Minireviews:

Patricia L. Opresko, Wen-Hsing Cheng, and Vilhelm A. Bohr

Junction of RecQ Helicase Biochemistry and Human Disease
J. Biol. Chem. 2004 279: 18099-18102. First Published on March 15, 2004; doi:10.1074/jbc.R300034200 [Full Text] [PDF]  

Accelerated Publications:

Wuxian Shi, Li-Min Ting, Gregory A. Kicska, Andrzej Lewandowicz, Peter C. Tyler, Gary B. Evans, Richard H. Furneaux, Kami Kim, Steve C. Almo, and Vern L. Schramm

Plasmodium falciparum Purine Nucleoside Phosphorylase: CRYSTAL STRUCTURES, IMMUCILLIN INHIBITORS, AND DUAL CATALYTIC FUNCTION
J. Biol. Chem. 2004 279: 18103-18106. First Published on February 23, 2004; doi:10.1074/jbc.C400068200 [Abstract] [Full Text] [PDF]  

Yusuf Kaya, Mark Del Campo, James Ofengand, and Arun Malhotra

Crystal Structure of TruD, a Novel Pseudouridine Synthase with a New Protein Fold
J. Biol. Chem. 2004 279: 18107-18110. First Published on March 3, 2004; doi:10.1074/jbc.C400072200 [Abstract] [Full Text] [PDF] Supplemental Data  

Rebecca P. Hughey, James B. Bruns, Carol L. Kinlough, Keri L. Harkleroad, Qiusheng Tong, Marcelo D. Carattino, John P. Johnson, James D. Stockand, and Thomas R. Kleyman

Epithelial Sodium Channels Are Activated by Furin-dependent Proteolysis
J. Biol. Chem. 2004 279: 18111-18114. First Published on March 7, 2004; doi:10.1074/jbc.C400080200 [Abstract] [Full Text] [PDF] Supplemental Data  

DNA: Replication, Repair, and Recombination:

Vincent J. Cannistraro and John-Stephen Taylor

DNA-Thumb Interactions and Processivity of T7 DNA Polymerase in Comparison to Yeast Polymerase
J. Biol. Chem. 2004 279: 18288-18295. First Published on February 10, 2004; doi:10.1074/jbc.M400282200 [Abstract] [Full Text] [PDF]  

Julian J. Raffoul, Diane C. Cabelof, Jun Nakamura, Lisiane B. Meira, Errol C. Friedberg, and Ahmad R. Heydari

Apurinic/Apyrimidinic Endonuclease (APE/REF-1) Haploinsufficient Mice Display Tissue-specific Differences in DNA Polymerase -Dependent Base Excision Repair
J. Biol. Chem. 2004 279: 18425-18433. First Published on February 18, 2004; doi:10.1074/jbc.M313983200 [Abstract] [Full Text] [PDF]  

Scott D. Kathe, Guang-Ping Shen, and Susan S. Wallace

Single-Stranded Breaks in DNA but Not Oxidative DNA Base Damages Block Transcriptional Elongation by RNA Polymerase II in HeLa Cell Nuclear Extracts
J. Biol. Chem. 2004 279: 18511-18520. First Published on February 21, 2004; doi:10.1074/jbc.M313598200 [Abstract] [Full Text] [PDF]  

Liping Song, Murari Chaudhuri, Charles W. Knopf, and Deborah S. Parris

Contribution of the 3'- to 5'-Exonuclease Activity of Herpes Simplex Virus Type 1 DNA Polymerase to the Fidelity of DNA Synthesis
J. Biol. Chem. 2004 279: 18535-18543. First Published on February 23, 2004; doi:10.1074/jbc.M309848200 [Abstract] [Full Text] [PDF]  

David Loegering, Sonnet J. H. Arlander, Jennifer Hackbarth, Benjamin T. Vroman, Pia Roos-Mattjus, Kevin M. Hopkins, Howard B. Lieberman, Larry M. Karnitz, and Scott H. Kaufmann

Rad9 Protects Cells from Topoisomerase Poison-induced Cell Death
J. Biol. Chem. 2004 279: 18641-18647. First Published on February 25, 2004; doi:10.1074/jbc.M313536200 [Abstract] [Full Text] [PDF]  

Ajaykumar Vora, Sibes Bera, and Duane Grandgenett

Structural Organization of Avian Retrovirus Integrase in Assembled Intasomes Mediating Full-site Integration
J. Biol. Chem. 2004 279: 18670-18678. First Published on February 26, 2004; doi:10.1074/jbc.M314270200 [Abstract] [Full Text] [PDF]  

Belinda S. Parker, Trevor Buley, Ben J. Evison, Suzanne M. Cutts, Greg M. Neumann, Magdy N. Iskander, and Don R. Phillips

A Molecular Understanding of Mitoxantrone-DNA Adduct Formation: EFFECT OF CYTOSINE METHYLATION AND FLANKING SEQUENCES
J. Biol. Chem. 2004 279: 18814-18823. First Published on February 12, 2004; doi:10.1074/jbc.M400931200 [Abstract] [Full Text] [PDF]  

Yujie Ma, Tongsheng Wang, Jana L. Villemain, David P. Giedroc, and Scott W. Morrical

Dual Functions of Single-stranded DNA-binding Protein in Helicase Loading at the Bacteriophage T4 DNA Replication Fork
J. Biol. Chem. 2004 279: 19035-19045. First Published on February 9, 2004; doi:10.1074/jbc.M311738200 [Abstract] [Full Text] [PDF]  

Angels Tapias, Jerome Auriol, Diane Forget, Jacqueline H. Enzlin, Orlando D. Schärer, Frederic Coin, Benoit Coulombe, and Jean-Marc Egly

Ordered Conformational Changes in Damaged DNA Induced by Nucleotide Excision Repair Factors
J. Biol. Chem. 2004 279: 19074-19083. First Published on February 23, 2004; doi:10.1074/jbc.M312611200 [Abstract] [Full Text] [PDF]  

Jeong-Yun Choi and F. Peter Guengerich

Analysis of the Effect of Bulk at N2-Alkylguanine DNA Adducts on Catalytic Efficiency and Fidelity of the Processive DNA Polymerases Bacteriophage T7 Exonuclease^- and HIV-1 Reverse Transcriptase
J. Biol. Chem. 2004 279: 19217-19229. First Published on February 25, 2004; doi:10.1074/jbc.M313759200 [Abstract] [Full Text] [PDF] Supplemental Data  

Genes: Structure and Regulation:

Baidong Hou, Mesut Eren, Corrie A. Painter, Joseph W. Covington, John D. Dixon, John A. Schoenhard, and Douglas E. Vaughan

Tumor Necrosis Factor Activates the Human Plasminogen Activator Inhibitor-1 Gene through a Distal Nuclear Factor B Site
J. Biol. Chem. 2004 279: 18127-18136. First Published on February 12, 2004; doi:10.1074/jbc.M310438200 [Abstract] [Full Text] [PDF]  

Wataru Miyazaki, Toshiharu Iwasaki, Akira Takeshita, Yoichiro Kuroda, and Noriyuki Koibuchi

Polychlorinated Biphenyls Suppress Thyroid Hormone Receptor-mediated Transcription through a Novel Mechanism
J. Biol. Chem. 2004 279: 18195-18202. First Published on February 25, 2004; doi:10.1074/jbc.M310531200 [Abstract] [Full Text] [PDF]  

Qi Luo, Xiaojing Ma, Sharon M. Wahl, James J. Bieker, Merlin Crossley, and Luis J. Montaner

Activation and Repression of Interleukin-12 p40 Transcription by Erythroid Kruppel-like Factor in Macrophages
J. Biol. Chem. 2004 279: 18451-18456. First Published on February 19, 2004; doi:10.1074/jbc.M400320200 [Abstract] [Full Text] [PDF]  

Josée Laganière, Gilles B. Tremblay, Catherine R. Dufour, Sylvie Giroux, François Rousseau, and Vincent Giguère

A Polymorphic Autoregulatory Hormone Response Element in the Human Estrogen-related Receptor (ERR) Promoter Dictates Peroxisome Proliferator-activated Receptor Coactivator-1 Control of ERR Expression
J. Biol. Chem. 2004 279: 18504-18510. First Published on February 20, 2004; doi:10.1074/jbc.M313543200 [Abstract] [Full Text] [PDF]  

Kenji Seki and Akiko Hata

Indian Hedgehog Gene Is a Target of the Bone Morphogenetic Protein Signaling Pathway
J. Biol. Chem. 2004 279: 18544-18549. First Published on February 23, 2004; doi:10.1074/jbc.M311592200 [Abstract] [Full Text] [PDF]  

Shohei Yamaoka, Michihiko Miyaji, Toshiyuki Kitano, Hisanori Umehara, and Toshiro Okazaki

