DNA: Replication, Repair, and Recombination:

Patrick C. Swanson, Dustin Volkmer, and Lei Wang

Full-length RAG-2, and Not Full-length RAG-1, Specifically Suppresses RAG-mediated Transposition but Not Hybrid Joint Formation or Disintegration
J. Biol. Chem. 2004 279: 4034-4044. First Published on November 11, 2003; doi:10.1074/jbc.M311100200 [Abstract] [Full Text] [PDF]  

Liping Liu, David L. Hachey, Gerardo Valadez, Kevin M. Williams, F. Peter Guengerich, Natalia A. Loktionova, Sreenivas Kanugula, and Anthony E. Pegg

Characterization of a Mutagenic DNA Adduct Formed from 1,2-Dibromoethane by O⁶-Alkylguanine-DNA Alkyltransferase
J. Biol. Chem. 2004 279: 4250-4259. First Published on November 25, 2003; doi:10.1074/jbc.M311105200 [Abstract] [Full Text] [PDF] Supplemental Data  

Christopher R. Williams, Anita K. Snyder, Petr Kuzmic, Mike O'Donnell, and Linda B. Bloom

Mechanism of Loading the Escherichia coli DNA Polymerase III Sliding Clamp: I. TWO DISTINCT ACTIVITIES FOR INDIVIDUAL ATP SITES IN THE COMPLEX
J. Biol. Chem. 2004 279: 4376-4385. First Published on November 10, 2003; doi:10.1074/jbc.M310429200 [Abstract] [Full Text] [PDF]  

Anita K. Snyder, Christopher R. Williams, Aaron Johnson, Mike O'Donnell, and Linda B. Bloom

Mechanism of Loading the Escherichia coli DNA Polymerase III Sliding Clamp: II. UNCOUPLING THE AND DNA BINDING ACTIVITIES OF THE COMPLEX
J. Biol. Chem. 2004 279: 4386-4393. First Published on November 10, 2003; doi:10.1074/jbc.M310430200 [Abstract] [Full Text] [PDF]  

Elena I. Zaika, Rebecca A. Perlow, Eileen Matz, Suse Broyde, Rotem Gilboa, Arthur P. Grollman, and Dmitry O. Zharkov

Substrate Discrimination by Formamidopyrimidine-DNA Glycosylase: A MUTATIONAL ANALYSIS
J. Biol. Chem. 2004 279: 4849-4861. First Published on November 7, 2003; doi:10.1074/jbc.M310262200 [Abstract] [Full Text] [PDF] Supplemental Data  

Hong S. Yoon and Vincent W. Yang

Requirement of Krüppel-like Factor 4 in Preventing Entry into Mitosis following DNA Damage
J. Biol. Chem. 2004 279: 5035-5041. First Published on November 19, 2003; doi:10.1074/jbc.M307631200 [Abstract] [Full Text] [PDF]  

Genes: Structure and Regulation:

Miroslava Buryskova, Martin Pospisek, Arnhild Grothey, Thomas Simmet, and Ladislav Burysek

Intracellular Interleukin-1 Functionally Interacts with Histone Acetyltransferase Complexes
J. Biol. Chem. 2004 279: 4017-4026. First Published on November 11, 2003; doi:10.1074/jbc.M306342200 [Abstract] [Full Text] [PDF] Supplemental Data  

Carmen Ruiz de Almodóvar, Carmen Ruiz-Ruiz, Antonio Rodríguez, Gustavo Ortiz-Ferrón, Juan Miguel Redondo, and Abelardo López-Rivas

Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Decoy Receptor TRAIL-R3 Is Up-regulated by p53 in Breast Tumor Cells through a Mechanism Involving an Intronic p53-binding Site
J. Biol. Chem. 2004 279: 4093-4101. First Published on November 17, 2003; doi:10.1074/jbc.M311243200 [Abstract] [Full Text] [PDF]  

Ruichuan Chen, Zhiyuan Yang, and Qiang Zhou

Phosphorylated Positive Transcription Elongation Factor b (P-TEFb) Is Tagged for Inhibition through Association with 7SK snRNA
J. Biol. Chem. 2004 279: 4153-4160. First Published on November 19, 2003; doi:10.1074/jbc.M310044200 [Abstract] [Full Text] [PDF]  

Cynthia J. Guidi, Timothy M. Veal, Stephen N. Jones, and Anthony N. Imbalzano

Transcriptional Compensation for Loss of an Allele of the Ini1 Tumor Suppressor
J. Biol. Chem. 2004 279: 4180-4185. First Published on November 20, 2003; doi:10.1074/jbc.M312043200 [Abstract] [Full Text] [PDF]  

Hongwei Li, Jeong Hoon Kim, Stephen S. Koh, and Michael R. Stallcup

Synergistic Effects of Coactivators GRIP1 and -Catenin on Gene Activation: CROSS-TALK BETWEEN ANDROGEN RECEPTOR AND Wnt SIGNALING PATHWAYS
J. Biol. Chem. 2004 279: 4212-4220. First Published on November 24, 2003; doi:10.1074/jbc.M311374200 [Abstract] [Full Text] [PDF]  

Dong U. Lee, Orly Avni, Lin Chen, and Anjana Rao

A Distal Enhancer in the Interferon- (IFN-) Locus Revealed by Genome Sequence Comparison
J. Biol. Chem. 2004 279: 4802-4810. First Published on November 8, 2003; doi:10.1074/jbc.M307904200 [Abstract] [Full Text] [PDF]  

Qingde Wang, Mana Miyakoda, Weidong Yang, Jaspal Khillan, David L. Stachura, Mitchell J. Weiss, and Kazuko Nishikura

Stress-induced Apoptosis Associated with Null Mutation of ADAR1 RNA Editing Deaminase Gene
J. Biol. Chem. 2004 279: 4952-4961. First Published on November 12, 2003; doi:10.1074/jbc.M310162200 [Abstract] [Full Text] [PDF]  

Adam J. Krieg, Sacha A. Krieg, Bonnie S. Ahn, and David J. Shapiro

Interplay between Estrogen Response Element Sequence and Ligands Controls in Vivo Binding of Estrogen Receptor to Regulated Genes
J. Biol. Chem. 2004 279: 5025-5034. First Published on November 14, 2003; doi:10.1074/jbc.M307076200 [Abstract] [Full Text] [PDF]  

RNA: Structure, Metabolism, and Catalysis:

Bünyamin Akgül and Chen-Pei D. Tu

Pentobarbital-mediated Regulation of Alternative Polyadenylation in Drosophila Glutathione S-Transferase D21 mRNAs
J. Biol. Chem. 2004 279: 4027-4033. First Published on November 11, 2003; doi:10.1074/jbc.M310151200 [Abstract] [Full Text] [PDF]  

Jonghwa Kim, John S. L. Parker, Kenneth E. Murray, and Max L. Nibert

Nucleoside and RNA Triphosphatase Activities of Orthoreovirus Transcriptase Cofactor µ2
J. Biol. Chem. 2004 279: 4394-4403. First Published on November 12, 2003; doi:10.1074/jbc.M308637200 [Abstract] [Full Text] [PDF]  

Céline Wagner, Chantal Ehresmann, Bernard Ehresmann, and Christine Brunel

Mechanism of Dimerization of Bicoid mRNA: INITIATION AND STABILIZATION
J. Biol. Chem. 2004 279: 4560-4569. First Published on November 7, 2003; doi:10.1074/jbc.M306511200 [Abstract] [Full Text] [PDF]  

Protein Synthesis, Post-Translation Modification, and Degradation:

Hiroyuki Nishikawa, Seido Ooka, Ko Sato, Kei Arima, Joji Okamoto, Rachel E. Klevit, Mamoru Fukuda, and Tomohiko Ohta

