JBC -- Table of Contents (Oct 15 2004, 279, (42))

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Minireviews:

Sayyed K. Zaidi, Daniel W. Young, Je-Yong Choi, Jitesh Pratap, Amjad Javed, Martin Montecino, Janet L. Stein, Jane B. Lian, Andre J. van Wijnen, and Gary S. Stein: Intranuclear Trafficking: Organization and Assembly of Regulatory Machinery for Combinatorial Biological Control
J. Biol. Chem. 2004 279: 43363-43366. First Published on July 23, 2004; doi:10.1074/jbc.R400020200 [Abstract] [Full Text] [PDF]

Accelerated Publications:

Maria E. Bulina, Konstantin A. Lukyanov, Ilia V. Yampolsky, Dmitry M. Chudakov, Dmitry B. Staroverov, Alexander S. Shcheglov, Nadya G. Gurskaya, and Sergey Lukyanov: New Class of Blue Animal Pigments Based on Frizzled and Kringle Protein Domains
J. Biol. Chem. 2004 279: 43367-43370. First Published on August 5, 2004; doi:10.1074/jbc.C400337200 [Abstract] [Full Text] [PDF]

Priscilla Turelli, Sandrine Vianin, and Didier Trono: The Innate Antiretroviral Factor APOBEC3G Does Not Affect Human LINE-1 Retrotransposition in a Cell Culture Assay
J. Biol. Chem. 2004 279: 43371-43373. First Published on August 18, 2004; doi:10.1074/jbc.C400334200 [Abstract] [Full Text] [PDF]

Rajendra K. Gangalum, Matthew J. Schibler, and Suraj P. Bhat: Small Heat Shock Protein ${alpha}$ B-Crystallin Is Part of Cell Cycle-dependent Golgi Reorganization
J. Biol. Chem. 2004 279: 43374-43377. First Published on August 31, 2004; doi:10.1074/jbc.C400371200 [Abstract] [Full Text] [PDF]

Xavier Pesesse, Kuicheon Choi, Tong Zhang, and Stephen B. Shears: Signaling by Higher Inositol Polyphosphates: SYNTHESIS OF BISDIPHOSPHOINOSITOL TETRAKISPHOSPHATE ("InsP₈") IS SELECTIVELY ACTIVATED BY HYPEROSMOTIC STRESS
J. Biol. Chem. 2004 279: 43378-43381. First Published on August 16, 2004; doi:10.1074/jbc.C400286200 [Abstract] [Full Text] [PDF] Supplemental Data

Geneviève Morrow, Sophie Battistini, Ping Zhang, and Robert M. Tanguay: Decreased Lifespan in the Absence of Expression of the Mitochondrial Small Heat Shock Protein Hsp22 in Drosophila
J. Biol. Chem. 2004 279: 43382-43385. First Published on August 25, 2004; doi:10.1074/jbc.C400357200 [Abstract] [Full Text] [PDF]

DNA: Replication, Repair, and Recombination:

William L. Neeley, James C. Delaney, Paul T. Henderson, and John M. Essigmann: In Vivo Bypass Efficiencies and Mutational Signatures of the Guanine Oxidation Products 2-Aminoimidazolone and 5-Guanidino-4-nitroimidazole
J. Biol. Chem. 2004 279: 43568-43573. First Published on August 6, 2004; doi:10.1074/jbc.M407117200 [Abstract] [Full Text] [PDF]

Sanjay Kumar and Joel A. Huberman: On the Slowing of S Phase in Response to DNA Damage in Fission Yeast
J. Biol. Chem. 2004 279: 43574-43580. First Published on August 5, 2004; doi:10.1074/jbc.M407819200 [Abstract] [Full Text] [PDF]

Sahn-ho Kim, Christian Beausejour, Albert R. Davalos, Patrick Kaminker, Seok-Jin Heo, and Judith Campisi: TIN2 Mediates Functions of TRF2 at Human Telomeres
J. Biol. Chem. 2004 279: 43799-43804. First Published on August 3, 2004; doi:10.1074/jbc.M408650200 [Abstract] [Full Text] [PDF]

Meindert H. Lamers, Dubravka Georgijevic, Joyce H. Lebbink, Herrie H. K. Winterwerp, Bogos Agianian, Niels de Wind, and Titia K. Sixma: ATP Increases the Affinity between MutS ATPase Domains: IMPLICATIONS FOR ATP HYDROLYSIS AND CONFORMATIONAL CHANGES
J. Biol. Chem. 2004 279: 43879-43885. First Published on August 4, 2004; doi:10.1074/jbc.M406380200 [Abstract] [Full Text] [PDF]

Inna I. Kruman, Elena Schwartz, Yuri Kruman, Roy G. Cutler, Xiaoxiang Zhu, Nigel H. Greig, and Mark P. Mattson: Suppression of Uracil-DNA Glycosylase Induces Neuronal Apoptosis
J. Biol. Chem. 2004 279: 43952-43960. First Published on August 5, 2004; doi:10.1074/jbc.M408025200 [Abstract] [Full Text] [PDF]

Franck Coste, Matthias Ober, Thomas Carell, Serge Boiteux, Charles Zelwer, and Bertrand Castaing: Structural Basis for the Recognition of the FapydG Lesion (2,6-Diamino-4-hydroxy-5-formamidopyrimidine) by Formamidopyrimidine-DNA Glycosylase
J. Biol. Chem. 2004 279: 44074-44083. First Published on July 10, 2004; doi:10.1074/jbc.M405928200 [Abstract] [Full Text] [PDF]

Susan L. Heilman-Miller, Tiyun Wu, and Judith G. Levin: Alteration of Nucleic Acid Structure and Stability Modulates the Efficiency of Minus-Strand Transfer Mediated by the HIV-1 Nucleocapsid Protein
J. Biol. Chem. 2004 279: 44154-44165. First Published on July 22, 2004; doi:10.1074/jbc.M401646200 [Abstract] [Full Text] [PDF]

Genes: Structure and Regulation:

Ahmad Utomo, Xianzhi Jiang, Saori Furuta, Jeanho Yun, David S. Levin, Yi-Chun J. Wang, Kartiki V. Desai, Jeffrey E. Green, Phang-Lang Chen, and Wen-Hwa Lee: Identification of a Novel Putative Non-selenocysteine Containing Phospholipid Hydroperoxide Glutathione Peroxidase (NPGPx) Essential for Alleviating Oxidative Stress Generated from Polyunsaturated Fatty Acids in Breast Cancer Cells
J. Biol. Chem. 2004 279: 43522-43529. First Published on August 4, 2004; doi:10.1074/jbc.M407141200 [Abstract] [Full Text] [PDF]

