Minireviews:

Thomas A. Kunkel

DNA Replication Fidelity
J. Biol. Chem. 2004 279: 16895-16898. First Published on February 26, 2004; doi:10.1074/jbc.R400006200 [Full Text] [PDF]  

Accelerated Publications:

Hee Jung Lee, Heon Man Lim, and Sankar Adhya

An Unsubstituted C2 Hydrogen of Adenine Is Critical and Sufficient at the –11 Position of a Promoter to Signal Base Pair Deformation
J. Biol. Chem. 2004 279: 16899-16902. First Published on February 26, 2004; doi:10.1074/jbc.C400054200 [Abstract] [Full Text] [PDF]  

Igor V. Peshenko and Alexander M. Dizhoor

Guanylyl Cyclase-activating Proteins (GCAPs) Are Ca²+/Mg²⁺ Sensors: IMPLICATIONS FOR PHOTORECEPTOR GUANYLYL CYCLASE (RetGC) REGULATION IN MAMMALIAN PHOTORECEPTORS
J. Biol. Chem. 2004 279: 16903-16906. First Published on March 1, 2004; doi:10.1074/jbc.C400065200 [Abstract] [Full Text] [PDF]  

DNA: Replication, Repair, and Recombination:

Shuangli Guo, Steven R. Presnell, Fenghua Yuan, Yanbin Zhang, Liya Gu, and Guo-Min Li

Differential Requirement for Proliferating Cell Nuclear Antigen in 5' and 3' Nick-directed Excision in Human Mismatch Repair
J. Biol. Chem. 2004 279: 16912-16917. First Published on February 9, 2004; doi:10.1074/jbc.M313213200 [Abstract] [Full Text] [PDF]  

Chiara Rampazzo, Paola Ferraro, Giovanna Pontarin, Sonia Fabris, Peter Reichard, and Vera Bianchi

Mitochondrial Deoxyribonucleotides, Pool Sizes, Synthesis, and Regulation
J. Biol. Chem. 2004 279: 17019-17026. First Published on January 26, 2004; doi:10.1074/jbc.M313957200 [Abstract] [Full Text] [PDF]  

Carol L. Farr, Yuichi Matsushima, Anthony T. Lagina, III, Ningguang Luo, and Laurie S. Kaguni

Physiological and Biochemical Defects in Functional Interactions of Mitochondrial DNA Polymerase and DNA-binding Mutants of Single-stranded DNA-binding Protein
J. Biol. Chem. 2004 279: 17047-17053. First Published on January 30, 2004; doi:10.1074/jbc.M400283200 [Abstract] [Full Text] [PDF]  

Enbo Liu, Xianghong Li, Feng Yan, Qiping Zhao, and Xiaohua Wu

Cyclin-dependent Kinases Phosphorylate Human Cdt1 and Induce Its Degradation
J. Biol. Chem. 2004 279: 17283-17288. First Published on March 5, 2004; doi:10.1074/jbc.C300549200 [Abstract] [Full Text] [PDF]  

S. Zzaman, Mayuresh M. Abhyankar, and Deepak Bastia

Reconstitution of F Factor DNA Replication in Vitro with Purified Proteins
J. Biol. Chem. 2004 279: 17404-17410. First Published on February 18, 2004; doi:10.1074/jbc.M400021200 [Abstract] [Full Text] [PDF]  

Laurent Gros, Andrei V. Maksimenko, Cyril V. Privezentzev, Jacques Laval, and Murat K. Saparbaev

Hijacking of the Human Alkyl-N-purine-DNA Glycosylase by 3,N⁴-Ethenocytosine, a Lipid Peroxidation-induced DNA Adduct
J. Biol. Chem. 2004 279: 17723-17730. First Published on February 2, 2004; doi:10.1074/jbc.M314010200 [Abstract] [Full Text] [PDF] Supplemental Data  

Deqin Ma, Joseph R. McCorkle, and David M. Kaetzel

The Metastasis Suppressor NM23-H1 Possesses 3'-5' Exonuclease Activity
J. Biol. Chem. 2004 279: 18073-18084. First Published on February 11, 2004; doi:10.1074/jbc.M400185200 [Abstract] [Full Text] [PDF]  

Genes: Structure and Regulation:

SunHwa Hong, Hyun Mi Choi, Min Jung Park, Young Hee Kim, Yoon Ha Choi, Hyung Hoi Kim, Young Hyun Choi, and JaeHun Cheong

Activation and Interaction of ATF2 with the Coactivator ASC-2 Are Responsive for Granulocytic Differentiation by Retinoic Acid
J. Biol. Chem. 2004 279: 16996-17003. First Published on January 20, 2004; doi:10.1074/jbc.M311752200 [Abstract] [Full Text] [PDF]  

Mónica Morales, Juan Bárcena, Miguel A. Ramírez, José A. Boga, Francisco Parra, and Juan M. Torres

Synthesis in Vitro of Rabbit Hemorrhagic Disease Virus Subgenomic RNA by Internal Initiation on (–)Sense Genomic RNA: MAPPING OF A SUBGENOMIC PROMOTER
J. Biol. Chem. 2004 279: 17013-17018. First Published on January 26, 2004; doi:10.1074/jbc.M313674200 [Abstract] [Full Text] [PDF]  

Naoko Hattori, Koichiro Nishino, Yeoung-gyu Ko, Naka Hattori, Jun Ohgane, Satoshi Tanaka, and Kunio Shiota

Epigenetic Control of Mouse Oct-4 Gene Expression in Embryonic Stem Cells and Trophoblast Stem Cells
J. Biol. Chem. 2004 279: 17063-17069. First Published on February 4, 2004; doi:10.1074/jbc.M309002200 [Abstract] [Full Text] [PDF]  

Xiaoling Zhong and Ahmad R. Safa

RNA Helicase A in the MEF1 Transcription Factor Complex Up-regulates the MDR1 Gene in Multidrug-resistant Cancer Cells
J. Biol. Chem. 2004 279: 17134-17141. First Published on February 9, 2004; doi:10.1074/jbc.M311057200 [Abstract] [Full Text] [PDF]  

Dinesh Warnakulasuriyarachchi, Sonia Cerquozzi, Herman H. Cheung, and Martin Holcík

Translational Induction of the Inhibitor of Apoptosis Protein HIAP2 during Endoplasmic Reticulum Stress Attenuates Cell Death and Is Mediated via an Inducible Internal Ribosome Entry Site Element
J. Biol. Chem. 2004 279: 17148-17157. First Published on February 11, 2004; doi:10.1074/jbc.M308737200 [Abstract] [Full Text] [PDF]  

Qianben Wang, T. S. Udayakumar, Tadas S. Vasaitis, Angela M. Brodie, and Joseph D. Fondell

Mechanistic Relationship between Androgen Receptor Polyglutamine Tract Truncation and Androgen-dependent Transcriptional Hyperactivity in Prostate Cancer Cells
J. Biol. Chem. 2004 279: 17319-17328. First Published on February 13, 2004; doi:10.1074/jbc.M400970200 [Abstract] [Full Text] [PDF]  

Kwon-Sik Park, Jeffrey A. Whitsett, Tina Di Palma, Jeong-Ho Hong, Michael B. Yaffe, and Mariastella Zannini

TAZ Interacts with TTF-1 and Regulates Expression of Surfactant Protein-C
J. Biol. Chem. 2004 279: 17384-17390. First Published on February 17, 2004; doi:10.1074/jbc.M312569200 [Abstract] [Full Text] [PDF]  

Steve D. Seredick and George B. Spiegelman

The Bacillus subtilis Response Regulator Spo0A Stimulates ^A-Dependent Transcription Prior to the Major Energetic Barrier
J. Biol. Chem. 2004 279: 17397-17403. First Published on February 18, 2004; doi:10.1074/jbc.M311190200 [Abstract] [Full Text] [PDF]  

Anguo Liu, Peter W. Hoffman, Weiwei Lu, and Guang Bai

NF-B Site Interacts with Sp Factors and Up-regulates the NR1 Promoter during Neuronal Differentiation
J. Biol. Chem. 2004 279: 17449-17458. First Published on February 16, 2004; doi:10.1074/jbc.M311267200 [Abstract] [Full Text] [PDF]  

Chen-Yu Wang, Yuh-Jin Liang, Young-Sun Lin, Hsiu-Ming Shih, Yuh-Shan Jou, and Winston C. Y. Yu