Mass Spectrometric and Mutational Analyses Reveal Lys-6-linked Polyubiquitin Chains Catalyzed by BRCA1-BARD1 Ubiquitin Ligase
J. Biol. Chem. 2004 279: 3916-3924. First Published on November 24, 2003; doi:10.1074/jbc.M308540200 [Abstract] [Full Text] [PDF]  

Yechiel Elkabetz, Ilana Shapira, Efrat Rabinovich, and Shoshana Bar-Nun

Distinct Steps in Dislocation of Luminal Endoplasmic Reticulum-associated Degradation Substrates: ROLES OF ENDOPLASMIC RETICULUM-BOUND p97/Cdc48p AND PROTEASOME
J. Biol. Chem. 2004 279: 3980-3989. First Published on November 8, 2003; doi:10.1074/jbc.M309938200 [Abstract] [Full Text] [PDF]  

Gisela Weskamp, Johannes Schlöndorff, Lawrence Lum, J. David Becherer, Tae-Wan Kim, Paul Saftig, Dieter Hartmann, Gillian Murphy, and Carl P. Blobel

Evidence for a Critical Role of the Tumor Necrosis Factor Convertase (TACE) in Ectodomain Shedding of the p75 Neurotrophin Receptor (p75^NTR)
J. Biol. Chem. 2004 279: 4241-4249. First Published on November 24, 2003; doi:10.1074/jbc.M307974200 [Abstract] [Full Text] [PDF]  

John Silke, Tobias Kratina, Paul G. Ekert, Miha Pakusch, and David L. Vaux

Unlike Diablo/smac, Grim Promotes Global Ubiquitination and Specific Degradation of X Chromosome-linked Inhibitor of Apoptosis (XIAP) and Neither Cause Apoptosis
J. Biol. Chem. 2004 279: 4313-4321. First Published on October 21, 2003; doi:10.1074/jbc.M305661200 [Abstract] [Full Text] [PDF] Supplemental Data  

Tomohisa Horibe, Mitsuhiro Gomi, Daisuke Iguchi, Hideaki Ito, Yukiko Kitamura, Toshio Masuoka, Ikuo Tsujimoto, Taiji Kimura, and Masakazu Kikuchi

Different Contributions of the Three CXXC Motifs of Human Protein-disulfide Isomerase-related Protein to Isomerase Activity and Oxidative Refolding
J. Biol. Chem. 2004 279: 4604-4611. First Published on November 19, 2003; doi:10.1074/jbc.M310922200 [Abstract] [Full Text] [PDF]  

Mikiei Tanaka, Yong Man Kim, Gwang Lee, Eunsung Junn, Takeshi Iwatsubo, and M. Maral Mouradian

Aggresomes Formed by -Synuclein and Synphilin-1 Are Cytoprotective
J. Biol. Chem. 2004 279: 4625-4631. First Published on November 19, 2003; doi:10.1074/jbc.M310994200 [Abstract] [Full Text] [PDF]  

Isabelle Brodeur, Isabelle Goulet, Cédric S. Tremblay, Chantal Charbonneau, Marie-Chantal Delisle, Chantal Godin, Caroline Huard, Edward W. Khandjian, Manuel Buchwald, Georges Lévesque, and Madeleine Carreau

Regulation of the Fanconi Anemia Group C Protein through Proteolytic Modification
J. Biol. Chem. 2004 279: 4713-4720. First Published on November 18, 2003; doi:10.1074/jbc.M301291200 [Abstract] [Full Text] [PDF]  

Jean-Benoît Peltier, Daniel R. Ripoll, Giulia Friso, Andrea Rudella, Yang Cai, Jimmy Ytterberg, Lisa Giacomelli, Jaroslaw Pillardy, and Klaas J. van Wijk

Clp Protease Complexes from Photosynthetic and Non-photosynthetic Plastids and Mitochondria of Plants, Their Predicted Three-dimensional Structures, and Functional Implications
J. Biol. Chem. 2004 279: 4768-4781. First Published on October 30, 2003; doi:10.1074/jbc.M309212200 [Abstract] [Full Text] [PDF] HTML Page - index.htslp  

Hideki Shimura, Daniel Schwartz, Steven P. Gygi, and Kenneth S. Kosik

CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival
J. Biol. Chem. 2004 279: 4869-4876. First Published on November 10, 2003; doi:10.1074/jbc.M305838200 [Abstract] [Full Text] [PDF]  

Dania Alarcon-Vargas and Ze'ev Ronai

c-Jun-NH₂ Kinase (JNK) Contributes to the Regulation of c-Myc Protein Stability
J. Biol. Chem. 2004 279: 5008-5016. First Published on November 17, 2003; doi:10.1074/jbc.M312054200 [Abstract] [Full Text] [PDF]  

Genomics, Proteomics, and Bioinformatics:

Steffen Ohlmeier, Alexander J. Kastaniotis, J. Kalervo Hiltunen, and Ulrich Bergmann

The Yeast Mitochondrial Proteome, a Study of Fermentative and Respiratory Growth
J. Biol. Chem. 2004 279: 3956-3979. First Published on November 3, 2003; doi:10.1074/jbc.M310160200 [Abstract] [Full Text] [PDF]  

Jeane Maria De Freitas, Jeung Hyoun Kim, Helen Poynton, Trent Su, Henri Wintz, Tama Fox, Patty Holman, Alex Loguinov, Sunduz Keles, Mark van der Laan, and Chris Vulpe

Exploratory and Confirmatory Gene Expression Profiling of mac1
J. Biol. Chem. 2004 279: 4450-4458. First Published on October 8, 2003; doi:10.1074/jbc.M212308200 [Abstract] [Full Text] [PDF] Supplemental Data  

Trine Nilsen, Thomas Slagsvold, Camilla Skiple Skjerpen, Andreas Brech, Harald Stenmark, and Sjur Olsnes

Peroxisomal Targeting as a Tool for Assaying Protein-Protein Interactions in the Living Cell: CYTOKINE-INDEPENDENT SURVIVAL KINASE (CISK) BINDS PDK-1 IN VIVO IN A PHOSPHORYLATION-DEPENDENT MANNER
J. Biol. Chem. 2004 279: 4794-4801. First Published on November 6, 2003; doi:10.1074/jbc.M309653200 [Abstract] [Full Text] [PDF]  

Protein Structure and Folding:

Xuedong Kang, Arnold M. Falick, Robert E. Nelson, Guanghan Gao, Kestrel Rogers, Ruslan Aphasizhev, and Larry Simpson

Disruption of the Zinc Finger Motifs in the Leishmania tarentolae LC-4 (=TbMP63) L-complex Editing Protein Affects the Stability of the L-complex
J. Biol. Chem. 2004 279: 3893-3899. First Published on November 6, 2003; doi:10.1074/jbc.M310185200 [Abstract] [Full Text] [PDF]  

C. Torrey Simons, An Staes, Heidi Rommelaere, Christophe Ampe, Sally A. Lewis, and Nicholas J. Cowan

Selective Contribution of Eukaryotic Prefoldin Subunits to Actin and Tubulin Binding
J. Biol. Chem. 2004 279: 4196-4203. First Published on November 22, 2003; doi:10.1074/jbc.M306053200 [Abstract] [Full Text] [PDF]  

Audrey Lartigue, Arnaud Gruez, Loïc Briand, Florence Blon, Valérie Bézirard, Martin Walsh, Jean-Claude Pernollet, Mariella Tegoni, and Christian Cambillau

Sulfur Single-wavelength Anomalous Diffraction Crystal Structure of a Pheromone-Binding Protein from the Honeybee Apis mellifera L
J. Biol. Chem. 2004 279: 4459-4464. First Published on October 31, 2003; doi:10.1074/jbc.M311212200 [Abstract] [Full Text] [PDF]  

Veronika Obsilova, Petr Herman, Jaroslav Vecer, Miroslav Sulc, Jan Teisinger, and Tomas Obsil

