Accelerated Publications:

Jay Gump, David Stokoe, and Frank McCormick

Phosphorylation of p16^INK4A Correlates with Cdk4 Association
J. Biol. Chem. 2003 278: 6619-6622. First Published on January 14, 2003; doi:10.1074/jbc.C200622200 [Abstract] [Full Text] [PDF] Supplemental Data  

DNA: Replication Repair and Recombination:

Matthew C. Whitby, Fekret Osman, and Julie Dixon

Cleavage of Model Replication Forks by Fission Yeast Mus81-Eme1 and Budding Yeast Mus81-Mms4
J. Biol. Chem. 2003 278: 6928-6935. First Published on December 8, 2002; doi:10.1074/jbc.M210006200 [Abstract] [Full Text] [PDF]  

Edel M. Hyland, Lisa F. Rezende, and Charles C. Richardson

The DNA Binding Domain of the Gene 2.5 Single-stranded DNA-binding Protein of Bacteriophage T7
J. Biol. Chem. 2003 278: 7247-7256. First Published on December 20, 2002; doi:10.1074/jbc.M210605200 [Abstract] [Full Text] [PDF]  

Isao Kuraoka, Masaki Endou, Yuki Yamaguchi, Tadashi Wada, Hiroshi Handa, and Kiyoji Tanaka

Effects of Endogenous DNA Base Lesions on Transcription Elongation by Mammalian RNA Polymerase II. IMPLICATIONS FOR TRANSCRIPTION-COUPLED DNA REPAIR AND TRANSCRIPTIONAL MUTAGENESIS
J. Biol. Chem. 2003 278: 7294-7299. First Published on December 3, 2002; doi:10.1074/jbc.M208102200 [Abstract] [Full Text] [PDF]  

Kenneth D. Bromberg, Alex B. Burgin, and Neil Osheroff

A Two-drug Model for Etoposide Action against Human Topoisomerase II
J. Biol. Chem. 2003 278: 7406-7412. First Published on December 8, 2002; doi:10.1074/jbc.M212056200 [Abstract] [Full Text] [PDF]  

Jin-Sam You, Mu Wang, and Suk-Hee Lee

Biochemical Analysis of the Damage Recognition Process in Nucleotide Excision Repair
J. Biol. Chem. 2003 278: 7476-7485. First Published on December 13, 2002; doi:10.1074/jbc.M210603200 [Abstract] [Full Text] [PDF]  

Genes: Structure and Regulation:

Valentina Salsi, Giuseppina Caretti, Mark Wasner, Wibke Reinhard, Ulrike Haugwitz, Kurt Engeland, and Roberto Mantovani

Interactions between p300 and Multiple NF-Y Trimers Govern Cyclin B2 Promoter Function
J. Biol. Chem. 2003 278: 6642-6650. First Published on December 12, 2002; doi:10.1074/jbc.M210065200 [Abstract] [Full Text] [PDF]  

Joachim Klein, Mark Nolden, Steven L. Sanders, Jay Kirchner, P. Anthony Weil, and Karsten Melcher

Use of a Genetically Introduced Cross-linker to Identify Interaction Sites of Acidic Activators within Native Transcription Factor IID and SAGA
J. Biol. Chem. 2003 278: 6779-6786. First Published on December 24, 2002; doi:10.1074/jbc.M212514200 [Abstract] [Full Text] [PDF]  

Christina Kast, Minglun Wang, and Malcolm Whiteway

The ERK/MAPK Pathway Regulates the Activity of the Human Tissue Factor Pathway Inhibitor-2 Promoter
J. Biol. Chem. 2003 278: 6787-6794. First Published on November 24, 2002; doi:10.1074/jbc.M210935200 [Abstract] [Full Text] [PDF]  

Florian Puehler, Heike Schwarz, Barbara Waidner, Jörn Kalinowski, Bernd Kaspers, Stefan Bereswill, and Peter Staeheli

An Interferon--binding Protein of Novel Structure Encoded by the Fowlpox Virus
J. Biol. Chem. 2003 278: 6905-6911. First Published on December 13, 2002; doi:10.1074/jbc.M207336200 [Abstract] [Full Text] [PDF]  

Paul Webb, Phuong Nguyen, and Peter J. Kushner

Differential SERM Effects on Corepressor Binding Dictate ER Activity in Vivo
J. Biol. Chem. 2003 278: 6912-6920. First Published on December 13, 2002; doi:10.1074/jbc.M208501200 [Abstract] [Full Text] [PDF]  

Daniela Botolin and Donald B. Jump

Selective Proteolytic Processing of Rat Hepatic Sterol Regulatory Element Binding Protein-1 (SREBP-1) and SREBP-2 During Postnatal Development
J. Biol. Chem. 2003 278: 6959-6962. First Published on December 17, 2002; doi:10.1074/jbc.M212846200 [Abstract] [Full Text] [PDF]  

Isabelle Dussault, Rick Beard, Min Lin, Kevin Hollister, Jasmine Chen, Jia-Hao Xiao, Rosh Chandraratna, and Barry M. Forman

Identification of Gene-selective Modulators of the Bile Acid Receptor FXR
J. Biol. Chem. 2003 278: 7027-7033. First Published on December 19, 2002; doi:10.1074/jbc.M209863200 [Abstract] [Full Text] [PDF]  

Kevin Wong, George A. Kassavetis, Jean-Paul Léonetti, and E. Peter Geiduschek

Mutational and Functional Analysis of a Segment of the Sigma Family Bacteriophage T4 Late Promoter Recognition Protein gp55
J. Biol. Chem. 2003 278: 7073-7080. First Published on December 20, 2002; doi:10.1074/jbc.M211447200 [Abstract] [Full Text] [PDF]  

Yi Pei, Beate Schwer, and Stewart Shuman

Interactions between Fission Yeast Cdk9, Its Cyclin Partner Pch1, and mRNA Capping Enzyme Pct1 Suggest an Elongation Checkpoint for mRNA Quality Control
J. Biol. Chem. 2003 278: 7180-7188. First Published on December 9, 2002; doi:10.1074/jbc.M211713200 [Abstract] [Full Text] [PDF]  

Mohamed-Ali Hakimi, Yuanshu Dong, William S. Lane, David W. Speicher, and Ramin Shiekhattar

A Candidate X-linked Mental Retardation Gene Is a Component of a New Family of Histone Deacetylase-containing Complexes
J. Biol. Chem. 2003 278: 7234-7239. First Published on December 18, 2002; doi:10.1074/jbc.M208992200 [Abstract] [Full Text] [PDF]  

Hung-Ying Kao, Chris C. Han, Anton A. Komar, and Ronald M. Evans

Co-repressor Release but Not Ligand Binding Is a Prerequisite for Transcription Activation by Human Retinoid Acid Receptor Ligand-binding Domain
J. Biol. Chem. 2003 278: 7366-7373. First Published on December 4, 2002; doi:10.1074/jbc.M207569200 [Abstract] [Full Text] [PDF]  

Chunghun Lim, Daeyoup Lee, Taegun Seo, Changtaek Choi, and Joonho Choe

Latency-associated Nuclear Antigen of Kaposi's Sarcoma-associated Herpesvirus Functionally Interacts with Heterochromatin Protein 1
J. Biol. Chem. 2003 278: 7397-7405. First Published on December 16, 2002; doi:10.1074/jbc.M211912200 [Abstract] [Full Text] [PDF]  

Mitsue Yamamichi-Nishina, Taiji Ito, Taketoshi Mizutani, Nobutake Yamamichi, Hirotaka Watanabe, and Hideo Iba

SW13 Cells Can Transition between Two Distinct Subtypes by Switching Expression of BRG1 and Brm Genes at the Post-transcriptional Level
J. Biol. Chem. 2003 278: 7422-7430. First Published on December 17, 2002; doi:10.1074/jbc.M208458200 [Abstract] [Full Text] [PDF]  

