JBC Focus on PI3-Kinase with Echelon

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Table of Contents: May 14 2004; 279 (20)   [Index by Author]  [Cover Figure and Caption]
       Minireviews
       Accelerated Publications
       DNA: Replication, Repair, and Recombination
       Genes: Structure and Regulation
       RNA: Structure, Metabolism, and Catalysis
       Protein Synthesis, Post-Translation Modification, and Degradation
       Genomics, Proteomics, and Bioinformatics
       Protein Structure and Folding
       Enzyme Catalysis and Regulation
       Metabolism and Bioenergetics
       Glycobiology and Extracellular Matrices
       Lipids and Lipoproteins
       Membrane Transport, Structure, Function, and Biogenesis
       Mechanisms Of Signal Transduction
       Molecular Basis Of Cell and Developmental Biology
       Additions and Corrections
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Minireviews:

Brigitte Anliker and Jerold Chun
Lysophospholipid G Protein-coupled Receptors
J. Biol. Chem. 2004 279: 20555-20558. First Published on March 15, 2004; doi:10.1074/jbc.R400013200 [Abstract] [Full Text] [PDF]  


Accelerated Publications:

Christian Mielke, Morten O. Christensen, Hans Ullrich Barthelmes, and Fritz Boege
Enhanced Processing of UVA-irradiated DNA by Human Topoisomerase II in Living Cells
J. Biol. Chem. 2004 279: 20559-20562. First Published on March 23, 2004; doi:10.1074/jbc.C400032200 [Abstract] [Full Text] [PDF] Supplemental Data  

Ruth Cordoba-Rodriguez, Hui Fang, Carla S. R. Lankford, and David M. Frucht
Anthrax Lethal Toxin Rapidly Activates Caspase-1/ICE and Induces Extracellular Release of Interleukin (IL)-1{beta} and IL-18
J. Biol. Chem. 2004 279: 20563-20566. First Published on March 9, 2004; doi:10.1074/jbc.C300539200 [Abstract] [Full Text] [PDF]  

Declan J. James, Christine Salaün, Fiona M. Brandie, John M. C. Connell, and Luke H. Chamberlain
Neomycin Prevents the Wortmannin Inhibition of Insulin-stimulated Glut4 Translocation and Glucose Transport in 3T3-L1 Adipocytes
J. Biol. Chem. 2004 279: 20567-20570. First Published on March 15, 2004; doi:10.1074/jbc.C400096200 [Abstract] [Full Text] [PDF]  


DNA: Replication, Repair, and Recombination:

Chunling Gong, Alexandra Martins, Paola Bongiorno, Michael Glickman, and Stewart Shuman
Biochemical and Genetic Analysis of the Four DNA Ligases of Mycobacteria
J. Biol. Chem. 2004 279: 20594-20606. First Published on February 25, 2004; doi:10.1074/jbc.M401841200 [Abstract] [Full Text] [PDF]  

Jerzy Majka, Brian Y. Chung, and Peter M. J. Burgers
Requirement for ATP by the DNA Damage Checkpoint Clamp Loader
J. Biol. Chem. 2004 279: 20921-20926. First Published on March 9, 2004; doi:10.1074/jbc.M400898200 [Abstract] [Full Text] [PDF]  

Fenghua Yuan, Liya Gu, Shuangli Guo, Chunmei Wang, and Guo-Min Li
Evidence for Involvement of HMGB1 Protein in Human DNA Mismatch Repair
J. Biol. Chem. 2004 279: 20935-20940. First Published on March 9, 2004; doi:10.1074/jbc.M401931200 [Abstract] [Full Text] [PDF]  

Wen-Hsing Cheng, Cayetano von Kobbe, Patricia L. Opresko, L. Matthew Arthur, Kenshi Komatsu, Michael M. Seidman, James P. Carney, and Vilhelm A. Bohr
Linkage between Werner Syndrome Protein and the Mre11 Complex via Nbs1
J. Biol. Chem. 2004 279: 21169-21176. First Published on March 16, 2004; doi:10.1074/jbc.M312770200 [Abstract] [Full Text] [PDF]  

Paola Fiorani, Robert J. D. Reid, Antonino Schepis, Hervé R. Jacquiau, Hong Guo, Padma Thimmaiah, Piero Benedetti, and Mary-Ann Bjornsti
The Deubiquitinating Enzyme Doa4p Protects Cells from DNA Topoisomerase I Poisons
J. Biol. Chem. 2004 279: 21271-21281. First Published on February 26, 2004; doi:10.1074/jbc.M312338200 [Abstract] [Full Text] [PDF]  

Peter McInerney and Mike O'Donnell
Functional Uncoupling of Twin Polymerases: MECHANISM OF POLYMERASE DISSOCIATION FROM A LAGGING-STRAND BLOCK
J. Biol. Chem. 2004 279: 21543-21551. First Published on March 9, 2004; doi:10.1074/jbc.M401649200 [Abstract] [Full Text] [PDF]  


Genes: Structure and Regulation:

Takashi Minami, Takeshi Murakami, Keiko Horiuchi, Mai Miura, Tamio Noguchi, Jun-ichi Miyazaki, Takao Hamakubo, William C. Aird, and Tatsuhiko Kodama
Interaction between Hex and GATA Transcription Factors in Vascular Endothelial Cells Inhibits flk-1/KDR-mediated Vascular Endothelial Growth Factor Signaling
J. Biol. Chem. 2004 279: 20626-20635. First Published on March 10, 2004; doi:10.1074/jbc.M308730200 [Abstract] [Full Text] [PDF]  

Elisa Guffanti, Roberto Corradini, Simone Ottonello, and Giorgio Dieci
Functional Dissection of RNA Polymerase III Termination Using a Peptide Nucleic Acid as a Transcriptional Roadblock
J. Biol. Chem. 2004 279: 20708-20716. First Published on February 17, 2004; doi:10.1074/jbc.M311295200 [Abstract] [Full Text] [PDF]  

Haiping Kou and B. Franklin Pugh
Engineering Dimer-stabilizing Mutations in the TATA-binding Protein
J. Biol. Chem. 2004 279: 20966-20973. First Published on March 12, 2004; doi:10.1074/jbc.M401535200 [Abstract] [Full Text] [PDF]  

Xiao-Ming Ou, Kevin Chen, and Jean C. Shih
Dual Functions of Transcription Factors, Transforming Growth Factor-{beta}-inducible Early Gene (TIEG)2 and Sp3, Are Mediated by CACCC Element and Sp1 Sites of Human Monoamine Oxidase (MAO) B Gene
J. Biol. Chem. 2004 279: 21021-21028. First Published on March 15, 2004; doi:10.1074/jbc.M312638200 [Abstract] [Full Text] [PDF]  

Matías Blaustein, Federico Pelisch, Omar A. Coso, Mina J. Bissell, Alberto R. Kornblihtt, and Anabella Srebrow
Mammary Epithelial-Mesenchymal Interaction Regulates Fibronectin Alternative Splicing via Phosphatidylinositol 3-Kinase
J. Biol. Chem. 2004 279: 21029-21037. First Published on March 17, 2004; doi:10.1074/jbc.M314260200 [Abstract] [Full Text] [PDF]  

Donna J. Thuerauf, Lisa Morrison, and Christopher C. Glembotski
Opposing Roles for ATF6{alpha} and ATF6{beta} in Endoplasmic Reticulum Stress Response Gene Induction
J. Biol. Chem. 2004 279: 21078-21084. First Published on February 18, 2004; doi:10.1074/jbc.M400713200 [Abstract] [Full Text] [PDF]  

Shazia Irshad, R. Barbara Pedley, John Anderson, David S. Latchman, and Vishwanie Budhram-Mahadeo
The Brn-3b Transcription Factor Regulates the Growth, Behavior, and Invasiveness of Human Neuroblastoma Cells in Vitro and in Vivo
J. Biol. Chem. 2004 279: 21617-21627. First Published on February 16, 2004; doi:10.1074/jbc.M312506200 [Abstract] [Full Text] [PDF]  


