JBC -- Table of Contents (Jul 29 2005, 280, (30))

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Classics:

Nicole Kresge, Robert D. Simoni, and Robert L. Hill: A Role for Phosphoinositides in Signaling: the Work of Mabel R. Hokin and Lowell E. Hokin
ENZYME SECRETION AND THE INCORPORATION OF P³² INTO PHOSPHOLIPIDES OF PANCREAS SLICES (Mabel R. Hokin and Lowell E. Hokin J. Biol. Chem. 203, 967-977)
Phosphoinositides and Protein Secretion in Pancreas Slices (Lowell E. Hokin and Mabel R. Hokin J. Biol. Chem. 233, 805-810)
J. Biol. Chem. 2005 280: e27. [Full Text]

Minireviews:

William E. Royer, Jr., Hao Zhu, Thomas A. Gorr, Jason F. Flores, and James E. Knapp: Allosteric Hemoglobin Assembly: Diversity and Similarity
J. Biol. Chem. 2005 280: 27477-27480. First Published on June 2, 2005; doi:10.1074/jbc.R500006200 [Full Text] [PDF]

DNA: Replication, Repair, and Recombination:

David B. Young, Jyoti Jonnalagadda, Magtouf Gatei, David A. Jans, Stephen Meyn, and Kum Kum Khanna: Identification of Domains of Ataxia-telangiectasia Mutated Required for Nuclear Localization and Chromatin Association
J. Biol. Chem. 2005 280: 27587-27594. First Published on June 1, 2005; doi:10.1074/jbc.M411689200 [Abstract] [Full Text] [PDF]

Yuichi J. Machida, Jamie K. Teer, and Anindya Dutta: Acute Reduction of an Origin Recognition Complex (ORC) Subunit in Human Cells Reveals a Requirement of ORC for Cdk2 Activation
J. Biol. Chem. 2005 280: 27624-27630. First Published on June 7, 2005; doi:10.1074/jbc.M502615200 [Abstract] [Full Text] [PDF]

Sudha Sharma, Joshua A. Sommers, Saba Choudhary, Jinnifer Korin Faulkner, Sheng Cui, Lucia Andreoli, Laura Muzzolini, Alessandro Vindigni, and Robert M. Brosh, Jr.: Biochemical Analysis of the DNA Unwinding and Strand Annealing Activities Catalyzed by Human RECQ1
J. Biol. Chem. 2005 280: 28072-28084. First Published on May 16, 2005; doi:10.1074/jbc.M500264200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Kevin M. Doherty, Sudha Sharma, Laura A. Uzdilla, Teresa M. Wilson, Sheng Cui, Alessandro Vindigni, and Robert M. Brosh, Jr.: RECQ1 Helicase Interacts with Human Mismatch Repair Factors That Regulate Genetic Recombination
J. Biol. Chem. 2005 280: 28085-28094. First Published on May 9, 2005; doi:10.1074/jbc.M500265200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Genes: Structure and Regulation:

Yuho Najima, Naoya Yahagi, Yoshinori Takeuchi, Takashi Matsuzaka, Motohiro Sekiya, Yoshimi Nakagawa, Michiyo Amemiya-Kudo, Hiroaki Okazaki, Sachiko Okazaki, Yoshiaki Tamura, Yoko Iizuka, Ken Ohashi, Kenji Harada, Takanari Gotoda, Ryozo Nagai, Takashi Kadowaki, Shun Ishibashi, Nobuhiro Yamada, Jun-ichi Osuga, and Hitoshi Shimano: High Mobility Group Protein-B1 Interacts with Sterol Regulatory Element-binding Proteins to Enhance Their DNA Binding
J. Biol. Chem. 2005 280: 27523-27532. First Published ; doi:10.1074/jbc.M414549200\|[sect ]\| [Abstract] [Full Text] [PDF]

Satoshi Nozawa, Takatoshi Ohno, Yoshiko Banno, Taikoh Dohjima, Kazuhiko Wakahara, De-Gang Fan, and Katsuji Shimizu: Inhibition of Platelet-derived Growth Factor-induced Cell Growth Signaling by a Short Interfering RNA for EWS-Fli1 via Down-regulation of Phospholipase D2 in Ewing Sarcoma Cells
J. Biol. Chem. 2005 280: 27544-27551. First Published on May 26, 2005; doi:10.1074/jbc.M411626200 [Abstract] [Full Text] [PDF]

Pascal Lefevre, Claire Lacroix, Hiromi Tagoh, Maarten Hoogenkamp, Svitlana Melnik, Richard Ingram, and Constanze Bonifer: Differentiation-dependent Alterations in Histone Methylation and Chromatin Architecture at the Inducible Chicken Lysozyme Gene
J. Biol. Chem. 2005 280: 27552-27560. First Published on May 27, 2005; doi:10.1074/jbc.M502422200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Liping Gu, Walter J. Esselman, and R. William Henry: Cooperation between Small Nuclear RNA-activating Protein Complex (SNAP_C) and TATA-box-binding Protein Antagonizes Protein Kinase CK2 Inhibition of DNA Binding by SNAP_C
J. Biol. Chem. 2005 280: 27697-27704. First Published on June 14, 2005; doi:10.1074/jbc.M503206200 [Abstract] [Full Text] [PDF]