Expression Cloning of a Human cDNA Restoring Sphingomyelin Synthesis and Cell Growth in Sphingomyelin Synthase-defective Lymphoid Cells
J. Biol. Chem. 2004 279: 18688-18693. First Published on February 19, 2004; doi:10.1074/jbc.M401205200 [Abstract] [Full Text] [PDF]  

Stéphanie Bornes, Mathieu Boulard, Corinne Hieblot, Catherine Zanibellato, Jason S. Iacovoni, Hervé Prats, and Christian Touriol

Control of the Vascular Endothelial Growth Factor Internal Ribosome Entry Site (IRES) Activity and Translation Initiation by Alternatively Spliced Coding Sequences
J. Biol. Chem. 2004 279: 18717-18726. First Published on February 5, 2004; doi:10.1074/jbc.M308410200 [Abstract] [Full Text] [PDF]  

Noriko Esumi, Yuji Oshima, Yuanyuan Li, Peter A. Campochiaro, and Donald J. Zack

Analysis of the VMD2 Promoter and Implication of E-box Binding Factors in Its Regulation
J. Biol. Chem. 2004 279: 19064-19073. First Published on February 24, 2004; doi:10.1074/jbc.M309881200 [Abstract] [Full Text] [PDF]  

Mary Ann Suico, Hiroki Yoshida, Yoshiyuki Seki, Tomoko Uchikawa, Zhuo Lu, Tsuyoshi Shuto, Kazuhito Matsuzaki, Mitsuyoshi Nakao, Jian-Dong Li, and Hirofumi Kai

Myeloid Elf-1-like Factor, an ETS Transcription Factor, Up-regulates Lysozyme Transcription in Epithelial Cells through Interaction with Promyelocytic Leukemia Protein
J. Biol. Chem. 2004 279: 19091-19098. First Published on February 19, 2004; doi:10.1074/jbc.M312439200 [Abstract] [Full Text] [PDF]  

Wenqin Luo, John Williams, Philip M. Smallwood, Jeffrey W. Touchman, Laura M. Roman, and Jeremy Nathans

Proximal and Distal Sequences Control UV Cone Pigment Gene Expression in Transgenic Zebrafish
J. Biol. Chem. 2004 279: 19286-19293. First Published on February 13, 2004; doi:10.1074/jbc.M400161200 [Abstract] [Full Text] [PDF]  

Nagarajan Selvamurugan, Sukyee Kwok, Tamara Alliston, Michael Reiss, and Nicola C. Partridge

Transforming Growth Factor-1 Regulation of Collagenase-3 Expression in Osteoblastic Cells by Cross-talk between the Smad and MAPK Signaling Pathways and Their Components, Smad2 and Runx2
J. Biol. Chem. 2004 279: 19327-19334. First Published on February 24, 2004; doi:10.1074/jbc.M314048200 [Abstract] [Full Text] [PDF]  

RNA: Structure, Metabolism, and Catalysis:

Qing Liu, Xue-hai Liang, Shai Uliel, Myriam Belahcen, Ron Unger, and Shulamit Michaeli

Identification and Functional Characterization of Lsm Proteins in Trypanosoma brucei
J. Biol. Chem. 2004 279: 18210-18219. First Published on February 26, 2004; doi:10.1074/jbc.M400678200 [Abstract] [Full Text] [PDF]  

Alexandra Martins and Stewart Shuman

Characterization of a Baculovirus Enzyme with RNA Ligase, Polynucleotide 5'-Kinase, and Polynucleotide 3'-Phosphatase Activities
J. Biol. Chem. 2004 279: 18220-18231. First Published on January 26, 2004; doi:10.1074/jbc.M313386200 [Abstract] [Full Text] [PDF]  

Yong-Joo Jeong, Dong-Eun Kim, and Smita S. Patel

Nucleotide Binding Induces Conformational Changes in Escherichia coli Transcription Termination Factor Rho
J. Biol. Chem. 2004 279: 18370-18376. First Published on February 17, 2004; doi:10.1074/jbc.M309162200 [Abstract] [Full Text] [PDF]  

Protein Synthesis, Post-Translation Modification, and Degradation:

Simone Eggert, Krzysztof Paliga, Peter Soba, Genevieve Evin, Colin L. Masters, Andreas Weidemann, and Konrad Beyreuther

The Proteolytic Processing of the Amyloid Precursor Protein Gene Family Members APLP-1 and APLP-2 Involves -, -, -, and -Like Cleavages: MODULATION OF APLP-1 PROCESSING BY N-GLYCOSYLATION
J. Biol. Chem. 2004 279: 18146-18156. First Published on February 17, 2004; doi:10.1074/jbc.M311601200 [Abstract] [Full Text] [PDF] Supplemental Data  

Ian Pitha-Rowe, Bret A. Hassel, and Ethan Dmitrovsky

Involvement of UBE1L in ISG15 Conjugation during Retinoid-induced Differentiation of Acute Promyelocytic Leukemia
J. Biol. Chem. 2004 279: 18178-18187. First Published on February 18, 2004; doi:10.1074/jbc.M309259200 [Abstract] [Full Text] [PDF]  

Andrea Dörner, Dingding Xiong, Kellie Couch, Toshitaka Yajima, and Kirk U. Knowlton

Alternatively Spliced Soluble Coxsackie-adenovirus Receptors Inhibit Coxsackievirus Infection
J. Biol. Chem. 2004 279: 18497-18503. First Published on February 21, 2004; doi:10.1074/jbc.M311754200 [Abstract] [Full Text] [PDF]  

Catherine Salvat, Guangli Wang, Anahita Dastur, Nancy Lyon, and Jon M. Huibregtse

The -4 Phenylalanine Is Required for Substrate Ubiquitination Catalyzed by HECT Ubiquitin Ligases
J. Biol. Chem. 2004 279: 18935-18943. First Published on February 13, 2004; doi:10.1074/jbc.M312201200 [Abstract] [Full Text] [PDF]  

Hiroyuki Yamano, Kin-ichiro Kominami, Clare Harrison, Kenji Kitamura, Satoshi Katayama, Susheela Dhut, Tim Hunt, and Takashi Toda

Requirement of the SCF^Pop1/Pop2 Ubiquitin Ligase for Degradation of the Fission Yeast S Phase Cyclin Cig2
J. Biol. Chem. 2004 279: 18974-18980. First Published on February 16, 2004; doi:10.1074/jbc.M311060200 [Abstract] [Full Text] [PDF] Supplemental Data  

Genomics, Proteomics, and Bioinformatics:

James J. Palacino, Dijana Sagi, Matthew S. Goldberg, Stefan Krauss, Claudia Motz, Maik Wacker, Joachim Klose, and Jie Shen

Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice
J. Biol. Chem. 2004 279: 18614-18622. First Published on February 24, 2004; doi:10.1074/jbc.M401135200 [Abstract] [Full Text] [PDF]  

Protein Structure and Folding:

Christopher D. Syme, Rebecca C. Nadal, Stephen E. J. Rigby, and John H. Viles

Copper Binding to the Amyloid- (A) Peptide Associated with Alzheimer's Disease: FOLDING, COORDINATION GEOMETRY, pH DEPENDENCE, STOICHIOMETRY, AND AFFINITY OF A-(1–28): INSIGHTS FROM A RANGE OF COMPLEMENTARY SPECTROSCOPIC TECHNIQUES
J. Biol. Chem. 2004 279: 18169-18177. First Published on February 20, 2004; doi:10.1074/jbc.M313572200 [Abstract] [Full Text] [PDF]  

Eva-Maria Frickel, Patrick Frei, Marlène Bouvier, Walter F. Stafford, Ari Helenius, Rudi Glockshuber, and Lars Ellgaard

ERp57 Is a Multifunctional Thiol-Disulfide Oxidoreductase
J. Biol. Chem. 2004 279: 18277-18287. First Published on February 10, 2004; doi:10.1074/jbc.M314089200 [Abstract] [Full Text] [PDF]  

Sophie Shnaper, Kelly Sackett, Stephen A. Gallo, Robert Blumenthal, and Yechiel Shai

The C- and the N-terminal Regions of Glycoprotein 41 Ectodomain Fuse Membranes Enriched and Not Enriched with Cholesterol, Respectively
J. Biol. Chem. 2004 279: 18526-18534. First Published on February 23, 2004; doi:10.1074/jbc.M304950200 [Abstract] [Full Text] [PDF]  

Jérôme Sallette, Sébastien Bohler, Pierre Benoit, Martine Soudant, Stéphanie Pons, Nicolas Le Novère, Jean-Pierre Changeux, and Pierre Jean Corringer

An Extracellular Protein Microdomain Controls Up-regulation of Neuronal Nicotinic Acetylcholine Receptors by Nicotine
J. Biol. Chem. 2004 279: 18767-18775. First Published on February 5, 2004; doi:10.1074/jbc.M308260200 [Abstract] [Full Text] [PDF]  