Soraya Gutierrez, Jilin Liu, Amjad Javed, Martin Montecino, Gary S. Stein, Jane B. Lian, and Janet L. Stein: The Vitamin D Response Element in the Distal Osteocalcin Promoter Contributes to Chromatin Organization of the Proximal Regulatory Domain
J. Biol. Chem. 2004 279: 43581-43588. First Published on August 5, 2004; doi:10.1074/jbc.M408335200 [Abstract] [Full Text] [PDF]

Heather L. B. Kiefer, Timothy M. Hanley, Jennifer E. Marcello, A. G. Karthik, and Gregory A. Viglianti: Retinoic Acid Inhibition of Chromatin Remodeling at the Human Immunodeficiency Virus Type 1 Promoter: UNCOUPLING OF HISTONE ACETYLATION AND CHROMATIN REMODELING
J. Biol. Chem. 2004 279: 43604-43613. First Published on August 6, 2004; doi:10.1074/jbc.M408069200 [Abstract] [Full Text] [PDF]

Patricia Ridgway, Karl D. Brown, Danny Rangasamy, Ulrica Svensson, and David J. Tremethick: Unique Residues on the H2A.Z Containing Nucleosome Surface Are Important for Xenopus laevis Development
J. Biol. Chem. 2004 279: 43815-43820. First Published on August 6, 2004; doi:10.1074/jbc.M408409200 [Abstract] [Full Text] [PDF] [Papers Of The Week]

Antonio Jesús Serrato, Juan Manuel Pérez-Ruiz, María Cristina Spínola, and Francisco Javier Cejudo: A Novel NADPH Thioredoxin Reductase, Localized in the Chloroplast, Which Deficiency Causes Hypersensitivity to Abiotic Stress in Arabidopsis thaliana
J. Biol. Chem. 2004 279: 43821-43827. First Published on July 28, 2004; doi:10.1074/jbc.M404696200 [Abstract] [Full Text] [PDF]

Naoto Yoshizuka, Ryozo Moriuchi, Tsuyoshi Mori, Kenji Yamada, Sumitaka Hasegawa, Takahiro Maeda, Takako Shimada, Yasuaki Yamada, Shimeru Kamihira, Masao Tomonaga, and Shigeru Katamine: An Alternative Transcript Derived from the Trio Locus Encodes a Guanosine Nucleotide Exchange Factor with Mouse Cell-transforming Potential
J. Biol. Chem. 2004 279: 43998-44004. First Published on August 11, 2004; doi:10.1074/jbc.M406082200 [Abstract] [Full Text] [PDF]

Véronique Bériault, Jean-François Clément, Kathy Lévesque, Catherine LeBel, Xiao Yong, Benoit Chabot, Éric A. Cohen, Alan W. Cochrane, William F. C. Rigby, and Andrew J. Mouland: A Late Role for the Association of hnRNP A2 with the HIV-1 hnRNP A2 Response Elements in Genomic RNA, Gag, and Vpr Localization
J. Biol. Chem. 2004 279: 44141-44153. First Published on August 3, 2004; doi:10.1074/jbc.M404691200 [Abstract] [Full Text] [PDF] Supplemental Data

RNA: Structure, Metabolism, and Catalysis:

Imke Ehlers, Sven Horke, Kerstin Reumann, Andreas Rang, Frank Grosse, Hans Will, and Tilman Heise: Functional Characterization of the Interaction between Human La and Hepatitis B Virus RNA
J. Biol. Chem. 2004 279: 43437-43447. First Published on August 9, 2004; doi:10.1074/jbc.M402227200 [Abstract] [Full Text] [PDF]

Tsutomu Fujimura and Rosa Esteban: The Bipartite 3'-cis-Acting Signal for Replication Is Required for Formation of a Ribonucleoprotein Complex in Vivo between the Viral Genome and Its RNA Polymerase in Yeast 23 S RNA Virus
J. Biol. Chem. 2004 279: 44219-44228. First Published on August 11, 2004; doi:10.1074/jbc.M408530200 [Abstract] [Full Text] [PDF]

Protein Synthesis, Post-Translation Modification, and Degradation:

Matthew Smith, Vinay Bhaskar, Joseph Fernandez, and Albert J. Courey: Drosophila Ulp1, a Nuclear Pore-associated SUMO Protease, Prevents Accumulation of Cytoplasmic SUMO Conjugates
J. Biol. Chem. 2004 279: 43805-43814. First Published on August 4, 2004; doi:10.1074/jbc.M404942200 [Abstract] [Full Text] [PDF] Supplemental Data

Atsuo Maemoto, Xiaoqing Qu, K. Johan Rosengren, Hiroki Tanabe, Agnes Henschen-Edman, David J. Craik, and Andre J. Ouellette: Functional Analysis of the ${alpha}$ -Defensin Disulfide Array in Mouse Cryptdin-4
J. Biol. Chem. 2004 279: 44188-44196. First Published on August 5, 2004; doi:10.1074/jbc.M406154200 [Abstract] [Full Text] [PDF]

Genomics, Proteomics, and Bioinformatics:

Daojing Wang, Jennifer S. Park, Julia S. F. Chu, Ari Krakowski, Kunxin Luo, David J. Chen, and Song Li: Proteomic Profiling of Bone Marrow Mesenchymal Stem Cells upon Transforming Growth Factor ${beta}$ 1 Stimulation
J. Biol. Chem. 2004 279: 43725-43734. First Published on August 9, 2004; doi:10.1074/jbc.M407368200 [Abstract] [Full Text] [PDF]

David Vergote, Pierre-Eric Sautière, Franck Vandenbulcke, Didier Vieau, Guillaume Mitta, Eduardo R. Macagno, and Michel Salzet: Up-regulation of Neurohemerythrin Expression in the Central Nervous System of the Medicinal Leech, Hirudo medicinalis, following Septic Injury
J. Biol. Chem. 2004 279: 43828-43837. First Published on July 16, 2004; doi:10.1074/jbc.M403073200 [Abstract] [Full Text] [PDF]

Protein Structure and Folding:

Dietmar Benke, Panagiotis Fakitsas, Christian Roggenmoser, Claudia Michel, Uwe Rudolph, and Hanns Mohler: Analysis of the Presence and Abundance of GABA_A Receptors Containing Two Different Types of ${alpha}$ Subunits in Murine Brain Using Point-mutated ${alpha}$ Subunits
J. Biol. Chem. 2004 279: 43654-43660. First Published on August 10, 2004; doi:10.1074/jbc.M407154200 [Abstract] [Full Text] [PDF]

Julio Varea, Begoña Monterroso, José L. Sáiz, Consuelo López-Zumel, José L. García, José Laynez, Pedro García, and Margarita Menéndez: Structural and Thermodynamic Characterization of Pal, a Phage Natural Chimeric Lysin Active against Pneumococci
J. Biol. Chem. 2004 279: 43697-43707. First Published on July 9, 2004; doi:10.1074/jbc.M407067200 [Abstract] [Full Text] [PDF]

David Perret, Catherine Guillet, Greg Elson, Josy Froger, Hélène Plun-Favreau, François Rousseau, Marie Chabbert, Jean-François Gauchat, and Hugues Gascan: Two Different Contact Sites Are Recruited by Cardiotrophin-like Cytokine (CLC) to Generate the CLC/CLF and CLC/sCNTFR ${alpha}$ Composite Cytokines
J. Biol. Chem. 2004 279: 43961-43970. First Published on July 22, 2004; doi:10.1074/jbc.M407686200 [Abstract] [Full Text] [PDF]

Julie C. Lougheed, Rui-Hong Chen, Polly Mak, and Thomas J. Stout: Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the Cdc42-associated Tyrosine Kinase ACK1
J. Biol. Chem. 2004 279: 44039-44045. First Published on August 11, 2004; doi:10.1074/jbc.M406703200 [Abstract] [Full Text] [PDF]

Hugo W. Tedford, Nicolas Gilles, André Ménez, Clinton J. Doering, Gerald W. Zamponi, and Glenn F. King: Scanning Mutagenesis of ${omega}$ -Atracotoxin-Hv1a Reveals a Spatially Restricted Epitope That Confers Selective Activity against Insect Calcium Channels
J. Biol. Chem. 2004 279: 44133-44140. First Published on August 11, 2004; doi:10.1074/jbc.M404006200 [Abstract] [Full Text] [PDF]

Enzyme Catalysis and Regulation:

Dirk Beher, Earl E. Clarke, Jonathan D. J. Wrigley, Agnes C. L. Martin, Alan Nadin, Ian Churcher, and Mark S. Shearman: Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target ${gamma}$ -Secretase at a Novel Site: EVIDENCE FOR AN ALLOSTERIC MECHANISM
J. Biol. Chem. 2004 279: 43419-43426. First Published on August 10, 2004; doi:10.1074/jbc.M404937200 [Abstract] [Full Text] [PDF] Supplemental Data

Brian G. Lawhorn, Svetlana Y. Gerdes, and Tadhg P. Begley: A Genetic Screen for the Identification of Thiamin Metabolic Genes
J. Biol. Chem. 2004 279: 43555-43559. First Published on July 28, 2004; doi:10.1074/jbc.M404284200 [Abstract] [Full Text] [PDF] Supplemental Data

Alex Theodossis, Helen Walden, Elaine J. Westwick, Helen Connaris, Henry J. Lamble, David W. Hough, Michael J. Danson, and Garry L. Taylor: The Structural Basis for Substrate Promiscuity in 2-Keto-3-deoxygluconate Aldolase from the Entner-Doudoroff Pathway in Sulfolobus solfataricus
J. Biol. Chem. 2004 279: 43886-43892. First Published on July 20, 2004; doi:10.1074/jbc.M407702200 [Abstract] [Full Text] [PDF]

Malgorzata Marcyjaniak, Sergey G. Odintsov, Izabela Sabala, and Matthias Bochtler: Peptidoglycan Amidase MepA Is a LAS Metallopeptidase
J. Biol. Chem. 2004 279: 43982-43989. First Published on July 29, 2004; doi:10.1074/jbc.M406735200 [Abstract] [Full Text] [PDF]

Nicole M. Koropatkin and Hazel M. Holden: Molecular Structure of ${alpha}$ -D-Glucose-1-phosphate Cytidylyltransferase from Salmonella typhi
J. Biol. Chem. 2004 279: 44023-44029. First Published on August 3, 2004; doi:10.1074/jbc.M407755200 [Abstract] [Full Text] [PDF]

Metabolism and Bioenergetics:

Sangeeta Tiwari, K. V. Radha Kishan, Tapan Chakrabarti, and Pradip K. Chakraborti: Amino Acid Residues Involved in Autophosphorylation and Phosphotransfer Activities Are Distinct in Nucleoside Diphosphate Kinase from Mycobacterium tuberculosis
J. Biol. Chem. 2004 279: 43595-43603. First Published on August 9, 2004; doi:10.1074/jbc.M401704200 [Abstract] [Full Text] [PDF]

Glycobiology and Extracellular Matrices:

Diane Baronas-Lowell, Janelle L. Lauer-Fields, Jeffrey A. Borgia, Gian Franco Sferrazza, Mohammad Al-Ghoul, Dmitriy Minond, and Gregg B. Fields: Differential Modulation of Human Melanoma Cell Metalloproteinase Expression by ${alpha}$ ₂ ${beta}$ ₁ Integrin and CD44 Triple-helical Ligands Derived from Type IV Collagen
J. Biol. Chem. 2004 279: 43503-43513. First Published on August 2, 2004; doi:10.1074/jbc.M405979200 [Abstract] [Full Text] [PDF]

Monika Hermansson, Yasunobu Sawaji, Mark Bolton, Susan Alexander, Andrew Wallace, Shajna Begum, Robin Wait, and Jeremy Saklatvala: Proteomic Analysis of Articular Cartilage Shows Increased Type II Collagen Synthesis in Osteoarthritis and Expression of Inhibin ${beta}$ A (Activin A), a Regulatory Molecule for Chondrocytes
J. Biol. Chem. 2004 279: 43514-43521. First Published on August 2, 2004; doi:10.1074/jbc.M407041200 [Abstract] [Full Text] [PDF] Supplemental Data