Tsurng-Juhn Huang, Cheng-Chan Lu, Jui-Chen Tsai, Wei-Jen Yao, Xuanyong Lu, Ming-Derg Lai, Hsiao-Sheng Liu, and Ai-Li Shiau: Novel Autoregulatory Function of Hepatitis B Virus M Protein on Surface Gene Expression
J. Biol. Chem. 2005 280: 27742-27754. First Published on May 16, 2005; doi:10.1074/jbc.M502209200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Dong-Kee Lee, Jae-Eun Kang, Hye-Jin Park, Myung-Hwa Kim, Tae-Hee Yim, Jung-Min Kim, Min-Kyu Heo, Kyu-Yeun Kim, Ho Jeong Kwon, and Man-Wook Hur: FBI-1 Enhances Transcription of the Nuclear Factor- ${kappa}$ B (NF- ${kappa}$ B)-responsive E-selectin Gene by Nuclear Localization of the p65 Subunit of NF- ${kappa}$ B
J. Biol. Chem. 2005 280: 27783-27791. First Published on May 24, 2005; doi:10.1074/jbc.M504909200 [Abstract] [Full Text] [PDF]

Jung-Ahn Lee, Dong-Chul Suh, Jae-Eun Kang, Myung-Hwa Kim, Hyejin Park, Min-Nyung Lee, Jung-Min Kim, Bu-Nam Jeon, Hee-Eun Roh, Mi-Young Yu, Kang-Yell Choi, Kyu Yeun Kim, and Man-Wook Hur: Transcriptional Activity of Sp1 Is Regulated by Molecular Interactions between the Zinc Finger DNA Binding Domain and the Inhibitory Domain with Corepressors, and This Interaction Is Modulated by MEK
J. Biol. Chem. 2005 280: 28061-28071. First Published on May 6, 2005; doi:10.1074/jbc.M414134200 [Abstract] [Full Text] [PDF]

Sreerama Shetty, Margaret R. Gyetko, and Andrew P. Mazar: Induction of p53 by Urokinase in Lung Epithelial Cells
J. Biol. Chem. 2005 280: 28133-28141. First Published on June 3, 2005; doi:10.1074/jbc.M413190200 [Abstract] [Full Text] [PDF]

RNA: Structure, Metabolism, and Catalysis:

Yan Zeng and Bryan R. Cullen: Efficient Processing of Primary microRNA Hairpins by Drosha Requires Flanking Nonstructured RNA Sequences
J. Biol. Chem. 2005 280: 27595-27603. First Published on June 1, 2005; doi:10.1074/jbc.M504714200 [Abstract] [Full Text] [PDF]

Protein Synthesis, Post-Translation Modification, and Degradation:

Seonil Kim, Andrea N. Lapham, Christopher G. K. Freedman, Tiffany L. Reed, and Walter K. Schmidt: Yeast as a Tractable Genetic System for Functional Studies of the Insulin-degrading Enzyme
J. Biol. Chem. 2005 280: 27481-27490. First Published on June 8, 2005; doi:10.1074/jbc.M414192200 [Abstract] [Full Text] [PDF]

Adam A. Wall, A. Marie Phillips, and Leonard E. Kelly: Effective Translation of the Second Cistron in Two Drosophila Dicistronic Transcripts Is Determined by the Absence of In-frame AUG Codons in the First Cistron
J. Biol. Chem. 2005 280: 27670-27678. First Published on June 10, 2005; doi:10.1074/jbc.M500255200 [Abstract] [Full Text] [PDF]

Tatiana Pushkarsky, Vyacheslav Yurchenko, Christophe Vanpouille, Beda Brichacek, Iosif Vaisman, Shigetsugu Hatakeyama, Keiichi I. Nakayama, Barbara Sherry, and Michael I. Bukrinsky: Cell Surface Expression of CD147/EMMPRIN Is Regulated by Cyclophilin 60
J. Biol. Chem. 2005 280: 27866-27871. First Published on June 9, 2005; doi:10.1074/jbc.M503770200 [Abstract] [Full Text] [PDF]

Michael Kothe, Yihong Ye, Jessica S. Wagner, Heidi E. De Luca, Eli Kern, Tom A. Rapoport, and Wayne I. Lencer: Role of p97 AAA-ATPase in the Retrotranslocation of the Cholera Toxin A1 Chain, a Non-ubiquitinated Substrate
J. Biol. Chem. 2005 280: 28127-28132. First Published on June 2, 2005; doi:10.1074/jbc.M503138200 [Abstract] [Full Text] [PDF]