RNA: Structure, Metabolism, and Catalysis:

Junjie Zhang, Yonglong Zhang, Ling Zhu, Motoo Suzuki, and Masayori Inouye
Interference of mRNA Function by Sequence-specific Endoribonuclease PemK
J. Biol. Chem. 2004 279: 20678-20684. First Published on March 15, 2004; doi:10.1074/jbc.M314284200 [Abstract] [Full Text] [PDF]  

Heping Cao, Jane S. Tuttle, and Perry J. Blackshear
Immunological Characterization of Tristetraprolin as a Low Abundance, Inducible, Stable Cytosolic Protein
J. Biol. Chem. 2004 279: 21489-21499. First Published on March 9, 2004; doi:10.1074/jbc.M400900200 [Abstract] [Full Text] [PDF]  


Protein Synthesis, Post-Translation Modification, and Degradation:

Gary D. Minsavage, Sang-ki Park, and Thomas A. Gasiewicz
The Aryl Hydrocarbon Receptor (AhR) Tyrosine 9, a Residue That Is Essential for AhR DNA Binding Activity, Is Not a Phosphoresidue but Augments AhR Phosphorylation
J. Biol. Chem. 2004 279: 20582-20593. First Published on February 20, 2004; doi:10.1074/jbc.M312977200 [Abstract] [Full Text] [PDF]  

Kenneth V. Mills, Jennifer S. Manning, Alicia M. Garcia, and Lisa A. Wuerdeman
Protein Splicing of a Pyrococcus abyssi Intein with a C-terminal Glutamine
J. Biol. Chem. 2004 279: 20685-20691. First Published on March 15, 2004; doi:10.1074/jbc.M400887200 [Abstract] [Full Text] [PDF]  

Jing Nie, Shawn S.-C. Li, and C. Jane McGlade
A Novel PTB-PDZ Domain Interaction Mediates Isoform-specific Ubiquitylation of Mammalian Numb
J. Biol. Chem. 2004 279: 20807-20815. First Published on February 27, 2004; doi:10.1074/jbc.M311396200 [Abstract] [Full Text] [PDF]  

Kenichi Otani, Dong-Ho Han, Eric L. Ford, Pablo M. Garcia-Roves, Honggang Ye, Yukio Horikawa, Graeme I. Bell, John O. Holloszy, and Kenneth S. Polonsky
Calpain System Regulates Muscle Mass and Glucose Transporter GLUT4 Turnover
J. Biol. Chem. 2004 279: 20915-20920. First Published on March 9, 2004; doi:10.1074/jbc.M400213200 [Abstract] [Full Text] [PDF]  

Sandro Goruppi and John M. Kyriakis
The Pro-hypertrophic Basic Helix-Loop-Helix Protein p8 Is Degraded by the Ubiquitin/Proteasome System in a Protein Kinase B/Akt- and Glycogen Synthase Kinase-3-dependent Manner, whereas Endothelin Induction of p8 mRNA and Renal Mesangial Cell Hypertrophy Require NFAT4
J. Biol. Chem. 2004 279: 20950-20958. First Published on March 11, 2004; doi:10.1074/jbc.M312401200 [Abstract] [Full Text] [PDF]  

Mingsheng Zhang, Alasdair I. MacDonald, Martin A. Hoyt, and Philip Coffino
Proteasomes Begin Ornithine Decarboxylase Digestion at the C Terminus
J. Biol. Chem. 2004 279: 20959-20965. First Published on March 11, 2004; doi:10.1074/jbc.M314043200 [Abstract] [Full Text] [PDF]  

Daniel M. Janse, Bernat Crosas, Daniel Finley, and George M. Church
Localization to the Proteasome Is Sufficient for Degradation
J. Biol. Chem. 2004 279: 21415-21420. First Published on March 23, 2004; doi:10.1074/jbc.M402954200 [Abstract] [Full Text] [PDF]  


Genomics, Proteomics, and Bioinformatics:

Yingming Zhao, Sung Won Kwon, Anthony Anselmo, Kiran Kaur, and Michael A. White
Broad Spectrum Identification of Cellular Small Ubiquitin-related Modifier (SUMO) Substrate Proteins
J. Biol. Chem. 2004 279: 20999-21002. First Published on March 11, 2004; doi:10.1074/jbc.M401541200 [Abstract] [Full Text] [PDF]  

Junmin Peng, Myung Jong Kim, Dongmei Cheng, Duc M. Duong, Steven P. Gygi, and Morgan Sheng
Semiquantitative Proteomic Analysis of Rat Forebrain Postsynaptic Density Fractions by Mass Spectrometry
J. Biol. Chem. 2004 279: 21003-21011. First Published on March 12, 2004; doi:10.1074/jbc.M400103200 [Abstract] [Full Text] [PDF] Supplemental Data  

Patricia S. Kho, Zhen Wang, Li Zhuang, Yuqing Li, Joon-Lin Chew, Huck-Hui Ng, Edison T. Liu, and Qiang Yu
p53-regulated Transcriptional Program Associated with Genotoxic Stress-induced Apoptosis
J. Biol. Chem. 2004 279: 21183-21192. First Published on March 11, 2004; doi:10.1074/jbc.M311912200 [Abstract] [Full Text] [PDF] Supplemental Data  

Ranjoo Hwang, Eun Jin Lee, Myoung Hee Kim, Song-Zhe Li, Yong-Jun Jin, Yumie Rhee, Yoo Mee Kim, and Sung-Kil Lim
Calcyclin, a Ca2+ Ion-binding Protein, Contributes to the Anabolic Effects of Simvastatin on Bone
J. Biol. Chem. 2004 279: 21239-21247. First Published on February 18, 2004; doi:10.1074/jbc.M312771200 [Abstract] [Full Text] [PDF]  

Natalya V. Narizhneva, Vicky J. Byers-Ward, Martin J. Quinn, Frank J. Zidar, Edward F. Plow, Eric J. Topol, and Tatiana V. Byzova
Molecular and Functional Differences Induced in Thrombospondin-1 by the Single Nucleotide Polymorphism Associated with the Risk of Premature, Familial Myocardial Infarction
J. Biol. Chem. 2004 279: 21651-21657. First Published on March 8, 2004; doi:10.1074/jbc.M311090200 [Abstract] [Full Text] [PDF]  


Protein Structure and Folding:

Tristan P. Wallis, Chang-Yi Huang, Subodh B. Nimkar, Paul R. Young, and Jeffrey J. Gorman
Determination of the Disulfide Bond Arrangement of Dengue Virus NS1 Protein
J. Biol. Chem. 2004 279: 20729-20741. First Published on February 23, 2004; doi:10.1074/jbc.M312907200 [Abstract] [Full Text] [PDF] Supplemental Data  

Brian Tripet, Megan W. Howard, Michael Jobling, Randall K. Holmes, Kathryn V. Holmes, and Robert S. Hodges
Structural Characterization of the SARS-Coronavirus Spike S Fusion Protein Core
J. Biol. Chem. 2004 279: 20836-20849. First Published on March 2, 2004; doi:10.1074/jbc.M400759200 [Abstract] [Full Text] [PDF]  

Christopher A. MacRaild, Cameron R. Stewart, Yee-Foong Mok, Menachem J. Gunzburg, Matthew A. Perugini, Lynne J. Lawrence, Viyada Tirtaatmadja, Justin J. Cooper-White, and Geoffrey J. Howlett
Non-fibrillar Components of Amyloid Deposits Mediate the Self-association and Tangling of Amyloid Fibrils
J. Biol. Chem. 2004 279: 21038-21045. First Published on March 18, 2004; doi:10.1074/jbc.M314008200 [Abstract] [Full Text] [PDF]  

