JBC -- Table of Contents (Jun 3 2005, 280, (22))

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Classics:

Nicole Kresge, Robert D. Simoni, and Robert L. Hill: George Emil Palade: How Sucrose and Electron Microscopy Led to the Birth of Cell Biology
CYTOCHEMICAL STUDIES OF MAMMALIAN TISSUES. I. ISOLATION OF INTACT MITOCHONDRIA FROM RAT LIVER; SOME BIOCHEMICAL PROPERTIES OF MITOCHONDRIA AND SUBMICROSCOPIC PARTICULATE MATERIAL (George H. Hogeboom, Walter C. Schneider, and George E. Pallade J. Biol. Chem. 172, 619-635)
J. Biol. Chem. 2005 280: e19. [Full Text]

Minireviews:

Ta-Yuan Chang, Patrick C. Reid, Shigeki Sugii, Nobutaka Ohgami, Jonathan C. Cruz, and Catherine C. Y. Chang: Niemann-Pick Type C Disease and Intracellular Cholesterol Trafficking
J. Biol. Chem. 2005 280: 20917-20920. First Published on April 14, 2005; doi:10.1074/jbc.R400040200 [Full Text] [PDF]

DNA: Replication, Repair, and Recombination:

Kathleen C. Dudas and Kenneth N. Kreuzer: Bacteriophage T4 Helicase Loader Protein gp59 Functions as Gatekeeper in Origin-dependent Replication in Vivo
J. Biol. Chem. 2005 280: 21561-21569. First Published on March 21, 2005; doi:10.1074/jbc.M502351200 [Abstract] [Full Text] [PDF]

Nadiya M. Druzhyna, Sergyi I. Musiyenko, Glenn L. Wilson, and Susan P. LeDoux: Cytokines Induce Nitric Oxide-mediated mtDNA Damage and Apoptosis in Oligodendrocytes: PROTECTIVE ROLE OF TARGETING 8-OXOGUANINE GLYCOSYLASE TO MITOCHONDRIA
J. Biol. Chem. 2005 280: 21673-21679. First Published on April 4, 2005; doi:10.1074/jbc.M411531200 [Abstract] [Full Text] [PDF]

Genes: Structure and Regulation:

Pritam Sengupta, Yong Xu, Lin Wang, Russell Widom, and Barbara D. Smith: Collagen ${alpha}$ 1(I) Gene (COL1A1) Is Repressed by RFX Family
J. Biol. Chem. 2005 280: 21004-21014. First Published on March 23, 2005; doi:10.1074/jbc.M413191200 [Abstract] [Full Text] [PDF]

Margo E. Mancl, Guodong Hu, Niquiche Sangster-Guity, Stacey L. Olshalsky, Katherine Hoops, Patricia Fitzgerald-Bocarsly, Paula M. Pitha, Karen Pinder, and Betsy J. Barnes: Two Discrete Promoters Regulate the Alternatively Spliced Human Interferon Regulatory Factor-5 Isoforms: MULTIPLE ISOFORMS WITH DISTINCT CELL TYPE-SPECIFIC EXPRESSION, LOCALIZATION, REGULATION, AND FUNCTION
J. Biol. Chem. 2005 280: 21078-21090. First Published on March 31, 2005; doi:10.1074/jbc.M500543200 [Abstract] [Full Text] [PDF]

Zhanguo Gao, Paul Chiao, Xia Zhang, Xiaohong Zhang, Mitchell A. Lazar, Edward Seto, Howard A. Young, and Jianping Ye: Coactivators and Corepressors of NF- ${kappa}$ B in I ${kappa}$ B ${alpha}$ Gene Promoter
J. Biol. Chem. 2005 280: 21091-21098. First Published on April 4, 2005; doi:10.1074/jbc.M500754200 [Abstract] [Full Text] [PDF]

Victoria L. Marsh, Sew Yeu Peak-Chew, and Stephen D. Bell: Sir2 and the Acetyltransferase, Pat, Regulate the Archaeal Chromatin Protein, Alba
J. Biol. Chem. 2005 280: 21122-21128. First Published on April 11, 2005; doi:10.1074/jbc.M501280200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Rajini Parakati and Joseph X. DiMario: Dynamic Transcriptional Regulatory Complexes, Including E2F4, p107, p130, and Sp1, Control Fibroblast Growth Factor Receptor 1 Gene Expression during Myogenesis
J. Biol. Chem. 2005 280: 21284-21294. First Published on April 4, 2005; doi:10.1074/jbc.M410744200 [Abstract] [Full Text] [PDF]

Ning Zhang, Muhammad H. Ahsan, Leanne Zhu, Lidia C. Sambucetti, Anthony F. Purchio, and David B. West: NF- ${kappa}$ B and Not the MAPK Signaling Pathway Regulates GADD45 ${beta}$ Expression during Acute Inflammation
J. Biol. Chem. 2005 280: 21400-21408. First Published on March 29, 2005; doi:10.1074/jbc.M411952200 [Abstract] [Full Text] [PDF]

Linan Chen, Barbara Cagniard, Tiffany Mathews, Sara Jones, Hyun Chul Koh, Yunmin Ding, Paul M. Carvey, Zaodung Ling, Un Jung Kang, and Xiaoxi Zhuang: Age-dependent Motor Deficits and Dopaminergic Dysfunction in DJ-1 Null Mice
J. Biol. Chem. 2005 280: 21418-21426. First Published on March 30, 2005; doi:10.1074/jbc.M413955200 [Abstract] [Full Text] [PDF]