Ryo Iizuka, Sena So, Tomonao Inobe, Takao Yoshida, Tamotsu Zako, Kunihiro Kuwajima, and Masafumi Yohda

Role of the Helical Protrusion in the Conformational Change and Molecular Chaperone Activity of the Archaeal Group II Chaperonin
J. Biol. Chem. 2004 279: 18834-18839. First Published on February 20, 2004; doi:10.1074/jbc.M400839200 [Abstract] [Full Text] [PDF]  

Sarah J. Russell, Lloyd W. Ruddock, Kirsi E. H. Salo, Jason D. Oliver, Quentin P. Roebuck, David H. Llewellyn, H. Llewelyn Roderick, Peppi Koivunen, Johanna Myllyharju, and Stephen High

The Primary Substrate Binding Site in the b' Domain of ERp57 Is Adapted for Endoplasmic Reticulum Lectin Association
J. Biol. Chem. 2004 279: 18861-18869. First Published on February 10, 2004; doi:10.1074/jbc.M400575200 [Abstract] [Full Text] [PDF]  

Christian Zahnd, Silvia Spinelli, Béatrice Luginbühl, Patrick Amstutz, Christian Cambillau, and Andreas Plückthun

Directed in Vitro Evolution and Crystallographic Analysis of a Peptide-binding Single Chain Antibody Fragment (scFv) with Low Picomolar Affinity
J. Biol. Chem. 2004 279: 18870-18877. First Published on January 30, 2004; doi:10.1074/jbc.M309169200 [Abstract] [Full Text] [PDF]  

François Alberto, Christophe Bignon, Gerlind Sulzenbacher, Bernard Henrissat, and Mirjam Czjzek

The Three-dimensional Structure of Invertase (-Fructosidase) from Thermotoga maritima Reveals a Bimodular Arrangement and an Evolutionary Relationship between Retaining and Inverting Glycosidases
J. Biol. Chem. 2004 279: 18903-18910. First Published on February 18, 2004; doi:10.1074/jbc.M313911200 [Abstract] [Full Text] [PDF]  

Hui Lu, Alexander P. Golovanov, Felicity Alcock, J. Günter Grossmann, Scott Allen, Lu-Yun Lian, and Kostas Tokatlidis

The Structural Basis of the TIM10 Chaperone Assembly
J. Biol. Chem. 2004 279: 18959-18966. First Published on February 18, 2004; doi:10.1074/jbc.M313046200 [Abstract] [Full Text] [PDF]  

Anthony A. Fodor and Richard W. Aldrich

On Evolutionary Conservation of Thermodynamic Coupling in Proteins
J. Biol. Chem. 2004 279: 19046-19050. First Published on March 15, 2004; doi:10.1074/jbc.M402560200 [Abstract] [Full Text] [PDF]  

William T. Heller, Dominico Vigil, Simon Brown, Donald K. Blumenthal, Susan S. Taylor, and Jill Trewhella

C Subunits Binding to the Protein Kinase A RI Dimer Induce a Large Conformational Change
J. Biol. Chem. 2004 279: 19084-19090. First Published on February 25, 2004; doi:10.1074/jbc.M313405200 [Abstract] [Full Text] [PDF]  

Marika Vitikainen, Ilkka Lappalainen, Raili Seppala, Haike Antelmann, Harry Boer, Suvi Taira, Harri Savilahti, Michael Hecker, Mauno Vihinen, Matti Sarvas, and Vesa P. Kontinen

Structure-Function Analysis of PrsA Reveals Roles for the Parvulin-like and Flanking N- and C-terminal Domains in Protein Folding and Secretion in Bacillus subtilis
J. Biol. Chem. 2004 279: 19302-19314. First Published on February 19, 2004; doi:10.1074/jbc.M400861200 [Abstract] [Full Text] [PDF]  

Enzyme Catalysis and Regulation:

Robin Maytum, Friederike Bathe, Manfred Konrad, and Michael A. Geeves

Tropomyosin Exon 6b Is Troponin-specific and Required for Correct Acto-myosin Regulation
J. Biol. Chem. 2004 279: 18203-18209. First Published on January 28, 2004; doi:10.1074/jbc.M311636200 [Abstract] [Full Text] [PDF]  

Chloé E. Atreya and Karen S. Anderson

Kinetic Characterization of Bifunctional Thymidylate Synthase-Dihydrofolate Reductase (TS-DHFR) from Cryptosporidium hominis: A PARADIGM SHIFT FOR TS ACTIVITY AND CHANNELING BEHAVIOR
J. Biol. Chem. 2004 279: 18314-18322. First Published on February 12, 2004; doi:10.1074/jbc.M400009200 [Abstract] [Full Text] [PDF] Supplemental Data  

Koustubh Panda, Subrata Adak, David Konas, Manisha Sharma, and Dennis J. Stuehr

A Conserved Aspartate (Asp-1393) Regulates NADPH Reduction of Neuronal Nitric-oxide Synthase: IMPLICATIONS FOR CATALYSIS
J. Biol. Chem. 2004 279: 18323-18333. First Published on February 13, 2004; doi:10.1074/jbc.M310391200 [Abstract] [Full Text] [PDF]  

Roberto A. S. Schweizer, Marcel Zürcher, Zoltan Balazs, Bernhard Dick, and Alex Odermatt

Rapid Hepatic Metabolism of 7-Ketocholesterol by 11-Hydroxysteroid Dehydrogenase Type 1: SPECIES-SPECIFIC DIFFERENCES BETWEEN THE RAT, HUMAN, AND HAMSTER ENZYME
J. Biol. Chem. 2004 279: 18415-18424. First Published on February 18, 2004; doi:10.1074/jbc.M313615200 [Abstract] [Full Text] [PDF]  

Scott W. Nelson, Richard B. Honzatko, and Herbert J. Fromm

Origin of Cooperativity in the Activation of Fructose-1,6-bisphosphatase by Mg²⁺
J. Biol. Chem. 2004 279: 18481-18487. First Published on February 20, 2004; doi:10.1074/jbc.M308811200 [Abstract] [Full Text] [PDF]  

Liisa Kukkola, Peppi Koivunen, Outi Pakkanen, Antony P. Page, and Johanna Myllyharju

Collagen Prolyl 4-Hydroxylase Tetramers and Dimers Show Identical Decreases in K_m Values for Peptide Substrates with Increasing Chain Length: MUTATION OF ONE OF THE TWO CATALYTIC SITES IN THE TETRAMER INACTIVATES THE ENZYME BY MORE THAN HALF
J. Biol. Chem. 2004 279: 18656-18661. First Published on February 25, 2004; doi:10.1074/jbc.M401514200 [Abstract] [Full Text] [PDF]  

Agnieszka Krakowiak, Helen C. Pace, G. Michael Blackburn, Martina Adams, Abdelaziz Mekhalfia, Renata Kaczmarek, Janina Baraniak, Wojciech J. Stec, and Charles Brenner

Biochemical, Crystallographic, and Mutagenic Characterization of Hint, the AMP-Lysine Hydrolase, with Novel Substrates and Inhibitors
J. Biol. Chem. 2004 279: 18711-18716. First Published on February 24, 2004; doi:10.1074/jbc.M314271200 [Abstract] [Full Text] [PDF]  

Theodora Zlateva, Luca Quaroni, Lawrence Que, and Marian T. Stankovich

Redox Studies of Subunit Interactivity in Aerobic Ribonucleotide Reductase from Escherichia coli
J. Biol. Chem. 2004 279: 18742-18747. First Published on February 13, 2004; doi:10.1074/jbc.M311355200 [Abstract] [Full Text] [PDF] Supplemental Data  

Ying Tong Gao, Susan M. E. Smith, J. Brice Weinberg, Heather J. Montgomery, Elena Newman, J. Guy Guillemette, Dipak K. Ghosh, Linda J. Roman, Pavel Martasek, and John C. Salerno

Thermodynamics of Oxidation-Reduction Reactions in Mammalian Nitric-oxide Synthase Isoforms
J. Biol. Chem. 2004 279: 18759-18766. First Published on January 10, 2004; doi:10.1074/jbc.M308936200 [Abstract] [Full Text] [PDF]  

Atze T. Das, Xue Zhou, Monique Vink, Bep Klaver, Koen Verhoef, Giuseppe Marzio, and Ben Berkhout

Viral Evolution as a Tool to Improve the Tetracycline-regulated Gene Expression System
J. Biol. Chem. 2004 279: 18776-18782. First Published on February 2, 2004; doi:10.1074/jbc.M313895200 [Abstract] [Full Text] [PDF]  

Amanda C. Barnett, Sergey Tsvetanov, Niranjali Gamage, Jennifer L. Martin, Ronald G. Duggleby, and Michael E. McManus

Active Site Mutations and Substrate Inhibition in Human Sulfotransferase 1A1 and 1A3
J. Biol. Chem. 2004 279: 18799-18805. First Published on February 10, 2004; doi:10.1074/jbc.M312253200 [Abstract] [Full Text] [PDF]  