Masaki Unno, Toshitaka Matsui, Grace C. Chu, Manon Couture, Tadashi Yoshida, Denis L. Rousseau, John. S. Olson, and Masao Ikeda-Saito
Crystal Structure of the Dioxygen-bound Heme Oxygenase from Corynebacterium diphtheriae: IMPLICATIONS FOR HEME OXYGENASE FUNCTION
J. Biol. Chem. 2004 279: 21055-21061. First Published on February 13, 2004; doi:10.1074/jbc.M400491200 [Abstract] [Full Text] [PDF] Supplemental Data  

Ibtihal Fadhil, Ralf Schmidt, Chris Walpole, and Katharine A. Carpenter
Exploring Deltorphin II Binding to the Third Extracellular Loop of the {delta}-Opioid Receptor
J. Biol. Chem. 2004 279: 21069-21077. First Published on March 3, 2004; doi:10.1074/jbc.M311468200 [Abstract] [Full Text] [PDF]  

Doron Gerber, Neta Sal-Man, and Yechiel Shai
Two Motifs within a Transmembrane Domain, One for Homodimerization and the Other for Heterodimerization
J. Biol. Chem. 2004 279: 21177-21182. First Published on February 25, 2004; doi:10.1074/jbc.M400847200 [Abstract] [Full Text] [PDF]  

Yoko Oma, Yoshihiro Kino, Noboru Sasagawa, and Shoichi Ishiura
Intracellular Localization of Homopolymeric Amino Acid-containing Proteins Expressed in Mammalian Cells
J. Biol. Chem. 2004 279: 21217-21222. First Published on March 1, 2004; doi:10.1074/jbc.M309887200 [Abstract] [Full Text] [PDF]  

Flemming Larsen, Hans O. Madsen, Robert B. Sim, Claus Koch, and Peter Garred
Disease-associated Mutations in Human Mannose-binding Lectin Compromise Oligomerization and Activity of the Final Protein
J. Biol. Chem. 2004 279: 21302-21311. First Published on February 5, 2004; doi:10.1074/jbc.M400520200 [Abstract] [Full Text] [PDF]  

Laurent Volpon, Hung Lamthanh, Julien Barbier, Nicolas Gilles, Jordi Molgó, André Ménez, and Jean-Marc Lancelin
NMR Solution Structures of {delta}-Conotoxin EVIA from Conus ermineus That Selectively Acts on Vertebrate Neuronal Na+ Channels
J. Biol. Chem. 2004 279: 21356-21366. First Published on February 19, 2004; doi:10.1074/jbc.M309594200 [Abstract] [Full Text] [PDF] Supplemental Data  

Taku Yamashita, Yohei Hoashi, Kimiko Watanabe, Yoshikazu Tomisugi, Yoshinobu Ishikawa, and Tadayuki Uno
Roles of Heme Axial Ligands in the Regulation of CO Binding to CooA
J. Biol. Chem. 2004 279: 21394-21400. First Published on March 16, 2004; doi:10.1074/jbc.M400512200 [Abstract] [Full Text] [PDF]  

Márcia Almeida Liz, Carlos José Faro, Maria João Saraiva, and Mónica Mendes Sousa
Transthyretin, a New Cryptic Protease
J. Biol. Chem. 2004 279: 21431-21438. First Published on March 19, 2004; doi:10.1074/jbc.M402212200 [Abstract] [Full Text] [PDF]  

Qing-xin Hua and Michael A. Weiss
Mechanism of Insulin Fibrillation: THE STRUCTURE OF INSULIN UNDER AMYLOIDOGENIC CONDITIONS RESEMBLES A PROTEIN-FOLDING INTERMEDIATE
J. Biol. Chem. 2004 279: 21449-21460. First Published on February 26, 2004; doi:10.1074/jbc.M314141200 [Abstract] [Full Text] [PDF] Supplemental Data  

Francisco J. Fernandez, M. Cristina Vega, Frank Lehmann, Erika Sandmeier, Heinz Gehring, Philipp Christen, and Matthias Wilmanns
Structural Studies of the Catalytic Reaction Pathway of a Hyperthermophilic Histidinol-phosphate Aminotransferase
J. Biol. Chem. 2004 279: 21478-21488. First Published on March 8, 2004; doi:10.1074/jbc.M400291200 [Abstract] [Full Text] [PDF]  

Alexander Wlodawer, Mi Li, Alla Gustchina, Naoki Tsuruoka, Masako Ashida, Hiroyuki Minakata, Hiroshi Oyama, Kohei Oda, Tokuzo Nishino, and Toru Nakayama
Crystallographic and Biochemical Investigations of Kumamolisin-As, a Serine-Carboxyl Peptidase with Collagenase Activity
J. Biol. Chem. 2004 279: 21500-21510. First Published on March 10, 2004; doi:10.1074/jbc.M401141200 [Abstract] [Full Text] [PDF]  

Mario Milani, Alessandra Pesce, Yannick Ouellet, Sylvia Dewilde, Joel Friedman, Paolo Ascenzi, Michel Guertin, and Martino Bolognesi
Heme-Ligand Tunneling in Group I Truncated Hemoglobins
J. Biol. Chem. 2004 279: 21520-21525. First Published on March 11, 2004; doi:10.1074/jbc.M401320200 [Abstract] [Full Text] [PDF]  

Asako Kamada, Hisao Nagaya, Taku Tamura, Masataka Kinjo, Hai-Ying Jin, Toshiharu Yamashita, Kowichi Jimbow, Hideo Kanoh, and Ikuo Wada
Regulation of Immature Protein Dynamics in the Endoplasmic Reticulum
J. Biol. Chem. 2004 279: 21533-21542. First Published on February 19, 2004; doi:10.1074/jbc.M401403200 [Abstract] [Full Text] [PDF]  

Joanna L. Henshaw, David N. Bolam, Virgínia M. R. Pires, Mirjam Czjzek, Bernard Henrissat, Luis M. A. Ferreira, Carlos M. G. A. Fontes, and Harry J. Gilbert
The Family 6 Carbohydrate Binding Module CmCBM6-2 Contains Two Ligand-binding Sites with Distinct Specificities
J. Biol. Chem. 2004 279: 21552-21559. First Published on March 5, 2004; doi:10.1074/jbc.M401620200 [Abstract] [Full Text] [PDF] Supplemental Data  

Virgínia M. R. Pires, Joanna L. Henshaw, José A. M. Prates, David N. Bolam, Luís M. A. Ferreira, Carlos M. G. A. Fontes, Bernard Henrissat, Antoni Planas, Harry J. Gilbert, and Mirjam Czjzek
The Crystal Structure of the Family 6 Carbohydrate Binding Module from Cellvibrio mixtus Endoglucanase 5A in Complex with Oligosaccharides Reveals Two Distinct Binding Sites with Different Ligand Specificities
J. Biol. Chem. 2004 279: 21560-21568. First Published on March 8, 2004; doi:10.1074/jbc.M401599200 [Abstract] [Full Text] [PDF]  

Stanley C. Kwok and Robert S. Hodges
Stabilizing and Destabilizing Clusters in the Hydrophobic Core of Long Two-stranded {alpha}-Helical Coiled-coils
J. Biol. Chem. 2004 279: 21576-21588. First Published on March 11, 2004; doi:10.1074/jbc.M401074200 [Abstract] [Full Text] [PDF]  


Enzyme Catalysis and Regulation:

Takashi Kikuma, Masaya Ohtsu, Takahiko Utsugi, Shoko Koga, Kohji Okuhara, Toshihiko Eki, Fumihiro Fujimori, and Yasufumi Murakami
Dbp9p, a Member of the DEAD Box Protein Family, Exhibits DNA Helicase Activity
J. Biol. Chem. 2004 279: 20692-20698. First Published on March 17, 2004; doi:10.1074/jbc.M400231200 [Abstract] [Full Text] [PDF]  

Michelle E. Peterson, Robert Eisenthal, Michael J. Danson, Alastair Spence, and Roy M. Daniel
A New Intrinsic Thermal Parameter for Enzymes Reveals True Temperature Optima
J. Biol. Chem. 2004 279: 20717-20722. First Published on February 18, 2004; doi:10.1074/jbc.M309143200 [Abstract] [Full Text] [PDF]  