Mara Giangrossi, Stefano Zattoni, Angela Tramonti, Daniela De Biase, and Maurizio Falconi: Antagonistic Role of H-NS and GadX in the Regulation of the Glutamate Decarboxylase-dependent Acid Resistance System in Escherichia coli
J. Biol. Chem. 2005 280: 21498-21505. First Published on March 28, 2005; doi:10.1074/jbc.M413255200 [Abstract] [Full Text] [PDF]

Yeon-Soo Kim, Jung-Min Kim, Deug-Lim Jung, Jae-Eun Kang, Sukyung Lee, Jin Soo Kim, Wongi Seol, Hyun-Chul Shin, Heung Sun Kwon, Carine Van Lint, Nouria Hernandez, and Man-Wook Hur: Artificial Zinc Finger Fusions Targeting Sp1-binding Sites and the trans-Activator-responsive Element Potently Repress Transcription and Replication of HIV-1
J. Biol. Chem. 2005 280: 21545-21552. First Published on March 2, 2005; doi:10.1074/jbc.M414136200 [Abstract] [Full Text] [PDF]

Timothy V. Beischlag and Gary H. Perdew: ER ${alpha}$ -AHR-ARNT Protein-Protein Interactions Mediate Estradiol-dependent Transrepression of Dioxin-inducible Gene Transcription
J. Biol. Chem. 2005 280: 21607-21611. First Published on April 18, 2005; doi:10.1074/jbc.C500090200 [Abstract] [Full Text] [PDF]

Protein Synthesis, Post-Translation Modification, and Degradation:

Eun-Hee Park, Joseph M. Lee, Jaime D. Blais, John C. Bell, and Jerry Pelletier: Internal Translation Initiation Mediated by the Angiogenic Factor Tie2
J. Biol. Chem. 2005 280: 20945-20953. First Published on March 31, 2005; doi:10.1074/jbc.M412744200 [Abstract] [Full Text] [PDF]

Kazuhiro Honda, Mark A. Smith, Xiongwei Zhu, Diane Baus, William C. Merrick, Alan M. Tartakoff, Thomas Hattier, Peggy L. Harris, Sandra L. Siedlak, Hisashi Fujioka, Quan Liu, Paula I. Moreira, Frank P. Miller, Akihiko Nunomura, Shun Shimohama, and George Perry: Ribosomal RNA in Alzheimer Disease Is Oxidized by Bound Redox-active Iron
J. Biol. Chem. 2005 280: 20978-20986. First Published on March 14, 2005; doi:10.1074/jbc.M500526200 [Abstract] [Full Text] [PDF] [Supplemental Data]

J. Daniel Aroca-Aguilar, Francisco Sánchez-Sánchez, Sikha Ghosh, Miguel Coca-Prados, and Julio Escribano: Myocilin Mutations Causing Glaucoma Inhibit the Intracellular Endoproteolytic Cleavage of Myocilin between Amino Acids Arg²²⁶ and Ile²²⁷
J. Biol. Chem. 2005 280: 21043-21051. First Published on March 28, 2005; doi:10.1074/jbc.M501340200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Reinald Pamplona, Esther Dalfó, Victòria Ayala, Maria Josep Bellmunt, Joan Prat, Isidre Ferrer, and Manuel Portero-Otín: Proteins in Human Brain Cortex Are Modified by Oxidation, Glycoxidation, and Lipoxidation: EFFECTS OF ALZHEIMER DISEASE AND IDENTIFICATION OF LIPOXIDATION TARGETS
J. Biol. Chem. 2005 280: 21522-21530. First Published on March 29, 2005; doi:10.1074/jbc.M502255200 [Abstract] [Full Text] [PDF]

Irina Piven, Ghada Ajlani, and Anna Sokolenko: Phycobilisome Linker Proteins Are Phosphorylated in Synechocystis sp. PCC 6803
J. Biol. Chem. 2005 280: 21667-21672. First Published on April 1, 2005; doi:10.1074/jbc.M412967200 [Abstract] [Full Text] [PDF]

Genomics, Proteomics, and Bioinformatics:

Sitharthan Kamalakaran, Senthil K. Radhakrishnan, and William T. Beck: Identification of Estrogen-responsive Genes Using a Genome-wide Analysis of Promoter Elements for Transcription Factor Binding Sites
J. Biol. Chem. 2005 280: 21491-21497. First Published on March 24, 2005; doi:10.1074/jbc.M409176200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Protein Structure and Folding:

Peipei Wu, Dongdong Ma, Marek Pierzchala, Jun Wu, Lee-Chuan Yang, Xiaoping Mai, Xiaoying Chang, and Thomas Schmidt-Glenewinkel: The Drosophila Acetylcholine Receptor Subunit D ${alpha}$ 5 Is Part of an ${alpha}$ -Bungarotoxin Binding Acetylcholine Receptor
J. Biol. Chem. 2005 280: 20987-20994. First Published on March 21, 2005; doi:10.1074/jbc.M409639200 [Abstract] [Full Text] [PDF]

Jodi L. Kreiling, James C. Byrd, and Richard G. MacDonald: Domain Interactions of the Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor
J. Biol. Chem. 2005 280: 21067-21077. First Published on March 30, 2005; doi:10.1074/jbc.M412971200 [Abstract] [Full Text] [PDF]

Victor J. Torres, Susan E. Ivie, Mark S. McClain, and Timothy L. Cover: Functional Properties of the p33 and p55 Domains of the Helicobacter pylori Vacuolating Cytotoxin
J. Biol. Chem. 2005 280: 21107-21114. First Published on April 6, 2005; doi:10.1074/jbc.M501042200 [Abstract] [Full Text] [PDF]