Jonathan A. Mills, Kelly Motichka, Markus Jucker, Henry P. Wu, Brian C. Uhlik, Richard J. Stern, Michael S. Scherman, Varalakshmi D. Vissa, Fei Pan, Manikuntala Kundu, Yu Fang Ma, and Michael McNeil: Inactivation of the Mycobacterial Rhamnosyltransferase, Which Is Needed for the Formation of the Arabinogalactan-Peptidoglycan Linker, Leads to Irreversible Loss of Viability
J. Biol. Chem. 2004 279: 43540-43546. First Published on August 4, 2004; doi:10.1074/jbc.M407782200 [Abstract] [Full Text] [PDF]

Malcolm Lyon, Jon A. Deakin, Daniel Lietha, Ermanno Gherardi, and John T. Gallagher: The Interactions of Hepatocyte Growth Factor/Scatter Factor and Its NK1 and NK2 Variants with Glycosaminoglycans Using a Modified Gel Mobility Shift Assay: ELUCIDATION OF THE MINIMAL SIZE OF BINDING AND ACTIVATORY OLIGOSACCHARIDES
J. Biol. Chem. 2004 279: 43560-43567. First Published on August 2, 2004; doi:10.1074/jbc.M408510200 [Abstract] [Full Text] [PDF]

Raúl Conde, Rosario Cueva, Guadalupe Pablo, Julio Polaina, and Germán Larriba: A Search for Hyperglycosylation Signals in Yeast Glycoproteins
J. Biol. Chem. 2004 279: 43789-43798. First Published on July 26, 2004; doi:10.1074/jbc.M406678200 [Abstract] [Full Text] [PDF]

Rabia Sadir, Anne Imberty, Françoise Baleux, and Hugues Lortat-Jacob: Heparan Sulfate/Heparin Oligosaccharides Protect Stromal Cell-derived Factor-1 (SDF-1)/CXCL12 against Proteolysis Induced by CD26/Dipeptidyl Peptidase IV
J. Biol. Chem. 2004 279: 43854-43860. First Published on August 2, 2004; doi:10.1074/jbc.M405392200 [Abstract] [Full Text] [PDF]

Svetlana Gingis-Velitski, Anna Zetser, Victoria Kaplan, Olga Ben-Zaken, Esti Cohen, Flonia Levy-Adam, Yulia Bashenko, Moshe Y. Flugelman, Israel Vlodavsky, and Neta Ilan: Heparanase Uptake Is Mediated by Cell Membrane Heparan Sulfate Proteoglycans
J. Biol. Chem. 2004 279: 44084-44092. First Published on July 29, 2004; doi:10.1074/jbc.M402131200 [Abstract] [Full Text] [PDF]

Ningyu Chen, Shr-Jeng Leu, Viktor Todorovic, Stephen C.-T. Lam, and Lester F. Lau: Identification of a Novel Integrin ${alpha}$ _v ${beta}$ ₃ Binding Site in CCN1 (CYR61) Critical for Pro-angiogenic Activities in Vascular Endothelial Cells
J. Biol. Chem. 2004 279: 44166-44176. First Published on August 10, 2004; doi:10.1074/jbc.M406813200 [Abstract] [Full Text] [PDF]

Shr-Jeng Leu, Ningyu Chen, Chih-Chiun Chen, Viktor Todorovic, Tao Bai, Vladislava Juric, Ying Liu, Guoqiang Yan, Stephen C.-T. Lam, and Lester F. Lau: Targeted Mutagenesis of the Angiogenic Protein CCN1 (CYR61): SELECTIVE INACTIVATION OF INTEGRIN ${alpha}$ ₆ ${beta}$ ₁-HEPARAN SULFATE PROTEOGLYCAN CORECEPTOR-MEDIATED CELLULAR FUNCTIONS
J. Biol. Chem. 2004 279: 44177-44187. First Published on August 17, 2004; doi:10.1074/jbc.M407850200 [Abstract] [Full Text] [PDF]

Lipids and Lipoproteins:

Yukihiro Yoshimura, Motohiro Tani, Nozomu Okino, Hiroshi Iida, and Makoto Ito: Molecular Cloning and Functional Analysis of Zebrafish Neutral Ceramidase
J. Biol. Chem. 2004 279: 44012-44022. First Published on July 22, 2004; doi:10.1074/jbc.M405598200 [Abstract] [Full Text] [PDF] Supplemental Data

Membrane Transport, Structure, Function, and Biogenesis:

Jihong Qu, Yelena Kryukova, Irina A. Potapova, Sergey V. Doronin, Michael Larsen, Ganga Krishnamurthy, Ira S. Cohen, and Richard B. Robinson: MiRP1 Modulates HCN2 Channel Expression and Gating in Cardiac Myocytes
J. Biol. Chem. 2004 279: 43497-43502. First Published on August 2, 2004; doi:10.1074/jbc.M405018200 [Abstract] [Full Text] [PDF]

Christel Schwegmann-Wessels, Marwan Al-Falah, David Escors, Zai Wang, Gert Zimmer, Hongkui Deng, Luis Enjuanes, Hassan Y. Naim, and Georg Herrler: A Novel Sorting Signal for Intracellular Localization Is Present in the S Protein of a Porcine Coronavirus but Absent from Severe Acute Respiratory Syndrome-associated Coronavirus
J. Biol. Chem. 2004 279: 43661-43666. First Published on August 10, 2004; doi:10.1074/jbc.M407233200 [Abstract] [Full Text] [PDF]

Laura Segall, Rosemarie Scanzano, Mari A. Kaunisto, Maija Wessman, Aarno Palotie, J. Jay Gargus, and Rhoda Blostein: Kinetic Alterations due to a Missense Mutation in the Na,K-ATPase ${alpha}$ 2 Subunit Cause Familial Hemiplegic Migraine Type 2
J. Biol. Chem. 2004 279: 43692-43696. First Published on August 11, 2004; doi:10.1074/jbc.M407471200 [Abstract] [Full Text] [PDF]

Long-Jun Wu, Bo Duan, Yi-De Mei, Jun Gao, Jian-Guo Chen, Min Zhuo, Lin Xu, Mian Wu, and Tian-Le Xu: Characterization of Acid-sensing Ion Channels in Dorsal Horn Neurons of Rat Spinal Cord
J. Biol. Chem. 2004 279: 43716-43724. First Published on August 9, 2004; doi:10.1074/jbc.M403557200 [Abstract] [Full Text] [PDF] Supplemental Data

