Published on December 9, 2002; doi:10.1074/jbc.M207732200 [Abstract] [Full Text] [PDF]  

Chinweike Ukomadu and Anindya Dutta

Inhibition of cdk2 Activating Phosphorylation by Mevastatin
J. Biol. Chem. 2003 278: 4840-4846. First Published on December 9, 2002; doi:10.1074/jbc.M208658200 [Abstract] [Full Text] [PDF]  

Louise Tatton, Gary M. Morley, Rajesh Chopra, and Asim Khwaja

The Src-selective Kinase Inhibitor PP1 Also Inhibits Kit and Bcr-Abl Tyrosine Kinases
J. Biol. Chem. 2003 278: 4847-4853. First Published on December 9, 2002; doi:10.1074/jbc.M209321200 [Abstract] [Full Text] [PDF]  

Natalia Sigal, Yara Gorzalczany, Rive Sarfstein, Carolyn Weinbaum, Yi Zheng, and Edgar Pick

The Guanine Nucleotide Exchange Factor Trio Activates the Phagocyte NADPH Oxidase in the Absence of GDP to GTP Exchange on Rac. "THE EMPEROR'S NEW CLOTHES"
J. Biol. Chem. 2003 278: 4854-4861. First Published on December 9, 2002; doi:10.1074/jbc.M211011200 [Abstract] [Full Text] [PDF]  

Ian F. Smith, John P. Boyle, Leigh D. Plant, Hugh A. Pearson, and Chris Peers

Hypoxic Remodeling of Ca²⁺ Stores in Type I Cortical Astrocytes
J. Biol. Chem. 2003 278: 4875-4881. First Published on December 10, 2002; doi:10.1074/jbc.M209206200 [Abstract] [Full Text] [PDF]  

Jingzhen Yuan, Lee W. Slice, Jennifer Gu, and Enrique Rozengurt

Cooperation of G_q, G_i, and G_12/13 in Protein Kinase D Activation and Phosphorylation Induced by Lysophosphatidic Acid
J. Biol. Chem. 2003 278: 4882-4891. First Published on December 10, 2002; doi:10.1074/jbc.M211175200 [Abstract] [Full Text] [PDF]  

Belinda C. Baliga, Paul A. Colussi, Stuart H. Read, Manisha M. Dias, David A. Jans, and Sharad Kumar

Role of Prodomain in Importin-mediated Nuclear Localization and Activation of Caspase-2
J. Biol. Chem. 2003 278: 4899-4905. First Published on December 10, 2002; doi:10.1074/jbc.M211512200 [Abstract] [Full Text] [PDF]  

Senena Corbalán-García, Josefa García-García, José A. Rodríguez-Alfaro, and Juan C. Gómez-Fernández

A New Phosphatidylinositol 4,5-Bisphosphate-binding Site Located in the C2 Domain of Protein Kinase C
J. Biol. Chem. 2003 278: 4972-4980. First Published on November 7, 2002; doi:10.1074/jbc.M209385200 [Abstract] [Full Text] [PDF]  

Toshifumi Sugatani, Ulises Alvarez, and Keith A. Hruska

PTEN Regulates RANKL- and Osteopontin-stimulated Signal Transduction during Osteoclast Differentiation and Cell Motility
J. Biol. Chem. 2003 278: 5001-5008. First Published on November 30, 2002; doi:10.1074/jbc.M209299200 [Abstract] [Full Text] [PDF]  

Evgeny Kobrinsky, Elena Schwartz, Darrell R. Abernethy, and Nikolai M. Soldatov

Voltage-gated Mobility of the Ca²⁺ Channel Cytoplasmic Tails and Its Regulatory Role
J. Biol. Chem. 2003 278: 5021-5028. First Published on December 6, 2002; doi:10.1074/jbc.M211254200 [Abstract] [Full Text] [PDF]  

Jiaqi Shi, Yongmei Feng, Anne-Christine Goulet, Richard R. Vaillancourt, Nancy A. Sachs, John W. Hershey, and Mark A. Nelson