14-3-3 C-terminal Stretch Changes Its Conformation upon Ligand Binding and Phosphorylation at Thr²³²
J. Biol. Chem. 2004 279: 4531-4540. First Published on November 12, 2003; doi:10.1074/jbc.M306939200 [Abstract] [Full Text] [PDF]  

Kenichiro Fujiwara, Takeshi Tenno, Kaoru Sugasawa, Jun-Goo Jee, Izuru Ohki, Chojiro Kojima, Hidehito Tochio, Hidekazu Hiroaki, Fumio Hanaoka, and Masahiro Shirakawa

Structure of the Ubiquitin-interacting Motif of S5a Bound to the Ubiquitin-like Domain of HR23B
J. Biol. Chem. 2004 279: 4760-4767. First Published on October 29, 2003; doi:10.1074/jbc.M309448200 [Abstract] [Full Text] [PDF]  

Brian J. Pope, Karen M. Zierler-Gould, Ronald Kühne, Alan G. Weeds, and Linda J. Ball

Solution Structure of Human Cofilin: ACTIN BINDING, pH SENSITIVITY, AND RELATIONSHIP TO ACTIN-DEPOLYMERIZING FACTOR
J. Biol. Chem. 2004 279: 4840-4848. First Published on November 18, 2003; doi:10.1074/jbc.M310148200 [Abstract] [Full Text] [PDF] Supplemental Data  

Rey-Ting Guo, Chih-Jung Kuo, Chia-Cheng Chou, Tzu-Ping Ko, Hui-Lin Shr, Po-Huang Liang, and Andrew H.-J. Wang

Crystal Structure of Octaprenyl Pyrophosphate Synthase from Hyperthermophilic Thermotoga maritima and Mechanism of Product Chain Length Determination
J. Biol. Chem. 2004 279: 4903-4912. First Published on November 15, 2003; doi:10.1074/jbc.M310161200 [Abstract] [Full Text] [PDF]  

Daniel J. D. Johnson and James A. Huntington

The Influence of Hinge Region Residue Glu-381 on Antithrombin Allostery and Metastability
J. Biol. Chem. 2004 279: 4913-4921. First Published on November 17, 2003; doi:10.1074/jbc.M311644200 [Abstract] [Full Text] [PDF]  

Ning Shi, Sheng Ye, Mark Bartlam, Maojun Yang, Jing Wu, Yiwei Liu, Fei Sun, Xueqing Han, Xiaozhong Peng, Boqing Qiang, Jiangang Yuan, and Zihe Rao

Structural Basis for the Specific Recognition of RET by the Dok1 Phosphotyrosine Binding Domain
J. Biol. Chem. 2004 279: 4962-4969. First Published on November 7, 2003; doi:10.1074/jbc.M311030200 [Abstract] [Full Text] [PDF]  

Koh Takeuchi, Hideo Takahashi, Mariko Sugai, Hideo Iwai, Toshiyuki Kohno, Kazuhisa Sekimizu, Shunji Natori, and Ichio Shimada

Channel-forming Membrane Permeabilization by an Antibacterial Protein, Sapecin: DETERMINATION OF MEMBRANE-BURIED AND OLIGOMERIZATION SURFACES BY NMR
J. Biol. Chem. 2004 279: 4981-4987. First Published on November 20, 2003; doi:10.1074/jbc.M307815200 [Abstract] [Full Text] [PDF]  

Enzyme Catalysis and Regulation:

Bijan Bambai, Corina E. Rogge, Boguslaw Stec, and Richard J. Kulmacz

Role of Asn-382 and Thr-383 in Activation and Inactivation of Human Prostaglandin H Synthase Cyclooxygenase Catalysis
J. Biol. Chem. 2004 279: 4084-4092. First Published on November 18, 2003; doi:10.1074/jbc.M304762200 [Abstract] [Full Text] [PDF]  

Sheu-Fen Lee, Sanjiv Shah, Cong Yu, W. Christian Wigley, Harry Li, Myungsil Lim, Kia Pedersen, Weiping Han, Philip Thomas, Johan Lundkvist, Yi-Heng Hao, and Gang Yu

A Conserved GXXXG Motif in APH-1 Is Critical for Assembly and Activity of the -Secretase Complex
J. Biol. Chem. 2004 279: 4144-4152. First Published on November 19, 2003; doi:10.1074/jbc.M309745200 [Abstract] [Full Text] [PDF]  

Clement Gautier, Michel Négrerie, Zhi-Qiang Wang, Jean-Christophe Lambry, Dennis J. Stuehr, Fabrice Collin, Jean-Louis Martin, and Anny Slama-Schwok

Dynamic Regulation of the Inducible Nitric-oxide Synthase by NO: COMPARISON WITH THE ENDOTHELIAL ISOFORM
J. Biol. Chem. 2004 279: 4358-4365. First Published on October 31, 2003; doi:10.1074/jbc.M305048200 [Abstract] [Full Text] [PDF]  

Jun Kotera, Takashi Sasaki, Tamaki Kobayashi, Kotomi Fujishige, Yoko Yamashita, and Kenji Omori

Subcellular Localization of Cyclic Nucleotide Phosphodiesterase Type 10A Variants, and Alteration of the Localization by cAMP-dependent Protein Kinase-dependent Phosphorylation
J. Biol. Chem. 2004 279: 4366-4375. First Published on November 6, 2003; doi:10.1074/jbc.M308471200 [Abstract] [Full Text] [PDF]  

Claus Schneider, William E. Boeglin, and Alan R. Brash

Identification of Two Cyclooxygenase Active Site Residues, Leucine 384 and Glycine 526, That Control Carbon Ring Cyclization in Prostaglandin Biosynthesis
J. Biol. Chem. 2004 279: 4404-4414. First Published on October 31, 2003; doi:10.1074/jbc.M307431200 [Abstract] [Full Text] [PDF]  

Eissa Hanna, Kit Fai Ng, Ian J. MacRae, Christopher J. Bley, Andrew J. Fisher, and Irwin H. Segel

Kinetic and Stability Properties of Penicillium chrysogenum ATP Sulfurylase Missing the C-terminal Regulatory Domain
J. Biol. Chem. 2004 279: 4415-4424. First Published on November 12, 2003; doi:10.1074/jbc.M311317200 [Abstract] [Full Text] [PDF]  

Guangjie Cheng and J. David Lambeth

NOXO1, Regulation of Lipid Binding, Localization, and Activation of Nox1 by the Phox Homology (PX) Domain
J. Biol. Chem. 2004 279: 4737-4742. First Published on November 14, 2003; doi:10.1074/jbc.M305968200 [Abstract] [Full Text] [PDF]  

Mark A. Baker, Darius J. R. Lane, Jennifer D. Ly, Vito De Pinto, and Alfons Lawen

VDAC1 Is a Transplasma Membrane NADH-Ferricyanide Reductase
J. Biol. Chem. 2004 279: 4811-4819. First Published on October 22, 2003; doi:10.1074/jbc.M311020200 [Abstract] [Full Text] [PDF]  

T. Renee Dawson, Christopher L. Sansam, and Ronald B. Emeson

Structure and Sequence Determinants Required for the RNA Editing of ADAR2 Substrates
J. Biol. Chem. 2004 279: 4941-4951. First Published on November 30, 2003; doi:10.1074/jbc.M310068200 [Abstract] [Full Text] [PDF]  

Maria Hrmova, Ross De Gori, Brian J. Smith, Andrea Vasella, Joseph N. Varghese, and Geoffrey B. Fincher

Three-dimensional Structure of the Barley -D-Glucan Glucohydrolase in Complex with a Transition State Mimic
J. Biol. Chem. 2004 279: 4970-4980. First Published on November 3, 2003; doi:10.1074/jbc.M307188200 [Abstract] [Full Text] [PDF]  