Yuh-Ping Chong, Terrence D. Mulhern, Hong-Jian Zhu, Donald J. Fujita, Jeffrey D. Bjorge, John-Paul Tantiongco, Nikolaos Sotirellis, Daisy Sio Seng Lio, Glen Scholz, and Heung-Chin Cheng
A Novel Non-catalytic Mechanism Employed by the C-terminal Src-homologous Kinase to Inhibit Src-family Kinase Activity
J. Biol. Chem. 2004 279: 20752-20766. First Published on February 25, 2004; doi:10.1074/jbc.M309865200 [Abstract] [Full Text] [PDF] Supplemental Data  

Peter Tompa, Peter Buzder-Lantos, Agnes Tantos, Attila Farkas, András Szilágyi, Zoltán Bánóczi, Ferenc Hudecz, and Peter Friedrich
On the Sequential Determinants of Calpain Cleavage
J. Biol. Chem. 2004 279: 20775-20785. First Published on February 26, 2004; doi:10.1074/jbc.M313873200 [Abstract] [Full Text] [PDF]  

Danilo S. Boskovic, Thomas Troxler, and Sriram Krishnaswamy
Active Site-independent Recognition of Substrates and Product by Bovine Prothrombinase: A FLUORESCENCE RESONANCE ENERGY TRANSFER STUDY
J. Biol. Chem. 2004 279: 20786-20793. First Published on February 26, 2004; doi:10.1074/jbc.M400469200 [Abstract] [Full Text] [PDF]  

Mario Gonzalez-Gronow, Michael S. Hershfield, Francisco X. Arredondo-Vega, and Salvatore V. Pizzo
Cell Surface Adenosine Deaminase Binds and Stimulates Plasminogen Activation on 1-LN Human Prostate Cancer Cells
J. Biol. Chem. 2004 279: 20993-20998. First Published on March 11, 2004; doi:10.1074/jbc.M401023200 [Abstract] [Full Text] [PDF]  

Mrinalini Puranik, Steen Brøndsted Nielsen, Hwan Youn, Angela N. Hvitved, James L. Bourassa, Martin A. Case, Charbel Tengroth, Gurusamy Balakrishnan, Marc V. Thorsteinsson, John T. Groves, George L. McLendon, Gary P. Roberts, John S. Olson, and Thomas G. Spiro
Dynamics of Carbon Monoxide Binding to CooA
J. Biol. Chem. 2004 279: 21096-21108. First Published on February 27, 2004; doi:10.1074/jbc.M400613200 [Abstract] [Full Text] [PDF]  

Jing-Ya Li, Yong-Mei Cui, Ling-Ling Chen, Min Gu, Jia Li, Fa-Jun Nan, and Qi-Zhuang Ye
Mutations at the S1 Sites of Methionine Aminopeptidases from Escherichia coli and Homo sapiens Reveal the Residues Critical for Substrate Specificity
J. Biol. Chem. 2004 279: 21128-21134. First Published on February 19, 2004; doi:10.1074/jbc.M401679200 [Abstract] [Full Text] [PDF]  

John E. Pimanda, Tim Ganderton, Akiko Maekawa, Cindy L. Yap, Jack Lawler, Geoff Kershaw, Colin N. Chesterman, and Philip J. Hogg
Role of Thrombospondin-1 in Control of von Willebrand Factor Multimer Size in Mice
J. Biol. Chem. 2004 279: 21439-21448. First Published on February 23, 2004; doi:10.1074/jbc.M313560200 [Abstract] [Full Text] [PDF]  

Hidenori Taru and Toshiharu Suzuki
Facilitation of Stress-induced Phosphorylation of {beta}-Amyloid Precursor Protein Family Members by X11-like/Mint2 Protein
J. Biol. Chem. 2004 279: 21628-21636. First Published on February 17, 2004; doi:10.1074/jbc.M312007200 [Abstract] [Full Text] [PDF] Supplemental Data  

Raffaella Toso and Rodney M. Camire
Removal of B-domain Sequences from Factor V Rather than Specific Proteolysis Underlies the Mechanism by Which Cofactor Function Is Realized
J. Biol. Chem. 2004 279: 21643-21650. First Published on March 5, 2004; doi:10.1074/jbc.M402107200 [Abstract] [Full Text] [PDF]  


Metabolism and Bioenergetics:

Naoya Yahagi, Hitoshi Shimano, Takashi Matsuzaka, Motohiro Sekiya, Yuho Najima, Sachiko Okazaki, Hiroaki Okazaki, Yoshiaki Tamura, Yoko Iizuka, Noriyuki Inoue, Yoshimi Nakagawa, Yoshinori Takeuchi, Ken Ohashi, Kenji Harada, Takanari Gotoda, Ryozo Nagai, Takashi Kadowaki, Shun Ishibashi, Jun-ichi Osuga, and Nobuhiro Yamada
p53 Involvement in the Pathogenesis of Fatty Liver Disease
J. Biol. Chem. 2004 279: 20571-20575. First Published on February 25, 2004; doi:10.1074/jbc.M400884200 [Abstract] [Full Text] [PDF]  

Glendon Parker, Rodrick Taylor, Deborah Jones, and Donald McClain
Hyperglycemia and Inhibition of Glycogen Synthase in Streptozotocin-treated Mice: ROLE OF O-LINKED N-ACETYLGLUCOSAMINE
J. Biol. Chem. 2004 279: 20636-20642. First Published on March 10, 2004; doi:10.1074/jbc.M312139200 [Abstract] [Full Text] [PDF]  

Ljuban Grgic, Klaus Zwicker, Noushin Kashani-Poor, Stefan Kerscher, and Ulrich Brandt
Functional Significance of Conserved Histidines and Arginines in the 49-kDa Subunit of Mitochondrial Complex I
J. Biol. Chem. 2004 279: 21193-21199. First Published on March 5, 2004; doi:10.1074/jbc.M313180200 [Abstract] [Full Text] [PDF]  

Karin Türk, Andrea Puhar, Frank Neese, Eckhard Bill, Günter Fritz, and Julia Steuber
NADH Oxidation by the Na+-translocating NADH:Quinone Oxidoreductase from Vibrio cholerae: FUNCTIONAL ROLE OF THE NqrF SUBUNIT
J. Biol. Chem. 2004 279: 21349-21355. First Published on March 9, 2004; doi:10.1074/jbc.M311692200 [Abstract] [Full Text] [PDF]  

Eugenia Carvalho, Sarah E. Schellhorn, Janice M. Zabolotny, Sally Martin, Effie Tozzo, Odile D. Peroni, Karen L. Houseknecht, Adrian Mundt, David E. James, and Barbara B. Kahn
GLUT4 Overexpression or Deficiency in Adipocytes of Transgenic Mice Alters the Composition of GLUT4 Vesicles and the Subcellular Localization of GLUT4 and Insulin-responsive Aminopeptidase
J. Biol. Chem. 2004 279: 21598-21605. First Published on February 24, 2004; doi:10.1074/jbc.M312269200 [Abstract] [Full Text] [PDF]  


Glycobiology and Extracellular Matrices:

Jamie Monslow, John D. Williams, Carol A. Guy, Iain K. Price, Kathrine J. Craig, Hywel J. Williams, Nigel M. Williams, John Martin, Sharon L. Coleman, Nicholas Topley, Andrew P. Spicer, Paul R. Buckland, Malcolm Davies, and Timothy Bowen
Identification and Analysis of the Promoter Region of the Human Hyaluronan Synthase 2 Gene
J. Biol. Chem. 2004 279: 20576-20581. First Published on February 25, 2004; doi:10.1074/jbc.M312666200 [Abstract] [Full Text] [PDF]  

Fábio R. Melo, Mariana S. Pereira, Débora Foguel, and Paulo A. S. Mourão
Antithrombin-mediated Anticoagulant Activity of Sulfated Polysaccharides: DIFFERENT MECHANISMS FOR HEPARIN AND SULFATED GALACTANS
J. Biol. Chem. 2004 279: 20824-20835. First Published on March 2, 2004; doi:10.1074/jbc.M308688200 [Abstract] [Full Text] [PDF]  