Sean P. Curran, Danielle Leuenberger, Edward P. Leverich, David K. Hwang, Kristen N. Beverly, and Carla M. Koehler: The Role of Hot13p and Redox Chemistry in the Mitochondrial TIM22 Import Pathway
J. Biol. Chem. 2004 279: 43744-43751. First Published on August 4, 2004; doi:10.1074/jbc.M404878200 [Abstract] [Full Text] [PDF]

Suk Ying Tsang, Heinte Lesso, and Ronald A. Li: Dissecting the Structural and Functional Roles of the S3-S4 Linker of Pacemaker (Hyperpolarization-activated Cyclic Nucleotide-modulated) Channels by Systematic Length Alterations
J. Biol. Chem. 2004 279: 43752-43759. First Published on August 8, 2004; doi:10.1074/jbc.M408747200 [Abstract] [Full Text] [PDF]

Biagio Gravante, Andrea Barbuti, Raffaella Milanesi, Ivan Zappi, Carlo Viscomi, and Dario DiFrancesco: Interaction of the Pacemaker Channel HCN1 with Filamin A
J. Biol. Chem. 2004 279: 43847-43853. First Published on July 30, 2004; doi:10.1074/jbc.M401598200 [Abstract] [Full Text] [PDF]

Nashaat Z. Gerges, Donald S. Backos, and José A. Esteban: Local Control of AMPA Receptor Trafficking at the Postsynaptic Terminal by a Small GTPase of the Rab Family
J. Biol. Chem. 2004 279: 43870-43878. First Published on August 5, 2004; doi:10.1074/jbc.M404982200 [Abstract] [Full Text] [PDF]

Cedric Montigny, Christine Jaxel, Alla Shainskaya, Joëlle Vinh, Valérie Labas, Jesper V. Møller, Steven J. D. Karlish, and Marc le Maire: Fe²⁺-catalyzed Oxidative Cleavages of Ca²⁺-ATPase Reveal Novel Features of Its Pumping Mechanism
J. Biol. Chem. 2004 279: 43971-43981. First Published on July 19, 2004; doi:10.1074/jbc.M407142200 [Abstract] [Full Text] [PDF]

Symeon Papadopoulos, Valérie Leuranguer, Roger A. Bannister, and Kurt G. Beam: Mapping Sites of Potential Proximity between the Dihydropyridine Receptor and RyR1 in Muscle Using a Cyan Fluorescent Protein-Yellow Fluorescent Protein Tandem as a Fluorescence Resonance Energy Transfer Probe
J. Biol. Chem. 2004 279: 44046-44056. First Published on July 27, 2004; doi:10.1074/jbc.M405317200 [Abstract] [Full Text] [PDF] Supplemental Data

Nancy M. Lorenzon, Claudia S. Haarmann, Ethan E. Norris, Symeon Papadopoulos, and Kurt G. Beam: Metabolic Biotinylation as a Probe of Supramolecular Structure of the Triad Junction in Skeletal Muscle
J. Biol. Chem. 2004 279: 44057-44064. First Published on July 27, 2004; doi:10.1074/jbc.M405318200 [Abstract] [Full Text] [PDF]

Hiroshi Hibino, Akikazu Fujita, Kaori Iwai, Mitsuhiko Yamada, and Yoshihisa Kurachi: Differential Assembly of Inwardly Rectifying K⁺ Channel Subunits, Kir4.1 and Kir5.1, in Brain Astrocytes
J. Biol. Chem. 2004 279: 44065-44073. First Published on August 13, 2004; doi:10.1074/jbc.M405985200 [Abstract] [Full Text] [PDF]

Mechanisms Of Signal Transduction:

Hiromichi Fujino, George A. Vielhauer, and John W. Regan: Prostaglandin E₂ Selectively Antagonizes Prostaglandin F₂-stimulated T-cell Factor/ ${beta}$ -Catenin Signaling Pathway by the FP_B Prostanoid Receptor
J. Biol. Chem. 2004 279: 43386-43391. First Published on July 27, 2004; doi:10.1074/jbc.M408276200 [Abstract] [Full Text] [PDF]

Xiaoyan Wu, Tatiana K. Zagranichnaya, Grzegorz T. Gurda, Eva M. Eves, and Mitchel L. Villereal: A TRPC1/TRPC3-mediated Increase in Store-operated Calcium Entry Is Required for Differentiation of H19-7 Hippocampal Neuronal Cells
J. Biol. Chem. 2004 279: 43392-43402. First Published on August 5, 2004; doi:10.1074/jbc.M408959200 [Abstract] [Full Text] [PDF] [Papers Of The Week]

Lev Solyakov, Kelvin Cain, Beryl M. Tracey, Rebekah Jukes, Andrew M. Riley, Barry V. L. Potter, and Andrew B. Tobin: Regulation of Casein Kinase-2 (CK2) Activity by Inositol Phosphates
J. Biol. Chem. 2004 279: 43403-43410. First Published on August 5, 2004; doi:10.1074/jbc.M403239200 [Abstract] [Full Text] [PDF]

Mark L. Leyland and Caroline Dart: An Alternatively Spliced Isoform of PSD-93/Chapsyn 110 Binds to the Inwardly Rectifying Potassium Channel, Kir2.1
J. Biol. Chem. 2004 279: 43427-43436. First Published on August 10, 2004; doi:10.1074/jbc.M407575200 [Abstract] [Full Text] [PDF]

Cynthia M. Rohde, Jason Schrum, and Angel W.-M. Lee: A Juxtamembrane Tyrosine in the Colony Stimulating Factor-1 Receptor Regulates Ligand-induced Src Association, Receptor Kinase Function, and Down-regulation
J. Biol. Chem. 2004 279: 43448-43461. First Published on August 5, 2004; doi:10.1074/jbc.M314170200 [Abstract] [Full Text] [PDF]

Tran C. Dong and Simon M. Cutting: The PDZ Domain of the SpoIVB Transmembrane Signaling Protein Enables cis-trans Interactions Involving Multiple Partners Leading to the Activation of the Pro- ${sigma}$ ^K Processing Complex in Bacillus subtilis
J. Biol. Chem. 2004 279: 43468-43478. First Published on July 29, 2004; doi:10.1074/jbc.M407048200 [Abstract] [Full Text] [PDF] Supplemental Data