YY1AP, A Novel Co-activator of YY1
J. Biol. Chem. 2004 279: 17750-17755. First Published on January 26, 2004; doi:10.1074/jbc.M310532200 [Abstract] [Full Text] [PDF]  

Andrea N. Ladd, Nicole H. Nguyen, Kavin Malhotra, and Thomas A. Cooper

CELF6, a Member of the CELF Family of RNA-binding Proteins, Regulates Muscle-specific Splicing Enhancer-dependent Alternative Splicing
J. Biol. Chem. 2004 279: 17756-17764. First Published on February 3, 2004; doi:10.1074/jbc.M310687200 [Abstract] [Full Text] [PDF]  

Dominique Sawka-Verhelle, Laure Escoubet-Lozach, Amy L. Fong, Kelly D. Hester, Stephan Herzig, Patricia Lebrun, and Christopher K. Glass

PE-1/METS, an Antiproliferative Ets Repressor Factor, Is Induced by CREB-1/CREM-1 during Macrophage Differentiation
J. Biol. Chem. 2004 279: 17772-17784. First Published on January 30, 2004; doi:10.1074/jbc.M311991200 [Abstract] [Full Text] [PDF]  

Tong Liu, Susumu Nakashima, Kazunobu Hirose, Mineo Shibasaka, Maki Katsuhara, Bunichi Ezaki, David P. Giedroc, and Kunihiro Kasamo

A Novel Cyanobacterial SmtB/ArsR Family Repressor Regulates the Expression of a CPx-ATPase and a Metallothionein in Response to Both Cu(I)/Ag(I) and Zn(II)/Cd(II)
J. Biol. Chem. 2004 279: 17810-17818. First Published on February 11, 2004; doi:10.1074/jbc.M310560200 [Abstract] [Full Text] [PDF]  

Faith Harrow, Jeanne U. Amuta, Shauna R. Hutchinson, Frank Akwaa, and Benjamin D. Ortiz

Factors Binding a Non-classical Cis-element Prevent Heterochromatin Effects on Locus Control Region Activity
J. Biol. Chem. 2004 279: 17842-17849. First Published on February 14, 2004; doi:10.1074/jbc.M401258200 [Abstract] [Full Text] [PDF]  

Feng Miao, Irene Gaw Gonzalo, Linda Lanting, and Rama Natarajan

In Vivo Chromatin Remodeling Events Leading to Inflammatory Gene Transcription under Diabetic Conditions
J. Biol. Chem. 2004 279: 18091-18097. First Published on February 19, 2004; doi:10.1074/jbc.M311786200 [Abstract] [Full Text] [PDF]  

RNA: Structure, Metabolism, and Catalysis:

Elisabetta Zuccato, Emanuele Buratti, Cristiana Stuani, Francisco E. Baralle, and Franco Pagani

An Intronic Polypyrimidine-rich Element Downstream of the Donor Site Modulates Cystic Fibrosis Transmembrane Conductance Regulator Exon 9 Alternative Splicing
J. Biol. Chem. 2004 279: 16980-16988. First Published on February 13, 2004; doi:10.1074/jbc.M313439200 [Abstract] [Full Text] [PDF]  

Hongjiang Wu, Walt F. Lima, Hong Zhang, Amy Fan, Hong Sun, and Stanley T. Crooke

Determination of the Role of the Human RNase H1 in the Pharmacology of DNA-like Antisense Drugs
J. Biol. Chem. 2004 279: 17181-17189. First Published on February 11, 2004; doi:10.1074/jbc.M311683200 [Abstract] [Full Text] [PDF]  

Feng Xing, Shawna L. Hiley, Timothy R. Hughes, and Eric M. Phizicky

The Specificities of Four Yeast Dihydrouridine Synthases for Cytoplasmic tRNAs
J. Biol. Chem. 2004 279: 17850-17860. First Published on February 16, 2004; doi:10.1074/jbc.M401221200 [Abstract] [Full Text] [PDF] Supplemental Data  

Protein Synthesis, Post-Translation Modification, and Degradation:

Keith D. Tardif, Kazutoshi Mori, Randal J. Kaufman, and Aleem Siddiqui

Hepatitis C Virus Suppresses the IRE1-XBP1 Pathway of the Unfolded Protein Response
J. Biol. Chem. 2004 279: 17158-17164. First Published on February 11, 2004; doi:10.1074/jbc.M312144200 [Abstract] [Full Text] [PDF]  

Philomena Pullikotil, Martin Vincent, Stuart T. Nichol, and Nabil G. Seidah

Development of Protein-based Inhibitors of the Proprotein of Convertase SKI-1/S1P: PROCESSING OF SREBP-2, ATF6, AND A VIRAL GLYCOPROTEIN
J. Biol. Chem. 2004 279: 17338-17347. First Published on February 16, 2004; doi:10.1074/jbc.M313764200 [Abstract] [Full Text] [PDF]  

Jeffrey Levengood, Sandro F. Ataide, Hervé Roy, and Michael Ibba

Divergence in Noncognate Amino Acid Recognition between Class I and Class II Lysyl-tRNA Synthetases
J. Biol. Chem. 2004 279: 17707-17714. First Published on January 27, 2004; doi:10.1074/jbc.M313665200 [Abstract] [Full Text] [PDF]  

Hideki Shimura, Yuko Miura-Shimura, and Kenneth S. Kosik

Binding of Tau to Heat Shock Protein 27 Leads to Decreased Concentration of Hyperphosphorylated Tau and Enhanced Cell Survival
J. Biol. Chem. 2004 279: 17957-17962. First Published on February 12, 2004; doi:10.1074/jbc.M400351200 [Abstract] [Full Text] [PDF]  

Genomics, Proteomics, and Bioinformatics:

Jiuru Sun, Catherina H. Bird, Kevin Y. Thia, Antony Y. Matthews, Joseph A. Trapani, and Phillip I. Bird

Granzyme B Encoded by the Commonly Occurring Human RAH Allele Retains Pro-apoptotic Activity
J. Biol. Chem. 2004 279: 16907-16911. First Published on January 29, 2004; doi:10.1074/jbc.M400563200 [Abstract] [Full Text] [PDF]  

Ameurfina D. Santos, J. Michael McIntosh, David R. Hillyard, Lourdes J. Cruz, and Baldomero M. Olivera

The A-superfamily of Conotoxins: STRUCTURAL AND FUNCTIONAL DIVERGENCE
J. Biol. Chem. 2004 279: 17596-17606. First Published on December 30, 2003; doi:10.1074/jbc.M309654200 [Abstract] [Full Text] [PDF]  

Robert Månsson, Panagiotis Tsapogas, Mikael Åkerlund, Anna Lagergren, Ramiro Gisler, and Mikael Sigvardsson

Pearson Correlation Analysis of Microarray Data Allows for the Identification of Genetic Targets for Early B-cell Factor
J. Biol. Chem. 2004 279: 17905-17913. First Published on February 11, 2004; doi:10.1074/jbc.M400589200 [Abstract] [Full Text] [PDF] Supplemental Data  

Protein Structure and Folding:

Elsa Phillips, Alison Reeve, Stuart Bevan, and Peter McIntyre

Identification of Species-specific Determinants of the Action of the Antagonist Capsazepine and the Agonist PPAHV on TRPV1
J. Biol. Chem. 2004 279: 17165-17172. First Published on February 11, 2004; doi:10.1074/jbc.M313328200 [Abstract] [Full Text] [PDF]  

Hadar Sutovsky and Ehud Gazit

The von Hippel-Lindau Tumor Suppressor Protein Is a Molten Globule under Native Conditions: IMPLICATIONS FOR ITS PHYSIOLOGICAL ACTIVITIES
J. Biol. Chem. 2004 279: 17190-17196. First Published on February 11, 2004; doi:10.1074/jbc.M311225200 [Abstract] [Full Text] [PDF]  

Toshio Miyazaki, Ryo Sagawa, Takenori Honma, Susumu Noguchi, Taisuke Harada, Atsushi Komatsuda, Hiroshi Ohtani, Hideki Wakui, Ken-ichi Sawada, Michiro Otaka, Sumio Watanabe, Mitsutoshi Jikei, Nobuaki Ogawa, Fumio Hamada, and Hideaki Itoh

73-kDa Molecular Chaperone HSP73 Is a Direct Target of Antibiotic Gentamicin
J. Biol. Chem. 2004 279: 17295-17300. First Published on February 13, 2004; doi:10.1074/jbc.M312217200 [Abstract] [Full Text] [PDF]  