Metabolism and Bioenergetics:

Zhunan Xia, Kimber L. Stanhope, Erin Digitale, Oana-Maria Simion, Lanying Chen, Peter Havel, and Katherine Cianflone

Acylation-stimulating Protein (ASP)/Complement C3adesArg Deficiency Results in Increased Energy Expenditure in Mice
J. Biol. Chem. 2004 279: 4051-4057. First Published on November 13, 2003; doi:10.1074/jbc.M311319200 [Abstract] [Full Text] [PDF]  

Yoko Uchida, Ken-ichi Ohba, Toshimasa Yoshioka, Kaoru Irie, Takamura Muraki, and Yoshiro Maru

Cellular Carbonyl Stress Enhances the Expression of Plasminogen Activator Inhibitor-1 in Rat White Adipocytes via Reactive Oxygen Species-dependent Pathway
J. Biol. Chem. 2004 279: 4075-4083. First Published on November 10, 2003; doi:10.1074/jbc.M304222200 [Abstract] [Full Text] [PDF]  

Alexei P. Kudin, Nana Yaw-B. Bimpong-Buta, Stefan Vielhaber, Christian E. Elger, and Wolfram S. Kunz

Characterization of Superoxide-producing Sites in Isolated Brain Mitochondria
J. Biol. Chem. 2004 279: 4127-4135. First Published on November 18, 2003; doi:10.1074/jbc.M310341200 [Abstract] [Full Text] [PDF]  

Franco Zoccarato, Lucia Cavallini, and Adolfo Alexandre

Respiration-dependent Removal of Exogenous H₂O₂ in Brain Mitochondria: INHIBITION BY Ca²⁺
J. Biol. Chem. 2004 279: 4166-4174. First Published on November 20, 2003; doi:10.1074/jbc.M308143200 [Abstract] [Full Text] [PDF]  

Geoffrey A. Walford, Rose-Laure Moussignac, Anne W. Scribner, Joseph Loscalzo, and Jane A. Leopold

Hypoxia Potentiates Nitric Oxide-mediated Apoptosis in Endothelial Cells via Peroxynitrite-induced Activation of Mitochondria-dependent and -independent Pathways
J. Biol. Chem. 2004 279: 4425-4432. First Published on November 3, 2003; doi:10.1074/jbc.M310582200 [Abstract] [Full Text] [PDF]  

John J. Tomashek, Olga B. Glagoleva, and William S. A. Brusilow

The Escherichia coli F₁F₀ ATP Synthase Displays Biphasic Synthesis Kinetics
J. Biol. Chem. 2004 279: 4465-4470. First Published on November 5, 2003; doi:10.1074/jbc.M310826200 [Abstract] [Full Text] [PDF]  

José M. Rodríguez, Pedro Ruíz-Sala, Magdalena Ugarte, and Miguel Á. Peñalva

Fungal Metabolic Model for 3-Methylcrotonyl-CoA Carboxylase Deficiency
J. Biol. Chem. 2004 279: 4578-4587. First Published on November 11, 2003; doi:10.1074/jbc.M310055200 [Abstract] [Full Text] [PDF]  

Anke Stroh, Oliver Anderka, Kathy Pfeiffer, Takao Yagi, Moshe Finel, Bernd Ludwig, and Hermann Schägger

Assembly of Respiratory Complexes I, III, and IV into NADH Oxidase Supercomplex Stabilizes Complex I in Paracoccus denitrificans
J. Biol. Chem. 2004 279: 5000-5007. First Published on November 10, 2003; doi:10.1074/jbc.M309505200 [Abstract] [Full Text] [PDF]  

Glycobiology and Extracellular Matrices:

Kate Koles, Kenneth D. Irvine, and Vladislav M. Panin

Functional Characterization of Drosophila Sialyltransferase
J. Biol. Chem. 2004 279: 4346-4357. First Published on November 11, 2003; doi:10.1074/jbc.M309912200 [Abstract] [Full Text] [PDF]  

Toshiyuki Murai, Yoshihiro Miyazaki, Hitomi Nishinakamura, Kazuki N. Sugahara, Takayuki Miyauchi, Yasushi Sako, Toshio Yanagida, and Masayuki Miyasaka

Engagement of CD44 Promotes Rac Activation and CD44 Cleavage during Tumor Cell Migration
J. Biol. Chem. 2004 279: 4541-4550. First Published on November 17, 2003; doi:10.1074/jbc.M307356200 [Abstract] [Full Text] [PDF]  

Jiale He and Linda G. Baum

Presentation of Galectin-1 by Extracellular Matrix Triggers T Cell Death
J. Biol. Chem. 2004 279: 4705-4712. First Published on November 14, 2003; doi:10.1074/jbc.M311183200 [Abstract] [Full Text] [PDF]  

Yuan-Ping Han, Ling Zhou, Jiaohong Wang, Shigang Xiong, Warren L. Garner, Samuel W. French, and Hidekazu Tsukamoto

Essential Role of Matrix Metalloproteinases in Interleukin-1-induced Myofibroblastic Activation of Hepatic Stellate Cell in Collagen
J. Biol. Chem. 2004 279: 4820-4828. First Published on November 14, 2003; doi:10.1074/jbc.M310999200 [Abstract] [Full Text] [PDF]  

Lipids and Lipoproteins:

Karin Thevissen, Dirk C. Warnecke, Isabelle E. J. A. François, Martina Leipelt, Ernst Heinz, Claudia Ott, Ulrich Zähringer, Bart P. H. J. Thomma, Kathelijne K. A. Ferket, and Bruno P. A. Cammue

Defensins from Insects and Plants Interact with Fungal Glucosylceramides
J. Biol. Chem. 2004 279: 3900-3905. First Published on November 6, 2003; doi:10.1074/jbc.M311165200 [Abstract] [Full Text] [PDF]  

Masayoshi Yokoyama, Hiroaki Yagyu, Yunying Hu, Toru Seo, Kumiko Hirata, Shunichi Homma, and Ira J. Goldberg

Apolipoprotein B Production Reduces Lipotoxic Cardiomyopathy: STUDIES IN HEART-SPECIFIC LIPOPROTEIN LIPASE TRANSGENIC MOUSE
J. Biol. Chem. 2004 279: 4204-4211. First Published on November 21, 2003; doi:10.1074/jbc.M311995200 [Abstract] [Full Text] [PDF]  

Guillaume Duménil, Timothy P. Montminy, May Tang, and Ralph R. Isberg

IcmR-regulated Membrane Insertion and Efflux by the Legionella pneumophila IcmQ Protein
J. Biol. Chem. 2004 279: 4686-4695. First Published on November 18, 2003; doi:10.1074/jbc.M309908200 [Abstract] [Full Text] [PDF] Supplemental Data  

Membrane Transport, Structure, Function, and Biogenesis:

Andrew D. Beavis and Mary Powers

Temperature Dependence of the Mitochondrial Inner Membrane Anion Channel: THE RELATIONSHIP BETWEEN TEMPERATURE AND INHIBITION BY MAGNESIUM
J. Biol. Chem. 2004 279: 4045-4050. First Published on November 13, 2003; doi:10.1074/jbc.M310475200 [Abstract] [Full Text] [PDF]  

Marcelo D. Carattino, Shaohu Sheng, and Thomas R. Kleyman

Epithelial Na⁺ Channels Are Activated by Laminar Shear Stress
J. Biol. Chem. 2004 279: 4120-4126. First Published on November 18, 2003; doi:10.1074/jbc.M311783200 [Abstract] [Full Text] [PDF]  

Subbulakshmi Chidambaram, Nina Müllers, Katrin Wiederhold, Volker Haucke, and Gabriele Fischer von Mollard