Audrey L. Eisen-Vandervelde, Stephen N. Waggoner, Zhi Qiang Yao, Evan M. Cale, Chang S. Hahn, and Young S. Hahn: Hepatitis C Virus Core Selectively Suppresses Interleukin-12 Synthesis in Human Macrophages by Interfering with AP-1 Activation
J. Biol. Chem. 2004 279: 43479-43486. First Published on July 30, 2004; doi:10.1074/jbc.M407640200 [Abstract] [Full Text] [PDF]

Magalie Bénard, Bruno J. Gonzalez, Marie-Thérèse Schouft, Anthony Falluel-Morel, David Vaudry, Philippe Chan, Hubert Vaudry, and Marc Fontaine: Characterization of C3a and C5a Receptors in Rat Cerebellar Granule Neurons during Maturation: NEUROPROTECTIVE EFFECT OF C5a AGAINST APOPTOTIC CELL DEATH
J. Biol. Chem. 2004 279: 43487-43496. First Published on August 2, 2004; doi:10.1074/jbc.M404124200 [Abstract] [Full Text] [PDF]

Dezheng Zhao, Yanai Zhan, Hon Wai Koon, Huiyan Zeng, Sarah Keates, Mary P. Moyer, and Charalabos Pothoulakis: Metalloproteinase-dependent Transforming Growth Factor- ${alpha}$ Release Mediates Neurotensin-stimulated MAP Kinase Activation in Human Colonic Epithelial Cells
J. Biol. Chem. 2004 279: 43547-43554. First Published on July 6, 2004; doi:10.1074/jbc.M401453200 [Abstract] [Full Text] [PDF]

Kanghyun Ryoo, Sung-Ho Huh, Yong Hee Lee, Kyoung Wan Yoon, Ssang-Goo Cho, and Eui-Ju Choi: Negative Regulation of MEKK1-induced Signaling by Glutathione S-Transferase Mu
J. Biol. Chem. 2004 279: 43589-43594. First Published on August 6, 2004; doi:10.1074/jbc.M404359200 [Abstract] [Full Text] [PDF]

Laia Viladevall, Raquel Serrano, Amparo Ruiz, Gema Domenech, Jesús Giraldo, Anna Barceló, and Joaquín Ariño: Characterization of the Calcium-mediated Response to Alkaline Stress in Saccharomyces cerevisiae
J. Biol. Chem. 2004 279: 43614-43624. First Published on August 6, 2004; doi:10.1074/jbc.M403606200 [Abstract] [Full Text] [PDF] Supplemental Data

Yuan Shao, Chun Yang, Chris Elly, and Yun-Cai Liu: Differential Regulation of the B Cell Receptor-mediated Signaling by the E3 Ubiquitin Ligase Cbl
J. Biol. Chem. 2004 279: 43646-43653. First Published on August 10, 2004; doi:10.1074/jbc.M404082200 [Abstract] [Full Text] [PDF]

Huabao Xiong, Hongxing Li, Yibang Chen, Jie Zhao, and Jay C. Unkeless: Interaction of TRAF6 with MAST205 Regulates NF- ${kappa}$ B Activation and MAST205 Stability
J. Biol. Chem. 2004 279: 43675-43683. First Published on August 11, 2004; doi:10.1074/jbc.M404328200 [Abstract] [Full Text] [PDF]

Chaojun Duan, Minghua Li, and Liangyou Rui: SH2-B Promotes Insulin Receptor Substrate 1 (IRS1)- and IRS2-mediated Activation of the Phosphatidylinositol 3-Kinase Pathway in Response to Leptin
J. Biol. Chem. 2004 279: 43684-43691. First Published on August 16, 2004; doi:10.1074/jbc.M408495200 [Abstract] [Full Text] [PDF]

Zoltán Szatmáry, Michael J. Garabedian, and Jan Vilcek: Inhibition of Glucocorticoid Receptor-mediated Transcriptional Activation by p38 Mitogen-activated Protein (MAP) Kinase
J. Biol. Chem. 2004 279: 43708-43715. First Published on August 2, 2004; doi:10.1074/jbc.M406568200 [Abstract] [Full Text] [PDF]

Silvia Giovedì, Paola Vaccaro, Flavia Valtorta, François Darchen, Paul Greengard, Gianni Cesareni, and Fabio Benfenati: Synapsin Is a Novel Rab3 Effector Protein on Small Synaptic Vesicles: I. IDENTIFICATION AND CHARACTERIZATION OF THE SYNAPSIN I-Rab3 INTERACTIONS IN VITRO AND IN INTACT NERVE TERMINALS
J. Biol. Chem. 2004 279: 43760-43768. First Published on July 20, 2004; doi:10.1074/jbc.M403293200 [Abstract] [Full Text] [PDF]

Silvia Giovedì, François Darchen, Flavia Valtorta, Paul Greengard, and Fabio Benfenati: Synapsin Is a Novel Rab3 Effector Protein on Small Synaptic Vesicles: II. FUNCTIONAL EFFECTS OF THE Rab3A-SYNAPSIN I INTERACTION
J. Biol. Chem. 2004 279: 43769-43779. First Published on July 20, 2004; doi:10.1074/jbc.M404168200 [Abstract] [Full Text] [PDF]

Sylvie Ducreux, Francesco Zorzato, Clemens Müller, Caroline Sewry, Francesco Muntoni, Ros Quinlivan, Gabriella Restagno, Thierry Girard, and Susan Treves: Effect of Ryanodine Receptor Mutations on Interleukin-6 Release and Intracellular Calcium Homeostasis in Human Myotubes from Malignant Hyperthermia-susceptible Individuals and Patients Affected by Central Core Disease
J. Biol. Chem. 2004 279: 43838-43846. First Published on August 8, 2004; doi:10.1074/jbc.M403612200 [Abstract] [Full Text] [PDF]

Siegfried Ussar and Tilman Voss: MEK1 and MEK2, Different Regulators of the G₁/S Transition
J. Biol. Chem. 2004 279: 43861-43869. First Published on July 28, 2004; doi:10.1074/jbc.M406240200 [Abstract] [Full Text] [PDF]

Isabelle Quélo, Claude Gauthier, Gregory E. Hannigan, Shoukat Dedhar, and René St-Arnaud: Integrin-linked Kinase Regulates the Nuclear Entry of the c-Jun Coactivator ${alpha}$ -NAC and Its Coactivation Potency
J. Biol. Chem. 2004 279: 43893-43899. First Published on August 6, 2004; doi:10.1074/jbc.M406310200 [Abstract] [Full Text] [PDF]