Ming-hui Li, Francis Kwok, Wen-rui Chang, Sheng-quan Liu, Samuel C. L. Lo, Ji-ping Zhang, Tao Jiang, and Dong-cai Liang

Conformational Changes in the Reaction of Pyridoxal Kinase
J. Biol. Chem. 2004 279: 17459-17465. First Published on January 13, 2004; doi:10.1074/jbc.M312380200 [Abstract] [Full Text] [PDF]  

Hyung-Sik Won, Yeon-Hee Lee, Ji-Hun Kim, In Seon Shin, Mann Hyung Lee, and Bong-Jin Lee

Structural Characterization of the Nickel-binding Properties of Bacillus pasteurii Urease Accessory Protein (Ure)E in Solution
J. Biol. Chem. 2004 279: 17466-17472. First Published on February 9, 2004; doi:10.1074/jbc.M308390200 [Abstract] [Full Text] [PDF]  

Shannon M. Doyle, Eric Anderson, Kristin N. Parent, and Carolyn M. Teschke

A Concerted Mechanism for the Suppression of a Folding Defect through Interactions with Chaperones
J. Biol. Chem. 2004 279: 17473-17482. First Published on February 4, 2004; doi:10.1074/jbc.M400467200 [Abstract] [Full Text] [PDF]  

Brian O'Nuallain, Angela D. Williams, Per Westermark, and Ronald Wetzel

Seeding Specificity in Amyloid Growth Induced by Heterologous Fibrils
J. Biol. Chem. 2004 279: 17490-17499. First Published on January 29, 2004; doi:10.1074/jbc.M311300200 [Abstract] [Full Text] [PDF]  

Hitendra S. Chand, Amy E. Schmidt, S. Paul Bajaj, and Walter Kisiel

Structure-Function Analysis of the Reactive Site in the First Kunitz-type Domain of Human Tissue Factor Pathway Inhibitor-2
J. Biol. Chem. 2004 279: 17500-17507. First Published on February 16, 2004; doi:10.1074/jbc.M400802200 [Abstract] [Full Text] [PDF]  

Michael R. Ziebell, Selvanayagam Nirthanan, S. Shaukat Husain, Keith W. Miller, and Jonathan B. Cohen

Identification of Binding Sites in the Nicotinic Acetylcholine Receptor for [³H]Azietomidate, a Photoactivatable General Anesthetic
J. Biol. Chem. 2004 279: 17640-17649. First Published on February 3, 2004; doi:10.1074/jbc.M313886200 [Abstract] [Full Text] [PDF] Supplemental Data  

Eduard V. Bocharov, Alexander G. Sobol, Konstantin V. Pavlov, Dmitry M. Korzhnev, Victor A. Jaravine, Anatoly T. Gudkov, and Alexander S. Arseniev

From Structure and Dynamics of Protein L7/L12 to Molecular Switching in Ribosome
J. Biol. Chem. 2004 279: 17697-17706. First Published on February 11, 2004; doi:10.1074/jbc.M313384200 [Abstract] [Full Text] [PDF] Supplemental Data  

Oliver Hecht, Nico A. van Nuland, Karin Schleinkofer, Andrew J. Dingley, Heike Bruhn, Matthias Leippe, and Joachim Grötzinger

Solution Structure of the Pore-forming Protein of Entamoeba histolytica
J. Biol. Chem. 2004 279: 17834-17841. First Published on February 17, 2004; doi:10.1074/jbc.M312978200 [Abstract] [Full Text] [PDF]  

Lin Chen and Alireza R. Rezaie

Proexosite-1-dependent Recognition and Activation of Prothrombin by Taipan Venom
J. Biol. Chem. 2004 279: 17869-17874. First Published on February 9, 2004; doi:10.1074/jbc.M314285200 [Abstract] [Full Text] [PDF]  

Raquel García-Castellanos, Goretti Mallorquí-Fernández, Aniebrys Marrero, Jan Potempa, Miquel Coll, and F. Xavier Gomis-Rüth

On the Transcriptional Regulation of Methicillin Resistance: MecI REPRESSOR IN COMPLEX WITH ITS OPERATOR
J. Biol. Chem. 2004 279: 17888-17896. First Published on February 11, 2004; doi:10.1074/jbc.M313123200 [Abstract] [Full Text] [PDF]  

Zhi Xu, Rashna D. Balsara, Natalia V. Gorlatova, Daniel A. Lawrence, Francis J. Castellino, and Victoria A. Ploplis

Conservation of Critical Functional Domains in Murine Plasminogen Activator Inhibitor-1
J. Biol. Chem. 2004 279: 17914-17920. First Published on February 12, 2004; doi:10.1074/jbc.M314197200 [Abstract] [Full Text] [PDF]  

Cheng Xu, Hailun Ma, Giuseppe Inesi, Marwan K. Al-Shawi, and Chikashi Toyoshima

Specific Structural Requirements for the Inhibitory Effect of Thapsigargin on the Ca²⁺ ATPase SERCA
J. Biol. Chem. 2004 279: 17973-17979. First Published on February 17, 2004; doi:10.1074/jbc.M313263200 [Abstract] [Full Text] [PDF]  

Paul Towler, Bart Staker, Sridhar G. Prasad, Saurabh Menon, Jin Tang, Thomas Parsons, Dominic Ryan, Martin Fisher, David Williams, Natalie A. Dales, Michael A. Patane, and Michael W. Pantoliano

ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis
J. Biol. Chem. 2004 279: 17996-18007. First Published on January 30, 2004; doi:10.1074/jbc.M311191200 [Abstract] [Full Text] [PDF]  

Adrian C. Apetri, Krystyna Surewicz, and Witold K. Surewicz

The Effect of Disease-associated Mutations on the Folding Pathway of Human Prion Protein
J. Biol. Chem. 2004 279: 18008-18014. First Published on February 2, 2004; doi:10.1074/jbc.M313581200 [Abstract] [Full Text] [PDF]  

Enzyme Catalysis and Regulation:

Haitao Li, Alexandre Samouilov, Xiaoping Liu, and Jay L. Zweier

Characterization of the Effects of Oxygen on Xanthine Oxidase-mediated Nitric Oxide Formation
J. Biol. Chem. 2004 279: 16939-16946. First Published on February 6, 2004; doi:10.1074/jbc.M314336200 [Abstract] [Full Text] [PDF]  

Peter R. Collins, Colin M. Stack, Sandra M. O'Neill, Sean Doyle, Thecla Ryan, Gerard P. Brennan, Angela Mousley, Michael Stewart, Aaron G. Maule, John P. Dalton, and Sheila Donnelly

Cathepsin L1, the Major Protease Involved in Liver Fluke (Fasciola hepatica) Virulence: PROPEPTIDE CLEAVAGE SITES AND AUTOACTIVATION OF THE ZYMOGEN SECRETED FROM GASTRODERMAL CELLS
J. Biol. Chem. 2004 279: 17038-17046. First Published on January 30, 2004; doi:10.1074/jbc.M308831200 [Abstract] [Full Text] [PDF]  

Roberta Leonardi and Peter L. Roach

Thiamine Biosynthesis in Escherichia coli: IN VITRO RECONSTITUTION OF THE THIAZOLE SYNTHASE ACTIVITY
J. Biol. Chem. 2004 279: 17054-17062. First Published on February 2, 2004; doi:10.1074/jbc.M312714200 [Abstract] [Full Text] [PDF]  

Genmin Lu, George J. Broze, Jr., and Sriram Krishnaswamy

Formation of Factors IXa and Xa by the Extrinsic Pathway: DIFFERENTIAL REGULATION BY TISSUE FACTOR PATHWAY INHIBITOR AND ANTITHROMBIN III
J. Biol. Chem. 2004 279: 17241-17249. First Published on February 12, 2004; doi:10.1074/jbc.M312827200 [Abstract] [Full Text] [PDF] Supplemental Data  

Ryan A. Dick and Thomas W. Kensler

The Catalytic and Kinetic Mechanisms of NADPH-dependent Alkenal/one Oxidoreductase
J. Biol. Chem. 2004 279: 17269-17277. First Published on February 13, 2004; doi:10.1074/jbc.M400427200 [Abstract] [Full Text] [PDF]  