Monica Borgatti, Ilaria Lampronti, Alessandra Romanelli, Carlo Pedone, Michele Saviano, Nicoletta Bianchi, Carlo Mischiati, and Roberto Gambari

Transcription Factor Decoy Molecules Based on a Peptide Nucleic Acid (PNA)-DNA Chimera Mimicking Sp1 Binding Sites
J. Biol. Chem. 2003 278: 7500-7509. First Published on November 20, 2002; doi:10.1074/jbc.M206780200 [Abstract] [Full Text] [PDF]  

Philip Berardi, Muthupalaniappan Meyyappan, and Karl T. Riabowol

A Novel Transcriptional Inhibitory Element Differentially Regulates the Cyclin D1 Gene in Senescent Cells
J. Biol. Chem. 2003 278: 7510-7519. First Published on December 2, 2002; doi:10.1074/jbc.M210864200 [Abstract] [Full Text] [PDF]  

Tin Htwe Thin, Liang Wang, Eungseok Kim, Loretta L. Collins, Ravi Basavappa, and Chawnshang Chang

Isolation and Characterization of Androgen Receptor Mutant, AR(M749L), with Hypersensitivity to 17- Estradiol Treatment
J. Biol. Chem. 2003 278: 7699-7708. First Published on December 23, 2002; doi:10.1074/jbc.M206172200 [Abstract] [Full Text] [PDF]  

RNA: Structure Metabolism and Catalysis:

Yoon Lee and Ross N. Nazar

Terminal Structure Mediates 5 S rRNA Stability and Integration during Ribosome Biogenesis
J. Biol. Chem. 2003 278: 6635-6641. First Published on December 5, 2002; doi:10.1074/jbc.M212220200 [Abstract] [Full Text] [PDF]  

Kavita A. Marfatia, Emily B. Crafton, Deanna M. Green, and Anita H. Corbett

Domain Analysis of the Saccharomyces cerevisiae Heterogeneous Nuclear Ribonucleoprotein, Nab2p. DISSECTING THE REQUIREMENTS FOR Nab2p-FACILITATED POLY(A) RNA EXPORT
J. Biol. Chem. 2003 278: 6731-6740. First Published on December 19, 2002; doi:10.1074/jbc.M207571200 [Abstract] [Full Text] [PDF]  

Timothy A. Vickers, Seongjoon Koo, C. Frank Bennett, Stanley T. Crooke, Nicholas M. Dean, and Brenda F. Baker

Efficient Reduction of Target RNAs by Small Interfering RNA and RNase H-dependent Antisense Agents. A COMPARATIVE ANALYSIS
J. Biol. Chem. 2003 278: 7108-7118. First Published on December 23, 2002; doi:10.1074/jbc.M210326200 [Abstract] [Full Text] [PDF]  

Dan Shu and Peixuan Guo

A Viral RNA That Binds ATP and Contains a Motif Similar to an ATP-binding Aptamer from SELEX
J. Biol. Chem. 2003 278: 7119-7125. First Published on November 20, 2002; doi:10.1074/jbc.M209895200 [Abstract] [Full Text] [PDF]  

Protein Synthesis Post-Translation Modification and Degradation:

Susanna Herold and Gabriele Röck

Reactions of Deoxy-, Oxy-, and Methemoglobin with Nitrogen Monoxide. MECHANISTIC STUDIES OF THE S-NITROSOTHIOL FORMATION UNDER DIFFERENT MIXING CONDITIONS
J. Biol. Chem. 2003 278: 6623-6634. First Published on December 4, 2002; doi:10.1074/jbc.M210275200 [Abstract] [Full Text] [PDF]  

Boaz Tirosh, Margo H. Furman, Domenico Tortorella, and Hidde L. Ploegh

Protein Unfolding Is Not a Prerequisite for Endoplasmic Reticulum-to-Cytosol Dislocation
J. Biol. Chem. 2003 278: 6664-6672. First Published on December 12, 2002; doi:10.1074/jbc.M210158200 [Abstract] [Full Text] [PDF]  

Patricia G. Santamaría, Daniel Finley, Juan P. G. Ballesta, and Miguel Remacha

Rpn6p, a Proteasome Subunit from Saccharomyces cerevisiae, Is Essential for the Assembly and Activity of the 26 S Proteasome
J. Biol. Chem. 2003 278: 6687-6695. First Published on December 16, 2002; doi:10.1074/jbc.M209420200 [Abstract] [Full Text] [PDF]  

Hieronim Jakubowski and Andrzej Guranowski

Metabolism of Homocysteine-thiolactone in Plants
J. Biol. Chem. 2003 278: 6765-6770. First Published on December 20, 2002; doi:10.1074/jbc.M211819200 [Abstract] [Full Text] [PDF]  

Jasmina Kurepa, Joseph M. Walker, Jan Smalle, Mark M. Gosink, Seth J. Davis, Tessa L. Durham, Dong-Yul Sung, and Richard D. Vierstra

The Small Ubiquitin-like Modifier (SUMO) Protein Modification System in Arabidopsis. ACCUMULATION OF SUMO1 AND -2 CONJUGATES IS INCREASED BY STRESS
J. Biol. Chem. 2003 278: 6862-6872. First Published on December 12, 2002; doi:10.1074/jbc.M209694200 [Abstract] [Full Text] [PDF]  

Sinead M. Miggin, Orlaith A. Lawler, and B. Therese Kinsella

Palmitoylation of the Human Prostacyclin Receptor. FUNCTIONAL IMPLICATIONS OF PALMITOYLATION AND ISOPRENYLATION
J. Biol. Chem. 2003 278: 6947-6958. First Published on December 17, 2002; doi:10.1074/jbc.M210637200 [Abstract] [Full Text] [PDF]  

Monika Anand, Kalpana Chakraburtty, Matthew J. Marton, Alan G. Hinnebusch, and Terri Goss Kinzy

Functional Interactions between Yeast Translation Eukaryotic Elongation Factor (eEF) 1A and eEF3
J. Biol. Chem. 2003 278: 6985-6991. First Published on December 18, 2002; doi:10.1074/jbc.M209224200 [Abstract] [Full Text] [PDF]  

Takeshi Ikeuchi, Georgia Dolios, Seong-Hun Kim, Rong Wang, and Sangram S. Sisodia

Familial Alzheimer Disease-linked Presenilin 1 Variants Enhance Production of Both A1-40 and A1-42 Peptides That Are Only Partially Sensitive to a Potent Aspartyl Protease Transition State Inhibitor of "-Secretase"
J. Biol. Chem. 2003 278: 7010-7018. First Published on December 19, 2002; doi:10.1074/jbc.M209252200 [Abstract] [Full Text] [PDF]  

Helle D. Ulrich

Protein-Protein Interactions within an E2-RING Finger Complex. IMPLICATIONS FOR UBIQUITIN-DEPENDENT DNA DAMAGE REPAIR
J. Biol. Chem. 2003 278: 7051-7058. First Published on December 19, 2002; doi:10.1074/jbc.M212195200 [Abstract] [Full Text] [PDF] Supplemental Data  

Adam A. Golabek, Elizabeth Kida, Marius Walus, Peter Wujek, Pankaj Mehta, and Krystyna E. Wisniewski

Biosynthesis, Glycosylation, and Enzymatic Processing in Vivo of Human Tripeptidyl-peptidase I
J. Biol. Chem. 2003 278: 7135-7145. First Published on December 17, 2002; doi:10.1074/jbc.M211872200 [Abstract] [Full Text] [PDF]  

Helen P. Price, Malini R. Menon, Chrysoula Panethymitaki, David Goulding, Paul G. McKean, and Deborah F. Smith

Myristoyl-CoA:Protein N-Myristoyltransferase, an Essential Enzyme and Potential Drug Target in Kinetoplastid Parasites
J. Biol. Chem. 2003 278: 7206-7214. First Published on December 17, 2002; doi:10.1074/jbc.M211391200 [Abstract] [Full Text] [PDF]  

