JBC -- Table of Contents (May 5 2006, 281, (18))

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Kensal van Holde and Jordanka Zlatanova: Scanning Chromatin: a New Paradigm?
J. Biol. Chem. 2006 281: 12197-12200. First Published on January 20, 2006; doi:10.1074/jbc.R500025200 [Full Text] [PDF]

DNA: Replication, Repair, and Recombination:

Anya Bakhrat, Keren Baranes, Oleg Krichevsky, Inna Rom, Gabriel Schlenstedt, Shmuel Pietrokovski, and Dina Raveh: Nuclear Import of Ho Endonuclease Utilizes Two Nuclear Localization Signals and Four Importins of the Ribosomal Import System
J. Biol. Chem. 2006 281: 12218-12226. First Published on February 28, 2006; doi:10.1074/jbc.M600238200 [Abstract] [Full Text] [PDF]

Jeong-Yun Choi and F. Peter Guengerich: Kinetic Evidence for Inefficient and Error-prone Bypass across Bulky N²-Guanine DNA Adducts by Human DNA Polymerase ${iota}$
J. Biol. Chem. 2006 281: 12315-12324. First Published on March 8, 2006; doi:10.1074/jbc.M600112200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Negar S. Rahman, LeAnn J. Godderz, Stephen J. Stray, J. Donald Capra, and Karla K. Rodgers: DNA Cleavage of a Cryptic Recombination Signal Sequence by RAG1 and RAG2: IMPLICATIONS FOR PARTIAL V_H GENE REPLACEMENT
J. Biol. Chem. 2006 281: 12370-12380. First Published on March 10, 2006; doi:10.1074/jbc.M507906200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Jens Baltin, Sandra Leist, Florian Odronitz, Hans-Peter Wollscheid, Martina Baack, Thomas Kapitza, Daniel Schaarschmidt, and Rolf Knippers: DNA Replication in Protein Extracts from Human Cells Requires ORC and Mcm Proteins
J. Biol. Chem. 2006 281: 12428-12435. First Published on March 13, 2006; doi:10.1074/jbc.M510758200 [Abstract] [Full Text] [PDF]

Anna Wieczorek and Charles S. McHenry: The NH₂-terminal php Domain of the ${alpha}$ Subunit of the Escherichia coli Replicase Binds the ${epsilon}$ Proofreading Subunit
J. Biol. Chem. 2006 281: 12561-12567. First Published on March 3, 2006; doi:10.1074/jbc.M513844200 [Abstract] [Full Text] [PDF]

Xing-Dong Zhang, Shuo-Xing Dou, Ping Xie, Jin-Shan Hu, Peng-Ye Wang, and Xu Guang Xi: Escherichia coli RecQ Is a Rapid, Efficient, and Monomeric Helicase
J. Biol. Chem. 2006 281: 12655-12663. First Published on February 28, 2006; doi:10.1074/jbc.M513089200 [Abstract] [Full Text] [PDF]

Michael P. Killoran and James L. Keck: Three HRDC Domains Differentially Modulate Deinococcus radiodurans RecQ DNA Helicase Biochemical Activity
J. Biol. Chem. 2006 281: 12849-12857. First Published on March 9, 2006; doi:10.1074/jbc.M600097200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Julia M. Cox, Stephen N. Abbott, Sindhu Chitteni-Pattu, Ross B. Inman, and Michael M. Cox: Complementation of One RecA Protein Point Mutation by Another: EVIDENCE FOR TRANS CATALYSIS OF ATP HYDROLYSIS
J. Biol. Chem. 2006 281: 12968-12975. First Published on March 8, 2006; doi:10.1074/jbc.M513736200 [Abstract] [Full Text] [PDF]

Genes: Structure and Regulation:

Yong-Heng Chen, Timothy V. Beischlag, Jeong Hoon Kim, Gary H. Perdew, and Michael R. Stallcup: Role of GAC63 in Transcriptional Activation Mediated by the Aryl Hydrocarbon Receptor
J. Biol. Chem. 2006 281: 12242-12247. First Published on March 2, 2006; doi:10.1074/jbc.M512537200 [Abstract] [Full Text] [PDF]