Jingsong Cao, Eric Hawkins, Joseph Brozinick, Xiaoyu Liu, Hongxing Zhang, Paul Burn, and Yuguang Shi

A Predominant Role of Acyl-CoA:monoacylglycerol Acyltransferase-2 in Dietary Fat Absorption Implicated by Tissue Distribution, Subcellular Localization, and Up-regulation by High Fat Diet
J. Biol. Chem. 2004 279: 18878-18886. First Published on February 13, 2004; doi:10.1074/jbc.M313272200 [Abstract] [Full Text] [PDF]  

Zhi-Qiang Wang, Chin-Chuan Wei, Manisha Sharma, Kartikeya Pant, Brian R. Crane, and Dennis J. Stuehr

A Conserved Val to Ile Switch near the Heme Pocket of Animal and Bacterial Nitric-oxide Synthases Helps Determine Their Distinct Catalytic Profiles
J. Biol. Chem. 2004 279: 19018-19025. First Published on February 19, 2004; doi:10.1074/jbc.M311663200 [Abstract] [Full Text] [PDF]  

Metabolism and Bioenergetics:

Stefan Stolpe and Thorsten Friedrich

The Escherichia coli NADH:Ubiquinone Oxidoreductase (Complex I) Is a Primary Proton Pump but May Be Capable of Secondary Sodium Antiport
J. Biol. Chem. 2004 279: 18377-18383. First Published on February 17, 2004; doi:10.1074/jbc.M311242200 [Abstract] [Full Text] [PDF]  

Anthony J. Kettle, Bruce M. Clark, and Christine C. Winterbourn

Superoxide Converts Indigo Carmine to Isatin Sulfonic Acid: IMPLICATIONS FOR THE HYPOTHESIS THAT NEUTROPHILS PRODUCE OZONE
J. Biol. Chem. 2004 279: 18521-18525. First Published on February 20, 2004; doi:10.1074/jbc.M400334200 [Abstract] [Full Text] [PDF]  

Amal El Fadili, Christoph Kündig, Gaétan Roy, and Marc Ouellette

Inactivation of the Leishmania tarentolae Pterin Transporter (BT1) and Reductase (PTR1) Genes Leads to Viable Parasites with Changes in Folate Metabolism and Hypersensitivity to the Antifolate Methotrexate
J. Biol. Chem. 2004 279: 18575-18582. First Published on February 23, 2004; doi:10.1074/jbc.M400652200 [Abstract] [Full Text] [PDF]  

Conrad C. Alano, Weihai Ying, and Raymond A. Swanson

Poly(ADP-ribose) Polymerase-1-mediated Cell Death in Astrocytes Requires NAD⁺ Depletion and Mitochondrial Permeability Transition
J. Biol. Chem. 2004 279: 18895-18902. First Published on February 11, 2004; doi:10.1074/jbc.M313329200 [Abstract] [Full Text] [PDF]  

Glycobiology and Extracellular Matrices:

Philippe H. Tartaix, Marie Doulaverakis, Anne George, Larry W. Fisher, William T. Butler, Chunlin Qin, Erdjan Salih, Melin Tan, Yukiji Fujimoto, Lyudmila Spevak, and Adele L. Boskey

In Vitro Effects of Dentin Matrix Protein-1 on Hydroxyapatite Formation Provide Insights into in Vivo Functions
J. Biol. Chem. 2004 279: 18115-18120. First Published on February 9, 2004; doi:10.1074/jbc.M314114200 [Abstract] [Full Text] [PDF]  

Andrew I. Jobling, Martin Nguyen, Alex Gentle, and Neville A. McBrien

Isoform-specific Changes in Scleral Transforming Growth Factor- Expression and the Regulation of Collagen Synthesis during Myopia Progression
J. Biol. Chem. 2004 279: 18121-18126. First Published on January 28, 2004; doi:10.1074/jbc.M400381200 [Abstract] [Full Text] [PDF]  

Nicoletta Zoppi, Rita Gardella, Anne De Paepe, Sergio Barlati, and Marina Colombi

Human Fibroblasts with Mutations in COL5A1 and COL3A1 Genes Do Not Organize Collagens and Fibronectin in the Extracellular Matrix, Down-regulate ₂₁ Integrin, and Recruit _v3 Instead of ₅₁ Integrin
J. Biol. Chem. 2004 279: 18157-18168. First Published on February 17, 2004; doi:10.1074/jbc.M312609200 [Abstract] [Full Text] [PDF]  

Eun Jeong Kim, Srinivasa-Gopalan Sampathkumar, Mark B. Jones, Jun Kyu Rhee, Gautam Baskaran, Scarlett Goon, and Kevin J. Yarema

Characterization of the Metabolic Flux and Apoptotic Effects of O-Hydroxyl- and N-Acyl-modified N-Acetylmannosamine Analogs in Jurkat Cells
J. Biol. Chem. 2004 279: 18342-18352. First Published on February 13, 2004; doi:10.1074/jbc.M400205200 [Abstract] [Full Text] [PDF]  

Kaisa K. Ivaska, Teuvo A. Hentunen, Jukka Vääräniemi, Hannele Ylipahkala, Kim Pettersson, and H. Kalervo Väänänen

Release of Intact and Fragmented Osteocalcin Molecules from Bone Matrix during Bone Resorption in Vitro
J. Biol. Chem. 2004 279: 18361-18369. First Published on February 16, 2004; doi:10.1074/jbc.M314324200 [Abstract] [Full Text] [PDF]  

Naoki Itano, Takahiro Sawai, Fukiko Atsumi, Osamu Miyaishi, Shun'ichiro Taniguchi, Reiji Kannagi, Michinari Hamaguchi, and Koji Kimata

Selective Expression and Functional Characteristics of Three Mammalian Hyaluronan Synthases in Oncogenic Malignant Transformation
J. Biol. Chem. 2004 279: 18679-18687. First Published on January 14, 2004; doi:10.1074/jbc.M313178200 [Abstract] [Full Text] [PDF]  

Satomi Takeo, Momoko Fujise, Takuya Akiyama, Hiroko Habuchi, Naoki Itano, Takashi Matsuo, Toshiro Aigaki, Koji Kimata, and Hiroshi Nakato

In Vivo Hyaluronan Synthesis upon Expression of the Mammalian Hyaluronan Synthase Gene in Drosophila
J. Biol. Chem. 2004 279: 18920-18925. First Published on February 13, 2004; doi:10.1074/jbc.M314293200 [Abstract] [Full Text] [PDF]  

Stephen V. Su, Patrick Hong, Sarah Baik, Oscar A. Negrete, Kevin B. Gurney, and Benhur Lee

DC-SIGN Binds to HIV-1 Glycoprotein 120 in a Distinct but Overlapping Fashion Compared with ICAM-2 and ICAM-3
J. Biol. Chem. 2004 279: 19122-19132. First Published on February 16, 2004; doi:10.1074/jbc.M400184200 [Abstract] [Full Text] [PDF]  

Paul A. Price, Helen H. June, Nicholas J. Hamlin, and Matthew K. Williamson

Evidence for a Serum Factor That Initiates the Re-calcification of Demineralized Bone
J. Biol. Chem. 2004 279: 19169-19180. First Published on February 20, 2004; doi:10.1074/jbc.M307880200 [Abstract] [Full Text] [PDF] Supplemental Data  

Lipids and Lipoproteins:

Ruud Out, J. Kar Kruijt, Patrick C. N. Rensen, Reeni B. Hildebrand, Paula de Vos, Miranda Van Eck, and Theo J. C. Van Berkel

Scavenger Receptor BI Plays a Role in Facilitating Chylomicron Metabolism
J. Biol. Chem. 2004 279: 18401-18406. First Published on February 17, 2004; doi:10.1074/jbc.M401170200 [Abstract] [Full Text] [PDF]  

Matthew J. Duncan, Guojie Li, Jeoung-Sook Shin, Johnny L. Carson, and Soman N. Abraham

Bacterial Penetration of Bladder Epithelium through Lipid Rafts
J. Biol. Chem. 2004 279: 18944-18951. First Published on February 19, 2004; doi:10.1074/jbc.M400769200 [Abstract] [Full Text] [PDF]  

Tatsuro Kishida, Igor Kostetskii, Zhibing Zhang, Federico Martinez, Pei Liu, Steven U. Walkley, Nancy K. Dwyer, E. Joan Blanchette-Mackie, Glenn L. Radice, and Jerome F. Strauss, III

Targeted Mutation of the MLN64 START Domain Causes Only Modest Alterations in Cellular Sterol Metabolism
J. Biol. Chem. 2004 279: 19276-19285. First Published on February 12, 2004; doi:10.1074/jbc.M400717200 [Abstract] [Full Text] [PDF]  