The p34^cdc2-related Cyclin-dependent kinase 11 Interacts with the p47 Subunit of Eukaryotic Initiation Factor 3 during Apoptosis
J. Biol. Chem. 2003 278: 5062-5071. First Published on November 20, 2002; doi:10.1074/jbc.M206427200 [Abstract] [Full Text] [PDF]  

Simone de Haij, Ian M. Adcock, Astrid C. Bakker, Sam J. P. Gobin, Mohamed R. Daha, and Cees van Kooten

Steroid Responsiveness of Renal Epithelial Cells. DISSOCIATION OF TRANSREPRESSION AND TRANSACTIVATION
J. Biol. Chem. 2003 278: 5091-5098. First Published on October 31, 2002; doi:10.1074/jbc.M209836200 [Abstract] [Full Text] [PDF]  

Daniel Hallmann, Katja Trümper, Heidi Trusheim, Kohjiro Ueki, C. Ronald Kahn, Lewis C. Cantley, David A. Fruman, and Dieter Hörsch

Altered Signaling and Cell Cycle Regulation in Embryonal Stem Cells with a Disruption of the Gene for Phosphoinositide 3-Kinase Regulatory Subunit p85
J. Biol. Chem. 2003 278: 5099-5108. First Published on November 14, 2002; doi:10.1074/jbc.M208451200 [Abstract] [Full Text] [PDF]  

Marina Dunaeva, Piret Michelson, Priit Kogerman, and Rune Toftgard

Characterization of the Physical Interaction of Gli Proteins with SUFU Proteins
J. Biol. Chem. 2003 278: 5116-5122. First Published on November 7, 2002; doi:10.1074/jbc.M209492200 [Abstract] [Full Text] [PDF]  

Yoshiro Otsuki, Masamitsu Tanaka, Takaharu Kamo, Chifumi Kitanaka, Yoshiyuki Kuchino, and Haruhiko Sugimura

Guanine Nucleotide Exchange Factor, Tiam1, Directly Binds to c-Myc and Interferes with c-Myc-mediated Apoptosis in Rat-1 Fibroblasts
J. Biol. Chem. 2003 278: 5132-5140. First Published on November 21, 2002; doi:10.1074/jbc.M206733200 [Abstract] [Full Text] [PDF]  

Frank D. Böhmer, Luchezar Karagyozov, Andrea Uecker, Hubert Serve, Alexander Botzki, Siavosh Mahboobi, and Stefan Dove

A Single Amino Acid Exchange Inverts Susceptibility of Related Receptor Tyrosine Kinases for the ATP Site Inhibitor STI-571
J. Biol. Chem. 2003 278: 5148-5155. First Published on November 14, 2002; doi:10.1074/jbc.M209861200 [Abstract] [Full Text] [PDF] Supplemental Data  

Péter Tamás, Zita Solti, Petra Bauer, András Illés, Szabolcs Sipeki, András Bauer, Anna Faragó, Julian Downward, and László Buday

Mechanism of Epidermal Growth Factor Regulation of Vav2, a Guanine Nucleotide Exchange Factor for Rac
J. Biol. Chem. 2003 278: 5163-5171. First Published on November 25, 2002; doi:10.1074/jbc.M207555200 [Abstract] [Full Text] [PDF]  

Paola Casarosa, Wiro M. Menge, Rosalba Minisini, Claas Otto, Jane van Heteren, Aldo Jongejan, Henk Timmerman, Barbara Moepps, Frank Kirchhoff, Thomas Mertens, Martine J. Smit, and Rob Leurs

Identification of the First Nonpeptidergic Inverse Agonist for a Constitutively Active Viral-encoded G Protein-coupled Receptor
J. Biol. Chem. 2003 278: 5172-5178. First Published on November 26, 2002; doi:10.1074/jbc.M210033200 [Abstract] [Full Text] [PDF]  

Yu Wei, Claire-Angélique Renard, Charlotte Labalette, Yuanfei Wu, Laurence Lévy, Christine Neuveut, Xavier Prieur, Marc Flajolet, Sylvie Prigent, and Marie-Annick Buendia

Identification of the LIM Protein FHL2 as a Coactivator of -Catenin
J. Biol. Chem. 2003 278: 5188-5194. First Published on December 3, 2002; doi:10.1074/jbc.M207216200 [Abstract] [Full Text] [PDF]  