Chao Lin, Kai Lin, Yu-Ping Luong, B. Govinda Rao, Yun-Yi Wei, Debra L. Brennan, John R. Fulghum, Hsun-Mei Hsiao, Sue Ma, John P. Maxwell, Kevin M. Cottrell, Robert B. Perni, Cynthia A. Gates, and Ann D. Kwong

In Vitro Resistance Studies of Hepatitis C Virus Serine Protease Inhibitors, VX-950 and BILN 2061: STRUCTURAL ANALYSIS INDICATES DIFFERENT RESISTANCE MECHANISMS
J. Biol. Chem. 2004 279: 17508-17514. First Published on February 6, 2004; doi:10.1074/jbc.M313020200 [Abstract] [Full Text] [PDF]  

Micky D. Tortorella, Elizabeth C. Arner, Robert Hills, Alan Easton, Jennifer Korte-Sarfaty, Kam Fok, Arthur J. Wittwer, Rui-Qin Liu, and Anne-Marie Malfait

₂-Macroglobulin Is a Novel Substrate for ADAMTS-4 and ADAMTS-5 and Represents an Endogenous Inhibitor of These Enzymes
J. Biol. Chem. 2004 279: 17554-17561. First Published on January 7, 2004; doi:10.1074/jbc.M313041200 [Abstract] [Full Text] [PDF]  

Meng-Huee Lee, Magdalini Rapti, Vera Knaüper, and Gillian Murphy

Threonine 98, the Pivotal Residue of Tissue Inhibitor of Metalloproteinases (TIMP)-1 in Metalloproteinase Recognition
J. Biol. Chem. 2004 279: 17562-17569. First Published on January 20, 2004; doi:10.1074/jbc.M312589200 [Abstract] [Full Text] [PDF]  

Burkhard Fleckenstein, Shuo-Wang Qiao, Martin R. Larsen, Günther Jung, Peter Roepstorff, and Ludvig M. Sollid

Molecular Characterization of Covalent Complexes between Tissue Transglutaminase and Gliadin Peptides
J. Biol. Chem. 2004 279: 17607-17616. First Published on January 27, 2004; doi:10.1074/jbc.M310198200 [Abstract] [Full Text] [PDF]  

Guangchao Liu, Chunsheng Jin, and Cheng Jin

CMP-N-Acetylneuraminic Acid Synthetase from Escherichia coli K1 Is a Bifunctional Enzyme: IDENTIFICATION OF MINIMAL CATALYTIC DOMAIN FOR SYNTHETASE ACTIVITY AND NOVEL FUNCTIONAL DOMAIN FOR PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE ACTIVITY
J. Biol. Chem. 2004 279: 17738-17749. First Published on February 11, 2004; doi:10.1074/jbc.M400143200 [Abstract] [Full Text] [PDF]  

Jacinta L. Chuang, R. Max Wynn, Clint C. Moss, Jiu-li Song, Jun Li, Nibal Awad, Hanna Mandel, and David T. Chuang

Structural and Biochemical Basis for Novel Mutations in Homozygous Israeli Maple Syrup Urine Disease Patients: A PROPOSED MECHANISM FOR THE THIAMIN-RESPONSIVE PHENOTYPE
J. Biol. Chem. 2004 279: 17792-17800. First Published on January 23, 2004; doi:10.1074/jbc.M313879200 [Abstract] [Full Text] [PDF]  

Júlia Kovári, Orsolya Barabás, Enikõ Takács, Angéla Békési, Zsófia Dubrovay, Veronika Pongrácz, Imre Zagyva, Timea Imre, Pál Szabó, and Beáta G. Vértessy

Altered Active Site Flexibility and a Structural Metal-binding Site in Eukaryotic dUTPase: KINETIC CHARACTERIZATION, FOLDING, AND CRYSTALLOGRAPHIC STUDIES OF THE HOMOTRIMERIC DROSOPHILA ENZYME
J. Biol. Chem. 2004 279: 17932-17944. First Published on January 14, 2004; doi:10.1074/jbc.M313643200 [Abstract] [Full Text] [PDF]  

Zsófia Dubrovay, Zoltán Gáspári, Éva Hunyadi-Gulyás, Katalin F. Medzihradszky, András Perczel, and Beáta G. Vértessy

Multidimensional NMR Identifies the Conformational Shift Essential for Catalytic Competence in the 60-kDa Drosophila melanogaster dUTPase Trimer
J. Biol. Chem. 2004 279: 17945-17950. First Published on January 14, 2004; doi:10.1074/jbc.M313644200 [Abstract] [Full Text] [PDF]  

Cheom-Gil Cheong, Dennis W. Wolan, Samantha E. Greasley, Patricia A. Horton, G. Peter Beardsley, and Ian A. Wilson

Crystal Structures of Human Bifunctional Enzyme Aminoimidazole-4-carboxamide Ribonucleotide Transformylase/IMP Cyclohydrolase in Complex with Potent Sulfonyl-containing Antifolates
J. Biol. Chem. 2004 279: 18034-18045. First Published on February 13, 2004; doi:10.1074/jbc.M313691200 [Abstract] [Full Text] [PDF]  

Elzbieta Pluskota, Dmitry A. Soloviev, Khalil Bdeir, Douglas B. Cines, and Edward F. Plow

Integrin _M2 Orchestrates and Accelerates Plasminogen Activation and Fibrinolysis by Neutrophils
J. Biol. Chem. 2004 279: 18063-18072. First Published on February 9, 2004; doi:10.1074/jbc.M310462200 [Abstract] [Full Text] [PDF]  

Metabolism and Bioenergetics:

Aymeric Goyer, Tanya L. Johnson, Laura J. Olsen, Eva Collakova, Yair Shachar-Hill, David Rhodes, and Andrew D. Hanson

Characterization and Metabolic Function of a Peroxisomal Sarcosine and Pipecolate Oxidase from Arabidopsis
J. Biol. Chem. 2004 279: 16947-16953. First Published on February 6, 2004; doi:10.1074/jbc.M400071200 [Abstract] [Full Text] [PDF]  

Karin L. C. Grönberg, Nicholas J. Watmough, Andrew J. Thomson, David J. Richardson, and Sarah J. Field

Redox-dependent Open and Closed Forms of the Active Site of the Bacterial Respiratory Nitric-oxide Reductase Revealed by Cyanide Binding Studies
J. Biol. Chem. 2004 279: 17120-17125. First Published on February 6, 2004; doi:10.1074/jbc.M400824200 [Abstract] [Full Text] [PDF]  

Bernard Lakaye, Barbara Wirtzfeld, Pierre Wins, Thierry Grisar, and Lucien Bettendorff

Thiamine Triphosphate, a New Signal Required for Optimal Growth of Escherichia coli during Amino Acid Starvation
J. Biol. Chem. 2004 279: 17142-17147. First Published on February 9, 2004; doi:10.1074/jbc.M313569200 [Abstract] [Full Text] [PDF]  

Cécile Batandier, Xavier Leverve, and Eric Fontaine

Opening of the Mitochondrial Permeability Transition Pore Induces Reactive Oxygen Species Production at the Level of the Respiratory Chain Complex I
J. Biol. Chem. 2004 279: 17197-17204. First Published on February 11, 2004; doi:10.1074/jbc.M310329200 [Abstract] [Full Text] [PDF]  

Yeong-Renn Chen, Chwen-Lih Chen, Weiguo Chen, Jay L. Zweier, Ohara Augusto, Rafael Radi, and Ronald P. Mason

Formation of Protein Tyrosine ortho-Semiquinone Radical and Nitrotyrosine from Cytochrome c-derived Tyrosyl Radical
J. Biol. Chem. 2004 279: 18054-18062. First Published on February 4, 2004; doi:10.1074/jbc.M307706200 [Abstract] [Full Text] [PDF]  

Hiromi Imamura, Chiyo Ikeda, Masasuke Yoshida, and Ken Yokoyama

The F Subunit of Thermus thermophilus V₁-ATPase Promotes ATPase Activity but Is Not Necessary for Rotation
J. Biol. Chem. 2004 279: 18085-18090. First Published on February 12, 2004; doi:10.1074/jbc.M314204200 [Abstract] [Full Text] [PDF]  

Glycobiology and Extracellular Matrices:

Nadia Papini, Luigi Anastasia, Cristina Tringali, Gianluigi Croci, Roberto Bresciani, Kazunori Yamaguchi, Taeko Miyagi, Augusto Preti, Alessandro Prinetti, Simona Prioni, Sandro Sonnino, Guido Tettamanti, Bruno Venerando, and Eugenio Monti