Shelya X. Zeng, Yetao Jin, David T. Kuninger, Peter Rotwein, and Hua Lu

The Acetylase Activity of p300 Is Dispensable for MDM2 Stabilization
J. Biol. Chem. 2003 278: 7453-7458. First Published on December 18, 2002; doi:10.1074/jbc.M209030200 [Abstract] [Full Text] [PDF]  

Jonathan H. Nedrelow, Carol D. Cianci, and Jon S. Morrow

c-Src Binds II Spectrin's Src Homology 3 (SH3) Domain and Blocks Calpain Susceptibility by Phosphorylating Tyr¹¹⁷⁶
J. Biol. Chem. 2003 278: 7735-7741. First Published on November 20, 2002; doi:10.1074/jbc.M210988200 [Abstract] [Full Text] [PDF]  

Genomics Proteomics and Bioinformatics:

Swapnil R. Chhabra, Keith R. Shockley, Shannon B. Conners, Kevin L. Scott, Russell D. Wolfinger, and Robert M. Kelly

Carbohydrate-induced Differential Gene Expression Patterns in the Hyperthermophilic Bacterium Thermotoga maritima
J. Biol. Chem. 2003 278: 7540-7552. First Published on December 9, 2002; doi:10.1074/jbc.M211748200 [Abstract] [Full Text] [PDF]  

Bong Kyung Shin, Hong Wang, Anne Marie Yim, Francois Le Naour, Franck Brichory, Jun Ho Jang, Rong Zhao, Eric Puravs, John Tra, Claire W. Michael, David E. Misek, and Samir M. Hanash

Global Profiling of the Cell Surface Proteome of Cancer Cells Uncovers an Abundance of Proteins with Chaperone Function
J. Biol. Chem. 2003 278: 7607-7616. First Published on December 18, 2002; doi:10.1074/jbc.M210455200 [Abstract] [Full Text] [PDF]  

Yan Xu, Jean C. Clark, Bruce J. Aronow, Chitta R. Dey, Cong Liu, Jamie L. Wooldridge, and Jeffrey A. Whitsett

Transcriptional Adaptation to Cystic Fibrosis Transmembrane Conductance Regulator Deficiency
J. Biol. Chem. 2003 278: 7674-7682. First Published on December 12, 2002; doi:10.1074/jbc.M210277200 [Abstract] [Full Text] [PDF]  

Protein Structure and Folding:

Yiming Li, Ray T. Syvitski, Grace C. Chu, Masao Ikeda-Saito, and Gerd N. La Mar

Solution ¹H NMR Investigation of the Active Site Molecular and Electronic Structures of Substrate-bound, Cyanide-inhibited HmuO, a Bacterial Heme Oxygenase from Corynebacterium diphtheriae
J. Biol. Chem. 2003 278: 6651-6663. First Published on December 11, 2002; doi:10.1074/jbc.M211249200 [Abstract] [Full Text] [PDF] Supplemental Data  

Anthony P. Garnett and John H. Viles

Copper Binding to the Octarepeats of the Prion Protein. AFFINITY, SPECIFICITY, FOLDING, AND COOPERATIVITY: INSIGHTS FROM CIRCULAR DICHROISM
J. Biol. Chem. 2003 278: 6795-6802. First Published on November 25, 2002; doi:10.1074/jbc.M209280200 [Abstract] [Full Text] [PDF]  

Beate Grziwa, Marcus O. W. Grimm, Colin L. Masters, Konrad Beyreuther, Tobias Hartmann, and Stefan F. Lichtenthaler

The Transmembrane Domain of the Amyloid Precursor Protein in Microsomal Membranes Is on Both Sides Shorter than Predicted
J. Biol. Chem. 2003 278: 6803-6808. First Published on November 25, 2002; doi:10.1074/jbc.M210047200 [Abstract] [Full Text] [PDF]  

Teresa Pereira, Xiaowei Zheng, Jorge L. Ruas, Keiji Tanimoto, and Lorenz Poellinger

Identification of Residues Critical for Regulation of Protein Stability and the Transactivation Function of the Hypoxia-inducible Factor-1 by the von Hippel-Lindau Tumor Suppressor Gene Product
J. Biol. Chem. 2003 278: 6816-6823. First Published on December 4, 2002; doi:10.1074/jbc.M209297200 [Abstract] [Full Text] [PDF]  

Olav Olsen and David S. Bredt

Functional Analysis of the Nucleotide Binding Domain of Membrane-associated Guanylate Kinases
J. Biol. Chem. 2003 278: 6873-6878. First Published on December 12, 2002; doi:10.1074/jbc.M210165200 [Abstract] [Full Text] [PDF]  

Odutayo O. Odunuga, Judith A. Hornby, Christiane Bies, Richard Zimmermann, David J. Pugh, and Gregory L. Blatch

Tetratricopeptide Repeat Motif-mediated Hsc70-mSTI1 Interaction. MOLECULAR CHARACTERIZATION OF THE CRITICAL CONTACTS FOR SUCCESSFUL BINDING AND SPECIFICITY
J. Biol. Chem. 2003 278: 6896-6904. First Published on December 13, 2002; doi:10.1074/jbc.M206867200 [Abstract] [Full Text] [PDF]  

Yael Pazy, Bilha Raboy, Meirav Matto, Edward A. Bayer, Meir Wilchek, and Oded Livnah

Structure-based Rational Design of Streptavidin Mutants with Pseudo-catalytic Activity
J. Biol. Chem. 2003 278: 7131-7134. First Published on December 18, 2002; doi:10.1074/jbc.M209983200 [Abstract] [Full Text] [PDF]  

Melissa Schwaller, Bonney Wilkinson, and Hiram F. Gilbert

Reduction-Reoxidation Cycles Contribute to Catalysis of disulfide Isomerization by Protein-disulfide Isomerase
J. Biol. Chem. 2003 278: 7154-7159. First Published on December 15, 2002; doi:10.1074/jbc.M211036200 [Abstract] [Full Text] [PDF]  

Lena Hammar, Sevak Markarian, Lars Haag, Hilkka Lankinen, Aimo Salmi, and R. Holland Cheng

Prefusion Rearrangements Resulting in Fusion Peptide Exposure in Semliki Forest Virus
J. Biol. Chem. 2003 278: 7189-7198. First Published on December 17, 2002; doi:10.1074/jbc.M206015200 [Abstract] [Full Text] [PDF]  

Simonetta Bernocco, Barry M. Steiglitz, Dmitri I. Svergun, Maxim V. Petoukhov, Florence Ruggiero, Sylvie Ricard-Blum, Christine Ebel, Christophe Geourjon, Gilbert Deléage, Bernard Font, Denise Eichenberger, Daniel S. Greenspan, and David J. S. Hulmes

Low Resolution Structure Determination Shows Procollagen C-Proteinase Enhancer to be an Elongated Multidomain Glycoprotein
J. Biol. Chem. 2003 278: 7199-7205. First Published on December 15, 2002; doi:10.1074/jbc.M210857200 [Abstract] [Full Text] [PDF]  

Dmitriy M. Chudakov, Alexei V. Feofanov, Nikolay N. Mudrik, Sergey Lukyanov, and Konstantin A. Lukyanov

Chromophore Environment Provides Clue to "Kindling Fluorescent Protein" Riddle
J. Biol. Chem. 2003 278: 7215-7219. First Published on December 19, 2002; doi:10.1074/jbc.M211988200 [Abstract] [Full Text] [PDF]  

Laura J. Juszczak, Christophe Fablet, Veronique Baudin-Creuza, Sophie Lesecq-Le Gall, Rhoda Elison Hirsch, Ronald L. Nagel, Joel M. Friedman, and Josée Pagnier