Justin R. Prigge and Edward E. Schmidt: Interaction of Protein Inhibitor of Activated STAT (PIAS) Proteins with the TATA-binding Protein, TBP
J. Biol. Chem. 2006 281: 12260-12269. First Published on March 6, 2006; doi:10.1074/jbc.M510835200 [Abstract] [Full Text] [PDF]

Kenichi Imai and Takashi Okamoto: Transcriptional Repression of Human Immunodeficiency Virus Type 1 by AP-4
J. Biol. Chem. 2006 281: 12495-12505. First Published on March 15, 2006; doi:10.1074/jbc.M511773200 [Abstract] [Full Text] [PDF]

Elizabeth A. Duncan, Vasiliki Anest, Patricia Cogswell, and Albert S. Baldwin: The Kinases MSK1 and MSK2 Are Required for Epidermal Growth Factor-induced, but Not Tumor Necrosis Factor-induced, Histone H3 Ser¹⁰ Phosphorylation
J. Biol. Chem. 2006 281: 12521-12525. First Published on March 3, 2006; doi:10.1074/jbc.M513333200 [Abstract] [Full Text] [PDF]

RNA: Structure, Metabolism, and Catalysis:

Véronique Douchin, Chantal Bohn, and Philippe Bouloc: Down-regulation of Porins by a Small RNA Bypasses the Essentiality of the Regulated Intramembrane Proteolysis Protease RseP in Escherichia coli
J. Biol. Chem. 2006 281: 12253-12259. First Published on March 2, 2006; doi:10.1074/jbc.M600819200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Julie L. Ponthier, Christina Schluepen, Weiguo Chen, Robert A. Lersch, Sherry L. Gee, Victor C. Hou, Annie J. Lo, Sarah A. Short, Joel A. Chasis, John C. Winkelmann, and John G. Conboy: Fox-2 Splicing Factor Binds to a Conserved Intron Motif to Promote Inclusion of Protein 4.1R Alternative Exon 16
J. Biol. Chem. 2006 281: 12468-12474. First Published on March 14, 2006; doi:10.1074/jbc.M511556200 [Abstract] [Full Text] [PDF]

Bibhuti Bhusan Roy, Jing Hu, Xiaofeng Guo, Rodney S. Russell, Fei Guo, Lawrence Kleiman, and Chen Liang: Association of RNA Helicase A with Human Immunodeficiency Virus Type 1 Particles
J. Biol. Chem. 2006 281: 12625-12635. First Published on March 8, 2006; doi:10.1074/jbc.M510596200 [Abstract] [Full Text] [PDF]

Protein Synthesis, Post-Translation Modification, and Degradation:

Bon-Hun Koo, Jean-Michel Longpré, Robert P. T. Somerville, J. Preston Alexander, Richard Leduc, and Suneel S. Apte: Cell-surface Processing of Pro-ADAMTS9 by Furin
J. Biol. Chem. 2006 281: 12485-12494. First Published on March 14, 2006; doi:10.1074/jbc.M511083200 [Abstract] [Full Text] [PDF]

Pankaj V. Alone and Thomas E. Dever: Direct Binding of Translation Initiation Factor eIF2 ${gamma}$ -G Domain to Its GTPase-activating and GDP-GTP Exchange Factors eIF5 and eIF2B ${epsilon}$
J. Biol. Chem. 2006 281: 12636-12644. First Published on March 7, 2006; doi:10.1074/jbc.M511700200 [Abstract] [Full Text] [PDF]

Jeong Eun Kwon, Muhnho La, Kyu Hee Oh, Young Mi Oh, Gi Ryang Kim, Jae Hong Seol, Sung Hee Baek, Tomoki Chiba, Keiji Tanaka, Ok Sun Bang, Cheol O. Joe, and Chin Ha Chung: BTB Domain-containing Speckle-type POZ Protein (SPOP) Serves as an Adaptor of Daxx for Ubiquitination by Cul3-based Ubiquitin Ligase
J. Biol. Chem. 2006 281: 12664-12672. First Published on March 8, 2006; doi:10.1074/jbc.M600204200 [Abstract] [Full Text] [PDF]