The Plasma Membrane-associated Sialidase MmNEU3 Modifies the Ganglioside Pattern of Adjacent Cells Supporting Its Involvement in Cell-to-Cell Interactions
J. Biol. Chem. 2004 279: 16989-16995. First Published on February 16, 2004; doi:10.1074/jbc.M400881200 [Abstract] [Full Text] [PDF]  

Kristen R. Taylor, Janet M. Trowbridge, Jennifer A. Rudisill, Christian C. Termeer, Jan C. Simon, and Richard L. Gallo

Hyaluronan Fragments Stimulate Endothelial Recognition of Injury through TLR4
J. Biol. Chem. 2004 279: 17079-17084. First Published on February 5, 2004; doi:10.1074/jbc.M310859200 [Abstract] [Full Text] [PDF]  

Paul H. Weinreb, Kenneth J. Simon, Paul Rayhorn, William J. Yang, Diane R. Leone, Brian M. Dolinski, Bradley R. Pearse, Yukako Yokota, Hisaaki Kawakatsu, Amha Atakilit, Dean Sheppard, and Shelia M. Violette

Function-blocking Integrin _v6 Monoclonal Antibodies: DISTINCT LIGAND-MIMETIC AND NONLIGAND-MIMETIC CLASSES
J. Biol. Chem. 2004 279: 17875-17887. First Published on February 11, 2004; doi:10.1074/jbc.M312103200 [Abstract] [Full Text] [PDF]  

Yuri D. Lobsanov, Pedro A. Romero, Barry Sleno, Bomina Yu, Patrick Yip, Annette Herscovics, and P. Lynne Howell

Structure of Kre2p/Mnt1p: A YEAST 1,2-MANNOSYLTRANSFERASE INVOLVED IN MANNOPROTEIN BIOSYNTHESIS
J. Biol. Chem. 2004 279: 17921-17931. First Published on January 28, 2004; doi:10.1074/jbc.M312720200 [Abstract] [Full Text] [PDF] Supplemental Data  

Staffan Sandgren, Anders Wittrup, Fang Cheng, Mats Jönsson, Erik Eklund, Susann Busch, and Mattias Belting

The Human Antimicrobial Peptide LL-37 Transfers Extracellular DNA Plasmid to the Nuclear Compartment of Mammalian Cells via Lipid Rafts and Proteoglycan-dependent Endocytosis
J. Biol. Chem. 2004 279: 17951-17956. First Published on February 11, 2004; doi:10.1074/jbc.M311440200 [Abstract] [Full Text] [PDF]  

Lipids and Lipoproteins:

Joji Yamamoto, Yukio Ikeda, Haruhisa Iguchi, Takahiro Fujino, Toshiya Tanaka, Hiroshi Asaba, Satoshi Iwasaki, Ryoichi X. Ioka, Izumi W. Kaneko, Kenta Magoori, Sadao Takahashi, Toshiyuki Mori, Hiroshi Sakaue, Tatsuhiko Kodama, Masashi Yanagisawa, Tokuo T. Yamamoto, Sadayoshi Ito, and Juro Sakai

A Krüppel-like factor KLF15 Contributes Fasting-induced Transcriptional Activation of Mitochondrial Acetyl-CoA Synthetase Gene AceCS2
J. Biol. Chem. 2004 279: 16954-16962. First Published on February 10, 2004; doi:10.1074/jbc.M312079200 [Abstract] [Full Text] [PDF]  

Susumu Mitsutake, Tack-Joong Kim, Yuichi Inagaki, Mariko Kato, Toshiyuki Yamashita, and Yasuyuki Igarashi

Ceramide Kinase Is a Mediator of Calcium-dependent Degranulation in Mast Cells
J. Biol. Chem. 2004 279: 17570-17577. First Published on February 9, 2004; doi:10.1074/jbc.M312885200 [Abstract] [Full Text] [PDF]  

Yoshihiko Tashima, Ryoko Oe, Sannamu Lee, Gohsuke Sugihara, Eric J. Chambers, Mitsuo Takahashi, and Tatsuo Yamada

The Effect of Cholesterol and Monosialoganglioside (GM1) on the Release and Aggregation of Amyloid -Peptide from Liposomes Prepared from Brain Membrane-like Lipids
J. Biol. Chem. 2004 279: 17587-17595. First Published on January 6, 2004; doi:10.1074/jbc.M308622200 [Abstract] [Full Text] [PDF]  

Rosa Salvioli, Susanna Scarpa, Fiorella Ciaffoni, Massimo Tatti, Carlo Ramoni, Marie T. Vanier, and Anna Maria Vaccaro

Glucosylceramidase Mass and Subcellular Localization Are Modulated by Cholesterol in Niemann-Pick Disease Type C
J. Biol. Chem. 2004 279: 17674-17680. First Published on February 2, 2004; doi:10.1074/jbc.M313517200 [Abstract] [Full Text] [PDF]  

Chong Yuan and Claudia Kent

Identification of Critical Residues of Choline Kinase A2 from Caenorhabditis elegans
J. Biol. Chem. 2004 279: 17801-17809. First Published on February 11, 2004; doi:10.1074/jbc.M401382200 [Abstract] [Full Text] [PDF]  

Membrane Transport, Structure, Function, and Biogenesis:

Yang Chao and Dax Fu

Thermodynamic Studies of the Mechanism of Metal Binding to the Escherichia coli Zinc Transporter YiiP
J. Biol. Chem. 2004 279: 17173-17180. First Published on February 11, 2004; doi:10.1074/jbc.M400208200 [Abstract] [Full Text] [PDF]  

Zijuan Liu, Eckhard Boles, and Barry P. Rosen

Arsenic Trioxide Uptake by Hexose Permeases in Saccharomyces cerevisiae
J. Biol. Chem. 2004 279: 17312-17318. First Published on February 14, 2004; doi:10.1074/jbc.M314006200 [Abstract] [Full Text] [PDF]  

Maria Sambade and Patricia M. Kane

The Yeast Vacuolar Proton-translocating ATPase Contains a Subunit Homologous to the Manduca sexta and Bovine e Subunits That Is Essential for Function
J. Biol. Chem. 2004 279: 17361-17365. First Published on February 16, 2004; doi:10.1074/jbc.M314104200 [Abstract] [Full Text] [PDF]  

Andrea Soza, Andrés Norambuena, Jorge Cancino, Erwin de la Fuente, Peter Henklein, and Alfonso González

Sorting Competition with Membrane-permeable Peptides in Intact Epithelial Cells Revealed Discrimination of Transmembrane Proteins Not Only at the trans-Golgi Network but Also at Pre-Golgi Stages
J. Biol. Chem. 2004 279: 17376-17383. First Published on February 4, 2004; doi:10.1074/jbc.M313197200 [Abstract] [Full Text] [PDF]  

Hongdong Bai, Balraj Doray, and Stuart Kornfeld

GGA1 Interacts with the Adaptor Protein AP-1 through a WNSF Sequence in Its Hinge Region
J. Biol. Chem. 2004 279: 17411-17417. First Published on February 18, 2004; doi:10.1074/jbc.M401158200 [Abstract] [Full Text] [PDF]  

Syed Jalal Khundmiri, Alejandro M. Bertorello, Nicholas A. Delamere, and Eleanor D. Lederer

Clathrin-mediated Endocytosis of Na⁺,K⁺-ATPase in Response to Parathyroid Hormone Requires ERK-dependent Phosphorylation of Ser-11 within the ₁-Subunit
J. Biol. Chem. 2004 279: 17418-17427. First Published on February 19, 2004; doi:10.1074/jbc.M311715200 [Abstract] [Full Text] [PDF]  

Yan Guo, Kathryn Smith, Jaekwon Lee, Dennis J. Thiele, and Michael J. Petris

Identification of Methionine-rich Clusters That Regulate Copper-stimulated Endocytosis of the Human Ctr1 Copper Transporter
J. Biol. Chem. 2004 279: 17428-17433. First Published on February 19, 2004; doi:10.1074/jbc.M401493200 [Abstract] [Full Text] [PDF]  

Connie M. Westhoff, Don L. Siegel, Chris G. Burd, and J. Kevin Foskett

Mechanism of Genetic Complementation of Ammonium Transport in Yeast by Human Erythrocyte Rh-associated Glycoprotein
J. Biol. Chem. 2004 279: 17443-17448. First Published on February 13, 2004; doi:10.1074/jbc.M311853200 [Abstract] [Full Text] [PDF]  