Jeehyeon Bae, Jill R. Donigian, and Aaron J. W. Hsueh

Tankyrase 1 Interacts with Mcl-1 Proteins and Inhibits Their Regulation of Apoptosis
J. Biol. Chem. 2003 278: 5195-5204. First Published on December 9, 2002; doi:10.1074/jbc.M201988200 [Abstract] [Full Text] [PDF]  

Panu E. Kovanen, Andreas Rosenwald, Jacqueline Fu, Elaine M. Hurt, Lloyd T. Lam, Jena M. Giltnane, George Wright, Louis M. Staudt, and Warren J. Leonard

Analysis of _c-Family Cytokine Target Genes. IDENTIFICATION OF DUAL-SPECIFICITY PHOSPHATASE 5 (DUSP5) AS A REGULATOR OF MITOGEN-ACTIVATED PROTEIN KINASE ACTIVITY IN INTERLEUKIN-2 SIGNALING
J. Biol. Chem. 2003 278: 5205-5213. First Published on November 14, 2002; doi:10.1074/jbc.M209015200 [Abstract] [Full Text] [PDF]  

Marcin Kortylewski, Florian Feld, Klaus-Dieter Krüger, Gregor Bahrenberg, Richard A. Roth, Hans-Georg Joost, Peter C. Heinrich, Iris Behrmann, and Andreas Barthel

Akt Modulates STAT3-mediated Gene Expression through a FKHR (FOXO1a)-dependent Mechanism
J. Biol. Chem. 2003 278: 5242-5249. First Published on November 26, 2002; doi:10.1074/jbc.M205403200 [Abstract] [Full Text] [PDF]  

Boyd Butler, Matthew P. Williams, and Scott D. Blystone

Ligand-dependent Activation of Integrin _v3
J. Biol. Chem. 2003 278: 5264-5270. First Published on November 22, 2002; doi:10.1074/jbc.M206997200 [Abstract] [Full Text] [PDF]  

Tae-Hee Lee, Hava Karsenty Avraham, Shuxian Jiang, and Shalom Avraham

Vascular Endothelial Growth Factor Modulates the Transendothelial Migration of MDA-MB-231 Breast Cancer Cells through Regulation of Brain Microvascular Endothelial Cell Permeability
J. Biol. Chem. 2003 278: 5277-5284. First Published on November 20, 2002; doi:10.1074/jbc.M210063200 [Abstract] [Full Text] [PDF]  

Sylvie J. Lavictoire, Doris A. E. Parolin, Alex C. Klimowicz, John F. Kelly, and Ian A. J. Lorimer

Interaction of Hsp90 with the Nascent Form of the Mutant Epidermal Growth Factor Receptor EGFRvIII
J. Biol. Chem. 2003 278: 5292-5299. First Published on December 5, 2002; doi:10.1074/jbc.M209494200 [Abstract] [Full Text] [PDF]  

Valery Mikhailov, Margarita Mikhailova, Kurt Degenhardt, Manjeri A. Venkatachalam, Eileen White, and Pothana Saikumar

Association of Bax and Bak Homo-oligomers in Mitochondria. Bax REQUIREMENT FOR Bak REORGANIZATION AND CYTOCHROME c RELEASE
J. Biol. Chem. 2003 278: 5367-5376. First Published on November 25, 2002; doi:10.1074/jbc.M203392200 [Abstract] [Full Text] [PDF]  

Jianzheng Zhou, Robert N. Fariss, and Peggy S. Zelenka

Synergy of Epidermal Growth Factor and 12(S)-Hydroxyeicosatetraenoate on Protein Kinase C Activation in Lens Epithelial Cells
J. Biol. Chem. 2003 278: 5388-5398. First Published on December 2, 2002; doi:10.1074/jbc.M209695200 [Abstract] [Full Text] [PDF]  

Andy V. Babwah, Lianne B. Dale, and Stephen S. G. Ferguson

Protein Kinase C Isoform-specific Differences in the Spatial-Temporal Regulation and Decoding of Metabotropic Glutamate Receptor1a-stimulated Second Messenger Responses
J. Biol. Chem. 2003 278: 5419-5426. First Published on November 25, 2002; doi:10.1074/jbc.M211053200 [Abstract] [Full Text] [PDF]  