Marta Ferraroni, Jana Seifert, Vasili M. Travkin, Monika Thiel, Stefan Kaschabek, Andrea Scozzafava, Ludmila Golovleva, Michael Schlömann, and Fabrizio Briganti: Crystal Structure of the Hydroxyquinol 1,2-Dioxygenase from Nocardioides simplex 3E, a Key Enzyme Involved in Polychlorinated Aromatics Biodegradation
J. Biol. Chem. 2005 280: 21144-21154. First Published on March 16, 2005; doi:10.1074/jbc.M500666200 [Abstract] [Full Text] [PDF]

Shouxiong Huang, Susan Gilfillan, Marina Cella, Michael J. Miley, Olivier Lantz, Lonnie Lybarger, Daved H. Fremont, and Ted H. Hansen: Evidence for MR1 Antigen Presentation to Mucosal-associated Invariant T Cells
J. Biol. Chem. 2005 280: 21183-21193. First Published on March 31, 2005; doi:10.1074/jbc.M501087200 [Abstract] [Full Text] [PDF]

Erin H. Norris, Benoit I. Giasson, Roberto Hodara, Shaohua Xu, John Q. Trojanowski, Harry Ischiropoulos, and Virginia M.-Y. Lee: Reversible Inhibition of ${alpha}$ -Synuclein Fibrillization by Dopaminochrome-mediated Conformational Alterations
J. Biol. Chem. 2005 280: 21212-21219. First Published on April 6, 2005; doi:10.1074/jbc.M412621200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Xiaoyi Hu, Kristin Kohler, Arnold M. Falick, Anne M. F. Moore, Patrick R. Jones, O. David Sparkman, and Craig Vierra: Egg Case Protein-1: A NEW CLASS OF SILK PROTEINS WITH FIBROIN-LIKE PROPERTIES FROM THE SPIDER LATRODECTUS HESPERUS
J. Biol. Chem. 2005 280: 21220-21230. First Published on March 29, 2005; doi:10.1074/jbc.M412316200 [Abstract] [Full Text] [PDF]

Laurent Verdier, Ahmed Al-Sabi, Jean E. F. Rivier, Baldomero M. Olivera, Heinrich Terlau, and Teresa Carlomagno: Identification of a Novel Pharmacophore for Peptide Toxins Interacting with K⁺ Channels
J. Biol. Chem. 2005 280: 21246-21255. First Published on March 30, 2005; doi:10.1074/jbc.M502376200 [Abstract] [Full Text] [PDF]

Romain R. Vivès, Anne Imberty, Quentin J. Sattentau, and Hugues Lortat-Jacob: Heparan Sulfate Targets the HIV-1 Envelope Glycoprotein gp120 Coreceptor Binding Site
J. Biol. Chem. 2005 280: 21353-21357. First Published on March 28, 2005; doi:10.1074/jbc.M500911200 [Abstract] [Full Text] [PDF]

Takeshi Uchida, Emiko Sato, Akira Sato, Ikuko Sagami, Toru Shimizu, and Teizo Kitagawa: CO-dependent Activity-controlling Mechanism of Heme-containing CO-sensor Protein, Neuronal PAS Domain Protein 2
J. Biol. Chem. 2005 280: 21358-21368. First Published on March 29, 2005; doi:10.1074/jbc.M412350200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Motoshi Suzuki, Albert Neutzner, Nico Tjandra, and Richard J. Youle: Novel Structure of the N Terminus in Yeast Fis1 Correlates with a Specialized Function in Mitochondrial Fission
J. Biol. Chem. 2005 280: 21444-21452. First Published on April 4, 2005; doi:10.1074/jbc.M414092200 [Abstract] [Full Text] [PDF]

Yeon-Jeong Kim, Reiko Nakatomi, Takumi Akagi, Tsutomu Hashikawa, and Ryosuke Takahashi: Unsaturated Fatty Acids Induce Cytotoxic Aggregate Formation of Amyotrophic Lateral Sclerosis-linked Superoxide Dismutase 1 Mutants
J. Biol. Chem. 2005 280: 21515-21521. First Published on March 29, 2005; doi:10.1074/jbc.M502230200 [Abstract] [Full Text] [PDF]

Enzyme Catalysis and Regulation:

Ruoyu Xiao, Johanna Lundström-Ljung, Arne Holmgren, and Hiram F. Gilbert: Catalysis of Thiol/Disulfide Exchange: GLUTAREDOXIN 1 AND PROTEIN-DISULFIDE ISOMERASE USE DIFFERENT MECHANISMS TO ENHANCE OXIDASE AND REDUCTASE ACTIVITIES
J. Biol. Chem. 2005 280: 21099-21106. First Published on April 6, 2005; doi:10.1074/jbc.M411476200 [Abstract] [Full Text] [PDF]

Audrey Clapéron, Christiane Rose, Pierre Gane, Emmanuel Collec, Olivier Bertrand, and Tanja Ouimet: The Kell Protein of the Common K2 Phenotype Is a Catalytically Active Metalloprotease, whereas the Rare Kell K1 Antigen Is Inactive: IDENTIFICATION OF NOVEL SUBSTRATES FOR THE KELL PROTEIN
J. Biol. Chem. 2005 280: 21272-21283. First Published on March 15, 2005; doi:10.1074/jbc.M500100200 [Abstract] [Full Text] [PDF]