Christian F. W. Becker, Myrta Oblatt-Montal, Gerd G. Kochendoerfer, and Mauricio Montal

Chemical Synthesis and Single Channel Properties of Tetrameric and Pentameric TASPs (Template-assembled Synthetic Proteins) Derived from the Transmembrane Domain of HIV Virus Protein u (Vpu)
J. Biol. Chem. 2004 279: 17483-17489. First Published on January 29, 2004; doi:10.1074/jbc.M313212200 [Abstract] [Full Text] [PDF] Supplemental Data  

S. Courtney Frasch, Peter M. Henson, Kaz Nagaosa, Michael B. Fessler, Niels Borregaard, and Donna L. Bratton

Phospholipid Flip-Flop and Phospholipid Scramblase 1 (PLSCR1) Co-localize to Uropod Rafts in Formylated Met-Leu-Phe-stimulated Neutrophils
J. Biol. Chem. 2004 279: 17625-17633. First Published on February 6, 2004; doi:10.1074/jbc.M313414200 [Abstract] [Full Text] [PDF]  

Noriyuki Suzuki, Yoshihisa Shibata, Takeshi Urano, Toyoaki Murohara, Takashi Muramatsu, and Kenji Kadomatsu

Proteasomal Degradation of the Nuclear Targeting Growth Factor Midkine
J. Biol. Chem. 2004 279: 17785-17791. First Published on February 17, 2004; doi:10.1074/jbc.M310772200 [Abstract] [Full Text] [PDF]  

Mechanisms Of Signal Transduction:

Hervé Le Stunff, Rodolphe Auger, Jean Kanellopoulos, and Marie-Noëlle Raymond

The Pro-451 to Leu Polymorphism within the C-terminal Tail of P2X7 Receptor Impairs Cell Death but Not Phospholipase D Activation in Murine Thymocytes
J. Biol. Chem. 2004 279: 16918-16926. First Published on February 3, 2004; doi:10.1074/jbc.M313064200 [Abstract] [Full Text] [PDF]  

Qi-Heng Yang and Chunying Du

Smac/DIABLO Selectively Reduces the Levels of c-IAP1 and c-IAP2 but Not That of XIAP and Livin in HeLa Cells
J. Biol. Chem. 2004 279: 16963-16970. First Published on February 11, 2004; doi:10.1074/jbc.M401253200 [Abstract] [Full Text] [PDF]  

Joo Y. Lee, Ling Zhao, Hyung S. Youn, Amy R. Weatherill, Richard Tapping, Lili Feng, Won H. Lee, Katherine A. Fitzgerald, and Daniel H. Hwang

Saturated Fatty Acid Activates but Polyunsaturated Fatty Acid Inhibits Toll-like Receptor 2 Dimerized with Toll-like Receptor 6 or 1
J. Biol. Chem. 2004 279: 16971-16979. First Published on February 13, 2004; doi:10.1074/jbc.M312990200 [Abstract] [Full Text] [PDF]  

Werner Kremer, Guido Steiner, Sophie Béraud-Dufour, and Hans Robert Kalbitzer

Conformational States of the Small G Protein Arf-1 in Complex with the Guanine Nucleotide Exchange Factor ARNO-Sec7
J. Biol. Chem. 2004 279: 17004-17012. First Published on January 22, 2004; doi:10.1074/jbc.M312780200 [Abstract] [Full Text] [PDF]  

Justin H. Turner, Andrew K. Gelasco, and John R. Raymond

Calmodulin Interacts with the Third Intracellular Loop of the Serotonin 5-Hydroxytryptamine_1A Receptor at Two Distinct Sites: PUTATIVE ROLE IN RECEPTOR PHOSPHORYLATION BY PROTEIN KINASE C
J. Biol. Chem. 2004 279: 17027-17037. First Published on January 29, 2004; doi:10.1074/jbc.M313919200 [Abstract] [Full Text] [PDF]  

Cristina de Alvaro, Teresa Teruel, Rosario Hernandez, and Margarita Lorenzo

Tumor Necrosis Factor Produces Insulin Resistance in Skeletal Muscle by Activation of Inhibitor B Kinase in a p38 MAPK-dependent Manner
J. Biol. Chem. 2004 279: 17070-17078. First Published on February 4, 2004; doi:10.1074/jbc.M312021200 [Abstract] [Full Text] [PDF]  

James F. Curtin and Thomas G. Cotter

JNK Regulates HIPK3 Expression and Promotes Resistance to Fas-mediated Apoptosis in DU 145 Prostate Carcinoma Cells
J. Biol. Chem. 2004 279: 17090-17100. First Published on February 6, 2004; doi:10.1074/jbc.M307629200 [Abstract] [Full Text] [PDF]  

Angela C. Wild, Jong W. Yu, Mark A. Lemmon, and Kendall J. Blumer

The p21-activated Protein Kinase-related Kinase Cla4 Is a Coincidence Detector of Signaling by Cdc42 and Phosphatidylinositol 4-Phosphate
J. Biol. Chem. 2004 279: 17101-17110. First Published on February 6, 2004; doi:10.1074/jbc.M314035200 [Abstract] [Full Text] [PDF]  

Patricia Rodriguez, Wayne A. Jackson, and John Colyer

Critical Evaluation of Cardiac Ca²+-ATPase Phosphorylation on Serine 38 Using a Phosphorylation Site-specific Antibody
J. Biol. Chem. 2004 279: 17111-17119. First Published on February 6, 2004; doi:10.1074/jbc.M400462200 [Abstract] [Full Text] [PDF]  

Hideaki Higashi, Akihiro Nakaya, Ryouhei Tsutsumi, Kazuyuki Yokoyama, Yumiko Fujii, Susumu Ishikawa, Megumi Higuchi, Atsushi Takahashi, Yo Kurashima, Yasuhiro Teishikata, Shinya Tanaka, Takeshi Azuma, and Masanori Hatakeyama

Helicobacter pylori CagA Induces Ras-independent Morphogenetic Response through SHP-2 Recruitment and Activation
J. Biol. Chem. 2004 279: 17205-17216. First Published on February 12, 2004; doi:10.1074/jbc.M309964200 [Abstract] [Full Text] [PDF]  

Sharon L. McCoy, Stephen E. Kurtz, Frances A. Hausman, Dennis R. Trune, Robert M. Bennett, and Steven H. Hefeneider

Activation of RAW264.7 Macrophages by Bacterial DNA and Lipopolysaccharide Increases Cell Surface DNA Binding and Internalization
J. Biol. Chem. 2004 279: 17217-17223. First Published on February 2, 2004; doi:10.1074/jbc.M303837200 [Abstract] [Full Text] [PDF]  

Chong-Shan Shi and John H. Kehrl

Pyk2 Amplifies Epidermal Growth Factor and c-Src-induced Stat3 Activation
J. Biol. Chem. 2004 279: 17224-17231. First Published on February 12, 2004; doi:10.1074/jbc.M311875200 [Abstract] [Full Text] [PDF]  

Linda Smit, Annette Baas, Jeroen Kuipers, Hendrik Korswagen, Marc van de Wetering, and Hans Clevers

Wnt Activates the Tak1/Nemo-like Kinase Pathway
J. Biol. Chem. 2004 279: 17232-17240. First Published on February 11, 2004; doi:10.1074/jbc.M307801200 [Abstract] [Full Text] [PDF]  

Haojie Wang, Michael Haas, Man Liang, Ting Cai, Jiang Tian, Shengwen Li, and Zijian Xie

Ouabain Assembles Signaling Cascades through the Caveolar Na⁺/K⁺-ATPase
J. Biol. Chem. 2004 279: 17250-17259. First Published on February 12, 2004; doi:10.1074/jbc.M313239200 [Abstract] [Full Text] [PDF]  

Tatiana Ivanina, Dalia Varon, Sagit Peleg, Ida Rishal, Yuri Porozov, Carmen W. Dessauer, Tal Keren-Raifman, and Nathan Dascal

G_i1 and G_i3 Differentially Interact with, and Regulate, the G Protein-activated K⁺ Channel
J. Biol. Chem. 2004 279: 17260-17268. First Published on February 12, 2004; doi:10.1074/jbc.M313425200 [Abstract] [Full Text] [PDF]  