Genomics, Proteomics, and Bioinformatics:

Jeffrey W. Streb and Joseph M. Miano: Cross-species Sequence Analysis Reveals Multiple Charged Residue-rich Domains That Regulate Nuclear/Cytoplasmic Partitioning and Membrane Localization of A Kinase Anchoring Protein 12 (SSeCKS/Gravin)
J. Biol. Chem. 2005 280: 28007-28014. First Published on May 27, 2005; doi:10.1074/jbc.M414017200 [Abstract] [Full Text] [PDF]

Protein Structure and Folding:

Ben F. Lucker, Robert H. Behal, Hongmin Qin, Laura C. Siron, W. David Taggart, Joel L. Rosenbaum, and Douglas G. Cole: Characterization of the Intraflagellar Transport Complex B Core: DIRECT INTERACTION OF THE IFT81 AND IFT74/72 SUBUNITS
J. Biol. Chem. 2005 280: 27688-27696. First Published on June 13, 2005; doi:10.1074/jbc.M505062200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Hua Jiang, K. Sudhindra Rao, Vivien C. Yee, and Jan P. Kraus: Characterization of Four Variant Forms of Human Propionyl-CoA Carboxylase Expressed in Escherichia coli
J. Biol. Chem. 2005 280: 27719-27727. First Published on May 12, 2005; doi:10.1074/jbc.M413281200 [Abstract] [Full Text] [PDF]

Sergey G. Odintsov, Izabela Sabala, Gleb Bourenkov, Vladimir Rybin, and Matthias Bochtler: Staphylococcus aureus Aminopeptidase S Is a Founding Member of a New Peptidase Clan
J. Biol. Chem. 2005 280: 27792-27799. First Published on June 2, 2005; doi:10.1074/jbc.M502023200 [Abstract] [Full Text] [PDF]

John P. H. Th'ng, Rohyun Sung, Ming Ye, and Michael J. Hendzel: H1 Family Histones in the Nucleus: CONTROL OF BINDING AND LOCALIZATION BY THE C-TERMINAL DOMAIN
J. Biol. Chem. 2005 280: 27809-27814. First Published on May 23, 2005; doi:10.1074/jbc.M501627200 [Abstract] [Full Text] [PDF]

Amy E. Schmidt, Hitendra S. Chand, Dulio Cascio, Walter Kisiel, and S. Paul Bajaj: Crystal Structure of Kunitz Domain 1 (KD1) of Tissue Factor Pathway Inhibitor-2 in Complex with Trypsin: IMPLICATIONS FOR KD1 SPECIFICITY OF INHIBITION
J. Biol. Chem. 2005 280: 27832-27838. First Published on June 2, 2005; doi:10.1074/jbc.M504105200 [Abstract] [Full Text] [PDF]

Christopher S. Newton, Elena Loukinova, Irina Mikhailenko, Sripriya Ranganathan, Yamei Gao, Christian Haudenschild, and Dudley K. Strickland: Platelet-derived Growth Factor Receptor- ${beta}$ (PDGFR- ${beta}$ ) Activation Promotes Its Association with the Low Density Lipoprotein Receptor-related Protein (LRP): EVIDENCE FOR CO-RECEPTOR FUNCTION
J. Biol. Chem. 2005 280: 27872-27878. First Published on June 8, 2005; doi:10.1074/jbc.M505410200 [Abstract] [Full Text] [PDF]

Karina Kitzing, Teresa B. Fitzpatrick, Corinna Wilken, Justyna Sawa, Gleb P. Bourenkov, Peter Macheroux, and Tim Clausen: The 1.3 Å Crystal Structure of the Flavoprotein YqjM Reveals a Novel Class of Old Yellow Enzymes
J. Biol. Chem. 2005 280: 27904-27913. First Published on May 12, 2005; doi:10.1074/jbc.M502587200 [Abstract] [Full Text] [PDF]

Jianghai Zhu, John W. Burgner, Etti Harms, Boris R. Belitsky, and Janet L. Smith: A New Arrangement of ( ${beta}$ / ${alpha}$ )₈ Barrels in the Synthase Subunit of PLP Synthase
J. Biol. Chem. 2005 280: 27914-27923. First Published on May 23, 2005; doi:10.1074/jbc.M503642200 [Abstract] [Full Text] [PDF] [Summary]

Stephanie A. Etchells, Anne S. Meyer, Alice Y. Yam, Anne Roobol, Yiwei Miao, Yuanlong Shao, Martin J. Carden, William R. Skach, Judith Frydman, and Arthur E. Johnson: The Cotranslational Contacts between Ribosome-bound Nascent Polypeptides and the Subunits of the Hetero-oligomeric Chaperonin TRiC Probed by Photocross-linking
J. Biol. Chem. 2005 280: 28118-28126. First Published on May 30, 2005; doi:10.1074/jbc.M504110200 [Abstract] [Full Text] [PDF]