James L. Thomas, Elizabeth L. Boswell, Launa A. Scaccia, Vladimir Pletnev, and Timothy C. Umland: Identification of Key Amino Acids Responsible for the Substantially Higher Affinities of Human Type 1 3 ${beta}$ -Hydroxysteroid Dehydrogenase/Isomerase (3 ${beta}$ -HSD1) for Substrates, Coenzymes, and Inhibitors Relative to Human 3 ${beta}$ -HSD2
J. Biol. Chem. 2005 280: 21321-21328. First Published on March 28, 2005; doi:10.1074/jbc.M501269200 [Abstract] [Full Text] [PDF]

Natalia Nemeria, Kai Tittmann, Ebenezer Joseph, Leon Zhou, Michelle B. Vazquez-Coll, Palaniappa Arjunan, Gerhard Hübner, William Furey, and Frank Jordan: Glutamate 636 of the Escherichia coli Pyruvate Dehydrogenase-E1 Participates in Active Center Communication and Behaves as an Engineered Acetolactate Synthase with Unusual Stereoselectivity
J. Biol. Chem. 2005 280: 21473-21482. First Published on March 31, 2005; doi:10.1074/jbc.M502691200 [Abstract] [Full Text] [PDF]

Metabolism and Bioenergetics:

Leszek Fiedor and Hugo Scheer: Trapping of an Assembly Intermediate of Photosynthetic LH1 Antenna beyond B820 Subunit: SIGNIFICANCE FOR THE ASSEMBLY OF PHOTOSYNTHETIC LH1 ANTENNA
J. Biol. Chem. 2005 280: 20921-20926. First Published on March 23, 2005; doi:10.1074/jbc.M501212200 [Abstract] [Full Text] [PDF]

Deliang Cao, Janine J. Leffert, James McCabe, Bradford Kim, and Giuseppe Pizzorno: Abnormalities in Uridine Homeostatic Regulation and Pyrimidine Nucleotide Metabolism as a Consequence of the Deletion of the Uridine Phosphorylase Gene
J. Biol. Chem. 2005 280: 21169-21175. First Published on March 16, 2005; doi:10.1074/jbc.M412343200 [Abstract] [Full Text] [PDF]

Andrew M. James, Helena M. Cochemé, Robin A. J. Smith, and Michael P. Murphy: Interactions of Mitochondria-targeted and Untargeted Ubiquinones with the Mitochondrial Respiratory Chain and Reactive Oxygen Species: IMPLICATIONS FOR THE USE OF EXOGENOUS UBIQUINONES AS THERAPIES AND EXPERIMENTAL TOOLS
J. Biol. Chem. 2005 280: 21295-21312. First Published on March 23, 2005; doi:10.1074/jbc.M501527200 [Abstract] [Full Text] [PDF] [Summary]

Lipids and Lipoproteins:

Marianne Benn, Børge G. Nordestgaard, Jan Skov Jensen, Karin Nilausen, Hans Meinertz, and Anne Tybjærg-Hansen: Mutation in Apolipoprotein B Associated with Hypobetalipoproteinemia Despite Decreased Binding to the Low Density Lipoprotein Receptor
J. Biol. Chem. 2005 280: 21052-21060. First Published on March 28, 2005; doi:10.1074/jbc.M413877200 [Abstract] [Full Text] [PDF]

C. Michael Reynolds, Suzanne R. Kalb, Robert J. Cotter, and Christian R. H. Raetz: A Phosphoethanolamine Transferase Specific for the Outer 3-Deoxy-D-manno-octulosonic Acid Residue of Escherichia coli Lipopolysaccharide: IDENTIFICATION OF THE eptB GENE AND Ca²⁺ HYPERSENSITIVITY OF AN eptB DELETION MUTANT
J. Biol. Chem. 2005 280: 21202-21211. First Published on March 28, 2005; doi:10.1074/jbc.M500964200 [Abstract] [Full Text] [PDF]

Tomomi Yamazaki, Eriko Sasaki, Chihaya Kakinuma, Takashi Yano, Shinji Miura, and Osamu Ezaki: Increased Very Low Density Lipoprotein Secretion and Gonadal Fat Mass in Mice Overexpressing Liver DGAT1
J. Biol. Chem. 2005 280: 21506-21514. First Published on March 29, 2005; doi:10.1074/jbc.M412989200 [Abstract] [Full Text] [PDF]

Martin Merkel, Britta Loeffler, Malte Kluger, Nathalie Fabig, Gesa Geppert, Len A. Pennacchio, Alexander Laatsch, and Joerg Heeren: Apolipoprotein AV Accelerates Plasma Hydrolysis of Triglyceriderich Lipoproteins by Interaction with Proteoglycan-bound Lipoprotein Lipase
J. Biol. Chem. 2005 280: 21553-21560. First Published on March 17, 2005; doi:10.1074/jbc.M411412200 [Abstract] [Full Text] [PDF]

Marianna Agassandian, Jiming Zhou, Linda A. Tephly, Alan J. Ryan, A. Brent Carter, and Rama K. Mallampalli: Oxysterols Inhibit Phosphatidylcholine Synthesis via ERK Docking and Phosphorylation of CTP:Phosphocholine Cytidylyltransferase
J. Biol. Chem. 2005 280: 21577-21587. First Published on March 23, 2005; doi:10.1074/jbc.M412409200 [Abstract] [Full Text] [PDF]

Hui Zheng, Robert S. Kiss, Vivian Franklin, Ming-Dong Wang, Bassam Haidar, and Yves L. Marcel: ApoA-I Lipidation in Primary Mouse Hepatocytes: SEPARATE CONTROLS FOR PHOSPHOLIPID AND CHOLESTEROL TRANSFERS
J. Biol. Chem. 2005 280: 21612-21621. First Published on March 29, 2005; doi:10.1074/jbc.M502200200 [Abstract] [Full Text] [PDF]