Conformational Changes in Hemoglobin S (E6V) Imposed by Mutation of the Glu⁷-Lys¹³² Salt Bridge and Detected by UV Resonance Raman Spectroscopy
J. Biol. Chem. 2003 278: 7257-7263. First Published on December 16, 2002; doi:10.1074/jbc.M200691200 [Abstract] [Full Text] [PDF]  

Scott C. Garman, William N. Simcoke, Anthony W. Stowers, and David N. Garboczi

Structure of the C-terminal Domains of Merozoite Surface Protein-1 from Plasmodium knowlesi Reveals a Novel Histidine Binding Site
J. Biol. Chem. 2003 278: 7264-7269. First Published on December 19, 2002; doi:10.1074/jbc.M210716200 [Abstract] [Full Text] [PDF]  

Gabino F. Sánchez-Pérez, María Gasset, Juan J. Calvete, and María A. Pajares

Role of an Intrasubunit Disulfide in the Association State of the Cytosolic Homo-oligomer Methionine Adenosyltransferase
J. Biol. Chem. 2003 278: 7285-7293. First Published on December 20, 2002; doi:10.1074/jbc.M210177200 [Abstract] [Full Text] [PDF]  

Ying-Jen Leu, Shuenn-Shing Chern, Sui-Chi Wang, Ya-Yun Hsiao, Imameddin Amiraslanov, Yen-Chywan Liaw, and You-Di Liao

Residues Involved in the Catalysis, Base Specificity, and Cytotoxicity of Ribonuclease from Rana catesbeiana Based upon Mutagenesis and X-ray Crystallography
J. Biol. Chem. 2003 278: 7300-7309. First Published on December 23, 2002; doi:10.1074/jbc.M206701200 [Abstract] [Full Text] [PDF]  

Yongjun Gu, Fusheng Chen, Nobuo Sanjo, Toshitaka Kawarai, Hiroshi Hasegawa, Monica Duthie, Wenping Li, Xueying Ruan, Anchla Luthra, Howard T. J. Mount, Anurag Tandon, Paul E. Fraser, and Peter St George-Hyslop

APH-1 Interacts with Mature and Immature Forms of Presenilins and Nicastrin and May Play a Role in Maturation of Presenilin·Nicastrin Complexes
J. Biol. Chem. 2003 278: 7374-7380. First Published on December 5, 2002; doi:10.1074/jbc.M209499200 [Abstract] [Full Text] [PDF]  

Filip Van Petegem, Tony Collins, Marie-Alice Meuwis, Charles Gerday, Georges Feller, and Jozef Van Beeumen

The Structure of a Cold-adapted Family 8 Xylanase at 1.3 Å Resolution. STRUCTURAL ADAPTATIONS TO COLD AND INVESTIGATION OF THE ACTIVE SITE
J. Biol. Chem. 2003 278: 7531-7539. First Published on December 9, 2002; doi:10.1074/jbc.M206862200 [Abstract] [Full Text] [PDF]  

Takumi Koshiba and David C. Chan

The Prefusogenic Intermediate of HIV-1 gp41 Contains Exposed C-peptide Regions
J. Biol. Chem. 2003 278: 7573-7579. First Published on December 13, 2002; doi:10.1074/jbc.M211154200 [Abstract] [Full Text] [PDF]  

Siew Siew Pang, Luke W. Guddat, and Ronald G. Duggleby

Molecular Basis of Sulfonylurea Herbicide Inhibition of Acetohydroxyacid Synthase
J. Biol. Chem. 2003 278: 7639-7644. First Published on December 20, 2002; doi:10.1074/jbc.M211648200 [Abstract] [Full Text] [PDF]  

Nicholas J. Skelton, Michael F. T. Koehler, Kerry Zobel, Wai Lee Wong, Sherry Yeh, M. Theresa Pisabarro, Jian Ping Yin, Laurence A. Lasky, and Sachdev S. Sidhu

Origins of PDZ Domain Ligand Specificity. STRUCTURE DETERMINATION AND MUTAGENESIS OF THE ERBIN PDZ DOMAIN
J. Biol. Chem. 2003 278: 7645-7654. First Published on November 20, 2002; doi:10.1074/jbc.M209751200 [Abstract] [Full Text] [PDF] Supplemental Data  

Niranjali U. Gamage, Ronald G. Duggleby, Amanda C. Barnett, Michael Tresillian, Catherine F. Latham, Nancy E. Liyou, Michael E. McManus, and Jennifer L. Martin

Structure of a Human Carcinogen-converting Enzyme, SULT1A1. STRUCTURAL AND KINETIC IMPLICATIONS OF SUBSTRATE INHIBITION
J. Biol. Chem. 2003 278: 7655-7662. First Published on December 5, 2002; doi:10.1074/jbc.M207246200 [Abstract] [Full Text] [PDF]  

Wataru Hashimoto, Hirokazu Nankai, Bunzo Mikami, and Kousaku Murata

Crystal Structure of Bacillus sp. GL1 Xanthan Lyase, Which Acts on the Side Chains of Xanthan
J. Biol. Chem. 2003 278: 7663-7673. First Published on December 9, 2002; doi:10.1074/jbc.M208100200 [Abstract] [Full Text] [PDF]  

Enzyme Catalysis and Regulation:

Tudor Borza, Cristina V. Iancu, Evan Pike, Richard B. Honzatko, and Herbert J. Fromm

Variations in the Response of Mouse Isozymes of Adenylosuccinate Synthetase to Inhibitors of Physiological Relevance
J. Biol. Chem. 2003 278: 6673-6679. First Published on December 12, 2002; doi:10.1074/jbc.M210838200 [Abstract] [Full Text] [PDF]  

Robin Maytum, Barbara Westerdorf, Kornelia Jaquet, and Michael A. Geeves

Differential Regulation of the Actomyosin Interaction by Skeletal and Cardiac Troponin Isoforms
J. Biol. Chem. 2003 278: 6696-6701. First Published on December 9, 2002; doi:10.1074/jbc.M210690200 [Abstract] [Full Text] [PDF]  

Nicole Brufatto and Michael E. Nesheim

Analysis of the Kinetics of Prothrombin Activation and Evidence That Two Equilibrating Forms of Prothrombinase Are Involved in the Process
J. Biol. Chem. 2003 278: 6755-6764. First Published on December 20, 2002; doi:10.1074/jbc.M206413200 [Abstract] [Full Text] [PDF]  

Henning Hillebrand, Armin Schmidt, and R. Luise Krauth-Siegel

A Second Class of Peroxidases Linked to the Trypanothione Metabolism
J. Biol. Chem. 2003 278: 6809-6815. First Published on December 3, 2002; doi:10.1074/jbc.M210392200 [Abstract] [Full Text] [PDF]  

Ivan Spasojevic, Ines Batinic-Haberle, Júlio S. Rebouças, Ynara Marina Idemori, and Irwin Fridovich

Electrostatic Contribution in the Catalysis of O^-₂ Dismutation by Superoxide Dismutase Mimics. Mn^IIITE-2-PyP⁵⁺ VERSUS Mn^IIIBr₈T-2-PyP⁺
J. Biol. Chem. 2003 278: 6831-6837. First Published on December 9, 2002; doi:10.1074/jbc.M211346200 [Abstract] [Full Text] [PDF]  

Christian NDong, Dominique Anzellotti, Ragai K. Ibrahim, Norman P. A. Huner, and Fathey Sarhan

Daphnetin Methylation by a Novel O-Methyltransferase Is Associated with Cold Acclimation and Photosystem II Excitation Pressure in Rye
J. Biol. Chem. 2003 278: 6854-6861. First Published on December 11, 2002; doi:10.1074/jbc.M209439200 [Abstract] [Full Text] [PDF]  