Yuan-Li Zhang, Antonio Hernandez-Ono, Carol Ko, Koichi Yasunaga, Li-Shin Huang, and Henry N. Ginsberg

Regulation of Hepatic Apolipoprotein B-lipoprotein Assembly and Secretion by the Availability of Fatty Acids: I. DIFFERENTIAL RESPONSE TO THE DELIVERY OF FATTY ACIDS VIA ALBUMIN OR REMNANT-LIKE EMULSION PARTICLES
J. Biol. Chem. 2004 279: 19362-19374. First Published on February 17, 2004; doi:10.1074/jbc.M400220200 [Abstract] [Full Text] [PDF]  

Membrane Transport, Structure, Function, and Biogenesis:

Nils Wiedemann, Kaye N. Truscott, Sylvia Pfannschmidt, Bernard Guiard, Chris Meisinger, and Nikolaus Pfanner

Biogenesis of the Protein Import Channel Tom40 of the Mitochondrial Outer Membrane: INTERMEMBRANE SPACE COMPONENTS ARE INVOLVED IN AN EARLY STAGE OF THE ASSEMBLY PATHWAY
J. Biol. Chem. 2004 279: 18188-18194. First Published on February 20, 2004; doi:10.1074/jbc.M400050200 [Abstract] [Full Text] [PDF]  

Tip W. Loo, M. Claire Bartlett, and David M. Clarke

Val¹³³ and Cys¹³⁷ in Transmembrane Segment 2 Are Close to Arg⁹³⁵ and Gly⁹³⁹ in Transmembrane Segment 11 of Human P-glycoprotein
J. Biol. Chem. 2004 279: 18232-18238. First Published on January 28, 2004; doi:10.1074/jbc.M400229200 [Abstract] [Full Text] [PDF]  

Qing Yan, Wei Sun, James A. McNew, Thomas A. Vida, and Andrew J. Bean

Ca²+ and N-Ethylmaleimide-sensitive Factor Differentially Regulate Disassembly of SNARE Complexes on Early Endosomes
J. Biol. Chem. 2004 279: 18270-18276. First Published on February 9, 2004; doi:10.1074/jbc.M400093200 [Abstract] [Full Text] [PDF]  

Candice C. Askwith, John A. Wemmie, Margaret P. Price, Tania Rokhlina, and Michael J. Welsh

Acid-sensing Ion Channel 2 (ASIC2) Modulates ASIC1 H⁺-activated Currents in Hippocampal Neurons
J. Biol. Chem. 2004 279: 18296-18305. First Published on February 11, 2004; doi:10.1074/jbc.M312145200 [Abstract] [Full Text] [PDF]  

Yu-Ling Meng, Zijuan Liu, and Barry P. Rosen

As(III) and Sb(III) Uptake by GlpF and Efflux by ArsB in Escherichia coli
J. Biol. Chem. 2004 279: 18334-18341. First Published on February 16, 2004; doi:10.1074/jbc.M400037200 [Abstract] [Full Text] [PDF]  

Francesca Scarlatti, Chantal Bauvy, Annamaria Ventruti, Giusy Sala, Françoise Cluzeaud, Alain Vandewalle, Riccardo Ghidoni, and Patrice Codogno

Ceramide-mediated Macroautophagy Involves Inhibition of Protein Kinase B and Up-regulation of Beclin 1
J. Biol. Chem. 2004 279: 18384-18391. First Published on February 17, 2004; doi:10.1074/jbc.M313561200 [Abstract] [Full Text] [PDF]  

Youssef El Fakhry, Marlène Bouillon, Claire Léveillé, Alexandre Brunet, Hayssam Khalil, Jacques Thibodeau, and Walid Mourad

Delineation of the HLA-DR Region and the Residues Involved in the Association with the Cytoskeleton
J. Biol. Chem. 2004 279: 18472-18480. First Published on February 19, 2004; doi:10.1074/jbc.M401159200 [Abstract] [Full Text] [PDF]  

Gábor Czirják, Zsuzsanna E. Tóth, and Péter Enyedi

The Two-pore Domain K⁺ Channel, TRESK, Is Activated by the Cytoplasmic Calcium Signal through Calcineurin
J. Biol. Chem. 2004 279: 18550-18558. First Published on February 23, 2004; doi:10.1074/jbc.M312229200 [Abstract] [Full Text] [PDF]  

Ji-Hyun Shin, Wan Namkung, Jae Young Choi, Joo-Heon Yoon, and Min Goo Lee

Purinergic Stimulation Induces Ca²⁺-dependent Activation of Na⁺-K⁺-2Cl^- Cotransporter in Human Nasal Epithelia
J. Biol. Chem. 2004 279: 18567-18574. First Published on February 24, 2004; doi:10.1074/jbc.M400639200 [Abstract] [Full Text] [PDF]  

Lorena Griparic, Nicole N. van der Wel, Ian J. Orozco, Peter J. Peters, and Alexander M. van der Bliek

Loss of the Intermembrane Space Protein Mgm1/OPA1 Induces Swelling and Localized Constrictions along the Lengths of Mitochondria
J. Biol. Chem. 2004 279: 18792-18798. First Published on February 16, 2004; doi:10.1074/jbc.M400920200 [Abstract] [Full Text] [PDF]  

David C. Alexander, Joses R. W. Jones, Tracy Tan, Jeffrey M. Chen, and Jun Liu

PimF, a Mannosyltransferase of Mycobacteria, Is Involved in the Biosynthesis of Phosphatidylinositol Mannosides and Lipoarabinomannan
J. Biol. Chem. 2004 279: 18824-18833. First Published on February 11, 2004; doi:10.1074/jbc.M400791200 [Abstract] [Full Text] [PDF]  

Hui Lu, Scott Allen, Leanne Wardleworth, Peter Savory, and Kostas Tokatlidis

Functional TIM10 Chaperone Assembly Is Redox-regulated in Vivo
J. Biol. Chem. 2004 279: 18952-18958. First Published on February 18, 2004; doi:10.1074/jbc.M313045200 [Abstract] [Full Text] [PDF]  

Marleen Otzen, Uta Perband, Dongyuan Wang, Richard J. S. Baerends, Wolf H. Kunau, Marten Veenhuis, and Ida J. Van der Klei

Hansenula polymorpha Pex19p Is Essential for the Formation of Functional Peroxisomal Membranes
J. Biol. Chem. 2004 279: 19181-19190. First Published on February 23, 2004; doi:10.1074/jbc.M314275200 [Abstract] [Full Text] [PDF]  

Lankupalle D. Jayanthi, Devadoss J. Samuvel, and Sammanda Ramamoorthy

Regulated Internalization and Phosphorylation of the Native Norepinephrine Transporter in Response to Phorbol Esters: EVIDENCE FOR LOCALIZATION IN LIPID RAFTS AND LIPID RAFT-MEDIATED INTERNALIZATION
J. Biol. Chem. 2004 279: 19315-19326. First Published on February 19, 2004; doi:10.1074/jbc.M311172200 [Abstract] [Full Text] [PDF]  

Mechanisms Of Signal Transduction:

Alison M. O'Mahony, Mauricio Montano, Katrien Van Beneden, Lin-Feng Chen, and Warner C. Greene

Human T-cell Lymphotropic Virus Type 1 Tax Induction of Biologically Active NF-B Requires IB Kinase-1-mediated Phosphorylation of RelA/p65
J. Biol. Chem. 2004 279: 18137-18145. First Published on February 12, 2004; doi:10.1074/jbc.M401397200 [Abstract] [Full Text] [PDF]  

Lucinda F. Reynolds, Carine de Bettignies, Trisha Norton, Alexander Beeser, Jonathan Chernoff, and Victor L. J. Tybulewicz

Vav1 Transduces T Cell Receptor Signals to the Activation of the Ras/ERK Pathway via LAT, Sos, and RasGRP1
J. Biol. Chem. 2004 279: 18239-18246. First Published on February 5, 2004; doi:10.1074/jbc.M400257200 [Abstract] [Full Text] [PDF]  

Solène Grazide, Anne-Dominique Terrisse, Sandra Lerouge, Guy Laurent, and Jean-Pierre Jaffrézou

Cytoprotective Effect of Glucosylceramide Synthase Inhibition against Daunorubicin-induced Apoptosis in Human Leukemic Cell Lines
J. Biol. Chem. 2004 279: 18256-18261. First Published on February 6, 2004; doi:10.1074/jbc.M314105200 [Abstract] [Full Text] [PDF]  

Mario Encinas, Robert J. Crowder, Jeffrey Milbrandt, and Eugene M. Johnson, Jr.