Yasu S. Morita, René Velasquez, Ellen Taig, Ross F. Waller, John H. Patterson, Dedreia Tull, Spencer J. Williams, Helen Billman-Jacobe, and Malcolm J. McConville: Compartmentalization of Lipid Biosynthesis in Mycobacteria
J. Biol. Chem. 2005 280: 21645-21652. First Published on March 31, 2005; doi:10.1074/jbc.M414181200 [Abstract] [Full Text] [PDF]

Membrane Transport, Structure, Function, and Biogenesis:

Jose Maza, Jayasri Das Sarma, and Michael Koval: Defining a Minimal Motif Required to Prevent Connexin Oligomerization in the Endoplasmic Reticulum
J. Biol. Chem. 2005 280: 21115-21121. First Published on April 7, 2005; doi:10.1074/jbc.M412612200 [Abstract] [Full Text] [PDF]

Fabienne Paumet, Vahid Rahimian, Maurizio Di Liberto, and James E. Rothman: Concerted Auto-regulation in Yeast Endosomal t-SNAREs
J. Biol. Chem. 2005 280: 21137-21143. First Published on March 30, 2005; doi:10.1074/jbc.M500841200 [Abstract] [Full Text] [PDF]

André Halbach, Stephan Lorenzen, Christiane Landgraf, Rudolf Volkmer-Engert, Ralf Erdmann, and Hanspeter Rottensteiner: Function of the PEX19-binding Site of Human Adrenoleukodystrophy Protein as Targeting Motif in Man and Yeast: PMP TARGETING IS EVOLUTIONARILY CONSERVED
J. Biol. Chem. 2005 280: 21176-21182. First Published on March 21, 2005; doi:10.1074/jbc.M501750200 [Abstract] [Full Text] [PDF]

Jocelyn Méré, Juliette Morlon-Guyot, Anne Bonhoure, Laurent Chiche, and Bruno Beaumelle: Acid-triggered Membrane Insertion of Pseudomonas Exotoxin A Involves an Original Mechanism Based on pH-regulated Tryptophan Exposure
J. Biol. Chem. 2005 280: 21194-21201. First Published on March 30, 2005; doi:10.1074/jbc.M412656200 [Abstract] [Full Text] [PDF]

Timothy Strassmaier, Chris T. Bond, Claudia A. Sailer, Hans-Guenther Knaus, James Maylie, and John P. Adelman: A Novel Isoform of SK2 Assembles with Other SK Subunits in Mouse Brain
J. Biol. Chem. 2005 280: 21231-21236. First Published on March 29, 2005; doi:10.1074/jbc.M413125200 [Abstract] [Full Text] [PDF]

Aguan D. Wei, Alice Butler, and Lawrence Salkoff: KCNQ-like Potassium Channels in Caenorhabditis elegans: CONSERVED PROPERTIES AND MODULATION
J. Biol. Chem. 2005 280: 21337-21345. First Published on March 29, 2005; doi:10.1074/jbc.M502734200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Yong Hoon Lee, Olatomirin O. Kolade, Kinya Nomura, Dennis N. Arvidson, and Sheng Yang He: Use of Dominant-negative HrpA Mutants to Dissect Hrp Pilus Assembly and Type III Secretion in Pseudomonas syringae pv. tomato
J. Biol. Chem. 2005 280: 21409-21417. First Published on March 29, 2005; doi:10.1074/jbc.M500972200 [Abstract] [Full Text] [PDF]

Armando Carpaneto, Dietmar Geiger, Ernst Bamberg, Norbert Sauer, Jörg Fromm, and Rainer Hedrich: Phloem-localized, Proton-coupled Sucrose Carrier ZmSUT1 Mediates Sucrose Efflux under the Control of the Sucrose Gradient and the Proton Motive Force
J. Biol. Chem. 2005 280: 21437-21443. First Published on April 1, 2005; doi:10.1074/jbc.M501785200 [Abstract] [Full Text] [PDF]

Padmavati Venkataraman, Robert A. Lamb, and Lawrence H. Pinto: Chemical Rescue of Histidine Selectivity Filter Mutants of the M2 Ion Channel of Influenza A Virus
J. Biol. Chem. 2005 280: 21463-21472. First Published on March 22, 2005; doi:10.1074/jbc.M412406200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Sean D. Conner and Sandra L. Schmid: CVAK104 Is a Novel Poly-L-lysine-stimulated Kinase That Targets the ${beta}$ 2-Subunit of AP2
J. Biol. Chem. 2005 280: 21539-21544. First Published on April 4, 2005; doi:10.1074/jbc.M502462200 [Abstract] [Full Text] [PDF]

Xibao Liu, Bidhan C. Bandyopadhyay, Brij B. Singh, Klaus Groschner, and Indu S. Ambudkar: Molecular Analysis of a Store-operated and 2-Acetyl-sn-glycerol-sensitive Non-selective Cation Channel: HETEROMERIC ASSEMBLY OF TRPC1-TRPC3
J. Biol. Chem. 2005 280: 21600-21606. First Published on April 17, 2005; doi:10.1074/jbc.C400492200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Olivia Paleotti, Eric Macia, Frederic Luton, Stephanie Klein, Mariagrazia Partisani, Pierre Chardin, Tom Kirchhausen, and Michel Franco: The Small G-protein Arf6_GTP Recruits the AP-2 Adaptor Complex to Membranes
J. Biol. Chem. 2005 280: 21661-21666. First Published on March 31, 2005; doi:10.1074/jbc.M503099200 [Abstract] [Full Text] [PDF]

Mechanisms Of Signal Transduction:

Heather F. Seidle, Pawel Bieganowski, and Charles Brenner: Disease-associated Mutations Inactivate AMP-Lysine Hydrolase Activity of Aprataxin
J. Biol. Chem. 2005 280: 20927-20931. First Published on March 23, 2005; doi:10.1074/jbc.M502889200 [Abstract] [Full Text] [PDF] [Supplemental Data] [Summary]

Jonathan Whittaker and Linda Whittaker: Characterization of the Functional Insulin Binding Epitopes of the Full-length Insulin Receptor
J. Biol. Chem. 2005 280: 20932-20936. First Published on March 30, 2005; doi:10.1074/jbc.M411320200 [Abstract] [Full Text] [PDF]

Christopher Rose, Wolfgang Kresse, and Helmut Kettenmann: Acute Insult of Ammonia Leads to Calcium-dependent Glutamate Release from Cultured Astrocytes, an Effect of pH
J. Biol. Chem. 2005 280: 20937-20944. First Published on March 31, 2005; doi:10.1074/jbc.M412448200 [Abstract] [Full Text] [PDF]

María C. Gravielle, Ramona Faris, Shelley J. Russek, and David H. Farb: GABA Induces Activity Dependent Delayed-onset Uncoupling of GABA/Benzodiazepine Site Interactions in Neocortical Neurons
J. Biol. Chem. 2005 280: 20954-20960. First Published on April 1, 2005; doi:10.1074/jbc.M500131200 [Abstract] [Full Text] [PDF]

Yonca Bulut, Kathrin S. Michelsen, Linda Hayrapetian, Yoshikazu Naiki, Ralf Spallek, Mahavir Singh, and Moshe Arditi: Mycobacterium Tuberculosis Heat Shock Proteins Use Diverse Toll-like Receptor Pathways to Activate Pro-inflammatory Signals
J. Biol. Chem. 2005 280: 20961-20967. First Published on April 4, 2005; doi:10.1074/jbc.M411379200 [Abstract] [Full Text] [PDF]

J. Calvin Coffey, Jiang Huai Wang, Myles J. F. Smith, Alan Laing, David Bouchier-Hayes, Tom G. Cotter, and H. Paul Redmond: Phosphoinositide 3-Kinase Accelerates Postoperative Tumor Growth by Inhibiting Apoptosis and Enhancing Resistance to Chemotherapy-induced Apoptosis: NOVEL ROLE FOR AN OLD ENEMY
J. Biol. Chem. 2005 280: 20968-20977. First Published on March 1, 2005; doi:10.1074/jbc.M414696200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Meghan E. McMullen, Patrick W. Bryant, Christopher C. Glembotski, Peter A. Vincent, and Kevin M. Pumiglia: Activation of p38 Has Opposing Effects on the Proliferation and Migration of Endothelial Cells
J. Biol. Chem. 2005 280: 20995-21003. First Published on March 24, 2005; doi:10.1074/jbc.M407060200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Zen Kouchi, Tomohide Shikano, Yoshikazu Nakamura, Hideki Shirakawa, Kiyoko Fukami, and Shunichi Miyazaki: The Role of EF-hand Domains and C2 Domain in Regulation of Enzymatic Activity of Phospholipase C ${zeta}$
J. Biol. Chem. 2005 280: 21015-21021. First Published on March 24, 2005; doi:10.1074/jbc.M412123200 [Abstract] [Full Text] [PDF]

Anna Maria Brunati, Renzo Deana, Alessandra Folda, Maria Lina Massimino, Oriano Marin, Silvia Ledro, Lorenzo A. Pinna, and Arianna Donella-Deana: Thrombin-induced Tyrosine Phosphorylation of HS1 in Human Platelets Is Sequentially Catalyzed by Syk and Lyn Tyrosine Kinases and Associated with the Cellular Migration of the Protein
J. Biol. Chem. 2005 280: 21029-21035. First Published on March 28, 2005; doi:10.1074/jbc.M412634200 [Abstract] [Full Text] [PDF]

Shougang Zhuang, Yan Yan, Jiahuai Han, and Rick G. Schnellmann: p38 Kinase-mediated Transactivation of the Epidermal Growth Factor Receptor Is Required for Dedifferentiation of Renal Epithelial Cells after Oxidant Injury
J. Biol. Chem. 2005 280: 21036-21042. First Published on March 28, 2005; doi:10.1074/jbc.M413300200 [Abstract] [Full Text] [PDF]

Jaap D. van Buul, Eloise C. Anthony, Mar Fernandez-Borja, Keith Burridge, and Peter L. Hordijk: Proline-rich Tyrosine Kinase 2 (Pyk2) Mediates Vascular Endothelial-Cadherin-based Cell-Cell Adhesion by Regulating ${beta}$ -Catenin Tyrosine Phosphorylation
J. Biol. Chem. 2005 280: 21129-21136. First Published on March 18, 2005; doi:10.1074/jbc.M500898200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Laurens A. van Meeteren, Paula Ruurs, Evangelos Christodoulou, James W. Goding, Hideo Takakusa, Kazuya Kikuchi, Anastassis Perrakis, Tetsuo Nagano, and Wouter H. Moolenaar: Inhibition of Autotaxin by Lysophosphatidic Acid and Sphingosine 1-Phosphate
J. Biol. Chem. 2005 280: 21155-21161. First Published on March 15, 2005; doi:10.1074/jbc.M413183200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Ho Kim, Sang Hoon Rhee, Efi Kokkotou, Xi Na, Tor Savidge, Mary P. Moyer, Charalabos Pothoulakis, and J. Thomas LaMont: Clostridium difficile Toxin A Regulates Inducible Cyclooxygenase-2 and Prostaglandin E₂ Synthesis in Colonocytes via Reactive Oxygen Species and Activation of p38 MAPK
J. Biol. Chem. 2005 280: 21237-21245. First Published on March 14, 2005; doi:10.1074/jbc.M413842200 [Abstract] [Full Text] [PDF]