Marco Strazynski, Johannes A. Eble, Hans Kresse, and Elke Schönherr
Interleukin (IL)-6 and IL-10 Induce Decorin mRNA in Endothelial Cells, but Interaction with Fibrillar Collagen Is Essential for Its Translation
J. Biol. Chem. 2004 279: 21266-21270. First Published on March 10, 2004; doi:10.1074/jbc.M309782200 [Abstract] [Full Text] [PDF]  

Simon Stephan, Michael J. Sherratt, Nigel Hodson, C. Adrian Shuttleworth, and Cay M. Kielty
Expression and Supramolecular Assembly of Recombinant {alpha}1(VIII) and {alpha}2(VIII) Collagen Homotrimers
J. Biol. Chem. 2004 279: 21469-21477. First Published on February 27, 2004; doi:10.1074/jbc.M305805200 [Abstract] [Full Text] [PDF]  

Susana M. Casalino-Matsuda, Maria Elena Monzon, Gregory E. Conner, Matthias Salathe, and Rosanna M. Forteza
Role of Hyaluronan and Reactive Oxygen Species in Tissue Kallikrein-mediated Epidermal Growth Factor Receptor Activation in Human Airways
J. Biol. Chem. 2004 279: 21606-21616. First Published on February 26, 2004; doi:10.1074/jbc.M309950200 [Abstract] [Full Text] [PDF]  


Lipids and Lipoproteins:

Michael Walter, Nicholas R. Forsyth, Woodring E. Wright, Jerry W. Shay, and Michael G. Roth
The Establishment of Telomerase-immortalized Tangier Disease Cell Lines Indicates the Existence of an Apolipoprotein A-I-inducible but ABCA1-independent Cholesterol Efflux Pathway
J. Biol. Chem. 2004 279: 20866-20873. First Published on March 4, 2004; doi:10.1074/jbc.M401714200 [Abstract] [Full Text] [PDF]  

Taro E. Akiyama, Gilles Lambert, Christopher J. Nicol, Kimihiko Matsusue, Jeffrey M. Peters, H. Bryan Brewer, Jr., and Frank J. Gonzalez
Peroxisome Proliferator-activated Receptor {beta}/{delta} Regulates Very Low Density Lipoprotein Production and Catabolism in Mice on a Western Diet
J. Biol. Chem. 2004 279: 20874-20881. First Published on March 4, 2004; doi:10.1074/jbc.M312802200 [Abstract] [Full Text] [PDF]  

Hiroyuki Saito, Padmaja Dhanasekaran, David Nguyen, Els Deridder, Paul Holvoet, Sissel Lund-Katz, and Michael C. Phillips
{alpha}-Helix Formation Is Required for High Affinity Binding of Human Apolipoprotein A-I to Lipids
J. Biol. Chem. 2004 279: 20974-20981. First Published on March 12, 2004; doi:10.1074/jbc.M402043200 [Abstract] [Full Text] [PDF]  

Ulrich Zähringer, Buko Lindner, Yuriy A. Knirel, Willem M. R. van den Akker, Rosemarie Hiestand, Holger Heine, and Christoph Dehio
Structure and Biological Activity of the Short-chain Lipopolysaccharide from Bartonella henselae ATCC 49882T
J. Biol. Chem. 2004 279: 21046-21054. First Published on February 7, 2004; doi:10.1074/jbc.M313370200 [Abstract] [Full Text] [PDF]  


Membrane Transport, Structure, Function, and Biogenesis:

Joo Hyun Nam, Ji-Eun Woo, Dae-Yong Uhm, and Sung Joon Kim
Membrane-delimited Regulation of Novel Background K+ Channels by MgATP in Murine Immature B Cells
J. Biol. Chem. 2004 279: 20643-20654. First Published on March 10, 2004; doi:10.1074/jbc.M312547200 [Abstract] [Full Text] [PDF]  

Yelena V. Budovskaya, Joseph S. Stephan, Fulvio Reggiori, Daniel J. Klionsky, and Paul K. Herman
The Ras/cAMP-dependent Protein Kinase Signaling Pathway Regulates an Early Step of the Autophagy Process in Saccharomyces cerevisiae
J. Biol. Chem. 2004 279: 20663-20671. First Published on March 11, 2004; doi:10.1074/jbc.M400272200 [Abstract] [Full Text] [PDF]  

Renae M. Ryan, Ann D. Mitrovic, and Robert J. Vandenberg
The Chloride Permeation Pathway of a Glutamate Transporter and Its Proximity to the Glutamate Translocation Pathway
J. Biol. Chem. 2004 279: 20742-20751. First Published on February 24, 2004; doi:10.1074/jbc.M304433200 [Abstract] [Full Text] [PDF]  

Angelo Vozza, Emanuela Blanco, Luigi Palmieri, and Ferdinando Palmieri
Identification of the Mitochondrial GTP/GDP Transporter in Saccharomyces cerevisiae
J. Biol. Chem. 2004 279: 20850-20857. First Published on March 3, 2004; doi:10.1074/jbc.M313610200 [Abstract] [Full Text] [PDF]  

Marie McConkey, Henry Gillin, Cynthia R. L. Webster, and M. Sawkat Anwer
Cross-talk between Protein Kinases C{zeta} and B in Cyclic AMP-mediated Sodium Taurocholate Co-transporting Polypeptide Translocation in Hepatocytes
J. Biol. Chem. 2004 279: 20882-20888. First Published on March 8, 2004; doi:10.1074/jbc.M309988200 [Abstract] [Full Text] [PDF]  

Natalia Filippova, Virginia E. Wotring, and David S. Weiss
Evidence that the TM1-TM2 Loop Contributes to the {rho}1 GABA Receptor Pore
J. Biol. Chem. 2004 279: 20906-20914. First Published on March 8, 2004; doi:10.1074/jbc.M401012200 [Abstract] [Full Text] [PDF]  

Li-Bin Li, Nianhang Chen, Sammanda Ramamoorthy, Limen Chi, Xiao-Nan Cui, Lijuan C. Wang, and Maarten E. A. Reith
The Role of N-Glycosylation in Function and Surface Trafficking of the Human Dopamine Transporter
J. Biol. Chem. 2004 279: 21012-21020. First Published on March 15, 2004; doi:10.1074/jbc.M311972200 [Abstract] [Full Text] [PDF]  

Renaud Robert, Vincent Thoreau, Caroline Norez, Anne Cantereau, Alain Kitzis, Yvette Mettey, Christian Rogier, and Frédéric Becq
Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Channel by {beta}-Adrenergic Agonists and Vasoactive Intestinal Peptide in Rat Smooth Muscle Cells and Its Role in Vasorelaxation
J. Biol. Chem. 2004 279: 21160-21168. First Published on March 11, 2004; doi:10.1074/jbc.M312199200 [Abstract] [Full Text] [PDF]  

Yasuhiko Nakamura, Hiroyuki Suzuki, Masao Sakaguchi, and Katsuyoshi Mihara
Targeting and Assembly of Rat Mitochondrial Translocase of Outer Membrane 22 (TOM22) into the TOM Complex
J. Biol. Chem. 2004 279: 21223-21232. First Published on February 25, 2004; doi:10.1074/jbc.M314156200 [Abstract] [Full Text] [PDF]  

Pilar Domenech, Michael B. Reed, Cynthia S. Dowd, Claudia Manca, Gilla Kaplan, and Clifton E. Barry, III
The Role of MmpL8 in Sulfatide Biogenesis and Virulence of Mycobacterium tuberculosis
J. Biol. Chem. 2004 279: 21257-21265. First Published on March 4, 2004; doi:10.1074/jbc.M400324200 [Abstract] [Full Text] [PDF]  