Liang-Guo Xu, Lian-Yun Li, and Hong-Bing Shu

TRAF7 Potentiates MEKK3-induced AP1 and CHOP Activation and Induces Apoptosis
J. Biol. Chem. 2004 279: 17278-17282. First Published on March 4, 2004; doi:10.1074/jbc.C400063200 [Abstract] [Full Text] [PDF]  

Choowong Auesukaree, Tomoyuki Homma, Hidehito Tochio, Masahiro Shirakawa, Yoshinobu Kaneko, and Satoshi Harashima

Intracellular Phosphate Serves as a Signal for the Regulation of the PHO Pathway in Saccharomyces cerevisiae
J. Biol. Chem. 2004 279: 17289-17294. First Published on February 13, 2004; doi:10.1074/jbc.M312202200 [Abstract] [Full Text] [PDF]  

John F. McDonald, Alex Zheleznyak, and William A. Frazier

Cholesterol-independent Interactions with CD47 Enhance _v3 Avidity
J. Biol. Chem. 2004 279: 17301-17311. First Published on February 13, 2004; doi:10.1074/jbc.M312782200 [Abstract] [Full Text] [PDF]  

Monideepa Roy, Zhigang Li, and David B. Sacks

IQGAP1 Binds ERK2 and Modulates Its Activity
J. Biol. Chem. 2004 279: 17329-17337. First Published on February 17, 2004; doi:10.1074/jbc.M308405200 [Abstract] [Full Text] [PDF]  

Jonathan P. Davis, Jack A Rall, Catalina Alionte, and Svetlana B. Tikunova

Mutations of Hydrophobic Residues in the N-terminal Domain of Troponin C Affect Calcium Binding and Exchange with the Troponin C-Troponin I_96–148 Complex and Muscle Force Production
J. Biol. Chem. 2004 279: 17348-17360. First Published on February 16, 2004; doi:10.1074/jbc.M314095200 [Abstract] [Full Text] [PDF]  

MiRan Seo, Chin-Ho Cho, Yun-Il Lee, Eun-Young Shin, Dongeun Park, Chang-Dae Bae, Jung Weon Lee, Eun-So Lee, and Yong-Sung Juhnn

Cdc42-dependent Mediation of UV-induced p38 Activation by G Protein Subunits
J. Biol. Chem. 2004 279: 17366-17375. First Published on February 17, 2004; doi:10.1074/jbc.M312442200 [Abstract] [Full Text] [PDF]  

Devasis Chatterjee, Yin Bai, Zhe Wang, Sandy Beach, Stephanie Mott, Rajat Roy, Corey Braastad, Yaping Sun, Asok Mukhopadhyay, Bharat B. Aggarwal, James Darnowski, Panayotis Pantazis, James Wyche, Zheng Fu, Yasuhide Kitagwa, Evan T. Keller, John M. Sedivy, and Kam C. Yeung

RKIP Sensitizes Prostate and Breast Cancer Cells to Drug-induced Apoptosis
J. Biol. Chem. 2004 279: 17515-17523. First Published on February 6, 2004; doi:10.1074/jbc.M313816200 [Abstract] [Full Text] [PDF]  

Sven Burgdorf, Peter Leister, and Karl Heinz Scheidtmann

TSG101 Interacts with Apoptosis-antagonizing Transcription Factor and Enhances Androgen Receptor-mediated Transcription by Promoting Its Monoubiquitination
J. Biol. Chem. 2004 279: 17524-17534. First Published on February 2, 2004; doi:10.1074/jbc.M313703200 [Abstract] [Full Text] [PDF]  

Alona Zilberberg, Abraham Yaniv, and Arnona Gazit

The Low Density Lipoprotein Receptor-1, LRP1, Interacts with the Human Frizzled-1 (HFz1) and Down-regulates the Canonical Wnt Signaling Pathway
J. Biol. Chem. 2004 279: 17535-17542. First Published on January 21, 2004; doi:10.1074/jbc.M311292200 [Abstract] [Full Text] [PDF]  

Susana Castro-Obregón, Rammohan V. Rao, Gabriel del Rio, Sylvia F. Chen, Karen S. Poksay, Shahrooz Rabizadeh, Sabino Vesce, Xiao-khun Zhang, Raymond A. Swanson, and Dale E. Bredesen

Alternative, Nonapoptotic Programmed Cell Death: MEDIATION BY ARRESTIN 2, ERK2, AND Nur77
J. Biol. Chem. 2004 279: 17543-17553. First Published on February 9, 2004; doi:10.1074/jbc.M312363200 [Abstract] [Full Text] [PDF]  

Miriam C. Souroujon, Lina Yao, Haibin Chen, Gerda Endemann, Hanita Khaner, Virginie Geeraert, Deborah Schechtman, Adrienne S. Gordon, Ivan Diamond, and Daria Mochly-Rosen

State-specific Monoclonal Antibodies Identify an Intermediate State in Epsilon Protein Kinase C Activation
J. Biol. Chem. 2004 279: 17617-17624. First Published on February 3, 2004; doi:10.1074/jbc.M400962200 [Abstract] [Full Text] [PDF]  

Kotaro Hama, Junken Aoki, Masahiro Fukaya, Yasuhiro Kishi, Teruyuki Sakai, Rika Suzuki, Hideo Ohta, Takao Yamori, Masahiko Watanabe, Jerold Chun, and Hiroyuki Arai

Lysophosphatidic Acid and Autotaxin Stimulate Cell Motility of Neoplastic and Non-neoplastic Cells through LPA₁
J. Biol. Chem. 2004 279: 17634-17639. First Published on January 26, 2004; doi:10.1074/jbc.M313927200 [Abstract] [Full Text] [PDF]  

Tsuyoshi Miyazaki, Archana Sanjay, Lynn Neff, Sakae Tanaka, William C. Horne, and Roland Baron

Src Kinase Activity Is Essential for Osteoclast Function
J. Biol. Chem. 2004 279: 17660-17666. First Published on January 22, 2004; doi:10.1074/jbc.M311032200 [Abstract] [Full Text] [PDF]  

Marcela Hermoso, Pablo Olivero, Rubén Torres, Ana Riveros, Andrew F. G. Quest, and Andrés Stutzin

Cell Volume Regulation in Response to Hypotonicity Is Impaired in HeLa Cells Expressing a Protein Kinase C Mutant Lacking Kinase Activity
J. Biol. Chem. 2004 279: 17681-17689. First Published on February 11, 2004; doi:10.1074/jbc.M304506200 [Abstract] [Full Text] [PDF]  

Becky A. Mercer, Natalia Kolesnikova, Joshua Sonett, and Jeanine D'Armiento

Extracellular Regulated Kinase/Mitogen Activated Protein Kinase Is Up-regulated in Pulmonary Emphysema and Mediates Matrix Metalloproteinase-1 Induction by Cigarette Smoke
J. Biol. Chem. 2004 279: 17690-17696. First Published on February 5, 2004; doi:10.1074/jbc.M313842200 [Abstract] [Full Text] [PDF]  

Jun Zhang, Liang-Guo Xu, Ke-Jun Han, and Hong-Bing Shu

Identification of a ZU5 and Death Domain-containing Inhibitor of NF-B
J. Biol. Chem. 2004 279: 17819-17825. First Published on February 9, 2004; doi:10.1074/jbc.M310737200 [Abstract] [Full Text] [PDF]  

Songhai Chen, Edward J. Dell, Fang Lin, Jiqing Sai, and Heidi E. Hamm

RACK1 Regulates Specific Functions of G
J. Biol. Chem. 2004 279: 17861-17868. First Published on February 12, 2004; doi:10.1074/jbc.M313727200 [Abstract] [Full Text] [PDF]  

Anders Kallin, Jean-Baptiste Demoulin, Keigo Nishida, Toshio Hirano, Lars Rönnstrand, and Carl-Henrik Heldin

Gab1 Contributes to Cytoskeletal Reorganization and Chemotaxis in Response to Platelet-derived Growth Factor
J. Biol. Chem. 2004 279: 17897-17904. First Published on February 17, 2004; doi:10.1074/jbc.M312996200 [Abstract] [Full Text] [PDF]  

Julius Aitsebaomo, Krister Wennerberg, Channing J. Der, Chunlian Zhang, Vishram Kedar, Martin Moser, Michelle L. Kingsley-Kallesen, Guo-Qing Zeng, and Cam Patterson

p68RacGAP Is a Novel GTPase-activating Protein That Interacts with Vascular Endothelial Zinc Finger-1 and Modulates Endothelial Cell Capillary Formation
J. Biol. Chem. 2004 279: 17963-17972. First Published on February 14, 2004; doi:10.1074/jbc.M311721200 [Abstract] [Full Text] [PDF]  