Pascal Schneider, Dian Olson, Aubry Tardivel, Beth Browning, Alexey Lugovskoy, DaHai Gong, Max Dobles, Sylvie Hertig, Kay Hofmann, Herman Van Vlijmen, Yen-Ming Hsu, Linda C. Burkly, Jurg Tschopp, and Timothy S. Zheng

Identification of a New Murine Tumor Necrosis Factor Receptor Locus That Contains Two Novel Murine Receptors for Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)
J. Biol. Chem. 2003 278: 5444-5454. First Published on December 3, 2002; doi:10.1074/jbc.M210783200 [Abstract] [Full Text] [PDF]  

Min Liu, Meng-Chuan Liu, Charalambos Magoulas, John V. Priestley, and Nick J. Willmott

Versatile Regulation of Cytosolic Ca²⁺ by Vanilloid Receptor I in Rat Dorsal Root Ganglion Neurons
J. Biol. Chem. 2003 278: 5462-5472. First Published on November 25, 2002; doi:10.1074/jbc.M209111200 [Abstract] [Full Text] [PDF]  

Molecular Basis Of Cell and Developmental Biology:

Claudia Castro, Antonio Díez-Juan, María José Cortés, and Vicente Andrés

Distinct Regulation of Mitogen-activated Protein Kinases and p27^Kip1 in Smooth Muscle Cells from Different Vascular Beds. A POTENTIAL ROLE IN ESTABLISHING REGIONAL PHENOTYPIC VARIANCE
J. Biol. Chem. 2003 278: 4482-4490. First Published on December 10, 2002; doi:10.1074/jbc.M204716200 [Abstract] [Full Text] [PDF]  

Inken G. Huttner, Thomas Strahl, Masanori Osawa, David S. King, James B. Ames, and Jeremy Thorner

Molecular Interactions of Yeast Frequenin (Frq1) with the Phosphatidylinositol 4-Kinase Isoform, Pik1
J. Biol. Chem. 2003 278: 4862-4874. First Published on December 10, 2002; doi:10.1074/jbc.M207920200 [Abstract] [Full Text] [PDF] Supplemental Data  

Kaoru Kawachi, Norihisa Masuyama, and Eisuke Nishida

Essential Role of the Transcription Factor Ets-2 in Xenopus Early Development
J. Biol. Chem. 2003 278: 5473-5477. First Published on December 4, 2002; doi:10.1074/jbc.M211054200 [Abstract] [Full Text] [PDF]  

Additions and Corrections:

Fabienne Rajas, Amandine Gautier, Isabelle Bady, Sandrine Montano, and Gilles Mithieux

Polyunsaturated fatty acyl coenzyme A suppress the glucose-6-phosphatase promoter activity by modulating the DNA binding of hepatocyte nuclear factor 4.
J. Biol. Chem. 2003 278: 5488. [Full Text] [PDF]  

Kuan Peng, Qin Shu, Zhonghua Liu, and Songping Liang

Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia huwena.
J. Biol. Chem. 2003 278: 5489. [Full Text] [PDF]  

Sarah Liv Elfering, Theresa Maria Sarkela, and Cecilia Giulivi

Biochemistry of mitochondrial nitric-oxide synthase.
J. Biol. Chem. 2003 278: 5489. [Full Text] [PDF]  

Annette Alfsen and Morgane Bomsel

HIV-1 gp41 envelope residues 650-685 exposed on native virus act as a lectin to bind epithelial cell galactosyl ceramide.
J. Biol. Chem. 2003 278: 5490-5491. [Full Text] [PDF]  

Joseph G. Joyce, William M. Hurni, Michael J. Bogusky, Victor M. Garsky, Xiaoping Liang, Michael P. Citron, Renee C. Danzeisen, Michael D. Miller, John W. Shiver, and Paul M. Keller

Enhancement of -helicity in the HIV-1 inhibitory peptide DP178 leads to an increased affinity for human monoclonal antibody 2F5 but does not elicit neutralizing responses in vitro. Implications for vaccine design.
J. Biol. Chem. 2003 278: 5492. [Full Text] [PDF]  

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