Tyrosine 981, a Novel Ret Autophosphorylation Site, Binds c-Src to Mediate Neuronal Survival
J. Biol. Chem. 2004 279: 18262-18269. First Published on February 6, 2004; doi:10.1074/jbc.M400505200 [Abstract] [Full Text] [PDF]  

Madeline Leahy, Anthony Lyons, Darren Krause, and Rosemary O'Connor

Impaired Shc, Ras, and MAPK Activation but Normal Akt Activation in FL5.12 Cells Expressing an Insulin-like Growth Factor I Receptor Mutated at Tyrosines 1250 and 1251
J. Biol. Chem. 2004 279: 18306-18313. First Published on February 12, 2004; doi:10.1074/jbc.M309234200 [Abstract] [Full Text] [PDF]  

Frank T. Zenke, Mira Krendel, Celine DerMardirossian, Charles C. King, Benjamin P. Bohl, and Gary M. Bokoch

p21-activated Kinase 1 Phosphorylates and Regulates 14-3-3 Binding to GEF-H1, a Microtubule-localized Rho Exchange Factor
J. Biol. Chem. 2004 279: 18392-18400. First Published on February 17, 2004; doi:10.1074/jbc.M400084200 [Abstract] [Full Text] [PDF] Supplemental Data  

Christina Schlatterer, Kathrin Happle, Daniel F. Lusche, and Jürgen Sonnemann

Cytosolic [Ca²⁺] Transients in Dictyostelium discoideum Depend on the Filling State of Internal Stores and on an Active Sarco/Endoplasmic Reticulum Calcium ATPase (SERCA) Ca²⁺ Pump
J. Biol. Chem. 2004 279: 18407-18414. First Published on February 18, 2004; doi:10.1074/jbc.M307096200 [Abstract] [Full Text] [PDF]  

Todd M. Quinton, Soochong Kim, Claudia K. Derian, Jianguo Jin, and Satya P. Kunapuli

Plasmin-mediated Activation of Platelets Occurs by Cleavage of Protease-activated Receptor 4
J. Biol. Chem. 2004 279: 18434-18439. First Published on February 18, 2004; doi:10.1074/jbc.M401431200 [Abstract] [Full Text] [PDF]  

Michelangelo Campanella, Arjan S. de Jong, Kjerstin W. H. Lanke, Willem J. G. Melchers, Peter H. G. M. Willems, Paolo Pinton, Rosario Rizzuto, and Frank J. M. van Kuppeveld

The Coxsackievirus 2B Protein Suppresses Apoptotic Host Cell Responses by Manipulating Intracellular Ca²+ Homeostasis
J. Biol. Chem. 2004 279: 18440-18450. First Published on February 19, 2004; doi:10.1074/jbc.M309494200 [Abstract] [Full Text] [PDF]  

Matthew C. Catley, Lisa M. Cambridge, Yasuyuki Nasuhara, Kazuhiro Ito, Joanna E. Chivers, Andrew Beaton, Neil S. Holden, Martin W. Bergmann, Peter J. Barnes, and Robert Newton

Inhibitors of Protein Kinase C (PKC) Prevent Activated Transcription: ROLE OF EVENTS DOWNSTREAM OF NF-B DNA BINDING
J. Biol. Chem. 2004 279: 18457-18466. First Published on February 19, 2004; doi:10.1074/jbc.M400765200 [Abstract] [Full Text] [PDF] Supplemental Data  

Wan-Nan U. Chen, Ronald L. Woodbury, Loel E. Kathmann, Lee K. Opresko, Richard C. Zangar, H. Steven Wiley, and Brian D. Thrall

Induced Autocrine Signaling through the Epidermal Growth Factor Receptor Contributes to the Response of Mammary Epithelial Cells to Tumor Necrosis Factor
J. Biol. Chem. 2004 279: 18488-18496. First Published on February 20, 2004; doi:10.1074/jbc.M310874200 [Abstract] [Full Text] [PDF]  

Botond Bánfi, Fabiana Tirone, Isabelle Durussel, Judit Knisz, Patryk Moskwa, Gergely Zoltán Molnár, Karl-Heinz Krause, and Jos A. Cox

Mechanism of Ca²⁺ Activation of the NADPH Oxidase 5 (NOX5)
J. Biol. Chem. 2004 279: 18583-18591. First Published on February 24, 2004; doi:10.1074/jbc.M310268200 [Abstract] [Full Text] [PDF] Supplemental Data  

Matthew J. Ludeman, Yao Wu Zheng, Kenji Ishii, and Shaun R. Coughlin

Regulated Shedding of PAR1 N-terminal Exodomain from Endothelial Cells
J. Biol. Chem. 2004 279: 18592-18599. First Published on February 24, 2004; doi:10.1074/jbc.M310836200 [Abstract] [Full Text] [PDF]  

Junji Matsui, Toshiaki Wakabayashi, Makoto Asada, Kentaro Yoshimatsu, and Masayuki Okada

Stem Cell Factor/c-kit Signaling Promotes the Survival, Migration, and Capillary Tube Formation of Human Umbilical Vein Endothelial Cells
J. Biol. Chem. 2004 279: 18600-18607. First Published on February 24, 2004; doi:10.1074/jbc.M311643200 [Abstract] [Full Text] [PDF]  

James G. Burchfield, Alecia J. Lennard, Sakura Narasimhan, William E. Hughes, Valerie C. Wasinger, Garry L. Corthals, Tomohiko Okuda, Hisato Kondoh, Trevor J. Biden, and Carsten Schmitz-Peiffer

Akt Mediates Insulin-stimulated Phosphorylation of Ndrg2: EVIDENCE FOR CROSS-TALK WITH PROTEIN KINASE C
J. Biol. Chem. 2004 279: 18623-18632. First Published on February 24, 2004; doi:10.1074/jbc.M401504200 [Abstract] [Full Text] [PDF]  

Sophie Malagarie-Cazenave, Bruno Ségui, Sophie Lévêque, Virginie Garcia, Stéphane Carpentier, Marie-Françoise Altié, Anne Brouchet, Valérie Gouazé, Nathalie Andrieu-Abadie, Yara Barreira, Hervé Benoist, and Thierry Levade

Role of FAN in Tumor Necrosis Factor- and Lipopolysaccharide-induced Interleukin-6 Secretion and Lethality in D-Galactosamine-sensitized Mice
J. Biol. Chem. 2004 279: 18648-18655. First Published on February 25, 2004; doi:10.1074/jbc.M314294200 [Abstract] [Full Text] [PDF]  

Patricia A. Valdez, Hua Wang, Dhaya Seshasayee, Menno van Lookeren Campagne, Austin Gurney, Wyne P. Lee, and Iqbal S. Grewal

NTB-A, a New Activating Receptor in T Cells That Regulates Autoimmune Disease
J. Biol. Chem. 2004 279: 18662-18669. First Published on February 26, 2004; doi:10.1074/jbc.M312313200 [Abstract] [Full Text] [PDF]  

Yongmin Liu, Gregory L. Borchert, and James M. Phang

Polyoma Enhancer Activator 3, an Ets Transcription Factor, Mediates the Induction of Cyclooxygenase-2 by Nitric Oxide in Colorectal Cancer Cells
J. Biol. Chem. 2004 279: 18694-18700. First Published on February 19, 2004; doi:10.1074/jbc.M308136200 [Abstract] [Full Text] [PDF]  

Selma Osmanagic-Myers and Gerhard Wiche

Plectin-RACK1 (Receptor for Activated C Kinase 1) Scaffolding: A NOVEL MECHANISM TO REGULATE PROTEIN KINASE C ACTIVITY
J. Biol. Chem. 2004 279: 18701-18710. First Published on February 14, 2004; doi:10.1074/jbc.M312382200 [Abstract] [Full Text] [PDF]  

Kieron Brown, Joanna M. Long, Sarah C. M. Vial, Neesha Dedi, Nicholas J. Dunster, Suzanne B. Renwick, Adam J. Tanner, J. Dan Frantz, Mark A. Fleming, and Graham M. T. Cheetham

Crystal Structures of Interleukin-2 Tyrosine Kinase and Their Implications for the Design of Selective Inhibitors
J. Biol. Chem. 2004 279: 18727-18732. First Published on February 6, 2004; doi:10.1074/jbc.M400031200 [Abstract] [Full Text] [PDF]  

Martin Paukert, Samuel Sidi, Claire Russell, Maria Siba, Stephen W. Wilson, Teresa Nicolson, and Stefan Gründer

A Family of Acid-sensing Ion Channels from the Zebrafish: WIDESPREAD EXPRESSION IN THE CENTRAL NERVOUS SYSTEM SUGGESTS A CONSERVED ROLE IN NEURONAL COMMUNICATION
J. Biol. Chem. 2004 279: 18783-18791. First Published on February 16, 2004; doi:10.1074/jbc.M401477200 [Abstract] [Full Text] [PDF]  

Srividya Balasubramanian, Jeremy A. Teissére, Dinesh V. Raju, and Randy A. Hall

Hetero-oligomerization between GABA_A and GABA_B Receptors Regulates GABA_B Receptor Trafficking
J. Biol. Chem. 2004 279: 18840-18850. First Published on February 13, 2004; doi:10.1074/jbc.M313470200 [Abstract] [Full Text] [PDF]  