Specific Interaction between SNAREs and Epsin N-terminal Homology (ENTH) Domains of Epsin-related Proteins in trans-Golgi Network to Endosome Transport
J. Biol. Chem. 2004 279: 4175-4179. First Published on November 20, 2003; doi:10.1074/jbc.M308667200 [Abstract] [Full Text] [PDF]  

Ewa A. Pasyk, Youhou Kang, Xiaohang Huang, Ningren Cui, Laura Sheu, and Herbert Y. Gaisano

Syntaxin-1A Binds the Nucleotide-binding Folds of Sulphonylurea Receptor 1 to Regulate the K_ATP Channel
J. Biol. Chem. 2004 279: 4234-4240. First Published on November 25, 2003; doi:10.1074/jbc.M309667200 [Abstract] [Full Text] [PDF]  

Ehud Ohana, Dror Segal, Raz Palty, Dien Ton-That, Arie Moran, Stefano L. Sensi, John H. Weiss, Michal Hershfinkel, and Israel Sekler

A Sodium Zinc Exchange Mechanism Is Mediating Extrusion of Zinc in Mammalian Cells
J. Biol. Chem. 2004 279: 4278-4284. First Published on October 27, 2003; doi:10.1074/jbc.M309229200 [Abstract] [Full Text] [PDF]  

Sandra R. Davis-Kaplan, Diane McVey Ward, Shelly L. Shiflett, and Jerry Kaplan

Genome-wide Analysis of Iron-dependent Growth Reveals a Novel Yeast Gene Required for Vacuolar Acidification
J. Biol. Chem. 2004 279: 4322-4329. First Published on November 21, 2003; doi:10.1074/jbc.M310680200 [Abstract] [Full Text] [PDF] Supplemental Data  

Rungaroon Waditee, Gazi Sakir Hossain, Yoshito Tanaka, Tatsunosuke Nakamura, Masamitsu Shikata, Jun Takano, Tetsuko Takabe, and Teruhiro Takabe

Isolation and Functional Characterization of Ca²⁺/H⁺ Antiporters from Cyanobacteria
J. Biol. Chem. 2004 279: 4330-4338. First Published on October 14, 2003; doi:10.1074/jbc.M310282200 [Abstract] [Full Text] [PDF]  

Yurong Lai, Chung-Ming Tse, and Jashvant D. Unadkat

Mitochondrial Expression of the Human Equilibrative Nucleoside Transporter 1 (hENT1) Results in Enhanced Mitochondrial Toxicity of Antiviral Drugs
J. Biol. Chem. 2004 279: 4490-4497. First Published on November 7, 2003; doi:10.1074/jbc.M307938200 [Abstract] [Full Text] [PDF]  

Rashid Ali, Christopher L. Brett, Sanchita Mukherjee, and Rajini Rao

Inhibition of Sodium/Proton Exchange by a Rab-GTPase-activating Protein Regulates Endosomal Traffic in Yeast
J. Biol. Chem. 2004 279: 4498-4506. First Published on November 10, 2003; doi:10.1074/jbc.M307446200 [Abstract] [Full Text] [PDF]  

Byung-Eun Kim, Fudi Wang, Jodi Dufner-Beattie, Glen K. Andrews, David J. Eide, and Michael J. Petris

Zn²⁺-stimulated Endocytosis of the mZIP4 Zinc Transporter Regulates Its Location at the Plasma Membrane
J. Biol. Chem. 2004 279: 4523-4530. First Published on November 11, 2003; doi:10.1074/jbc.M310799200 [Abstract] [Full Text] [PDF]  

Li-Fong Seet, Ningsheng Liu, Brendon J. Hanson, and Wanjin Hong

Endofin Recruits TOM1 to Endosomes
J. Biol. Chem. 2004 279: 4670-4679. First Published on November 12, 2003; doi:10.1074/jbc.M311228200 [Abstract] [Full Text] [PDF]  

Peter M. Snyder, Jennifer C. Steines, and Diane R. Olson

Relative Contribution of Nedd4 and Nedd4-2 to ENaC Regulation in Epithelia Determined by RNA Interference
J. Biol. Chem. 2004 279: 5042-5046. First Published on November 26, 2003; doi:10.1074/jbc.M312477200 [Abstract] [Full Text] [PDF]  

Mechanisms Of Signal Transduction:

Thomas Anger, Wei Zhang, and Ulrike Mende

Differential Contribution of GTPase Activation and Effector Antagonism to the Inhibitory Effect of RGS Proteins on G_q-mediated Signaling in Vivo
J. Biol. Chem. 2004 279: 3906-3915. First Published on November 20, 2003; doi:10.1074/jbc.M309496200 [Abstract] [Full Text] [PDF]  

Giovanni Monteleone, Jelena Mann, Ivan Monteleone, Piero Vavassori, Ronald Bremner, Massimo Fantini, Giovanna Del Vecchio Blanco, Roberto Tersigni, Luciano Alessandroni, Derek Mann, Francesco Pallone, and Thomas T. MacDonald

A Failure of Transforming Growth Factor-1 Negative Regulation Maintains Sustained NF-B Activation in Gut Inflammation
J. Biol. Chem. 2004 279: 3925-3932. First Published on November 4, 2003; doi:10.1074/jbc.M303654200 [Abstract] [Full Text] [PDF]  

Kimberly W. Raines, Guan-Liang Cao, Supatra Porsuphatana, Pei Tsai, Gerald M. Rosen, and Paul Shapiro

Nitric Oxide Inhibition of ERK1/2 Activity in Cells Expressing Neuronal Nitric-oxide Synthase
J. Biol. Chem. 2004 279: 3933-3940. First Published on November 5, 2003; doi:10.1074/jbc.M304813200 [Abstract] [Full Text] [PDF]  

Matthias Neid, Kaustubh Datta, Susann Stephan, Ila Khanna, Soumitro Pal, Leslie Shaw, Morris White, and Debabrata Mukhopadhyay

Role of Insulin Receptor Substrates and Protein Kinase C- in Vascular Permeability Factor/Vascular Endothelial Growth Factor Expression in Pancreatic Cancer Cells
J. Biol. Chem. 2004 279: 3941-3948. First Published on November 6, 2003; doi:10.1074/jbc.M303975200 [Abstract] [Full Text] [PDF]  

Reena Rao, Chuan-Ming Hao, and Matthew D. Breyer

Hypertonic Stress Activates Glycogen Synthase Kinase 3-mediated Apoptosis of Renal Medullary Interstitial Cells, Suppressing an NFB-driven Cyclooxygenase-2-dependent Survival Pathway
J. Biol. Chem. 2004 279: 3949-3955. First Published on November 7, 2003; doi:10.1074/jbc.M309325200 [Abstract] [Full Text] [PDF]  

Gang Li and Li Niu

How Fast Does the GluR1Q_flip Channel Open?
J. Biol. Chem. 2004 279: 3990-3997. First Published on November 10, 2003; doi:10.1074/jbc.M310410200 [Abstract] [Full Text] [PDF]  

Simon A. Hinke, Susanne Manhart, Kerstin Kühn-Wache, Cuilan Nian, Hans-Ulrich Demuth, Raymond A. Pederson, and Christopher H. S. McIntosh

[Ser²]- and [Ser(P)²]Incretin Analogs: COMPARISON OF DIPEPTIDYL PEPTIDASE IV RESISTANCE AND BIOLOGICAL ACTIVITIES IN VITRO AND IN VIVO
J. Biol. Chem. 2004 279: 3998-4006. First Published on November 10, 2003; doi:10.1074/jbc.M311304200 [Abstract] [Full Text] [PDF]  

Lei Li, Zhiwei Feng, and Alan G. Porter

JNK-dependent Phosphorylation of c-Jun on Serine 63 Mediates Nitric Oxide-induced Apoptosis of Neuroblastoma Cells
J. Biol. Chem. 2004 279: 4058-4065. First Published on November 14, 2003; doi:10.1074/jbc.M310415200 [Abstract] [Full Text] [PDF]  