Gail K. Grabner and Robert L. Switzer

Kinetic Studies of the Uracil Phosphoribosyltransferase Reaction Catalyzed by the Bacillus subtilis Pyrimidine Attenuation Regulatory Protein PyrR
J. Biol. Chem. 2003 278: 6921-6927. First Published on December 13, 2002; doi:10.1074/jbc.M211111200 [Abstract] [Full Text] [PDF]  

Liya Wang, Ann Saada, and Staffan Eriksson

Kinetic Properties of Mutant Human Thymidine Kinase 2 Suggest a Mechanism for Mitochondrial DNA Depletion Myopathy
J. Biol. Chem. 2003 278: 6963-6968. First Published on December 18, 2002; doi:10.1074/jbc.M206143200 [Abstract] [Full Text] [PDF]  

Peter Mellroth, Jenny Karlsson, and Håkan Steiner

A Scavenger Function for a Drosophila Peptidoglycan Recognition Protein
J. Biol. Chem. 2003 278: 7059-7064. First Published on December 20, 2002; doi:10.1074/jbc.M208900200 [Abstract] [Full Text] [PDF]  

B. Martin Hallberg, Gunnar Henriksson, Göran Pettersson, Andrea Vasella, and Christina Divne

Mechanism of the Reductive Half-reaction in Cellobiose Dehydrogenase
J. Biol. Chem. 2003 278: 7160-7166. First Published on December 19, 2002; doi:10.1074/jbc.M210961200 [Abstract] [Full Text] [PDF]  

Luigi Bubacco, Maurice van Gastel, Edgar J. J. Groenen, Erik Vijgenboom, and Gerard W. Canters

Spectroscopic Characterization of the Electronic Changes in the Active Site of Streptomyces antibioticus Tyrosinase upon Binding of Transition State Analogue Inhibitors
J. Biol. Chem. 2003 278: 7381-7389. First Published on December 6, 2002; doi:10.1074/jbc.M206394200 [Abstract] [Full Text] [PDF]  

Cheolju Lee, Seung Jun Kim, Dae Gwin Jeong, Soon Mi Lee, and Seong Eon Ryu

Structure of Human FIH-1 Reveals a Unique Active Site Pocket and Interaction Sites for HIF-1 and von Hippel-Lindau
J. Biol. Chem. 2003 278: 7558-7563. First Published on December 12, 2002; doi:10.1074/jbc.M210385200 [Abstract] [Full Text] [PDF]  

Glycobiology and Extracellular Matrices:

Wan-Ming Zhang, Jarmo Käpylä, J. Santeri Puranen, C. Graham Knight, Carl-Fredrik Tiger, Olli T. Pentikäinen, Mark S. Johnson, Richard W. Farndale, Jyrki Heino, and Donald Gullberg

₁₁₁ Integrin Recognizes the GFOGER Sequence in Interstitial Collagens
J. Biol. Chem. 2003 278: 7270-7277. First Published on December 20, 2002; doi:10.1074/jbc.M210313200 [Abstract] [Full Text] [PDF]  

Maho Amano, Marisa Galvan, Jiale He, and Linda G. Baum

The ST6Gal I Sialyltransferase Selectively Modifies N-Glycans on CD45 to Negatively Regulate Galectin-1-induced CD45 Clustering, Phosphatase Modulation, and T Cell Death
J. Biol. Chem. 2003 278: 7469-7475. First Published on December 23, 2002; doi:10.1074/jbc.M209595200 [Abstract] [Full Text] [PDF]  

Daniel K. Greene, Sarka Tumova, John R. Couchman, and Anne Woods

Syndecan-4 Associates with -Actinin
J. Biol. Chem. 2003 278: 7617-7623. First Published on December 18, 2002; doi:10.1074/jbc.M207123200 [Abstract] [Full Text] [PDF]  

Victor L. Sousa, Catarina Brito, Teresa Costa, Joël Lanoix, Tommy Nilsson, and Julia Costa

Importance of Cys, Gln, and Tyr from the Transmembrane Domain of Human 3/4 Fucosyltransferase III for Its Localization and Sorting in the Golgi of Baby Hamster Kidney Cells
J. Biol. Chem. 2003 278: 7624-7629. First Published on December 18, 2002; doi:10.1074/jbc.M209325200 [Abstract] [Full Text] [PDF]  

Lipids and Lipoproteins:

Angeliki Chroni, Tong Liu, Irina Gorshkova, Horng-Yuan Kan, Yoshinari Uehara, Arnold von Eckardstein, and Vassilis I. Zannis

The Central Helices of ApoA-I Can Promote ATP-binding Cassette Transporter A1 (ABCA1)-mediated Lipid Efflux. AMINO ACID RESIDUES 220-231 OF THE WILD-TYPE ApoA-I ARE REQUIRED FOR LIPID EFFLUX IN VITRO AND HIGH DENSITY LIPOPROTEIN FORMATION IN VIVO
J. Biol. Chem. 2003 278: 6719-6730. First Published on December 17, 2002; doi:10.1074/jbc.M205232200 [Abstract] [Full Text] [PDF]  

Juan Santiago-García, Tatsuhiko Kodama, and Robert E. Pitas

The Class A Scavenger Receptor Binds to Proteoglycans and Mediates Adhesion of Macrophages to the Extracellular Matrix
J. Biol. Chem. 2003 278: 6942-6946. First Published on December 17, 2002; doi:10.1074/jbc.M208358200 [Abstract] [Full Text] [PDF]  

Premkumar Dinadayala, Françoise Laval, Catherine Raynaud, Anne Lemassu, Marie-Antoinette Lanéelle, Gilbert Lanéelle, and Mamadou Daffé

Tracking the Putative Biosynthetic Precursors of Oxygenated Mycolates of Mycobacterium tuberculosis. STRUCTURAL ANALYSIS OF FATTY ACIDS OF A MUTANT STRAIN DEVOID OF METHOXY- AND KETOMYCOLATES
J. Biol. Chem. 2003 278: 7310-7319. First Published on December 6, 2002; doi:10.1074/jbc.M210501200 [Abstract] [Full Text] [PDF]  

Young-Ah Moon and Jay D. Horton

Identification of Two Mammalian Reductases Involved in the Two-carbon Fatty Acyl Elongation Cascade
J. Biol. Chem. 2003 278: 7335-7343. First Published on December 13, 2002; doi:10.1074/jbc.M211684200 [Abstract] [Full Text] [PDF]  

Ryoichi X. Ioka, Man-Jong Kang, Shin Kamiyama, Dong-Ho Kim, Kenta Magoori, Akihisa Kamataki, Yuichiro Ito, Yumiko A. Takei, Masako Sasaki, Takashi Suzuki, Hironobu Sasano, Sadao Takahashi, Juro Sakai, Takahiro Fujino, and Tokuo T. Yamamoto

Expression Cloning and Characterization of a Novel Glycosylphosphatidylinositol-anchored High Density Lipoprotein-binding Protein, GPI-HBP1
J. Biol. Chem. 2003 278: 7344-7349. First Published on December 20, 2002; doi:10.1074/jbc.M211932200 [Abstract] [Full Text] [PDF]  

Jianying Zhang and Haya Herscovitz

Nascent Lipidated Apolipoprotein B Is Transported to the Golgi as an Incompletely Folded Intermediate as Probed by Its Association with Network of Endoplasmic Reticulum Molecular Chaperones, GRP94, ERp72, BiP, Calreticulin, and Cyclophilin B
J. Biol. Chem. 2003 278: 7459-7468. First Published on October 22, 2002; doi:10.1074/jbc.M207976200 [Abstract] [Full Text] [PDF]  

Amy P. Patterson, Zhigang Chen, Deborah C. Rubin, Virginie Moucadel, Juan Lucio Iovanna, H. Bryan Brewer, Jr., and Thomas L. Eggerman

Developmental Regulation of Apolipoprotein B mRNA Editing Is an Autonomous Function of Small Intestine Involving Homeobox Gene Cdx1
J. Biol. Chem. 2003 278: 7600-7606. First Published on December 18, 2002; doi:10.1074/jbc.M201601200 [Abstract] [Full Text] [PDF]  