Jong Wook Hong, Min Sook Ryu, and In Kyoung Lim: Phosphorylation of Serine 147 of tis21/BTG2/pc3 by p-Erk1/2 Induces Pin-1 Binding in Cytoplasm and Cell Death
J. Biol. Chem. 2005 280: 21256-21263. First Published on March 23, 2005; doi:10.1074/jbc.M500318200 [Abstract] [Full Text] [PDF]

Hong Bing Chen, Jonathan G. Rud, Kai Lin, and Lan Xu: Nuclear Targeting of Transforming Growth Factor- ${beta}$ -activated Smad Complexes
J. Biol. Chem. 2005 280: 21329-21336. First Published on March 30, 2005; doi:10.1074/jbc.M500362200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Caroline Morel, Géraldine Ibarz, Catherine Oiry, Eric Carnazzi, Gilbert Bergé, Didier Gagne, Jean-Claude Galleyrand, and Jean Martinez: Cross-interactions of Two p38 Mitogen-activated Protein (MAP) Kinase Inhibitors and Two Cholecystokinin (CCK) Receptor Antagonists with the CCK1 Receptor and P38 MAP Kinase
J. Biol. Chem. 2005 280: 21384-21393. First Published on March 16, 2005; doi:10.1074/jbc.M408851200 [Abstract] [Full Text] [PDF]

Werner Dammermann and Andreas H. Guse: Functional Ryanodine Receptor Expression Is Required for NAADP-mediated Local Ca²⁺ Signaling in T-lymphocytes
J. Biol. Chem. 2005 280: 21394-21399. First Published on March 17, 2005; doi:10.1074/jbc.M413085200 [Abstract] [Full Text] [PDF]

Zeng-qiang Yuan, Donghwa Kim, Satoshi Kaneko, Melissa Sussman, Gary M. Bokoch, Gary D. Kruh, Santo V. Nicosia, Joseph R. Testa, and Jin Q. Cheng: ArgBP2 ${gamma}$ Interacts with Akt and p21-activated Kinase-1 and Promotes Cell Survival
J. Biol. Chem. 2005 280: 21483-21490. First Published on March 22, 2005; doi:10.1074/jbc.M500097200 [Abstract] [Full Text] [PDF]

Maria A. Shoumskaya, Kalyanee Paithoonrangsarid, Yu Kanesaki, Dmitry A. Los, Vladislav V. Zinchenko, Morakot Tanticharoen, Iwane Suzuki, and Norio Murata: Identical Hik-Rre Systems Are Involved in Perception and Transduction of Salt Signals and Hyperosmotic Signals but Regulate the Expression of Individual Genes to Different Extents in Synechocystis
J. Biol. Chem. 2005 280: 21531-21538. First Published on March 31, 2005; doi:10.1074/jbc.M412174200 [Abstract] [Full Text] [PDF]

Jürgen Kopp, Ellen Preis, Harun Said, Bernd Hafemann, Lucia Wickert, Axel M. Gressner, Norbert Pallua, and Steven Dooley||: Abrogation of Transforming Growth Factor- ${beta}$ Signaling by SMAD7 Inhibits Collagen Gel Contraction of Human Dermal Fibroblasts
J. Biol. Chem. 2005 280: 21570-21576. First Published on March 23, 2005; doi:10.1074/jbc.M502071200 [Abstract] [Full Text] [PDF]

Hai-Yan Wu, Eunice Y. Yuen, Yun-Fei Lu, Masayuki Matsushita, Hideki Matsui, Zhen Yan, and Kazuhito Tomizawa: Regulation of N-Methyl-D-aspartate Receptors by Calpain in Cortical Neurons
J. Biol. Chem. 2005 280: 21588-21593. First Published on March 24, 2005; doi:10.1074/jbc.M501603200 [Abstract] [Full Text] [PDF]

Alexander Bubikat, León J. De Windt, Bernd Zetsche, Larissa Fabritz, Heidrun Sickler, Dominik Eckardt, Axel Gödecke, Hideo A. Baba, and Michaela Kuhn: Local Atrial Natriuretic Peptide Signaling Prevents Hypertensive Cardiac Hypertrophy in Endothelial Nitric-oxide Synthase-deficient Mice
J. Biol. Chem. 2005 280: 21594-21599. First Published on March 26, 2005; doi:10.1074/jbc.M501103200 [Abstract] [Full Text] [PDF]

Zhen Y. Jiang, Qiong L. Zhou, John Holik, Shraddha Patel, John Leszyk, Kerri Coleman, My Chouinard, and Michael P. Czech: Identification of WNK1 as a Substrate of Akt/Protein Kinase B and a Negative Regulator of Insulin-stimulated Mitogenesis in 3T3-L1 Cells
J. Biol. Chem. 2005 280: 21622-21628. First Published on March 30, 2005; doi:10.1074/jbc.M414464200 [Abstract] [Full Text] [PDF]

Krista P. Kauppinen, Faping Duan, Jared I. Wels, and Danny Manor: Regulation of the Dbl Proto-oncogene by Heat Shock Cognate Protein 70 (Hsc70)
J. Biol. Chem. 2005 280: 21638-21644. First Published on March 31, 2005; doi:10.1074/jbc.M413984200 [Abstract] [Full Text] [PDF]