Annalisa Natalicchio, Luigi Laviola, Claudia De Tullio, Lucia Adelaide Renna, Carmela Montrone, Sebastio Perrini, Giovanna Valenti, Giuseppe Procino, Maria Svelto, and Francesco Giorgino: Role of the p66^Shc Isoform in Insulin-like Growth Factor I Receptor Signaling through MEK/Erk and Regulation of Actin Cytoskeleton in Rat Myoblasts
J. Biol. Chem. 2004 279: 43900-43909. First Published on July 19, 2004; doi:10.1074/jbc.M403936200 [Abstract] [Full Text] [PDF]

Xiaoling Zhang, June Li, Daniel P. Sejas, Keaney R. Rathbun, Grover C. Bagby, and Qishen Pang: The Fanconi Anemia Proteins Functionally Interact with the Protein Kinase Regulated by RNA (PKR)
J. Biol. Chem. 2004 279: 43910-43919. First Published on August 6, 2004; doi:10.1074/jbc.M403884200 [Abstract] [Full Text] [PDF]

Michela Errico, Teresa Riccioni, Shalini Iyer, Claudio Pisano, K. Ravi Acharya, M. Graziella Persico, and Sandro De Falco: Identification of Placenta Growth Factor Determinants for Binding and Activation of Flt-1 Receptor
J. Biol. Chem. 2004 279: 43929-43939. First Published on July 21, 2004; doi:10.1074/jbc.M401418200 [Abstract] [Full Text] [PDF]

Ming-Hui Zou, Stacy S. Kirkpatrick, Bradley J. Davis, John S. Nelson, Walter G. Wiles, IV, Uwe Schlattner, Dietbert Neumann, Michael Brownlee, Michael B. Freeman, and Mitch H. Goldman: Activation of the AMP-activated Protein Kinase by the Anti-diabetic Drug Metformin in Vivo: ROLE OF MITOCHONDRIAL REACTIVE NITROGEN SPECIES
J. Biol. Chem. 2004 279: 43940-43951. First Published on July 19, 2004; doi:10.1074/jbc.M404421200 [Abstract] [Full Text] [PDF]

Derek K. Marsee, Anjli Venkateswaran, Haiyang Tao, Douangsone Vadysirisack, Zhaoxia Zhang, Dale D. Vandre, and Sissy M. Jhiang: Inhibition of Heat Shock Protein 90, a Novel RET/PTC1-associated Protein, Increases Radioiodide Accumulation in Thyroid Cells
J. Biol. Chem. 2004 279: 43990-43997. First Published on August 9, 2004; doi:10.1074/jbc.M407503200 [Abstract] [Full Text] [PDF]

Stefan Krautwald, Ekkehard Ziegler, Karen Tiede, Rainer Pust, and Ulrich Kunzendorf: Transduction of the TAT-FLIP Fusion Protein Results in Transient Resistance to Fas-induced Apoptosis in Vivo
J. Biol. Chem. 2004 279: 44005-44011. First Published on August 10, 2004; doi:10.1074/jbc.M401327200 [Abstract] [Full Text] [PDF]

Md. Ruhul Abid, Ivo G. Schoots, Katherine C. Spokes, Sheng-Qian Wu, Christina Mawhinney, and William C. Aird: Vascular Endothelial Growth Factor-mediated Induction of Manganese Superoxide Dismutase Occurs through Redox-dependent Regulation of Forkhead and I ${kappa}$ B/NF- ${kappa}$ B
J. Biol. Chem. 2004 279: 44030-44038. First Published on August 11, 2004; doi:10.1074/jbc.M408285200 [Abstract] [Full Text] [PDF]

Thomas R. Hynes, Stacy M. Mervine, Evan A. Yost, Jonathan L. Sabo, and Catherine H. Berlot: Live Cell Imaging of G_s and the ${beta}$ ₂-Adrenergic Receptor Demonstrates That Both ${alpha}$ _s and ${beta}$ ₁ ${gamma}$ ₇ Internalize upon Stimulation and Exhibit Similar Trafficking Patterns That Differ from That of the ${beta}$ ₂-Adrenergic Receptor
J. Biol. Chem. 2004 279: 44101-44112. First Published on August 5, 2004; doi:10.1074/jbc.M405151200 [Abstract] [Full Text] [PDF] Supplemental Data

Sibylla Martinelli, Mirjana Urosevic, Arezoo Daryadel, Patrick Antony Oberholzer, Christa Baumann, Martin F. Fey, Reinhard Dummer, Hans-Uwe Simon, and Shida Yousefi: Induction of Genes Mediating Interferon-dependent Extracellular Trap Formation during Neutrophil Differentiation
J. Biol. Chem. 2004 279: 44123-44132. First Published on August 9, 2004; doi:10.1074/jbc.M405883200 [Abstract] [Full Text] [PDF]

Cathy Cole Lanning, Janelle L. Daddona, Rebecca Ruiz-Velasco, Shulamith H. Shafer, and Carol L. Williams: The Rac1 C-terminal Polybasic Region Regulates the Nuclear Localization and Protein Degradation of Rac1
J. Biol. Chem. 2004 279: 44197-44210. First Published on August 10, 2004; doi:10.1074/jbc.M404977200 [Abstract] [Full Text] [PDF]

Ying-Yu Wu, Yung-Chi Chang, Tsui-Ling Hsu, Shie-Liang Hsieh, and Ming-Zong Lai: Sensitization of Cells to TRAIL-induced Apoptosis by Decoy Receptor 3
J. Biol. Chem. 2004 279: 44211-44218. First Published ; doi:10.1074/jbc.408842200 [Abstract] [Full Text] [PDF]

Molecular Basis Of Cell and Developmental Biology:

Arunkumar B. Deora, Geri Kreitzer, Andrew T. Jacovina, and Katherine A. Hajjar: An Annexin 2 Phosphorylation Switch Mediates p11-dependent Translocation of Annexin 2 to the Cell Surface
J. Biol. Chem. 2004 279: 43411-43418. First Published on August 9, 2004; doi:10.1074/jbc.M408078200 [Abstract] [Full Text] [PDF]