Membrane Transport Structure Function and Biogenesis:

Yehuda G. Assaraf, Lilah Rothem, Jan Hendrik Hooijberg, Michal Stark, Ilan Ifergan, Ietje Kathmann, Ben A. C. Dijkmans, Godefridus J. Peters, and Gerrit Jansen

Loss of Multidrug Resistance Protein 1 Expression and Folate Efflux Activity Results in a Highly Concentrative Folate Transport in Human Leukemia Cells
J. Biol. Chem. 2003 278: 6680-6686. First Published on December 16, 2002; doi:10.1074/jbc.M209186200 [Abstract] [Full Text] [PDF]  

Emanuele Giurisato, Deirdre P. McIntosh, Maristella Tassi, Alessandra Gamberucci, and Angelo Benedetti

T Cell Receptor Can Be Recruited to a Subset of Plasma Membrane Rafts, Independently of Cell Signaling and Attendantly to Raft Clustering
J. Biol. Chem. 2003 278: 6771-6778. First Published on December 22, 2002; doi:10.1074/jbc.M210758200 [Abstract] [Full Text] [PDF]  

Seon Hee Chang and Philip S. Low

Identification of a Critical Ankyrin-binding Loop on the Cytoplasmic Domain of Erythrocyte Membrane Band 3 by Crystal Structure Analysis and Site-directed Mutagenesis
J. Biol. Chem. 2003 278: 6879-6884. First Published on December 12, 2002; doi:10.1074/jbc.M211137200 [Abstract] [Full Text] [PDF]  

Matthieu Rousset, Thierry Cens, Sophie Gavarini, Andreas Jeromin, and Pierre Charnet

Down-regulation of Voltage-gated Ca²⁺ Channels by Neuronal Calcium Sensor-1 Is Subunit-specific
J. Biol. Chem. 2003 278: 7019-7026. First Published on December 19, 2002; doi:10.1074/jbc.M209537200 [Abstract] [Full Text] [PDF]  

Jantra Ngosuwan, Nancy M. Wang, Katie L. Fung, and William J. Chirico

Roles of Cytosolic Hsp70 and Hsp40 Molecular Chaperones in Post-translational Translocation of Presecretory Proteins into the Endoplasmic Reticulum
J. Biol. Chem. 2003 278: 7034-7042. First Published on December 19, 2002; doi:10.1074/jbc.M210544200 [Abstract] [Full Text] [PDF]  

Etienne A. Cartier, Shu Shen, and Show-Ling Shyng

Modulation of the Trafficking Efficiency and Functional Properties of ATP-sensitive Potassium Channels through a Single Amino Acid in the Sulfonylurea Receptor
J. Biol. Chem. 2003 278: 7081-7090. First Published on December 21, 2002; doi:10.1074/jbc.M211395200 [Abstract] [Full Text] [PDF]  

Jinzhe Mao, Jianping Wu, Fuxue Chen, Xueren Wang, and Chun Jiang

Inhibition of G-protein-coupled Inward Rectifying K⁺ Channels by Intracellular Acidosis
J. Biol. Chem. 2003 278: 7091-7098. First Published on December 25, 2002; doi:10.1074/jbc.M211461200 [Abstract] [Full Text] [PDF]  

Kouichi Funato, Ruben Lombardi, Béatrice Vallée, and Howard Riezman

Lcb4p Is a Key Regulator of Ceramide Synthesis from Exogenous Long Chain Sphingoid Base in Saccharomyces cerevisiae
J. Biol. Chem. 2003 278: 7325-7334. First Published on December 18, 2002; doi:10.1074/jbc.M209925200 [Abstract] [Full Text] [PDF]  

Guido Hermey, Sady J. Keat, Peder Madsen, Christian Jacobsen, Claus M. Petersen, and Jørgen Gliemann

Characterization of sorCS1, an Alternatively Spliced Receptor with Completely Different Cytoplasmic Domains That Mediate Different Trafficking in Cells
J. Biol. Chem. 2003 278: 7390-7396. First Published on December 12, 2002; doi:10.1074/jbc.M210851200 [Abstract] [Full Text] [PDF]  

Deepak K. Sharma, Amit Choudhury, Raman Deep Singh, Christine L. Wheatley, David L. Marks, and Richard E. Pagano

Glycosphingolipids Internalized via Caveolar-related Endocytosis Rapidly Merge with the Clathrin Pathway in Early Endosomes and Form Microdomains for Recycling
J. Biol. Chem. 2003 278: 7564-7572. First Published on December 12, 2002; doi:10.1074/jbc.M210457200 [Abstract] [Full Text] [PDF]  

Mechanisms Of Signal Transduction:

Dong Yu, Hiroshi Watanabe, Hitoshi Shibuya, and Masahiko Miura

Redundancy of Radioresistant Signaling Pathways Originating from Insulin-like Growth Factor I Receptor
J. Biol. Chem. 2003 278: 6702-6709. First Published on December 18, 2002; doi:10.1074/jbc.M209809200 [Abstract] [Full Text] [PDF]  

Rastislav Tamaskovic, Samuel J. Bichsel, Hélène Rogniaux, Mario R. Stegert, and Brian A. Hemmings

Mechanism of Ca²⁺-mediated Regulation of NDR Protein Kinase through Autophosphorylation and Phosphorylation by an Upstream Kinase
J. Biol. Chem. 2003 278: 6710-6718. First Published on December 17, 2002; doi:10.1074/jbc.M210590200 [Abstract] [Full Text] [PDF]  

Nir Weizman, Yosef Shiloh, and Ari Barzilai

Contribution of the Atm Protein to Maintaining Cellular Homeostasis Evidenced by Continuous Activation of the AP-1 Pathway in Atm-deficient Brains
J. Biol. Chem. 2003 278: 6741-6747. First Published on December 19, 2002; doi:10.1074/jbc.M211168200 [Abstract] [Full Text] [PDF]  

Feng Chen, Roger Chang, Marcus Trivedi, Yassemi Capetanaki, and Vincent L. Cryns

Caspase Proteolysis of Desmin Produces a Dominant-negative Inhibitor of Intermediate Filaments and Promotes Apoptosis
J. Biol. Chem. 2003 278: 6848-6853. First Published on December 10, 2002; doi:10.1074/jbc.M212021200 [Abstract] [Full Text] [PDF]  

Monique C. A. Duyndam, Saskia T. M. Hulscher, Elsken van der Wall, Herbert M. Pinedo, and Epie Boven

Evidence for a Role of p38 Kinase in Hypoxia-inducible Factor 1-independent Induction of Vascular Endothelial Growth Factor Expression by Sodium Arsenite
J. Biol. Chem. 2003 278: 6885-6895. First Published on December 13, 2002; doi:10.1074/jbc.M206320200 [Abstract] [Full Text] [PDF]  

Jian Zhou, Jessica Scholes, and Jer-Tsong Hsieh

Characterization of a Novel Negative Regulator (DOC-2/DAB2) of c-Src in Normal Prostatic Epithelium and Cancer
J. Biol. Chem. 2003 278: 6936-6941. First Published on December 8, 2002; doi:10.1074/jbc.M210628200 [Abstract] [Full Text] [PDF]  

Takashi Minami, Md. Ruhul Abid, Jie Zhang, George King, Tatsuhiko Kodama, and William C. Aird

Thrombin Stimulation of Vascular Adhesion Molecule-1 in Endothelial Cells Is Mediated by Protein Kinase C (PKC)--NF-B and PKC--GATA Signaling Pathways
J. Biol. Chem. 2003 278: 6976-6984. First Published on December 18, 2002; doi:10.1074/jbc.M208974200 [Abstract] [Full Text] [PDF]  