Svetlana Bahatyrova, Raoul N. Frese, Kees O. van der Werf, Cees Otto, C. Neil Hunter, and John D. Olsen
Flexibility and Size Heterogeneity of the LH1 Light Harvesting Complex Revealed by Atomic Force Microscopy: FUNCTIONAL SIGNIFICANCE FOR BACTERIAL PHOTOSYNTHESIS
J. Biol. Chem. 2004 279: 21327-21333. First Published on March 1, 2004; doi:10.1074/jbc.M313039200 [Abstract] [Full Text] [PDF] Supplemental Data  

Jianbo Dong, Wei Chen, Angela Welford, and Angela Wandinger-Ness
The Proteasome {alpha}-Subunit XAPC7 Interacts Specifically with Rab7 and Late Endosomes
J. Biol. Chem. 2004 279: 21334-21342. First Published on March 2, 2004; doi:10.1074/jbc.M401022200 [Abstract] [Full Text] [PDF]  

Aleksandar Vojta, Marcel Alavi, Thomas Becker, Friederike Hörmann, Michael Küchler, Jürgen Soll, Rowena Thomson, and Enrico Schleiff
The Protein Translocon of the Plastid Envelopes
J. Biol. Chem. 2004 279: 21401-21405. First Published on March 21, 2004; doi:10.1074/jbc.M401968200 [Abstract] [Full Text] [PDF] Supplemental Data  


Mechanisms Of Signal Transduction:

Deepak Raina, Surender Kharbanda, and Donald Kufe
The MUC1 Oncoprotein Activates the Anti-apoptotic Phosphoinositide 3-Kinase/Akt and Bcl-xL Pathways in Rat 3Y1 Fibroblasts
J. Biol. Chem. 2004 279: 20607-20612. First Published on March 3, 2004; doi:10.1074/jbc.M310538200 [Abstract] [Full Text] [PDF]  

Michelle T. Harreman, Trisha M. Kline, Heidi G. Milford, M. Beth Harben, Alec E. Hodel, and Anita H. Corbett
Regulation of Nuclear Import by Phosphorylation Adjacent to Nuclear Localization Signals
J. Biol. Chem. 2004 279: 20613-20621. First Published on March 3, 2004; doi:10.1074/jbc.M401720200 [Abstract] [Full Text] [PDF]  

Dong Wang and Stephen J. Lippard
Cisplatin-induced Post-translational Modification of Histones H3 and H4
J. Biol. Chem. 2004 279: 20622-20625. First Published on March 9, 2004; doi:10.1074/jbc.M402547200 [Abstract] [Full Text] [PDF]  

Cyrus J. Parsa, Jihee Kim, Ryan U. Riel, Laura S. Pascal, Richard B. Thompson, Jason A. Petrofski, Akio Matsumoto, Jonathan S. Stamler, and Walter J. Koch
Cardioprotective Effects of Erythropoietin in the Reperfused Ischemic Heart: A POTENTIAL ROLE FOR CARDIAC FIBROBLASTS
J. Biol. Chem. 2004 279: 20655-20662. First Published on March 11, 2004; doi:10.1074/jbc.M314099200 [Abstract] [Full Text] [PDF]  

Paul A Townsend, Ramsey I. Cutress, Christopher J. Carroll, Kevin M. Lawrence, Tiziano M. Scarabelli, Graham Packham, Anastasis Stephanou, and David S. Latchman
BAG-1 Proteins Protect Cardiac Myocytes from Simulated Ischemia/Reperfusion-induced Apoptosis via an Alternate Mechanism of Cell Survival Independent of the Proteasome
J. Biol. Chem. 2004 279: 20723-20728. First Published on February 20, 2004; doi:10.1074/jbc.M400399200 [Abstract] [Full Text] [PDF]  

Geneviève Pilon, Patrice Dallaire, and André Marette
Inhibition of Inducible Nitric-oxide Synthase by Activators of AMP-activated Protein Kinase: A NEW MECHANISM OF ACTION OF INSULIN-SENSITIZING DRUGS
J. Biol. Chem. 2004 279: 20767-20774. First Published on February 25, 2004; doi:10.1074/jbc.M401390200 [Abstract] [Full Text] [PDF] Supplemental Data  

Mohamed El-Tanani, Angela Platt-Higgins, Philip S. Rudland, and Frederick Charles Campbell
Ets Gene PEA3 Cooperates with {beta}-Catenin-Lef-1 and c-Jun in Regulation of Osteopontin Transcription
J. Biol. Chem. 2004 279: 20794-20806. First Published on February 27, 2004; doi:10.1074/jbc.M311131200 [Abstract] [Full Text] [PDF]  

O. Jameel Shah and Tony Hunter
Critical Role of T-Loop and H-Motif Phosphorylation in the Regulation of S6 Kinase 1 by the Tuberous Sclerosis Complex
J. Biol. Chem. 2004 279: 20816-20823. First Published on March 1, 2004; doi:10.1074/jbc.M400957200 [Abstract] [Full Text] [PDF]  

Lingzhi Zhang and Paul A. Insel
The Pro-apoptotic Protein Bim Is a Convergence Point for cAMP/Protein Kinase A- and Glucocorticoid-promoted Apoptosis of Lymphoid Cells
J. Biol. Chem. 2004 279: 20858-20865. First Published on March 2, 2004; doi:10.1074/jbc.M310643200 [Abstract] [Full Text] [PDF]  

Bing-Chang Chen, Ya-Sheng Chang, Ju-Chiun Kang, Ming-Jen Hsu, Joen-Rong Sheu, Ta-Liang Chen, Che-Ming Teng, and Chien-Huang Lin
Peptidoglycan Induces Nuclear Factor-{kappa}B Activation and Cyclooxygenase-2 Expression via Ras, Raf-1, and ERK in RAW 264.7 Macrophages
J. Biol. Chem. 2004 279: 20889-20897. First Published on March 8, 2004; doi:10.1074/jbc.M311279200 [Abstract] [Full Text] [PDF]  

Ning Yang, Yao Huang, Jing Jiang, and Stuart J. Frank
Caveolar and Lipid Raft Localization of the Growth Hormone Receptor and Its Signaling Elements: IMPACT ON GROWTH HORMONE SIGNALING
J. Biol. Chem. 2004 279: 20898-20905. First Published on March 8, 2004; doi:10.1074/jbc.M400625200 [Abstract] [Full Text] [PDF]  

Dalila Darmoul, Valérie Gratio, Hélène Devaud, and Marc Laburthe
Protease-activated Receptor 2 in Colon Cancer: TRYPSIN-INDUCED MAPK PHOSPHORYLATION AND CELL PROLIFERATION ARE MEDIATED BY EPIDERMAL GROWTH FACTOR RECEPTOR TRANSACTIVATION
J. Biol. Chem. 2004 279: 20927-20934. First Published on March 9, 2004; doi:10.1074/jbc.M401430200 [Abstract] [Full Text] [PDF]  

Gias U. Ahmmed, Dolly Mehta, Stephen Vogel, Michael Holinstat, Biman C. Paria, Chinnaswamy Tiruppathi, and Asrar B. Malik
Protein Kinase C{alpha} Phosphorylates the TRPC1 Channel and Regulates Store-operated Ca2+ Entry in Endothelial Cells
J. Biol. Chem. 2004 279: 20941-20949. First Published on March 10, 2004; doi:10.1074/jbc.M313975200 [Abstract] [Full Text] [PDF]  

Dirk Rüsch, Huijun Zhong, and Stuart A. Forman
Gating Allosterism at a Single Class of Etomidate Sites on {alpha}1{beta}2{gamma}2L GABAA Receptors Accounts for Both Direct Activation and Agonist Modulation
J. Biol. Chem. 2004 279: 20982-20992. First Published on March 11, 2004; doi:10.1074/jbc.M400472200 [Abstract] [Full Text] [PDF]  

Silke Seeber, Andreas Humeny, Matthias Herkert, Thomas Rau, Thomas Eschenhagen, and Cord-Michael Becker
Formation of Molecular Complexes by N-Methyl-D-aspartate Receptor Subunit NR2B and Ryanodine Receptor 2 in Neonatal Rat Myocard
J. Biol. Chem. 2004 279: 21062-21068. First Published on March 9, 2004; doi:10.1074/jbc.M313009200 [Abstract] [Full Text] [PDF]  