Porntula Panorchan, Benjamin W. Schafer, Denis Wirtz, and Yiider Tseng: Nuclear Envelope Breakdown Requires Overcoming the Mechanical Integrity of the Nuclear Lamina
J. Biol. Chem. 2004 279: 43462-43467. First Published on July 30, 2004; doi:10.1074/jbc.M402474200 [Abstract] [Full Text] [PDF] Supplemental Data

Kenneth D. Belanger, Laura A. Simmons, Jessica K. Roth, Kristin A. VanderPloeg, Lauren B. Lichten, and Birthe Fahrenkrog: The Karyopherin Msn5/Kap142 Requires Nup82 for Nuclear Export and Performs a Function Distinct from Translocation in RPA Protein Import
J. Biol. Chem. 2004 279: 43530-43539. First Published on August 4, 2004; doi:10.1074/jbc.M407641200 [Abstract] [Full Text] [PDF]

Myint Hlaing, Paul Spitz, Krishnan Padmanabhan, Blanca Cabezas, Christopher S. Barker, and Harold S. Bernstein: E2F-1 Regulates the Expression of a Subset of Target Genes during Skeletal Myoblast Hypertrophy
J. Biol. Chem. 2004 279: 43625-43633. First Published on August 9, 2004; doi:10.1074/jbc.M408391200 [Abstract] [Full Text] [PDF] Supplemental Data

Lisa M. Taylor, Alexander James, Christine E. Schuller, Jesena Brce, Richard B. Lock, and Karen L. MacKenzie: Inactivation of p16^INK4a, with Retention of pRB and p53/p21^cip1 Function, in Human MRC5 Fibroblasts That Overcome a Telomere-independent Crisis during Immortalization
J. Biol. Chem. 2004 279: 43634-43645. First Published on August 10, 2004; doi:10.1074/jbc.M402388200 [Abstract] [Full Text] [PDF]

Walker Wharton: Repression of G₀/G₁ Traverse in Human Fibroblasts Exposed to Low Levels of Ionizing Radiation
J. Biol. Chem. 2004 279: 43667-43674. First Published on August 10, 2004; doi:10.1074/jbc.M407959200 [Abstract] [Full Text] [PDF]

Ying Cao, Sigrun Knöchel, Cornelia Donow, Josef Miethe, Eckhard Kaufmann, and Walter Knöchel: The POU Factor Oct-25 Regulates the Xvent-2B Gene and Counteracts Terminal Differentiation in Xenopus Embryos
J. Biol. Chem. 2004 279: 43735-43743. First Published on August 2, 2004; doi:10.1074/jbc.M407544200 [Abstract] [Full Text] [PDF]

Weiwei Li, Lee Walus, Sylvia A. Rabacchi, Adrienna Jirik, Ernie Chang, Jessica Schauer, Betty H. Zheng, Nancy J. Benedetti, Betty P. Liu, Eugene Choi, Dane Worley, Laura Silvian, Wenjun Mo, Colleen Mullen, Weixing Yang, Stephen M. Strittmatter, Dinah W. Y. Sah, Blake Pepinsky, and Daniel H. S. Lee: A Neutralizing Anti-Nogo66 Receptor Monoclonal Antibody Reverses Inhibition of Neurite Outgrowth by Central Nervous System Myelin
J. Biol. Chem. 2004 279: 43780-43788. First Published on August 5, 2004; doi:10.1074/jbc.M401803200 [Abstract] [Full Text] [PDF]

Zhi Zhang, Suzanne M. Lapolla, Matthew G. Annis, Mary Truscott, G. Jane Roberts, Yiwei Miao, Yuanlong Shao, Chibing Tan, Jun Peng, Arthur E. Johnson, Xuejun C. Zhang, David W. Andrews, and Jialing Lin: Bcl-2 Homodimerization Involves Two Distinct Binding Surfaces, a Topographic Arrangement That Provides an Effective Mechanism for Bcl-2 to Capture Activated Bax
J. Biol. Chem. 2004 279: 43920-43928. First Published on August 9, 2004; doi:10.1074/jbc.M406412200 [Abstract] [Full Text] [PDF]

Ling Zhao, Stefan Hart, JrGang Cheng, J. Joseph Melenhorst, Brian Bierie, Matthias Ernst, Colin Stewart, Fred Schaper, Peter C. Heinrich, Axel Ullrich, Gertraud W. Robinson, and Lothar Hennighausen: Mammary Gland Remodeling Depends on gp130 Signaling through Stat3 and MAPK
J. Biol. Chem. 2004 279: 44093-44100. First Published on July 30, 2004; doi:10.1074/jbc.M313131200 [Abstract] [Full Text] [PDF]

Geneviève Dufour, Marie-Josée Demers, David Gagné, Anders Bondo Dydensborg, Inga C. Teller, Véronique Bouchard, Isabelle Degongre, Jean-François Beaulieu, Jin Q. Cheng, Naoya Fujita, Takashi Tsuruo, Karine Vallée, and Pierre H. Vachon: Human Intestinal Epithelial Cell Survival and Anoikis: DIFFERENTIATION STATE-DISTINCT REGULATION AND ROLES OF PROTEIN KINASE B/Akt ISOFORMS
J. Biol. Chem. 2004 279: 44113-44122. First Published on August 6, 2004; doi:10.1074/jbc.M405323200 [Abstract] [Full Text] [PDF]

Additions and Corrections:

Nicolas Joly, Alex Böhm, Winfried Boos, and Evelyne Richet: MalK, the ATP-binding cassette component of the Escherichia coli maltodextrin transporter, inhibits the transcriptional activator MalT by antagonizing inducer binding. Vol. 279 (2004) 33123-33130
J. Biol. Chem. 2004 279: 44229. [Full Text] [PDF]

Joacir Stolarz Oliveira, Elisa Redaelli, André J. Zaharenko, Rita Restano Cassulini, Katsuhiro Konno, Daniel C. Pimenta, José C. Freitas, Jeffrey J. Clare, and Enzo Wanke: Binding specificity of sea anemone toxins to Na_v 1.1-1.6 sodium channels. Unexpected contributions from differences in the IV/S3-S4 outer loop. Vol. 279 (2004) 33323-33335
J. Biol. Chem. 2004 279: 44229-a. [Full Text] [PDF]

Emhonta Johnson, Christopher S. Theisen, Keith R. Johnson, and Margaret J. Wheelock: R-cadherin influences cell motility via Rho family GTPases. Vol. 279 (2004) 31041-31049
J. Biol. Chem. 2004 279: 44230. [Full Text] [PDF]