Juan J. Sironi and Toru Ouchi

STAT1-induced Apoptosis Is Mediated by Caspases 2, 3, and 7
J. Biol. Chem. 2004 279: 4066-4074. First Published on November 17, 2003; doi:10.1074/jbc.M307774200 [Abstract] [Full Text] [PDF]  

Ganesan L. Kamatchi, Ruthie Franke, Carl Lynch, III, and Julianne J. Sando

Identification of Sites Responsible for Potentiation of Type 2.3 Calcium Currents by Acetyl--methylcholine
J. Biol. Chem. 2004 279: 4102-4109. First Published on November 18, 2003; doi:10.1074/jbc.M308606200 [Abstract] [Full Text] [PDF]  

Yu-Dan Wei, Katherine Tepperman, Ming-ya Huang, Maureen A. Sartor, and Alvaro Puga

Chromium Inhibits Transcription from Polycyclic Aromatic Hydrocarbon-inducible Promoters by Blocking the Release of Histone Deacetylase and Preventing the Binding of p300 to Chromatin
J. Biol. Chem. 2004 279: 4110-4119. First Published on November 18, 2003; doi:10.1074/jbc.M310800200 [Abstract] [Full Text] [PDF]  

Vidya Mamidipudi, Chunru Lin, M. Lamar Seibenhener, and Marie W. Wooten

Regulation of Interleukin Receptor-associated Kinase (IRAK) Phosphorylation and Signaling by Iota Protein Kinase C
J. Biol. Chem. 2004 279: 4161-4165. First Published on December 18, 2003; doi:10.1074/jbc.C300431200 [Abstract] [Full Text] [PDF]  

Soochong Kim, Jianguo Jin, and Satya P. Kunapuli

Akt Activation in Platelets Depends on G_i Signaling Pathways
J. Biol. Chem. 2004 279: 4186-4195. First Published on November 17, 2003; doi:10.1074/jbc.M306162200 [Abstract] [Full Text] [PDF]  

Miki Okada, Takashi Hatakeyama, Hideaki Itoh, Naoki Tokuta, Hiroshi Tokumitsu, and Ryoji Kobayashi

S100A1 Is a Novel Molecular Chaperone and a Member of the Hsp70/Hsp90 Multichaperone Complex
J. Biol. Chem. 2004 279: 4221-4233. First Published on November 24, 2003; doi:10.1074/jbc.M309014200 [Abstract] [Full Text] [PDF]  

Qijin Xu, Ben Yan, Shenghua Li, and Cunming Duan

Fibronectin Binds Insulin-like Growth Factor-binding Protein 5 and Abolishes Its Ligand-dependent Action on Cell Migration
J. Biol. Chem. 2004 279: 4269-4277. First Published on November 24, 2003; doi:10.1074/jbc.M311586200 [Abstract] [Full Text] [PDF]  

Sunghoon Kim, Claire Domon-Dell, Junghee Kang, Dai H. Chung, Jean-Noel Freund, and B. Mark Evers

Down-regulation of the Tumor Suppressor PTEN by the Tumor Necrosis Factor-/Nuclear Factor-B (NF-B)-inducing Kinase/NF-B Pathway Is Linked to a Default IB- Autoregulatory Loop
J. Biol. Chem. 2004 279: 4285-4291. First Published on November 17, 2003; doi:10.1074/jbc.M308383200 [Abstract] [Full Text] [PDF]  

Qi Cao, Ki M. Mak, Chaoling Ren, and Charles S. Lieber

Leptin Stimulates Tissue Inhibitor of Metalloproteinase-1 in Human Hepatic Stellate Cells: RESPECTIVE ROLES OF THE JAK/STAT AND JAK-MEDIATED H₂O₂-DEPENDENT MAPK PATHWAYS
J. Biol. Chem. 2004 279: 4292-4304. First Published on November 18, 2003; doi:10.1074/jbc.M308351200 [Abstract] [Full Text] [PDF]  

Joslyn K. Brunelle, Matthew T. Santore, G. R. Scott Budinger, Yueming Tang, Terrence A. Barrett, Wei-Xing Zong, Eugene Kandel, Brian Keith, M. Celeste Simon, Craig B. Thompson, Nissim Hay, and Navdeep S. Chandel

c-Myc Sensitization to Oxygen Deprivation-induced Cell Death Is Dependent on Bax/Bak, but Is Independent of p53 and Hypoxia-inducible Factor-1
J. Biol. Chem. 2004 279: 4305-4312. First Published on November 19, 2003; doi:10.1074/jbc.M312241200 [Abstract] [Full Text] [PDF]  

Gong Yang, Kathy Qi Cai, Jennifer A. Thompson-Lanza, Robert C. Bast, Jr., and Jinsong Liu

Inhibition of Breast and Ovarian Tumor Growth through Multiple Signaling Pathways by Using Retrovirus-mediated Small Interfering RNA against Her-2/neu Gene Expression
J. Biol. Chem. 2004 279: 4339-4345. First Published on November 18, 2003; doi:10.1074/jbc.M311153200 [Abstract] [Full Text] [PDF]  

Axel G. Stöver, Jean Da Silva Correia, Jay T. Evans, Christopher W. Cluff, Mark W. Elliott, Eric W. Jeffery, David A. Johnson, Michael J. Lacy, Jory R. Baldridge, Peter Probst, Richard J. Ulevitch, David H. Persing, and Robert M. Hershberg

Structure-Activity Relationship of Synthetic Toll-like Receptor 4 Agonists
J. Biol. Chem. 2004 279: 4440-4449. First Published on October 21, 2003; doi:10.1074/jbc.M310760200 [Abstract] [Full Text] [PDF]  

Tzong-Der Way, Ming-Ching Kao, and Jen-Kun Lin

Apigenin Induces Apoptosis through Proteasomal Degradation of HER2/neu in HER2/neu-overexpressing Breast Cancer Cells via the Phosphatidylinositol 3-Kinase/Akt-dependent Pathway
J. Biol. Chem. 2004 279: 4479-4489. First Published on November 5, 2003; doi:10.1074/jbc.M305529200 [Abstract] [Full Text] [PDF]  

Xiaohua Chen, Bo Zhang, Philip M. Harmon, Walter Schaffner, David O. Peterson, and David P. Giedroc

A Novel Cysteine Cluster in Human Metal-responsive Transcription Factor 1 Is Required for Heavy Metal-induced Transcriptional Activation in Vivo
J. Biol. Chem. 2004 279: 4515-4522. First Published on November 10, 2003; doi:10.1074/jbc.M308924200 [Abstract] [Full Text] [PDF]  

Wei-Ping Li, Leonidas Tsiokas, Steven C. Sansom, and Rong Ma

Epidermal Growth Factor Activates Store-operated Ca²⁺ Channels through an Inositol 1,4,5-Trisphosphate-independent Pathway in Human Glomerular Mesangial Cells
J. Biol. Chem. 2004 279: 4570-4577. First Published on November 11, 2003; doi:10.1074/jbc.M304334200 [Abstract] [Full Text] [PDF]  

Katrin de Graaf, Paul Hekerman, Oliver Spelten, Andreas Herrmann, Len C. Packman, Konrad Büssow, Gerhard Müller-Newen, and Walter Becker

Characterization of Cyclin L2, a Novel Cyclin with an Arginine/Serine-rich Domain: PHOSPHORYLATION BY DYRK1A AND COLOCALIZATION WITH SPLICING FACTORS
J. Biol. Chem. 2004 279: 4612-4624. First Published on November 17, 2003; doi:10.1074/jbc.M310794200 [Abstract] [Full Text] [PDF]  