Enzyme Catalysis and Regulation:

Raji E. Joseph and F. A. Norris: Substrate Specificity and Recognition Is Conferred by the Pleckstrin Homology Domain of the Dbl Family Guanine Nucleotide Exchange Factor P-Rex2
J. Biol. Chem. 2005 280: 27508-27512. First Published on May 16, 2005; doi:10.1074/jbc.M412495200 [Abstract] [Full Text] [PDF]

Mahua Ghosh, Gregor Meiss, Alfred Pingoud, Robert E. London, and Lars C. Pedersen: Structural Insights into the Mechanism of Nuclease A, a ${beta}$ ${beta}$ ${alpha}$ Metal Nuclease from Anabaena
J. Biol. Chem. 2005 280: 27990-27997. First Published on May 15, 2005; doi:10.1074/jbc.M501798200 [Abstract] [Full Text] [PDF]

Metabolism and Bioenergetics:

Alexander R. Moise, Vladimir Kuksa, William S. Blaner, Wolfgang Baehr, and Krzysztof Palczewski: Metabolism and Transactivation Activity of 13,14-Dihydroretinoic Acid
J. Biol. Chem. 2005 280: 27815-27825. First Published on May 23, 2005; doi:10.1074/jbc.M503520200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Petra Rohrbach, Oliver Friedrich, Joachim Hentschel, Helmut Plattner, Rainer H. A. Fink, and Michael Lanzer: Quantitative Calcium Measurements in Subcellular Compartments of Plasmodium falciparum-infected Erythrocytes
J. Biol. Chem. 2005 280: 27960-27969. First Published on May 31, 2005; doi:10.1074/jbc.M500777200 [Abstract] [Full Text] [PDF]

Zulfiqar Ahmad and Alan E. Senior: Modulation of Charge in the Phosphate Binding Site of Escherichia coli ATP Synthase
J. Biol. Chem. 2005 280: 27981-27989. First Published on June 6, 2005; doi:10.1074/jbc.M503955200 [Abstract] [Full Text] [PDF]

Glycobiology and Extracellular Matrices:

Hsu Chao and Andrew P. Spicer: Natural Antisense mRNAs to Hyaluronan Synthase 2 Inhibit Hyaluronan Biosynthesis and Cell Proliferation
J. Biol. Chem. 2005 280: 27513-27522. First Published on April 19, 2005; doi:10.1074/jbc.M411544200 [Abstract] [Full Text] [PDF]

Nikola Kostlánová, Edward P. Mitchell, Hugues Lortat-Jacob, Stefan Oscarson, Martina Lahmann, Nechama Gilboa-Garber, Gérard Chambat, Michaela Wimmerová, and Anne Imberty: The Fucose-binding Lectin from Ralstonia solanacearum: A NEW TYPE OF ${beta}$ -PROPELLER ARCHITECTURE FORMED BY OLIGOMERIZATION AND INTERACTING WITH FUCOSIDE, FUCOSYLLACTOSE, AND PLANT XYLOGLUCAN
J. Biol. Chem. 2005 280: 27839-27849. First Published on May 27, 2005; doi:10.1074/jbc.M505184200 [Abstract] [Full Text] [PDF]

Konerirajapuram N. Sulochana, Huapeng Fan, Seetharama Jois, Vivekanandan Subramanian, Feng Sun, R. Manjunatha Kini, and Ruowen Ge: Peptides Derived from Human Decorin Leucine-rich Repeat 5 Inhibit Angiogenesis
J. Biol. Chem. 2005 280: 27935-27948. First Published on May 27, 2005; doi:10.1074/jbc.M414320200 [Abstract] [Full Text] [PDF]

Kate E. Gregory, Robert N. Ono, Noe L. Charbonneau, Chiu-Liang Kuo, Douglas R. Keene, Hans Peter Bächinger, and Lynn Y. Sakai: The Prodomain of BMP-7 Targets the BMP-7 Complex to the Extracellular Matrix
J. Biol. Chem. 2005 280: 27970-27980. First Published on June 1, 2005; doi:10.1074/jbc.M504270200 [Abstract] [Full Text] [PDF]

Lipids and Lipoproteins:

Xavier Prieur, Thierry Huby, Hervé Coste, Frank G. Schaap, M. John Chapman, and Joan C. Rodríguez: Thyroid Hormone Regulates the Hypotriglyceridemic Gene APOA5
J. Biol. Chem. 2005 280: 27533-27543. First Published on June 7, 2005; doi:10.1074/jbc.M503139200 [Abstract] [Full Text] [PDF]