Chihiro Hisatsune, Yukiko Kuroda, Kyoko Nakamura, Takafumi Inoue, Takeshi Nakamura, Takayuki Michikawa, Akihiro Mizutani, and Katsuhiko Mikoshiba

Regulation of TRPC6 Channel Activity by Tyrosine Phosphorylation
J. Biol. Chem. 2004 279: 18887-18894. First Published on February 3, 2004; doi:10.1074/jbc.M311274200 [Abstract] [Full Text] [PDF]  

Judit Boczan, A. G. Miriam Leenders, and Zu-Hang Sheng

Phosphorylation of Syntaphilin by cAMP-dependent Protein Kinase Modulates Its Interaction with Syntaxin-1 and Annuls Its Inhibitory Effect on Vesicle Exocytosis
J. Biol. Chem. 2004 279: 18911-18919. First Published on February 25, 2004; doi:10.1074/jbc.M400496200 [Abstract] [Full Text] [PDF]  

Yukihiko Takano, Seiji Adachi, Masataka Okuno, Yoshinori Muto, Takashi Yoshioka, Rie Matsushima-Nishiwaki, Hisashi Tsurumi, Kenichi Ito, Scott L. Friedman, Hisataka Moriwaki, Soichi Kojima, and Yukio Okano

The RING Finger Protein, RNF8, Interacts with Retinoid X Receptor and Enhances Its Transcription-stimulating Activity
J. Biol. Chem. 2004 279: 18926-18934. First Published on February 23, 2004; doi:10.1074/jbc.M309148200 [Abstract] [Full Text] [PDF]  

Huang Shao, Xuejun Xu, Mary-Ann A. Mastrangelo, Naijie Jing, Richard G. Cook, Glen B. Legge, and David J. Tweardy

Structural Requirements for Signal Transducer and Activator of Transcription 3 Binding to Phosphotyrosine Ligands Containing the YXXQ Motif
J. Biol. Chem. 2004 279: 18967-18973. First Published on February 13, 2004; doi:10.1074/jbc.M314037200 [Abstract] [Full Text] [PDF]  

Moulay Driss Rochdi, Geneviève Laroche, Émilie Dupré, Patrick Giguère, Annie Lebel, Valérie Watier, Émilie Hamelin, Marie-Claude Lépine, Gilles Dupuis, and Jean-Luc Parent

Nm23-H2 Interacts with a G Protein-coupled Receptor to Regulate Its Endocytosis through an Rac1-dependent Mechanism
J. Biol. Chem. 2004 279: 18981-18989. First Published on February 19, 2004; doi:10.1074/jbc.M312621200 [Abstract] [Full Text] [PDF]  

Christophe Petrel, Albane Kessler, Philippe Dauban, Robert H. Dodd, Didier Rognan, and Martial Ruat

Positive and Negative Allosteric Modulators of the Ca²⁺-sensing Receptor Interact within Overlapping but Not Identical Binding Sites in the Transmembrane Domain
J. Biol. Chem. 2004 279: 18990-18997. First Published on February 19, 2004; doi:10.1074/jbc.M400724200 [Abstract] [Full Text] [PDF]  

Thomas Meyer, Lisa Hendry, Andreas Begitt, Susan John, and Uwe Vinkemeier

A Single Residue Modulates Tyrosine Dephosphorylation, Oligomerization, and Nuclear Accumulation of Stat Transcription Factors
J. Biol. Chem. 2004 279: 18998-19007. First Published on March 9, 2004; doi:10.1074/jbc.M400766200 [Abstract] [Full Text] [PDF]  

Tadashi Nishiya and Anthony L. DeFranco

Ligand-regulated Chimeric Receptor Approach Reveals Distinctive Subcellular Localization and Signaling Properties of the Toll-like Receptors
J. Biol. Chem. 2004 279: 19008-19017. First Published on February 19, 2004; doi:10.1074/jbc.M311618200 [Abstract] [Full Text] [PDF]  

Dmitri Leonoudakis, Lisa R. Conti, Carolyn M. Radeke, Leah M. M. McGuire, and Carol A. Vandenberg

A Multiprotein Trafficking Complex Composed of SAP97, CASK, Veli, and Mint1 Is Associated with Inward Rectifier Kir2 Potassium Channels
J. Biol. Chem. 2004 279: 19051-19063. First Published on February 11, 2004; doi:10.1074/jbc.M400284200 [Abstract] [Full Text] [PDF]  

Tiesong Shang, Srigiridhar Kotamraju, Shasi V. Kalivendi, Cecilia J. Hillard, and B. Kalyanaraman

1-Methyl-4-phenylpyridinium-induced Apoptosis in Cerebellar Granule Neurons Is Mediated by Transferrin Receptor Iron-dependent Depletion of Tetrahydrobiopterin and Neuronal Nitric-oxide Synthase-derived Superoxide
J. Biol. Chem. 2004 279: 19099-19112. First Published on January 29, 2004; doi:10.1074/jbc.M400101200 [Abstract] [Full Text] [PDF]  

Milena Girotti, John H. Evans, Danielle Burke, and Christina C. Leslie

Cytosolic Phospholipase A₂ Translocates to Forming Phagosomes during Phagocytosis of Zymosan in Macrophages
J. Biol. Chem. 2004 279: 19113-19121. First Published on February 11, 2004; doi:10.1074/jbc.M313867200 [Abstract] [Full Text] [PDF] Supplemental Data  

Jing An, Yingming Chen, and Ziwei Huang

Critical Upstream Signals of Cytochrome c Release Induced by a Novel Bcl-2 Inhibitor
J. Biol. Chem. 2004 279: 19133-19140. First Published on February 13, 2004; doi:10.1074/jbc.M400295200 [Abstract] [Full Text] [PDF]  

Maxim Sokolov, Katherine J. Strissel, Ilya B. Leskov, Norman A. Michaud, Viktor I. Govardovskii, and Vadim Y. Arshavsky

Phosducin Facilitates Light-driven Transducin Translocation in Rod Photoreceptors: EVIDENCE FROM THE PHOSDUCIN KNOCKOUT MOUSE
J. Biol. Chem. 2004 279: 19149-19156. First Published on February 18, 2004; doi:10.1074/jbc.M311058200 [Abstract] [Full Text] [PDF]  

Thomas R. Salas, Jeri Kim, Funda Vakar-Lopez, Anita L. Sabichi, Patricia Troncoso, Guido Jenster, Akira Kikuchi, Shao-Yong Chen, Lirim Shemshedini, Milind Suraokar, Christopher J. Logothetis, John DiGiovanni, Scott M. Lippman, and David G. Menter

Glycogen Synthase Kinase-3 Is Involved in the Phosphorylation and Suppression of Androgen Receptor Activity
J. Biol. Chem. 2004 279: 19191-19200. First Published on February 24, 2004; doi:10.1074/jbc.M309560200 [Abstract] [Full Text] [PDF]  

Danya Liu, Xue Yan Liu, Daniel Robinson, Christie Burnett, Charity Jackson, Louis Seele, Ruth Ann Veach, Sheila Downs, Robert D. Collins, Dean W. Ballard, and Jacek Hawiger

Suppression of Staphylococcal Enterotoxin B-induced Toxicity by a Nuclear Import Inhibitor
J. Biol. Chem. 2004 279: 19239-19246. First Published on January 19, 2004; doi:10.1074/jbc.M313442200 [Abstract] [Full Text] [PDF]  

Morgan Dupuis, Arlette Lévy, and Sakina Mhaouty-Kodja

Functional Coupling of Rat Myometrial 1-Adrenergic Receptors to Gh/Tissue Transglutaminase 2 during Pregnancy
J. Biol. Chem. 2004 279: 19257-19263. First Published on February 17, 2004; doi:10.1074/jbc.M314299200 [Abstract] [Full Text] [PDF]  

Yu-Hauh Wu, Sheue-Fang Shih, and Jung-Yaw Lin

Ricin Triggers Apoptotic Morphological Changes through Caspase-3 Cleavage of BAT3
J. Biol. Chem. 2004 279: 19264-19275. First Published on February 11, 2004; doi:10.1074/jbc.M307049200 [Abstract] [Full Text] [PDF]  

Kathleen H. Cox, Jennifer J. Tate, and Terrance G. Cooper

Actin Cytoskeleton Is Required For Nuclear Accumulation of Gln3 in Response to Nitrogen Limitation but Not Rapamycin Treatment in Saccharomyces cerevisiae
J. Biol. Chem. 2004 279: 19294-19301. First Published on February 16, 2004; doi:10.1074/jbc.M309240200 [Abstract] [Full Text] [PDF]  