Kwang S. Suh, Michihiro Mutoh, Kunio Nagashima, Ester Fernandez-Salas, Lindsay E. Edwards, Daniel D. Hayes, John M. Crutchley, Keith G. Marin, Rebecca A. Dumont, Joshua M. Levy, Christina Cheng, Susan Garfield, and Stuart H. Yuspa

The Organellular Chloride Channel Protein CLIC4/mtCLIC Translocates to the Nucleus in Response to Cellular Stress and Accelerates Apoptosis
J. Biol. Chem. 2004 279: 4632-4641. First Published on November 10, 2003; doi:10.1074/jbc.M311632200 [Abstract] [Full Text] [PDF]  

Atsushi Suenaga, Anatoly B. Kiyatkin, Mariko Hatakeyama, Noriyuki Futatsugi, Noriaki Okimoto, Yoshinori Hirano, Tetsu Narumi, Atsushi Kawai, Ryutaro Susukita, Takahiro Koishi, Hideaki Furusawa, Kenji Yasuoka, Naoki Takada, Yousuke Ohno, Makoto Taiji, Toshikazu Ebisuzaki, Jan B. Hoek, Akihiko Konagaya, and Boris N. Kholodenko

Tyr-317 Phosphorylation Increases Shc Structural Rigidity and Reduces Coupling of Domain Motions Remote from the Phosphorylation Site as Revealed by Molecular Dynamics Simulations
J. Biol. Chem. 2004 279: 4657-4662. First Published on November 12, 2003; doi:10.1074/jbc.M310598200 [Abstract] [Full Text] [PDF]  

Julien Barbier, Hung Lamthanh, Frédéric Le Gall, Philippe Favreau, Evelyne Benoit, Haijun Chen, Nicolas Gilles, Nitza Ilan, Stefan H. Heinemann, Dalia Gordon, André Ménez, and Jordi Molgó

A -Conotoxin from Conus ermineus Venom Inhibits Inactivation in Vertebrate Neuronal Na⁺ Channels but Not in Skeletal and Cardiac Muscles
J. Biol. Chem. 2004 279: 4680-4685. First Published on November 13, 2003; doi:10.1074/jbc.M309576200 [Abstract] [Full Text] [PDF]  

Gerlinde Kugler, Regina G. Weiss, Bernhard E. Flucher, and Manfred Grabner

Structural Requirements of the Dihydropyridine Receptor _1S II-III Loop for Skeletal-type Excitation-Contraction Coupling
J. Biol. Chem. 2004 279: 4721-4728. First Published on November 18, 2003; doi:10.1074/jbc.M307538200 [Abstract] [Full Text] [PDF]  

Dennis Fiegen, Lars-Christian Haeusler, Lars Blumenstein, Ulrike Herbrand, Radovan Dvorsky, Ingrid R. Vetter, and Mohammad R. Ahmadian

Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase
J. Biol. Chem. 2004 279: 4743-4749. First Published on November 18, 2003; doi:10.1074/jbc.M310281200 [Abstract] [Full Text] [PDF]  

Yasunari Takada and Bharat B. Aggarwal

Flavopiridol Inhibits NF-B Activation Induced by Various Carcinogens and Inflammatory Agents through Inhibition of IB Kinase and p65 Phosphorylation: ABROGATION OF CYCLIN D1, CYCLOOXYGENASE-2, AND MATRIX METALLOPROTEASE-9
J. Biol. Chem. 2004 279: 4750-4759. First Published on November 20, 2003; doi:10.1074/jbc.M304546200 [Abstract] [Full Text] [PDF]  

Julie R. McMullen, Tetsuo Shioi, Weei-Yuarn Huang, Li Zhang, Oleg Tarnavski, Egbert Bisping, Martina Schinke, Sekwon Kong, Megan C. Sherwood, Jeffrey Brown, Lauren Riggi, Peter M. Kang, and Seigo Izumo

The Insulin-like Growth Factor 1 Receptor Induces Physiological Heart Growth via the Phosphoinositide 3-Kinase(p110) Pathway
J. Biol. Chem. 2004 279: 4782-4793. First Published on November 3, 2003; doi:10.1074/jbc.M310405200 [Abstract] [Full Text] [PDF] Supplemental Data  

Dan Chen, Aruna Purohit, Ensar Halilovic, Stephen J. Doxsey, and Alexandra C. Newton

Centrosomal Anchoring of Protein Kinase C II by Pericentrin Controls Microtubule Organization, Spindle Function, and Cytokinesis
J. Biol. Chem. 2004 279: 4829-4839. First Published on November 1, 2003; doi:10.1074/jbc.M311196200 [Abstract] [Full Text] [PDF]  

Thomas L. Kash, Maria-Johanna F. Dizon, James R. Trudell, and Neil L. Harrison

Charged Residues in the ₂ Subunit Involved in GABA_A Receptor Activation
J. Biol. Chem. 2004 279: 4887-4893. First Published on November 10, 2003; doi:10.1074/jbc.M311441200 [Abstract] [Full Text] [PDF]  

Andres Alonso, Nunzio Bottini, Shane Bruckner, Souad Rahmouni, Scott Williams, Stephen P. Schoenberger, and Tomas Mustelin

Lck Dephosphorylation at Tyr-394 and Inhibition of T Cell Antigen Receptor Signaling by Yersinia Phosphatase YopH
J. Biol. Chem. 2004 279: 4922-4928. First Published on November 17, 2003; doi:10.1074/jbc.M308978200 [Abstract] [Full Text] [PDF]  

Hai-Yan Wu, Kazuhito Tomizawa, Yoshiya Oda, Fan-Yan Wei, Yun-Fei Lu, Masayuki Matsushita, Sheng-Tian Li, Akiyoshi Moriwaki, and Hideki Matsui

Critical Role of Calpain-mediated Cleavage of Calcineurin in Excitotoxic Neurodegeneration
J. Biol. Chem. 2004 279: 4929-4940. First Published on November 19, 2003; doi:10.1074/jbc.M309767200 [Abstract] [Full Text] [PDF]  

Deepali Sachdev, Julie S. Hartell, Adrian V. Lee, Xihong Zhang, and Douglas Yee

A Dominant Negative Type I Insulin-like Growth Factor Receptor Inhibits Metastasis of Human Cancer Cells
J. Biol. Chem. 2004 279: 5017-5024. First Published on November 13, 2003; doi:10.1074/jbc.M305403200 [Abstract] [Full Text] [PDF]  

Molecular Basis Of Cell and Developmental Biology:

Shigeru Kanda, Yasuyoshi Miyata, and Hiroshi Kanetake

Fibroblast Growth Factor-2-mediated Capillary Morphogenesis of Endothelial Cells Requires Signals via Flt-1/Vascular Endothelial Growth Factor Receptor-1: POSSIBLE INVOLVEMENT OF c-Akt
J. Biol. Chem. 2004 279: 4007-4016. First Published on November 10, 2003; doi:10.1074/jbc.M307569200 [Abstract] [Full Text] [PDF]  

Stefano Buttiglieri, Maria Chiara Deregibus, Stefania Bravo, Paola Cassoni, Roberto Chiarle, Benedetta Bussolati, and Giovanni Camussi

Role of Pax2 in Apoptosis Resistance and Proinvasive Phenotype of Kaposi's Sarcoma Cells
J. Biol. Chem. 2004 279: 4136-4143. First Published on November 19, 2003; doi:10.1074/jbc.M306824200 [Abstract] [Full Text] [PDF]  

Dmitri V. Rozanov, Elizabeth Hahn-Dantona, Dudley K. Strickland, and Alex Y. Strongin

The Low Density Lipoprotein Receptor-related Protein LRP Is Regulated by Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Proteolysis in Malignant Cells
J. Biol. Chem. 2004 279: 4260-4268. First Published on November 25, 2003; doi:10.1074/jbc.M311569200 [Abstract] [Full Text] [PDF]  