Mats X. Andersson, Karin E. Larsson, Henrik Tjellström, Conny Liljenberg, and Anna Stina Sandelius: Phosphate-limited Oat: THE PLASMA MEMBRANE AND THE TONOPLAST AS MAJOR TARGETS FOR PHOSPHOLIPID-TO-GLYCOLIPID REPLACEMENT AND STIMULATION OF PHOSPHOLIPASES IN THE PLASMA MEMBRANE
J. Biol. Chem. 2005 280: 27578-27586. First Published on May 31, 2005; doi:10.1074/jbc.M503273200 [Abstract] [Full Text] [PDF]

Yutaka Ikeno, Naoko Konno, So-hyun Cheon, Angelo Bolchi, Simone Ottonello, Katsuhiko Kitamoto, and Manabu Arioka: Secretory Phospholipases A₂ Induce Neurite Outgrowth in PC12 Cells through Lysophosphatidylcholine Generation and Activation of G2A Receptor
J. Biol. Chem. 2005 280: 28044-28052. First Published on May 31, 2005; doi:10.1074/jbc.M503343200 [Abstract] [Full Text] [PDF]

Mark A. Valasek, Jian Weng, Philip W. Shaul, Richard G. W. Anderson, and Joyce J. Repa: Caveolin-1 Is Not Required for Murine Intestinal Cholesterol Transport
J. Biol. Chem. 2005 280: 28103-28109. First Published on May 26, 2005; doi:10.1074/jbc.M504609200 [Abstract] [Full Text] [PDF]

Membrane Transport, Structure, Function, and Biogenesis:

Claudine Menard, H. Robert Horvitz, and Stephen Cannon: Chimeric Mutations in the M2 Segment of the 5-Hydroxytryptamine-gated Chloride Channel MOD-1 Define a Minimal Determinant of Anion/Cation Permeability
J. Biol. Chem. 2005 280: 27502-27507. First Published on May 4, 2005; doi:10.1074/jbc.M501624200 [Abstract] [Full Text] [PDF]

Emilisa Frirdich, Catrien Bouwman, Evgeny Vinogradov, and Chris Whitfield: The Role of Galacturonic Acid in Outer Membrane Stability in Klebsiella pneumoniae
J. Biol. Chem. 2005 280: 27604-27612. First Published on June 1, 2005; doi:10.1074/jbc.M504987200 [Abstract] [Full Text] [PDF]

Pierre Fotso, Yulia Koryakina, Oleksandra Pavliv, Arnold B. Tsiomenko, and Vladimir V. Lupashin: Cog1p Plays a Central Role in the Organization of the Yeast Conserved Oligomeric Golgi Complex
J. Biol. Chem. 2005 280: 27613-27623. First Published on June 2, 2005; doi:10.1074/jbc.M504597200 [Abstract] [Full Text] [PDF] [Supplemental Data]

William T. Doerrler and Christian R. H. Raetz: Loss of Outer Membrane Proteins without Inhibition of Lipid Export in an Escherichia coli YaeT Mutant
J. Biol. Chem. 2005 280: 27679-27687. First Published on June 10, 2005; doi:10.1074/jbc.M504796200 [Abstract] [Full Text] [PDF]

Regina Kuliawat, Jose Ramos-Castañeda, Youfang Liu, and Peter Arvan: Intracellular Trafficking of Thyroid Peroxidase to the Cell Surface
J. Biol. Chem. 2005 280: 27713-27718. First Published on May 24, 2005; doi:10.1074/jbc.M503804200 [Abstract] [Full Text] [PDF]

Yasser Ahmed Mahmmoud, Henrik Vorum, and Flemming Cornelius: Interaction of FXYD10 (PLMS) with Na,K-ATPase from Shark Rectal Glands: CLOSE PROXIMITY OF Cys⁷⁴ OF FXYD10 TO Cys²⁵⁴ IN THE A DOMAIN OF THE ${alpha}$ -SUBUNIT REVEALED BY INTERMOLECULAR THIOL CROSS-LINKING
J. Biol. Chem. 2005 280: 27776-27782. First Published on May 26, 2005; doi:10.1074/jbc.M503150200 [Abstract] [Full Text] [PDF]

Takao Inoue and Michael Forgac: Cysteine-mediated Cross-linking Indicates That Subunit C of the V-ATPase Is in Close Proximity to Subunits E and G of the V₁ Domain and Subunit a of the V₀ Domain
J. Biol. Chem. 2005 280: 27896-27903. First Published on June 10, 2005; doi:10.1074/jbc.M504890200 [Abstract] [Full Text] [PDF]

Taruho S. Kuroda and Mitsunori Fukuda: Functional Analysis of Slac2-c/MyRIP as a Linker Protein between Melanosomes and Myosin VIIa
J. Biol. Chem. 2005 280: 28015-28022. First Published on May 30, 2005; doi:10.1074/jbc.M501465200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Hagit Cohen Ben-Ami, Lina Yassin, Hanna Farah, Avner Michaeli, Margalit Eshel, and Millet Treinin: RIC-3 Affects Properties and Quantity of Nicotinic Acetylcholine Receptors via a Mechanism That Does Not Require the Coiled-coil Domains
J. Biol. Chem. 2005 280: 28053-28060. First Published on June 2, 2005; doi:10.1074/jbc.M504369200 [Abstract] [Full Text] [PDF]