Shyra J. Gardai, David A. Hildeman, Steve K. Frankel, Ben B. Whitlock, S. Courtney Frasch, Niels Borregaard, Philippa Marrack, Donna L. Bratton, and Peter M. Henson
xPhosphorylation of Bax Ser184 by Akt Regulates Its Activity and Apoptosis in Neutrophils
J. Biol. Chem. 2004 279: 21085-21095. First Published on February 6, 2004; doi:10.1074/jbc.M400063200 [Abstract] [Full Text] [PDF]  

Marika Hedengren-Olcott, Michael C. Olcott, Duane T. Mooney, Sophia Ekengren, Bruce L. Geller, and Barbara J. Taylor
Differential Activation of the NF-{kappa}B-like Factors Relish and Dif in Drosophila melanogaster by Fungi and Gram-positive Bacteria
J. Biol. Chem. 2004 279: 21121-21127. First Published on February 25, 2004; doi:10.1074/jbc.M313856200 [Abstract] [Full Text] [PDF]  

Lidia A. Gardner, Noel M. Delos Santos, Shannon G. Matta, Michael A. Whitt, and Suleiman W. Bahouth
Role of the Cyclic AMP-dependent Protein Kinase in Homologous Resensitization of the {beta}1-Adrenergic Receptor
J. Biol. Chem. 2004 279: 21135-21143. First Published on February 27, 2004; doi:10.1074/jbc.M313652200 [Abstract] [Full Text] [PDF]  

Lena J. Heung, Chiara Luberto, Allyson Plowden, Yusuf A. Hannun, and Maurizio Del Poeta
The Sphingolipid Pathway Regulates Pkc1 through the Formation of Diacylglycerol in Cryptococcus neoformans
J. Biol. Chem. 2004 279: 21144-21153. First Published on March 10, 2004; doi:10.1074/jbc.M312995200 [Abstract] [Full Text] [PDF]  

Perumal Sivashanmugam, Linda Tang, and Yehia Daaka
Interleukin 6 Mediates the Lysophosphatidic Acid-regulated Cross-talk between Stromal and Epithelial Prostate Cancer Cells
J. Biol. Chem. 2004 279: 21154-21159. First Published on March 15, 2004; doi:10.1074/jbc.M313776200 [Abstract] [Full Text] [PDF]  

Anne Stefansson, Annika Armulik, IngMarie Nilsson, Gunnar von Heijne, and Staffan Johansson
Determination of N- and C-terminal Borders of the Transmembrane Domain of Integrin Subunits
J. Biol. Chem. 2004 279: 21200-21205. First Published on March 10, 2004; doi:10.1074/jbc.M400771200 [Abstract] [Full Text] [PDF]  

Åsa B. Gustafsson, Joseph G. Tsai, Susan E. Logue, Michael T. Crow, and Roberta A. Gottlieb
Apoptosis Repressor with Caspase Recruitment Domain Protects against Cell Death by Interfering with Bax Activation
J. Biol. Chem. 2004 279: 21233-21238. First Published on March 5, 2004; doi:10.1074/jbc.M400695200 [Abstract] [Full Text] [PDF]  

Leah S. Bernstein, Suneela Ramineni, Chris Hague, Wendy Cladman, Peter Chidiac, Allan I. Levey, and John R. Hepler
RGS2 Binds Directly and Selectively to the M1 Muscarinic Acetylcholine Receptor Third Intracellular Loop to Modulate Gq/11{alpha} Signaling
J. Biol. Chem. 2004 279: 21248-21256. First Published on February 19, 2004; doi:10.1074/jbc.M312407200 [Abstract] [Full Text] [PDF]  

Jean-Luc Morel, Lala Rakotoarisoa, Loice H. Jeyakumar, Sidney Fleischer, Chantal Mironneau, and Jean Mironneau
Decreased Expression of Ryanodine Receptors Alters Calcium-induced Calcium Release Mechanism in mdx Duodenal Myocytes
J. Biol. Chem. 2004 279: 21287-21293. First Published on February 25, 2004; doi:10.1074/jbc.M311124200 [Abstract] [Full Text] [PDF]  

Freimut Schliess, Regina Reissmann, Roland Reinehr, Stephan vom Dahl, and Dieter Häussinger
Involvement of Integrins and Src in Insulin Signaling toward Autophagic Proteolysis in Rat Liver
J. Biol. Chem. 2004 279: 21294-21301. First Published on February 24, 2004; doi:10.1074/jbc.M313901200 [Abstract] [Full Text] [PDF]  

Emanuela Grassilli, Andrea Ballabeni, Emilia Maellaro, Barbara Del Bello, and Kristian Helin
Loss of MYC Confers Resistance to Doxorubicin-induced Apoptosis by Preventing the Activation of Multiple Serine Protease- and Caspase-mediated Pathways
J. Biol. Chem. 2004 279: 21318-21326. First Published on February 27, 2004; doi:10.1074/jbc.M313532200 [Abstract] [Full Text] [PDF]  

Giovanni Tulipano, Ralf Stumm, Manuela Pfeiffer, Hans-Jürgen Kreienkamp, Volker Höllt, and Stefan Schulz
Differential {beta}-Arrestin Trafficking and Endosomal Sorting of Somatostatin Receptor Subtypes
J. Biol. Chem. 2004 279: 21374-21382. First Published on March 4, 2004; doi:10.1074/jbc.M313522200 [Abstract] [Full Text] [PDF]  

Ashour Michael, Syed Haq, Xin Chen, Eileen Hsich, Lei Cui, Brian Walters, Zhili Shao, Kausik Bhattacharya, Heiko Kilter, Gordon Huggins, Michele Andreucci, Muthu Periasamy, Robert N. Solomon, Ronglih Liao, Richard Patten, Jeffery D. Molkentin, and Thomas Force
Glycogen Synthase Kinase-3{beta} Regulates Growth, Calcium Homeostasis, and Diastolic Function in the Heart
J. Biol. Chem. 2004 279: 21383-21393. First Published on March 11, 2004; doi:10.1074/jbc.M401413200 [Abstract] [Full Text] [PDF]  

Guangju Ji, Morris E. Feldman, Ke-Yu Deng, Kai Su Greene, Jason Wilson, Jane C. Lee, Robyn C. Johnston, Mark Rishniw, Yvonne Tallini, Jin Zhang, Winthrop G. Wier, Mordecai P. Blaustein, Hong-Bo Xin, Junichi Nakai, and Michael I. Kotlikoff
Ca2+-sensing Transgenic Mice: POSTSYNAPTIC SIGNALING IN SMOOTH MUSCLE
J. Biol. Chem. 2004 279: 21461-21468. First Published on February 29, 2004; doi:10.1074/jbc.M401084200 [Abstract] [Full Text] [PDF]  

Jian Yao, Qin Li, Jin Chen, and Shmuel Muallem
Subpopulation of Store-operated Ca2+ Channels Regulate Ca2+-induced Ca2+ Release in Non-excitable Cells
J. Biol. Chem. 2004 279: 21511-21519. First Published on March 11, 2004; doi:10.1074/jbc.M314028200 [Abstract] [Full Text] [PDF]  

Mee-Young Ahn, Kostas D. Katsanakis, Farheen Bheda, and Tahir S. Pillay
Primary and Essential Role of the Adaptor Protein APS for Recruitment of Both c-Cbl and Its Associated Protein CAP in Insulin Signaling
J. Biol. Chem. 2004 279: 21526-21532. First Published on March 18, 2004; doi:10.1074/jbc.M307740200 [Abstract] [Full Text] [PDF]  