Jeong S. Oh, Pasquale Manzerra, and Mary B. Kennedy

Regulation of the Neuron-specific Ras GTPase-activating Protein, synGAP, by Ca²⁺/Calmodulin-dependent Protein Kinase II
J. Biol. Chem. 2004 279: 17980-17988. First Published on February 17, 2004; doi:10.1074/jbc.M314109200 [Abstract] [Full Text] [PDF]  

Manimekalai M. Thiyagarajan, RoseAnn P. Stracquatanio, Alexey N. Pronin, Daniel S. Evanko, Jeffrey L. Benovic, and Philip B. Wedegaertner

A Predicted Amphipathic Helix Mediates Plasma Membrane Localization of GRK5
J. Biol. Chem. 2004 279: 17989-17995. First Published on February 19, 2004; doi:10.1074/jbc.M310738200 [Abstract] [Full Text] [PDF]  

HaJeung Park, Il Yeong Park, EunJung Kim, Buhyun Youn, Kelly Fields, A. Keith Dunker, and ChulHee Kang

Comparing Skeletal and Cardiac Calsequestrin Structures and Their Calcium Binding: A PROPOSED MECHANISM FOR COUPLED CALCIUM BINDING AND PROTEIN POLYMERIZATION
J. Biol. Chem. 2004 279: 18026-18033. First Published on February 10, 2004; doi:10.1074/jbc.M311553200 [Abstract] [Full Text] [PDF]  

Tal Peleg-Shulman, Laila C. Roisman, Gordin Zupkovitz, and Gideon Schreiber

Optimizing the Binding Affinity of a Carrier Protein: A CASE STUDY ON THE INTERACTION BETWEEN SOLUBLE ifnar2 AND INTERFERON
J. Biol. Chem. 2004 279: 18046-18053. First Published on February 11, 2004; doi:10.1074/jbc.M400033200 [Abstract] [Full Text] [PDF]  

Molecular Basis Of Cell and Developmental Biology:

Chandan Sharma, Anamika Pradeep, Richard G. Pestell, and Basabi Rana

Peroxisome Proliferator-activated Receptor Activation Modulates Cyclin D1 Transcription via -Catenin-independent and cAMP-response Element-binding Protein-dependent Pathways in Mouse Hepatocytes
J. Biol. Chem. 2004 279: 16927-16938. First Published on February 5, 2004; doi:10.1074/jbc.M309045200 [Abstract] [Full Text] [PDF]  

Young-nam Park and Peter Arvan

The Acetylcholinesterase Homology Region Is Essential for Normal Conformational Maturation and Secretion of Thyroglobulin
J. Biol. Chem. 2004 279: 17085-17089. First Published on February 5, 2004; doi:10.1074/jbc.M314042200 [Abstract] [Full Text] [PDF]  

Julie Secombe and Susan M. Parkhurst

Drosophila Topors Is a RING Finger-containing Protein That Functions as a Ubiquitin-protein Isopeptide Ligase for the Hairy Basic Helix-Loop-Helix Repressor Protein
J. Biol. Chem. 2004 279: 17126-17133. First Published on February 9, 2004; doi:10.1074/jbc.M310097200 [Abstract] [Full Text] [PDF]  

Wu Xiang Liao, R. Kelly Moore, and Shunichi Shimasaki

Functional and Molecular Characterization of Naturally Occurring Mutations in the Oocyte-secreted Factors Bone Morphogenetic Protein-15 and Growth and Differentiation Factor-9
J. Biol. Chem. 2004 279: 17391-17396. First Published on February 17, 2004; doi:10.1074/jbc.M401050200 [Abstract] [Full Text] [PDF]  

Anjan G. Thakurta, Ganesh Gopal, Jin Ho Yoon, Tapas Saha, and Ravi Dhar

Conserved Nuclear Export Sequences in Schizosaccharomyces pombe Mex67 and Human TAP Function in mRNA Export by Direct Nuclear Pore Interactions
J. Biol. Chem. 2004 279: 17434-17442. First Published on February 12, 2004; doi:10.1074/jbc.M309731200 [Abstract] [Full Text] [PDF]  

Kevin L. Du, Mary Chen, Jian Li, John J. Lepore, Patricia Mericko, and Michael S. Parmacek

Megakaryoblastic Leukemia Factor-1 Transduces Cytoskeletal Signals and Induces Smooth Muscle Cell Differentiation from Undifferentiated Embryonic Stem Cells
J. Biol. Chem. 2004 279: 17578-17586. First Published on February 17, 2004; doi:10.1074/jbc.M400961200 [Abstract] [Full Text] [PDF]  

Amanda Charlesworth, Linda L. Cox, and Angus M. MacNicol

Cytoplasmic Polyadenylation Element (CPE)- and CPE-binding Protein (CPEB)-independent Mechanisms Regulate Early Class Maternal mRNA Translational Activation in Xenopus Oocytes
J. Biol. Chem. 2004 279: 17650-17659. First Published on January 29, 2004; doi:10.1074/jbc.M313837200 [Abstract] [Full Text] [PDF]  

Qin Chen, Dongcai Liang, Larry D. Fromm, and Paul A. Overbeek

Inhibition of Lens Fiber Cell Morphogenesis by Expression of a Mutant SV40 Large T Antigen That Binds CREB-binding Protein/p300 but Not pRb
J. Biol. Chem. 2004 279: 17667-17673. First Published on January 23, 2004; doi:10.1074/jbc.M311678200 [Abstract] [Full Text] [PDF]  

Shigeki Tashiro, Tadateru Sumi, Naonori Uozumi, Takao Shimizu, and Takashi Nakamura

B-Myb-Dependent Regulation of c-Myc Expression by Cytosolic Phospholipase A₂
J. Biol. Chem. 2004 279: 17715-17722. First Published on February 9, 2004; doi:10.1074/jbc.M310561200 [Abstract] [Full Text] [PDF]  

Thomas Kaido, Brandon Perez, Mayra Yebra, Jesse Hill, Vincenzo Cirulli, Alberto Hayek, and Anthony M. Montgomery

_v-Integrin Utilization in Human -Cell Adhesion, Spreading, and Motility
J. Biol. Chem. 2004 279: 17731-17737. First Published on February 6, 2004; doi:10.1074/jbc.M308425200 [Abstract] [Full Text] [PDF]  

Mun-Su Jung, Dong-Hoon Jin, Hee-Don Chae, Seokwon Kang, Sun-Chang Kim, Yung-Jue Bang, Tae-Saeng Choi, Kyeong-sook Choi, and Deug Y. Shin

Bcl-x_L and E1B-19K Proteins Inhibit p53-induced Irreversible Growth Arrest and Senescence by Preventing Reactive Oxygen Species-dependent p38 Activation
J. Biol. Chem. 2004 279: 17765-17771. First Published on February 5, 2004; doi:10.1074/jbc.M305015200 [Abstract] [Full Text] [PDF]  

Carmen Martin-Ruiz, Gabriele Saretzki, Joanne Petrie, Juliane Ladhoff, Jessie Jeyapalan, Wenyi Wei, John Sedivy, and Thomas von Zglinicki

Stochastic Variation in Telomere Shortening Rate Causes Heterogeneity of Human Fibroblast Replicative Life Span
J. Biol. Chem. 2004 279: 17826-17833. First Published on February 12, 2004; doi:10.1074/jbc.M311980200 [Abstract] [Full Text] [PDF]  

Wataru Ikeda, Shigeki Kakunaga, Kyoji Takekuni, Tatsushi Shingai, Keiko Satoh, Koji Morimoto, Masakazu Takeuchi, Toshio Imai, and Yoshimi Takai

Nectin-like Molecule-5/Tage4 Enhances Cell Migration in an Integrin-dependent, Nectin-3-independent Manner
J. Biol. Chem. 2004 279: 18015-18025. First Published on February 9, 2004; doi:10.1074/jbc.M312969200 [Abstract] [Full Text] [PDF]  

Additions and Corrections:

Laura J. Juszczak

Comparative vibrational spectroscopy of intracellular tau and extracellular collagen I reveals parallels of gelation and fibrillar structure. Vol. 279 (2004) 7395-7404
J. Biol. Chem. 2004 279: 18098. [Full Text] [PDF]  

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