Corinne Barat and Michel J. Tremblay

Treatment of Human T Cells with Bisperoxovanadium Phosphotyrosyl Phosphatase Inhibitors Leads to Activation of Cyclooxygenase-2 Gene
J. Biol. Chem. 2003 278: 6992-7000. First Published on December 18, 2002; doi:10.1074/jbc.M212433200 [Abstract] [Full Text] [PDF]  

Ignacio A. Demarco, Felipe Espinosa, Jennifer Edwards, Julian Sosnik, José Luis de la Vega-Beltrán, Joel W. Hockensmith, Gregory S. Kopf, Alberto Darszon, and Pablo E. Visconti

Involvement of a Na⁺/HCO^-₃ Cotransporter in Mouse Sperm Capacitation
J. Biol. Chem. 2003 278: 7001-7009. First Published on December 19, 2002; doi:10.1074/jbc.M206284200 [Abstract] [Full Text] [PDF]  

Bao Feng Yang, Chang Xiao, Wilson H. Roa, Peter H. Krammer, and Chunhai Hao

Calcium/Calmodulin-dependent Protein Kinase II Regulation of c-FLIP Expression and Phosphorylation in Modulation of Fas-mediated Signaling in Malignant Glioma Cells
J. Biol. Chem. 2003 278: 7043-7050. First Published on December 19, 2002; doi:10.1074/jbc.M211278200 [Abstract] [Full Text] [PDF]  

Albrecht Piiper, Robert Elez, Se-Jong You, Bernd Kronenberger, Stefan Loitsch, Serge Roche, and Stefan Zeuzem

Cholecystokinin Stimulates Extracellular Signal-regulated Kinase through Activation of the Epidermal Growth Factor Receptor, Yes, and Protein Kinase C. SIGNAL AMPLIFICATION AT THE LEVEL OF Raf BY ACTIVATION OF PROTEIN KINASE C
J. Biol. Chem. 2003 278: 7065-7072. First Published on December 20, 2002; doi:10.1074/jbc.M211234200 [Abstract] [Full Text] [PDF]  

Marlène Bouillon, Youssef El Fakhry, Julie Girouard, Hayssam Khalil, Jacques Thibodeau, and Walid Mourad

Lipid Raft-dependent and -independent Signaling through HLA-DR Molecules
J. Biol. Chem. 2003 278: 7099-7107. First Published on December 22, 2002; doi:10.1074/jbc.M211566200 [Abstract] [Full Text] [PDF]  

Isabelle Foucault, Yun-Cai Liu, Alain Bernard, and Marcel Deckert

The Chaperone Protein 14-3-3 Interacts with 3BP2/SH3BP2 and Regulates Its Adapter Function
J. Biol. Chem. 2003 278: 7146-7153. First Published on December 24, 2002; doi:10.1074/jbc.M209509200 [Abstract] [Full Text] [PDF]  

Joshua Cottom, Lisa M. Salvador, Evelyn T. Maizels, Scott Reierstad, Youngkyu Park, Daniel W. Carr, Monika A. Davare, Johannes W. Hell, Stephen S. Palmer, Paul Dent, Hisaaki Kawakatsu, Masato Ogata, and Mary Hunzicker-Dunn

Follicle-stimulating Hormone Activates Extracellular Signal-regulated Kinase but Not Extracellular Signal-regulated Kinase Kinase through a 100-kDa Phosphotyrosine Phosphatase
J. Biol. Chem. 2003 278: 7167-7179. First Published on December 18, 2002; doi:10.1074/jbc.M203901200 [Abstract] [Full Text] [PDF]  

Friederike Cuello, Rüdiger A. Schulze, Frank Heemeyer, Helmut E. Meyer, Susanne Lutz, Karl H. Jakobs, Feraydoon Niroomand, and Thomas Wieland

Activation of Heterotrimeric G Proteins by a High Energy Phosphate Transfer via Nucleoside Diphosphate Kinase (NDPK) B and G Subunits. COMPLEX FORMATION OF NDPK B WITH G DIMERS AND PHOSPHORYLATION OF His-266 IN G
J. Biol. Chem. 2003 278: 7220-7226. First Published on December 16, 2002; doi:10.1074/jbc.M210304200 [Abstract] [Full Text] [PDF]  

Hans-Joerg Hippe, Susanne Lutz, Friederike Cuello, Katrin Knorr, Achim Vogt, Karl H. Jakobs, Thomas Wieland, and Feraydoon Niroomand

Activation of Heterotrimeric G Proteins by a High Energy Phosphate Transfer via Nucleoside Diphosphate Kinase (NDPK) B and G Subunits. SPECIFIC ACTIVATION OF G_s BY AN NDPK B·G COMPLEX IN H10 CELLS
J. Biol. Chem. 2003 278: 7227-7233. First Published on December 16, 2002; doi:10.1074/jbc.M210305200 [Abstract] [Full Text] [PDF]  

Huailing Zhong, Susan M. Wade, Peter J. Woolf, Jennifer J. Linderman, John R. Traynor, and Richard R. Neubig

A Spatial Focusing Model for G Protein Signals. REGULATOR OF G PROTEIN SIGNALING (RGS) PROTEIN-MEDIATED KINETIC SCAFFOLDING
J. Biol. Chem. 2003 278: 7278-7284. First Published on November 21, 2002; doi:10.1074/jbc.M208819200 [Abstract] [Full Text] [PDF]  

Sung O. Kim, Qing Jing, Kasper Hoebe, Bruce Beutler, Nicholas S. Duesbery, and Jiahuai Han

Sensitizing Anthrax Lethal Toxin-resistant Macrophages to Lethal Toxin-induced Killing by Tumor Necrosis Factor-
J. Biol. Chem. 2003 278: 7413-7421. First Published on December 17, 2002; doi:10.1074/jbc.M209279200 [Abstract] [Full Text] [PDF]  

Rajnish A. Gupta, Pasha Sarraf, Jeffrey A. Brockman, Scott B. Shappell, Laurel A. Raftery, Timothy M. Willson, and Raymond N. DuBois

Peroxisome Proliferator-activated Receptor and Transforming Growth Factor- Pathways Inhibit Intestinal Epithelial Cell Growth by Regulating Levels of TSC-22
J. Biol. Chem. 2003 278: 7431-7438. First Published on December 4, 2002; doi:10.1074/jbc.M208076200 [Abstract] [Full Text] [PDF]  

Yun-Jin Jung, Jennifer S. Isaacs, Sunmin Lee, Jane Trepel, and Len Neckers

Microtubule Disruption Utilizes an NFB-dependent Pathway to Stabilize HIF-1 Protein
J. Biol. Chem. 2003 278: 7445-7452. First Published on December 17, 2002; doi:10.1074/jbc.M209804200 [Abstract] [Full Text] [PDF]  

Satoshi Jodo, John T. Kung, Sheng Xiao, Derek V. Chan, Seiichi Kobayashi, Masatoshi Tateno, Robert Lafyatis, and Shyr-Te Ju

Anti-CD95-induced Lethality Requires Radioresistant FcRII⁺ Cells. A NOVEL MECHANISM FOR FULMINANT HEPATIC FAILURE
J. Biol. Chem. 2003 278: 7553-7557. First Published on December 10, 2002; doi:10.1074/jbc.M211229200 [Abstract] [Full Text] [PDF]  

Aiwu Cheng, Shuqin Wang, Dongmei Yang, Ruiping Xiao, and Mark P. Mattson

Calmodulin Mediates Brain-derived Neurotrophic Factor Cell Survival Signaling Upstream of Akt Kinase in Embryonic Neocortical Neurons
J. Biol. Chem. 2003 278: 7591-7599. First Published on December 17, 2002; doi:10.1074/jbc.M207232200 [Abstract] [Full Text] [PDF]  