Man-Kyo Chung, Hyosang Lee, Atsuko Mizuno, Makoto Suzuki, and Michael J. Caterina
TRPV3 and TRPV4 Mediate Warmth-evoked Currents in Primary Mouse Keratinocytes
J. Biol. Chem. 2004 279: 21569-21575. First Published on March 5, 2004; doi:10.1074/jbc.M401872200 [Abstract] [Full Text] [PDF]  

Jun-Sub Kim, Becky A. Diebold, Jong-Il Kim, Jaebong Kim, Jae-Yong Lee, and Jae-Bong Park
Rho Is Involved in Superoxide Formation during Phagocytosis of Opsonized Zymosans
J. Biol. Chem. 2004 279: 21589-21597. First Published on February 17, 2004; doi:10.1074/jbc.M308386200 [Abstract] [Full Text] [PDF] Supplemental Data  

Jianyun Huang, Yutong Sun, and Xin-Yun Huang
Distinct Roles for Src Tyrosine Kinase in {beta}2-Adrenergic Receptor Signaling to MAPK and in Receptor Internalization
J. Biol. Chem. 2004 279: 21637-21642. First Published on February 27, 2004; doi:10.1074/jbc.M400956200 [Abstract] [Full Text] [PDF]  

Klaus Podar, Gustavo Mostoslavsky, Martin Sattler, Yu-Tzu Tai, Toshiaki Hayashi, Laurence P. Catley, Teru Hideshima, Richard C. Mulligan, Dharminder Chauhan, and Kenneth C. Anderson
Critical Role for Hematopoietic Cell Kinase (Hck)-mediated Phosphorylation of Gab1 and Gab2 Docking Proteins in Interleukin 6-induced Proliferation and Survival of Multiple Myeloma Cells
J. Biol. Chem. 2004 279: 21658-21665. First Published on March 9, 2004; doi:10.1074/jbc.M305783200 [Abstract] [Full Text] [PDF]  


Molecular Basis Of Cell and Developmental Biology:

Evgeny V. Kuzmin, Olga V. Karpova, Thomas E. Elthon, and Kathleen J. Newton
Mitochondrial Respiratory Deficiencies Signal Up-regulation of Genes for Heat Shock Proteins
J. Biol. Chem. 2004 279: 20672-20677. First Published on March 11, 2004; doi:10.1074/jbc.M400640200 [Abstract] [Full Text] [PDF] Supplemental Data  

Patrick G. Sullivan, Natasa B. Dragicevic, Jian-Hong Deng, Yidong Bai, Edgardo Dimayuga, Qunxing Ding, Qinghua Chen, Annadora J. Bruce-Keller, and Jeffrey N. Keller
Proteasome Inhibition Alters Neural Mitochondrial Homeostasis and Mitochondria Turnover
J. Biol. Chem. 2004 279: 20699-20707. First Published on January 22, 2004; doi:10.1074/jbc.M313579200 [Abstract] [Full Text] [PDF]  

Deng-Fu Guo, Valerie Tardif, Karin Ghelima, John S. D. Chan, Julie R. Ingelfinger, XiangMei Chen, and Isabelle Chenier
A Novel Angiotensin II Type 1 Receptor-associated Protein Induces Cellular Hypertrophy in Rat Vascular Smooth Muscle and Renal Proximal Tubular Cells
J. Biol. Chem. 2004 279: 21109-21120. First Published on February 24, 2004; doi:10.1074/jbc.M401544200 [Abstract] [Full Text] [PDF]  

Jean-François Paré, Daniel Malenfant, Chantal Courtemanche, Mariève Jacob-Wagner, Sylvie Roy, Denis Allard, and Luc Bélanger
The Fetoprotein Transcription Factor (FTF) Gene Is Essential to Embryogenesis and Cholesterol Homeostasis and Is Regulated by a DR4 Element
J. Biol. Chem. 2004 279: 21206-21216. First Published on March 10, 2004; doi:10.1074/jbc.M401523200 [Abstract] [Full Text] [PDF]  

Akio Ito, Yasuyuki Sasaguri, Sakae Kitada, Yoshitomo Kusaka, Kyoko Kuwano, Kenjiro Masutomi, Eiichi Mizuki, Tetsuyuki Akao, and Michio Ohba
A Bacillus thuringiensis Crystal Protein with Selective Cytocidal Action to Human Cells
J. Biol. Chem. 2004 279: 21282-21286. First Published on March 16, 2004; doi:10.1074/jbc.M401881200 [Abstract] [Full Text] [PDF]  

Shunan Li, David M. Perlman, Mark S. Peterson, David Burrichter, Svetlana Avdulov, Vitaly A. Polunovsky, and Peter B. Bitterman
Translation Initiation Factor 4E Blocks Endoplasmic Reticulum-mediated Apoptosis
J. Biol. Chem. 2004 279: 21312-21317. First Published on February 27, 2004; doi:10.1074/jbc.M312467200 [Abstract] [Full Text] [PDF]  

Jing Zhao, Li-Hong Zhang, Lin-Tao Jia, Li Zhang, Yan-Ming Xu, Zhi Wang, Cui-Juan Yu, Wei-Dan Peng, Wei-Hong Wen, Cheng-Ji Wang, Si-Yi Chen, and An-Gang Yang
Secreted Antibody/Granzyme B Fusion Protein Stimulates Selective Killing of HER2-overexpressing Tumor Cells
J. Biol. Chem. 2004 279: 21343-21348. First Published on March 5, 2004; doi:10.1074/jbc.M312648200 [Abstract] [Full Text] [PDF]  

Junjun Liu, Andrea L. Lewellyn, Lin G. Chen, and James L. Maller
The Polo Box Is Required for Multiple Functions of Plx1 in Mitosis
J. Biol. Chem. 2004 279: 21367-21373. First Published on March 11, 2004; doi:10.1074/jbc.M400482200 [Abstract] [Full Text] [PDF]  

Masaki Suzuki, Yumi Takamura, Mitsugu Maéno, Shin Tochinai, Daisuke Iyaguchi, Isao Tanaka, Jun Nishihira, and Teruo Ishibashi
Xenopus laevis Macrophage Migration Inhibitory Factor Is Essential for Axis Formation and Neural Development
J. Biol. Chem. 2004 279: 21406-21414. First Published on March 15, 2004; doi:10.1074/jbc.M311416200 [Abstract] [Full Text] [PDF]  

Koji Kuronuma, Hitomi Sano, Kazunori Kato, Kazumi Kudo, Naoki Hyakushima, Shin-ichi Yokota, Hiroki Takahashi, Nobuhiro Fujii, Hiroshi Suzuki, Tatsuhiko Kodama, Shosaku Abe, and Yoshio Kuroki
Pulmonary Surfactant Protein A Augments the Phagocytosis of Streptococcus pneumoniae by Alveolar Macrophages through a Casein Kinase 2-dependent Increase of Cell Surface Localization of Scavenger Receptor A
J. Biol. Chem. 2004 279: 21421-21430. First Published on March 1, 2004; doi:10.1074/jbc.M312490200 [Abstract] [Full Text] [PDF]  

Linda M. DiBella, Elizabeth F. Smith, Ramila S. Patel-King, Ken-ichi Wakabayashi, and Stephen M. King
A Novel Tctex2-related Light Chain Is Required for Stability of Inner Dynein Arm I1 and Motor Function in the Chlamydomonas Flagellum
J. Biol. Chem. 2004 279: 21666-21676. First Published on March 11, 2004; doi:10.1074/jbc.M313540200 [Abstract] [Full Text] [PDF]  


Additions and Corrections:

Brian C. Tripp, Caleb B. Bell, III, Francisco Cruz, Carsten Krebs, and James G. Ferry
A role for iron in an ancient carbonic anhydrase. Vol. 279 (2004) 6683-6687
J. Biol. Chem. 2004 279: 21677. [Full Text] [PDF]  

Edgar B. Cahoon and Anthony J. Kinney
Dimorphecolic acid is synthesized by the coordinate activities of two divergent {Delta}12-oleic acid desaturases. Vol. 279 (2004) 12495-12502
J. Biol. Chem. 2004 279: 21678. [Full Text] [PDF]  


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