Stuart G. Dashper, Catherine A. Butler, J. Patricia Lissel, Rita A. Paolini, Brigitte Hoffmann, Paul D. Veith, Neil M. O'Brien-Simpson, Sarah L. Snelgrove, John T. Tsiros, and Eric C. Reynolds: A Novel Porphyromonas gingivalis FeoB Plays a Role in Manganese Accumulation
J. Biol. Chem. 2005 280: 28095-28102. First Published on May 18, 2005; doi:10.1074/jbc.M503896200 [Abstract] [Full Text] [PDF]

Irfan Y. Tamboli, Kai Prager, Esther Barth, Michael Heneka, Konrad Sandhoff, and Jochen Walter: Inhibition of Glycosphingolipid Biosynthesis Reduces Secretion of the ${beta}$ -Amyloid Precursor Protein and Amyloid ${beta}$ -Peptide
J. Biol. Chem. 2005 280: 28110-28117. First Published on May 27, 2005; doi:10.1074/jbc.M414525200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Mechanisms Of Signal Transduction:

Linda Wooldridge, Hugo A. van den Berg, Meir Glick, Emma Gostick, Bruno Laugel, Sarah L. Hutchinson, Anita Milicic, Jason M. Brenchley, Daniel C. Douek, David A. Price, and Andrew K. Sewell: Interaction between the CD8 Coreceptor and Major Histocompatibility Complex Class I Stabilizes T Cell Receptor-Antigen Complexes at the Cell Surface
J. Biol. Chem. 2005 280: 27491-27501. First Published on April 18, 2005; doi:10.1074/jbc.M500555200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Lu Deng, Reiko Sugiura, Kazuki Ohta, Kazuki Tada, Masahiro Suzuki, Masato Hirata, Shun-ichi Nakamura, Hisato Shuntoh, and Takayoshi Kuno: Phosphatidylinositol-4-phosphate 5-Kinase Regulates Fission Yeast Cell Integrity through a Phospholipase C-mediated Protein Kinase C-independent Pathway
J. Biol. Chem. 2005 280: 27561-27568. First Published on May 27, 2005; doi:10.1074/jbc.M502660200 [Abstract] [Full Text] [PDF]

Pankaj Goyal, Dharmendra Pandey, Antje Behring, and Wolfgang Siess: Inhibition of Nuclear Import of LIMK2 in Endothelial Cells by Protein Kinase C-dependent Phosphorylation at Ser-283
J. Biol. Chem. 2005 280: 27569-27577. First Published on May 27, 2005; doi:10.1074/jbc.M504448200 [Abstract] [Full Text] [PDF] [Supplemental Data]

François Lallemand, Su Ryeon Seo, Nathalie Ferrand, Marcia Pessah, Sebastien L'Hoste, Georges Rawadi, Sergio Roman-Roman, Jacques Camonis, and Azeddine Atfi: AIP4 Restricts Transforming Growth Factor- ${beta}$ Signaling through a Ubiquitination-independent Mechanism
J. Biol. Chem. 2005 280: 27645-27653. First Published on June 8, 2005; doi:10.1074/jbc.M500188200 [Abstract] [Full Text] [PDF]

Andrew M. Seeds, Robert J. Bastidas, and John D. York: Molecular Definition of a Novel Inositol Polyphosphate Metabolic Pathway Initiated by Inositol 1,4,5-Trisphosphate 3-Kinase Activity in Saccharomyces cerevisiae
J. Biol. Chem. 2005 280: 27654-27661. First Published on June 8, 2005; doi:10.1074/jbc.M505089200 [Abstract] [Full Text] [PDF]

Mariana M. Belcheva, Amy L. Clark, Paul D. Haas, Jannie S. Serna, Jason W. Hahn, Alexi Kiss, and Carmine J. Coscia: µ and ${kappa}$ Opioid Receptors Activate ERK/MAPK via Different Protein Kinase C Isoforms and Secondary Messengers in Astrocytes
J. Biol. Chem. 2005 280: 27662-27669. First Published on June 8, 2005; doi:10.1074/jbc.M502593200 [Abstract] [Full Text] [PDF]

Guoyong Yin, Qinlei Zheng, Chen Yan, and Bradford C. Berk: GIT1 Is a Scaffold for ERK1/2 Activation in Focal Adhesions
J. Biol. Chem. 2005 280: 27705-27712. First Published on May 27, 2005; doi:10.1074/jbc.M502271200 [Abstract] [Full Text] [PDF]