Sandra Timm Pearce, Hong Liu, and V. Craig Jordan

Modulation of Estrogen Receptor Function and Stability by Tamoxifen and a Critical Amino Acid (Asp-538) in Helix 12
J. Biol. Chem. 2003 278: 7630-7638. First Published on December 20, 2002; doi:10.1074/jbc.M211129200 [Abstract] [Full Text] [PDF]  

Yue Yang, Xin Wang, Tiefei Dong, Eungseok Kim, Wen-Jye Lin, and Chawnshang Chang

Identification of a Novel Testicular Orphan Receptor-4 (TR4)-associated Protein as Repressor for the Selective Suppression of TR4-mediated Transactivation
J. Biol. Chem. 2003 278: 7709-7717. First Published on December 16, 2002; doi:10.1074/jbc.M207116200 [Abstract] [Full Text] [PDF]  

Katrien Janssens, Peter ten Dijke, Stuart H. Ralston, Carsten Bergmann, and Wim Van Hul

Transforming Growth Factor-1 Mutations in Camurati-Engelmann Disease Lead to Increased Signaling by Altering either Activation or Secretion of the Mutant Protein
J. Biol. Chem. 2003 278: 7718-7724. First Published on December 18, 2002; doi:10.1074/jbc.M208857200 [Abstract] [Full Text] [PDF]  

Molecular Basis Of Cell and Developmental Biology:

John B. J. Kwok, Glenda M. Halliday, William S. Brooks, Georgia Dolios, Hanna Laudon, Ohoshi Murayama, Marianne Hallupp, Renee F. Badenhop, James Vickers, Rong Wang, Jan Naslund, Akihiko Takashima, Samuel E. Gandy, and Peter R. Schofield

Presenilin-1 Mutation L271V Results in Altered Exon 8 Splicing and Alzheimer's Disease with Non-cored Plaques and No Neuritic Dystrophy
J. Biol. Chem. 2003 278: 6748-6754. First Published on December 19, 2002; doi:10.1074/jbc.M211827200 [Abstract] [Full Text] [PDF]  

Violeta Serra, Thomas von Zglinicki, Mario Lorenz, and Gabriele Saretzki

Extracellular Superoxide Dismutase Is a Major Antioxidant in Human Fibroblasts and Slows Telomere Shortening
J. Biol. Chem. 2003 278: 6824-6830. First Published on December 9, 2002; doi:10.1074/jbc.M207939200 [Abstract] [Full Text] [PDF]  

Rosalind J. Gusterson, Elen Jazrawi, Ian M. Adcock, and David S. Latchman

The Transcriptional Co-activators CREB-binding Protein (CBP) and p300 Play a Critical Role in Cardiac Hypertrophy That Is Dependent on Their Histone Acetyltransferase Activity
J. Biol. Chem. 2003 278: 6838-6847. First Published on December 10, 2002; doi:10.1074/jbc.M211762200 [Abstract] [Full Text] [PDF]  

James M. Holaska, Kenneth K. Lee, Amy K. Kowalski, and Katherine L. Wilson

Transcriptional Repressor Germ Cell-less (GCL) and Barrier to Autointegration Factor (BAF) Compete for Binding to Emerin in Vitro
J. Biol. Chem. 2003 278: 6969-6975. First Published on December 18, 2002; doi:10.1074/jbc.M208811200 [Abstract] [Full Text] [PDF]  

János Kovács, Péter Löw, Anita Pácz, István Horváth, Judit Oláh, and Judit Ovádi

Phosphoenolpyruvate-dependent Tubulin-Pyruvate Kinase Interaction at Different Organizational Levels
J. Biol. Chem. 2003 278: 7126-7130. First Published on December 13, 2002; doi:10.1074/jbc.M210244200 [Abstract] [Full Text] [PDF]  

Anne Marie Moody, Simon J. North, Bruce Reinhold, Steven J. Van Dyken, Mark E. Rogers, Maria Panico, Anne Dell, Howard R. Morris, Jamey D. Marth, and Ellis L. Reinherz

Sialic Acid Capping of CD8 Core 1-O-Glycans Controls Thymocyte-Major Histocompatibility Complex Class I Interaction
J. Biol. Chem. 2003 278: 7240-7246. First Published on November 28, 2002; doi:10.1074/jbc.M210468200 [Abstract] [Full Text] [PDF]  

Yongmun Choi, Yoshinori Kawazoe, Koji Murakami, Hiroyuki Misawa, and Motonari Uesugi

Identification of Bioactive Molecules by Adipogenesis Profiling of Organic Compounds
J. Biol. Chem. 2003 278: 7320-7324. First Published on December 19, 2002; doi:10.1074/jbc.M210283200 [Abstract] [Full Text] [PDF] Supplemental Data  

Martijn Moransard, Lucia S. Borges, Raffaella Willmann, P. Angelo Marangi, Hans Rudolf Brenner, Michael J. Ferns, and Christian Fuhrer

Agrin Regulates Rapsyn Interaction with Surface Acetylcholine Receptors, and This Underlies Cytoskeletal Anchoring and Clustering
J. Biol. Chem. 2003 278: 7350-7359. First Published on December 16, 2002; doi:10.1074/jbc.M210865200 [Abstract] [Full Text] [PDF]  

Chengqun Huang, Qiang Zhou, Peihua Liang, Melinda S. Hollander, Farah Sheikh, Xiaodong Li, Marion Greaser, G. Diane Shelton, Sylvia Evans, and Ju Chen

Characterization and in Vivo Functional Analysis of Splice Variants of Cypher
J. Biol. Chem. 2003 278: 7360-7365. First Published on December 23, 2002; doi:10.1074/jbc.M211875200 [Abstract] [Full Text] [PDF]  

Kerstin Sollerbrant, Elisabeth Raschperger, Momina Mirza, Ulla Engström, Lennart Philipson, Per O. Ljungdahl, and Ralf F. Pettersson

The Coxsackievirus and Adenovirus Receptor (CAR) Forms a Complex with the PDZ Domain-containing Protein Ligand-of-Numb Protein-X (LNX)
J. Biol. Chem. 2003 278: 7439-7444. First Published on December 4, 2002; doi:10.1074/jbc.M205927200 [Abstract] [Full Text] [PDF]  

Noriko Funato, Kimie Ohyama, Takayuki Kuroda, and Masataka Nakamura

Basic Helix-Loop-Helix Transcription Factor Epicardin/Capsulin/Pod-1 Suppresses Differentiation by Negative Regulation of Transcription
J. Biol. Chem. 2003 278: 7486-7493. First Published on December 19, 2002; doi:10.1074/jbc.M212248200 [Abstract] [Full Text] [PDF]  

Allison M. Hunter, Dan Kottachchi, Jennifer Lewis, Colin S. Duckett, Robert G. Korneluk, and Peter Liston

A Novel Ubiquitin Fusion System Bypasses the Mitochondria and Generates Biologically Active Smac/DIABLO
J. Biol. Chem. 2003 278: 7494-7499. First Published on January 2, 2003; doi:10.1074/jbc.C200695200 [Abstract] [Full Text] [PDF]  

Gerd Elvert, Andreas Kappel, Regina Heidenreich, Ursula Englmeier, Stephan Lanz, Till Acker, Manuel Rauter, Karl Plate, Michael Sieweke, Georg Breier, and Ingo Flamme

Cooperative Interaction of Hypoxia-inducible Factor-2 (HIF-2) and Ets-1 in the Transcriptional Activation of Vascular Endothelial Growth Factor Receptor-2 (Flk-1)
J. Biol. Chem. 2003 278: 7520-7530. First Published on December 2, 2002; doi:10.1074/jbc.M211298200 [Abstract] [Full Text] [PDF]  

Xin Zhang, Tao Zhu, Yong Chen, Hichem C. Mertani, Kok-Onn Lee, and Peter E. Lobie

Human Growth Hormone-regulated HOXA1 Is a Human Mammary Epithelial Oncogene
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Additions and Corrections:

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