Arda Bedirian, Cindy Baldwin, Jun-ichi Abe, Tomoko Takano, and Serge Lemay

Pleckstrin Homology and Phosphotyrosine-binding Domain-dependent Membrane Association and Tyrosine Phosphorylation of Dok-4, an Inhibitory Adapter Molecule Expressed in Epithelial Cells
J. Biol. Chem. 2004 279: 19335-19349. First Published on February 12, 2004; doi:10.1074/jbc.M310689200 [Abstract] [Full Text] [PDF]  

Vitalyi O. Rybin, Jianfen Guo, Abdelkarim Sabri, Hasnae Elouardighi, Erik Schaefer, and Susan F. Steinberg

Stimulus-specific Differences in Protein Kinase C Localization and Activation Mechanisms in Cardiomyocytes
J. Biol. Chem. 2004 279: 19350-19361. First Published on February 17, 2004; doi:10.1074/jbc.M311096200 [Abstract] [Full Text] [PDF]  

Huiping Tu, Tie-Shan Tang, Zhengnan Wang, and Ilya Bezprozvanny

Association of Type 1 Inositol 1,4,5-Trisphosphate Receptor with AKAP9 (Yotiao) and Protein Kinase A
J. Biol. Chem. 2004 279: 19375-19382. First Published on February 24, 2004; doi:10.1074/jbc.M313476200 [Abstract] [Full Text] [PDF]  

Molecular Basis Of Cell and Developmental Biology:

Márcia R. Cominetti, Cristina H. B. Terruggi, Oscar H. P. Ramos, Jay W. Fox, Andrea Mariano-Oliveira, Marta S. De Freitas, Camila C. Figueiredo, Veronica Morandi, and Heloisa S. Selistre-de-Araujo

Alternagin-C, a Disintegrin-like Protein, Induces Vascular Endothelial Cell Growth Factor (VEGF) Expression and Endothelial Cell Proliferation in Vitro
J. Biol. Chem. 2004 279: 18247-18255. First Published on February 6, 2004; doi:10.1074/jbc.M311771200 [Abstract] [Full Text] [PDF]  

Bonnie L. Goodwin, Larry P. Solomonson, and Duane C. Eichler

Argininosuccinate Synthase Expression Is Required to Maintain Nitric Oxide Production and Cell Viability in Aortic Endothelial Cells
J. Biol. Chem. 2004 279: 18353-18360. First Published on February 16, 2004; doi:10.1074/jbc.M308160200 [Abstract] [Full Text] [PDF]  

Dimitrios Cakouros, Tasman J. Daish, Kathryn Mills, and Sharad Kumar

An Arginine-Histone Methyltransferase, CARMER, Coordinates Ecdysone-mediated Apoptosis in Drosophila Cells
J. Biol. Chem. 2004 279: 18467-18471. First Published on February 19, 2004; doi:10.1074/jbc.M400972200 [Abstract] [Full Text] [PDF]  

Kaija Alfthan, Leena Heiska, Mikaela Grönholm, G. Herma Renkema, and Olli Carpén

Cyclic AMP-dependent Protein Kinase Phosphorylates Merlin at Serine 518 Independently of p21-activated Kinase and Promotes Merlin-Ezrin Heterodimerization
J. Biol. Chem. 2004 279: 18559-18566. First Published on February 23, 2004; doi:10.1074/jbc.M313916200 [Abstract] [Full Text] [PDF]  

Guie Gu, Jing Yang, Kathleen A. Mitchell, and Joseph E. O'Tousa

Drosophila NinaB and NinaD Act Outside of Retina to Produce Rhodopsin Chromophore
J. Biol. Chem. 2004 279: 18608-18613. First Published on February 24, 2004; doi:10.1074/jbc.M400323200 [Abstract] [Full Text] [PDF]  

Eiko Oita, Kaori Harada, and Kazuyoshi Chiba

Degradation of Polyubiquitinated Cyclin B Is Blocked by the MAPK Pathway at the Metaphase I Arrest in Starfish Oocytes
J. Biol. Chem. 2004 279: 18633-18640. First Published on February 25, 2004; doi:10.1074/jbc.M311122200 [Abstract] [Full Text] [PDF]  

Nils Schrader, Eun Young Kim, Jan Winking, Jens Paulukat, Hermann Schindelin, and Günter Schwarz

Biochemical Characterization of the High Affinity Binding between the Glycine Receptor and Gephyrin
J. Biol. Chem. 2004 279: 18733-18741. First Published on February 19, 2004; doi:10.1074/jbc.M311245200 [Abstract] [Full Text] [PDF]  

Wanli Liu, Li Tang, Ge Zhang, Handong Wei, Yufang Cui, Lihai Guo, Zikuan Gou, Xiaoxiao Chen, Daifeng Jiang, Yunping Zhu, Gefei Kang, and Fuchu He

Characterization of a Novel C-type Lectin-like Gene, LSECtin: DEMONSTRATION OF CARBOHYDRATE BINDING AND EXPRESSION IN SINUSOIDAL ENDOTHELIAL CELLS OF LIVER AND LYMPH NODE
J. Biol. Chem. 2004 279: 18748-18758. First Published on January 7, 2004; doi:10.1074/jbc.M311227200 [Abstract] [Full Text] [PDF]  

Peter L. Ferguson and Gary S. Shaw

Human S100B Protein Interacts with the Escherichia coli Division Protein FtsZ in a Calcium-sensitive Manner
J. Biol. Chem. 2004 279: 18806-18813. First Published on February 15, 2004; doi:10.1074/jbc.M313948200 [Abstract] [Full Text] [PDF]  

Diane C. Lagace and Mark W. Nachtigal

Inhibition of Histone Deacetylase Activity by Valproic Acid Blocks Adipogenesis
J. Biol. Chem. 2004 279: 18851-18860. First Published on February 24, 2004; doi:10.1074/jbc.M312795200 [Abstract] [Full Text] [PDF]  

Timothy F. Plageman, Jr. and Katherine E. Yutzey

Differential Expression and Function of Tbx5 and Tbx20 in Cardiac Development
J. Biol. Chem. 2004 279: 19026-19034. First Published on February 20, 2004; doi:10.1074/jbc.M314041200 [Abstract] [Full Text] [PDF]  

Ling Ye, Mary MacDougall, Shubin Zhang, Yixia Xie, Jianghong Zhang, Zubing Li, Yongbo Lu, Yuji Mishina, and Jian Q. Feng

Deletion of Dentin Matrix Protein-1 Leads to a Partial Failure of Maturation of Predentin into Dentin, Hypomineralization, and Expanded Cavities of Pulp and Root Canal during Postnatal Tooth Development
J. Biol. Chem. 2004 279: 19141-19148. First Published on February 13, 2004; doi:10.1074/jbc.M400490200 [Abstract] [Full Text] [PDF]  

Tamsin Thomas, Debra Telford, and Dale W. Laird

Functional Domain Mapping and Selective Trans-dominant Effects Exhibited by Cx26 Disease-causing Mutations
J. Biol. Chem. 2004 279: 19157-19168. First Published on February 19, 2004; doi:10.1074/jbc.M314117200 [Abstract] [Full Text] [PDF]  

Lee A. Ligon, Mariko Tokito, Jeffrey M. Finklestein, Francesca E. Grossman, and Erika L. F. Holzbaur

A Direct Interaction between Cytoplasmic Dynein and Kinesin I May Coordinate Motor Activity
J. Biol. Chem. 2004 279: 19201-19208. First Published on February 24, 2004; doi:10.1074/jbc.M313472200 [Abstract] [Full Text] [PDF]  

Togo Ikuta, Yasuhito Kobayashi, and Kaname Kawajiri

Cell Density Regulates Intracellular Localization of Aryl Hydrocarbon Receptor
J. Biol. Chem. 2004 279: 19209-19216. First Published on February 25, 2004; doi:10.1074/jbc.M310492200 [Abstract] [Full Text] [PDF]  

Christopher G. Kevil, A. Wayne Orr, Will Langston, Kathryn Mickett, Joanne Murphy-Ullrich, Rakesh P. Patel, Dennis F. Kucik, and Daniel C. Bullard

Intercellular Adhesion Molecule-1 (ICAM-1) Regulates Endothelial Cell Motility through a Nitric Oxide-dependent Pathway
J. Biol. Chem. 2004 279: 19230-19238. First Published on February 24, 2004; doi:10.1074/jbc.M312025200 [Abstract] [Full Text] [PDF]  

Kohsuke Kanekura, Yuichi Hashimoto, Takako Niikura, Sadakazu Aiso, Masaaki Matsuoka, and Ikuo Nishimoto

Alsin, the Product of ALS2 Gene, Suppresses SOD1 Mutant Neurotoxicity through RhoGEF Domain by Interacting with SOD1 Mutants
J. Biol. Chem. 2004 279: 19247-19256. First Published on February 16, 2004; doi:10.1074/jbc.M313236200 [Abstract] [Full Text] [PDF]  

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