Anthony C. B. Lim, Sock-Yeen Tiu, Qing Li, and Robert Z. Qi

Direct Regulation of Microtubule Dynamics by Protein Kinase CK2
J. Biol. Chem. 2004 279: 4433-4439. First Published on November 22, 2003; doi:10.1074/jbc.M310563200 [Abstract] [Full Text] [PDF]  

Jiang-Wen Zhang, Dwight J. Klemm, Charles Vinson, and M. Daniel Lane

Role of CREB in Transcriptional Regulation of CCAAT/Enhancer-binding Protein Gene during Adipogenesis
J. Biol. Chem. 2004 279: 4471-4478. First Published on October 30, 2003; doi:10.1074/jbc.M311327200 [Abstract] [Full Text] [PDF]  

Yu Liu, Chaowei Wu, and Konstantin Galaktionov

p42, a Novel Cyclin-dependent Kinase-activating Kinase in Mammalian Cells
J. Biol. Chem. 2004 279: 4507-4514. First Published on November 3, 2003; doi:10.1074/jbc.M309995200 [Abstract] [Full Text] [PDF]  

Ai Takemoto, Keiji Kimura, Shigeyuki Yokoyama, and Fumio Hanaoka

Cell Cycle-dependent Phosphorylation, Nuclear Localization, and Activation of Human Condensin
J. Biol. Chem. 2004 279: 4551-4559. First Published on November 6, 2003; doi:10.1074/jbc.M310925200 [Abstract] [Full Text] [PDF]  

Brent E. Bobick and William M. Kulyk

The MEK-ERK Signaling Pathway Is a Negative Regulator of Cartilage-specific Gene Expression in Embryonic Limb Mesenchyme
J. Biol. Chem. 2004 279: 4588-4595. First Published on November 14, 2003; doi:10.1074/jbc.M309805200 [Abstract] [Full Text] [PDF]  

Qing Guo and Jun Xie

AATF Inhibits Aberrant Production of Amyloid Peptide 1-42 by Interacting Directly with Par-4
J. Biol. Chem. 2004 279: 4596-4603. First Published on November 18, 2003; doi:10.1074/jbc.M309811200 [Abstract] [Full Text] [PDF]  

Shufang Wu and Francesco De Luca

Role of Cholesterol in the Regulation of Growth Plate Chondrogenesis and Longitudinal Bone Growth
J. Biol. Chem. 2004 279: 4642-4647. First Published on November 11, 2003; doi:10.1074/jbc.M305518200 [Abstract] [Full Text] [PDF]  

Agnieszka E. Topolska, Angela Lidgett, Dirk Truman, Hisashi Fujioka, and Ross L. Coppel

Characterization of a Membrane-associated Rhoptry Protein of Plasmodium falciparum
J. Biol. Chem. 2004 279: 4648-4656. First Published on November 12, 2003; doi:10.1074/jbc.M307859200 [Abstract] [Full Text] [PDF]  

Xin Bian, Thomas D. Giordano, Huey-Jen Lin, Gabriel Solomon, Valerie P. Castle, and Anthony W. Opipari, Jr.

Chemotherapy-induced Apoptosis of S-type Neuroblastoma Cells Requires Caspase-9 and Is Augmented by CD95/Fas Stimulation
J. Biol. Chem. 2004 279: 4663-4669. First Published on November 14, 2003; doi:10.1074/jbc.M306905200 [Abstract] [Full Text] [PDF]  

Sosuke Iwai, Atsushi Ishiji, Issei Mabuchi, and Kazuo Sutoh

A Novel Actin-bundling Kinesin-related Protein from Dictyostelium discoideum
J. Biol. Chem. 2004 279: 4696-4704. First Published on November 17, 2003; doi:10.1074/jbc.M308022200 [Abstract] [Full Text] [PDF]  

Martin O. Bergo, Hsiao D. Lieu, Bryant J. Gavino, Patricia Ambroziak, James C. Otto, Patrick J. Casey, Quinn M. Walker, and Stephen G. Young

On the Physiological Importance of Endoproteolysis of CAAX Proteins: HEART-SPECIFIC RCE1 KNOCKOUT MICE DEVELOP A LETHAL CARDIOMYOPATHY
J. Biol. Chem. 2004 279: 4729-4736. First Published on November 18, 2003; doi:10.1074/jbc.M310081200 [Abstract] [Full Text] [PDF]  

Nancy J. Boudreau and Judith A. Varner

The Homeobox Transcription Factor Hox D3 Promotes Integrin ₅₁ Expression and Function during Angiogenesis
J. Biol. Chem. 2004 279: 4862-4868. First Published on November 10, 2003; doi:10.1074/jbc.M305190200 [Abstract] [Full Text] [PDF]  

Heather A. Steinman, Ezra Burstein, Christopher Lengner, Joseph Gosselin, German Pihan, Colin S. Duckett, and Stephen N. Jones

An Alternative Splice Form of Mdm2 Induces p53-independent Cell Growth and Tumorigenesis
J. Biol. Chem. 2004 279: 4877-4886. First Published on November 10, 2003; doi:10.1074/jbc.M305966200 [Abstract] [Full Text] [PDF]  

Jochen C. Hartner, Carolin Schmittwolf, Andreas Kispert, Albrecht M. Müller, Miyoko Higuchi, and Peter H. Seeburg

Liver Disintegration in the Mouse Embryo Caused by Deficiency in the RNA-editing Enzyme ADAR1
J. Biol. Chem. 2004 279: 4894-4902. First Published on November 12, 2003; doi:10.1074/jbc.M311347200 [Abstract] [Full Text] [PDF]  

Katharine L. Sugars, Rosemary Brown, Lynnette J. Cook, Jina Swartz, and David C. Rubinsztein

Decreased cAMP Response Element-mediated Transcription: AN EARLY EVENT IN EXON 1 AND FULL-LENGTH CELL MODELS OF HUNTINGTON'S DISEASE THAT CONTRIBUTES TO POLYGLUTAMINE PATHOGENESIS
J. Biol. Chem. 2004 279: 4988-4999. First Published on November 18, 2003; doi:10.1074/jbc.M310226200 [Abstract] [Full Text] [PDF]  

Additions and Corrections:

Seunghwan Lim, Kideok Jin, and Eileen Friedman

Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1. Vol. 277 (2002) 25040-25046
J. Biol. Chem. 2004 279: 5047. [Full Text] [PDF]  

Tomonori Kaneko, Takashi Kumasaka, Tadashi Ganbe, Takao Sato, Keiji Miyazawa, Naomi Kitamura, and Nobuo Tanaka

Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain. Vol. 278 (2003) 48162-48168
J. Biol. Chem. 2004 279: 5047. [Full Text] [PDF]  

Dolores Pérez-Sala, Eva Cernuda-Morollón, and F. Javier Cañada

Molecular basis for the direct inhibition of AP-1 DNA binding by 15-deoxy-^12,14-prostaglandin J₂. Vol. 278 (2003) 51251-51260
J. Biol. Chem. 2004 279: 5048. [Full Text] [PDF]  

John P. Evans, Kyunghye Ahn, and Judith P. Klinman

Evidence that dioxygen and substrate activation are tightly coupled in dopamine -monooxygenase. Implications for the reactive oxygen species. Vol. 278 (2003) 49691-49698
J. Biol. Chem. 2004 279: 5048. [Full Text] [PDF]  

James Fernandez, Alex B. Lopez, Chuanping Wang, Rangnath Mishra, Lingyin Zhou, Ibrahim Yaman, Martin D. Snider, and Maria Hatzoglou

Transcriptional control of the arginine/lysine transporter, Cat-1, by physiological stress. Vol. 278 (2003) 50000-50009
J. Biol. Chem. 2004 279: 5048. [Full Text] [PDF]  

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