Axel Thiefes, Sabine Wolter, J. Frederic Mushinski, Elke Hoffmann, Oliver Dittrich-Breiholz, Nadine Graue, Anneke Dörrie, Heike Schneider, Dagmar Wirth, Bruno Luckow, Klaus Resch, and Michael Kracht: Simultaneous Blockade of NF ${kappa}$ B, JNK, and p38 MAPK by a Kinase-inactive Mutant of the Protein Kinase TAK1 Sensitizes Cells to Apoptosis and Affects a Distinct Spectrum of Tumor Necrosis Target Genes
J. Biol. Chem. 2005 280: 27728-27741. First Published on April 18, 2005; doi:10.1074/jbc.M411657200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Marion P. Butler, Jennifer A. Hanly, and Paul N. Moynagh: Pellino3 Is a Novel Upstream Regulator of p38 MAPK and Activates CREB in a p38-dependent Manner
J. Biol. Chem. 2005 280: 27759-27768. First Published on May 25, 2005; doi:10.1074/jbc.M500756200 [Abstract] [Full Text] [PDF]

Nadia Pece-Barbara, Sonia Vera, Kirishanthy Kathirkamathamby, Stefan Liebner, Gianni M. Di Guglielmo, Elisabetta Dejana, Jeffrey L. Wrana, and Michelle Letarte: Endoglin Null Endothelial Cells Proliferate Faster and Are More Responsive to Transforming Growth Factor ${beta}$ 1 with Higher Affinity Receptors and an Activated Alk1 Pathway
J. Biol. Chem. 2005 280: 27800-27808. First Published on May 27, 2005; doi:10.1074/jbc.M503471200 [Abstract] [Full Text] [PDF]

Michael Keese, Richard J. Magdeburg, Torsten Herzog, Till Hasenberg, Martin Offterdinger, Rainer Pepperkok, Jörg W. Sturm, and Philippe I. H. Bastiaens: Imaging Epidermal Growth Factor Receptor Phosphorylation in Human Colorectal Cancer Cells and Human Tissues
J. Biol. Chem. 2005 280: 27826-27831. First Published on May 20, 2005; doi:10.1074/jbc.M504485200 [Abstract] [Full Text] [PDF]

S. Chandra Shekar, Haiyan Wu, Zheng Fu, Shu-Chin Yip, Nagajyothi, Sean M. Cahill, Mark E. Girvin, and Jonathan M. Backer: Mechanism of Constitutive Phosphoinositide 3-Kinase Activation by Oncogenic Mutants of the p85 Regulatory Subunit
J. Biol. Chem. 2005 280: 27850-27855. First Published on June 2, 2005; doi:10.1074/jbc.M506005200 [Abstract] [Full Text] [PDF]

Yosuke Osawa, Hiroshi Uchinami, Jacek Bielawski, Robert F. Schwabe, Yusuf A. Hannun, and David A. Brenner: Roles for C₁₆-ceramide and Sphingosine 1-Phosphate in Regulating Hepatocyte Apoptosis in Response to Tumor Necrosis Factor- ${alpha}$
J. Biol. Chem. 2005 280: 27879-27887. First Published on June 9, 2005; doi:10.1074/jbc.M503002200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Rentian Feng, Yongju Lu, Linda L. Bowman, Yong Qian, Vincent Castranova, and Min Ding: Inhibition of Activator Protein-1, NF- ${kappa}$ B, and MAPKs and Induction of Phase 2 Detoxifying Enzyme Activity by Chlorogenic Acid
J. Biol. Chem. 2005 280: 27888-27895. First Published on June 8, 2005; doi:10.1074/jbc.M503347200 [Abstract] [Full Text] [PDF]

Gaël Barthet, Florence Gaven, Bérénice Framery, Katsuhiro Shinjo, Takaaki Nakamura, Sylvie Claeysen, Joël Bockaert, and Aline Dumuis: Uncoupling and Endocytosis of 5-Hydroxytryptamine 4 Receptors: DISTINCT MOLECULAR EVENTS WITH DIFFERENT GRK2 REQUIREMENTS
J. Biol. Chem. 2005 280: 27924-27934. First Published on May 26, 2005; doi:10.1074/jbc.M502272200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Christelle Langlet, Ingrid Langer, Pascale Vertongen, Nathalie Gaspard, Jean-Marie Vanderwinden, and Patrick Robberecht: Contribution of the Carboxyl Terminus of the VPAC₁ Receptor to Agonist-induced Receptor Phosphorylation, Internalization, and Recycling
J. Biol. Chem. 2005 280: 28034-28043. First Published on June 2, 2005; doi:10.1074/jbc.M500449200 [Abstract] [Full Text] [PDF]

Rodolphe Auger, Iris Motta, Karim Benihoud, David M. Ojcius, and Jean M. Kanellopoulos: A Role for Mitogen-activated Protein Kinase^Erk1/2 Activation and Non-selective Pore Formation in P2X7 Receptor-mediated Thymocyte Death
J. Biol. Chem. 2005 280: 28142-28151. First Published on June 3, 2005; doi:10.1074/jbc.M501290200 [Abstract] [Full Text] [PDF]