Jungmook Lyu and Choun-Ki Joo: Wnt-7a Up-regulates Matrix Metalloproteinase-12 Expression and Promotes Cell Proliferation in Corneal Epithelial Cells during Wound Healing
J. Biol. Chem. 2005 280: 21653-21660. First Published on March 31, 2005; doi:10.1074/jbc.M500374200 [Abstract] [Full Text] [PDF]

Molecular Basis Of Cell and Developmental Biology:

Peter J. Gianakopoulos and Ilona S. Skerjanc: Hedgehog Signaling Induces Cardiomyogenesis in P19 Cells
J. Biol. Chem. 2005 280: 21022-21028. First Published on March 26, 2005; doi:10.1074/jbc.M502977200 [Abstract] [Full Text] [PDF]

Bernard F. Godley, Farrukh A. Shamsi, Fong-Qi Liang, Stuart G. Jarrett, Sallyanne Davies, and Mike Boulton: Blue Light Induces Mitochondrial DNA Damage and Free Radical Production in Epithelial Cells
J. Biol. Chem. 2005 280: 21061-21066. First Published on March 29, 2005; doi:10.1074/jbc.M502194200 [Abstract] [Full Text] [PDF]

Sheri L. Holmen, Cassandra R. Zylstra, Aditi Mukherjee, Robert E. Sigler, Marie-Claude Faugere, Mary L. Bouxsein, Lianfu Deng, Thomas L. Clemens, and Bart O. Williams: Essential Role of ${beta}$ -Catenin in Postnatal Bone Acquisition
J. Biol. Chem. 2005 280: 21162-21168. First Published on March 31, 2005; doi:10.1074/jbc.M501900200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Monzy Thomas, Zhigang Yu, Nahid Dadgar, Sooryanarayana Varambally, Jianjun Yu, Arul M. Chinnaiyan, and Andrew P. Lieberman: The Unfolded Protein Response Modulates Toxicity of the Expanded Glutamine Androgen Receptor
J. Biol. Chem. 2005 280: 21264-21271. First Published on March 30, 2005; doi:10.1074/jbc.M500144200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Gregory Liszt, Ethan Ford, Martin Kurtev, and Leonard Guarente: Mouse Sir2 Homolog SIRT6 Is a Nuclear ADP-ribosyltransferase
J. Biol. Chem. 2005 280: 21313-21320. First Published on March 28, 2005; doi:10.1074/jbc.M413296200 [Abstract] [Full Text] [PDF]

Fabio Klamt and Emily Shacter: Taurine Chloramine, an Oxidant Derived from Neutrophils, Induces Apoptosis in Human B Lymphoma Cells through Mitochondrial Damage
J. Biol. Chem. 2005 280: 21346-21352. First Published on March 30, 2005; doi:10.1074/jbc.M501170200 [Abstract] [Full Text] [PDF]

Akio Sakamoto, Min Chen, Takashi Nakamura, Tao Xie, Gerard Karsenty, and Lee S. Weinstein: Deficiency of the G-protein ${alpha}$ -Subunit G_s ${alpha}$ in Osteoblasts Leads to Differential Effects on Trabecular and Cortical Bone
J. Biol. Chem. 2005 280: 21369-21375. First Published on March 28, 2005; doi:10.1074/jbc.M500346200 [Abstract] [Full Text] [PDF]

Dolena R. Ledee, Chun Y. Gao, Ranjana Seth, Robert N. Fariss, Brajendra K. Tripathi, and Peggy S. Zelenka: A Specific Interaction between Muskelin and the Cyclin-dependent Kinase 5 Activator p39 Promotes Peripheral Localization of Muskelin
J. Biol. Chem. 2005 280: 21376-21383. First Published on March 28, 2005; doi:10.1074/jbc.M501215200 [Abstract] [Full Text] [PDF]

Cheol Yong Choi, Young Ho Kim, Yong-Ou Kim, Sang Joon Park, Eun-A Kim, William Riemenschneider, Kathleen Gajewski, Robert A. Schulz, and Yongsok Kim: Phosphorylation by the DHIPK2 Protein Kinase Modulates the Corepressor Activity of Groucho
J. Biol. Chem. 2005 280: 21427-21436. First Published on March 30, 2005; doi:10.1074/jbc.M500496200 [Abstract] [Full Text] [PDF]

Rosario Luna-Medina, Marta Cortes-Canteli, Mercedes Alonso, Angel Santos, Ana Martínez, and Ana Perez-Castillo: Regulation of Inflammatory Response in Neural Cells in Vitro by Thiadiazolidinones Derivatives through Peroxisome Proliferator-activated Receptor ${gamma}$ Activation
J. Biol. Chem. 2005 280: 21453-21462. First Published on April 6, 2005; doi:10.1074/jbc.M414390200 [Abstract] [Full Text] [PDF]

Ju-Eun Oh, Joong-Ki Kook, and Byung-Moo Min: ${beta}$ ig-h3 Induces Keratinocyte Differentiation via Modulation of Involucrin and Transglutaminase Expression through the Integrin ${alpha}$ 3 ${beta}$ 1 and the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway
J. Biol. Chem. 2005 280: 21629-21637. First Published on March 31, 2005; doi:10.1074/jbc.M412293200 [Abstract] [Full Text] [PDF]

David P. LaLonde, Michael C. Brown, Brian P. Bouverat, and Christopher E. Turner: Actopaxin Interacts with TESK1 to Regulate Cell Spreading on Fibronectin
J. Biol. Chem. 2005 280: 21680-21688. First Published on April 6, 2005; doi:10.1074/jbc.M500752200 [Abstract] [Full Text] [PDF]