Jason M. Moran, R. Mark L. Buller, Jane McHowat, John Turk, Mary Wohltmann, Richard W. Gross, and John A. Corbett: Genetic and Pharmacologic Evidence That Calcium-independent Phospholipase A₂ ${beta}$ Regulates Virus-induced Inducible Nitric-oxide Synthase Expression by Macrophages
J. Biol. Chem. 2005 280: 28162-28168. First Published on June 8, 2005; doi:10.1074/jbc.M500013200 [Abstract] [Full Text] [PDF]

Molecular Basis Of Cell and Developmental Biology:

Zhen Xu, Tomohiko Fukuda, You Li, Xiliang Zha, Jun Qin, and Chuanyue Wu: Molecular Dissection of PINCH-1 Reveals a Mechanism of Coupling and Uncoupling of Cell Shape Modulation and Survival
J. Biol. Chem. 2005 280: 27631-27637. First Published on June 7, 2005; doi:10.1074/jbc.M504189200 [Abstract] [Full Text] [PDF]

Kyoko Tsujimoto, Takeshi Ono, Masaki Sato, Takashi Nishida, Takemi Oguma, and Takushi Tadakuma: Regulation of the Expression of Caspase-9 by the Transcription Factor Activator Protein-4 in Glucocorticoid-induced Apoptosis
J. Biol. Chem. 2005 280: 27638-27644. First Published on June 8, 2005; doi:10.1074/jbc.M501304200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Alexei Y. Savinov, Dmitri V. Rozanov, Vladislav S. Golubkov, F. Susan Wong, and Alex Y. Strongin: Inhibition of Membrane Type-1 Matrix Metalloproteinase by Cancer Drugs Interferes with the Homing of Diabetogenic T Cells into the Pancreas
J. Biol. Chem. 2005 280: 27755-27758. First Published on June 8, 2005; doi:10.1074/jbc.M506016200 [Abstract] [Full Text] [PDF]

Chongwoo A. Kim, Michael R. Sawaya, Duilio Cascio, Woojae Kim, and James U. Bowie: Structural Organization of a Sex-comb-on-midleg/Polyhomeotic Copolymer
J. Biol. Chem. 2005 280: 27769-27775. First Published on May 19, 2005; doi:10.1074/jbc.M503055200 [Abstract] [Full Text] [PDF]

Liezhen Fu, Atsuko Ishizuya-Oka, Daniel R. Buchholz, Tosikazu Amano, Hiroki Matsuda, and Yun-Bo Shi: A Causative Role of Stromelysin-3 in Extracellular Matrix Remodeling and Epithelial Apoptosis during Intestinal Metamorphosis in Xenopus laevis
J. Biol. Chem. 2005 280: 27856-27865. First Published on June 1, 2005; doi:10.1074/jbc.M413275200 [Abstract] [Full Text] [PDF]

Matthias Wiens, Michael Korzhev, Anatoli Krasko, Narsinh L. Thakur, Sanja Perovic-Ottstadt, Hans J. Breter, Hiroshi Ushijima, Bärbel Diehl-Seifert, Isabel M. Müller, and Werner E. G. Müller: Innate Immune Defense of the Sponge Suberites domuncula against Bacteria Involves a MyD88-dependent Signaling Pathway: INDUCTION OF A PERFORIN-LIKE MOLECULE
J. Biol. Chem. 2005 280: 27949-27959. First Published on May 27, 2005; doi:10.1074/jbc.M504049200 [Abstract] [Full Text] [PDF]

Aglaia Pappa, Donald Brown, Yiannis Koutalos, James DeGregori, Carl White, and Vasilis Vasiliou: Human Aldehyde Dehydrogenase 3A1 Inhibits Proliferation and Promotes Survival of Human Corneal Epithelial Cells
J. Biol. Chem. 2005 280: 27998-28006. First Published on May 19, 2005; doi:10.1074/jbc.M503698200 [Abstract] [Full Text] [PDF]

James B. Moseley and Bruce L. Goode: Differential Activities and Regulation of Saccharomyces cerevisiae Formin Proteins Bni1 and Bnr1 by Bud6
J. Biol. Chem. 2005 280: 28023-28033. First Published on May 27, 2005; doi:10.1074/jbc.M503094200 [Abstract] [Full Text] [PDF]

Verónica Torrano, Igor Chernukhin, France Docquier, Vivien D'Arcy, Javier León, Elena Klenova, and M. Dolores Delgado: CTCF Regulates Growth and Erythroid Differentiation of Human Myeloid Leukemia Cells
J. Biol. Chem. 2005 280: 28152-28161. First Published on June 6, 2005; doi:10.1074/jbc.M501481200 [Abstract] [Full Text] [PDF]