Jennifer K. Sims, Sabrina I. Houston, Tanya Magazinnik, and Judd C. Rice: A Trans-tail Histone Code Defined by Monomethylated H4 Lys-20 and H3 Lys-9 Demarcates Distinct Regions of Silent Chromatin
J. Biol. Chem. 2006 281: 12760-12766. First Published on March 3, 2006; doi:10.1074/jbc.M513462200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Peiqi Hu, Paula Berkowitz, Victoria J. Madden, and David S. Rubenstein: Stabilization of Plakoglobin and Enhanced Keratinocyte Cell-Cell Adhesion by Intracellular O-Glycosylation
J. Biol. Chem. 2006 281: 12786-12791. First Published on March 1, 2006; doi:10.1074/jbc.M511702200 [Abstract] [Full Text] [PDF]

Kenneth M. Rosen, Vimal Veereshwarayya, Charbel E-H. Moussa, Qinghao Fu, Matthew S. Goldberg, Michael G. Schlossmacher, Jie Shen, and Henry W. Querfurth: Parkin Protects against Mitochondrial Toxins and $beta$ -Amyloid Accumulation in Skeletal Muscle Cells
J. Biol. Chem. 2006 281: 12809-12816. First Published on March 3, 2006; doi:10.1074/jbc.M512649200 [Abstract] [Full Text] [PDF]

Genomics, Proteomics, and Bioinformatics:

Vijayendran Raghevendran, Kiran Raosaheb Patil, Lisbeth Olsson, and Jens Nielsen: Hap4 Is Not Essential for Activation of Respiration at Low Specific Growth Rates in Saccharomyces cerevisiae
J. Biol. Chem. 2006 281: 12308-12314. First Published on March 7, 2006; doi:10.1074/jbc.M512972200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Protein Structure and Folding:

Gordana Cogelja Cajo, B. Erin Horne, William L. Kelley, Françoise Schwager, Costa Georgopoulos, and Pierre Genevaux: The Role of the DIF Motif of the DnaJ (Hsp40) Co-chaperone in the Regulation of the DnaK (Hsp70) Chaperone Cycle
J. Biol. Chem. 2006 281: 12436-12444. First Published on March 13, 2006; doi:10.1074/jbc.M511192200 [Abstract] [Full Text] [PDF]

Anne Chapman-Smith and Murray L. Whitelaw: Novel DNA Binding by a Basic Helix-Loop-Helix Protein: THE ROLE OF THE DIOXIN RECEPTOR PAS DOMAIN
J. Biol. Chem. 2006 281: 12535-12545. First Published on March 6, 2006; doi:10.1074/jbc.M512145200 [Abstract] [Full Text] [PDF]

Kenji Maeda, Debananda Das, Hiromi Ogata-Aoki, Hirotomo Nakata, Toshikazu Miyakawa, Yasushi Tojo, Rachael Norman, Yoshikazu Takaoka, Jianping Ding, Gail F. Arnold, Eddy Arnold, and Hiroaki Mitsuya: Structural and Molecular Interactions of CCR5 Inhibitors with CCR5
J. Biol. Chem. 2006 281: 12688-12698. First Published on February 13, 2006; doi:10.1074/jbc.M512688200 [Abstract] [Full Text] [PDF]

Ann Glithero, Jose Tormo, Klaus Doering, Mayumi Kojima, E. Yvonne Jones, and Tim Elliott: The Crystal Structure of H-2D^b Complexed with a Partial Peptide Epitope Suggests a Major Histocompatibility Complex Class I Assembly Intermediate
J. Biol. Chem. 2006 281: 12699-12704. First Published on February 14, 2006; doi:10.1074/jbc.M511683200 [Abstract] [Full Text] [PDF]

Samantha L. Kaye, Mark S. P. Sansom, and Philip C. Biggin: Molecular Dynamics Simulations of the Ligand-binding Domain of an N-Methyl-D-aspartate Receptor
J. Biol. Chem. 2006 281: 12736-12742. First Published on March 2, 2006; doi:10.1074/jbc.M512728200 [Abstract] [Full Text] [PDF]

Warren Sun, Sasha Singh, Rongguang Zhang, Joanne L. Turnbull, and Dinesh Christendat: Crystal Structure of Prephenate Dehydrogenase from Aquifex aeolicus: INSIGHTS INTO THE CATALYTIC MECHANISM
J. Biol. Chem. 2006 281: 12919-12928. First Published on March 2, 2006; doi:10.1074/jbc.M511986200 [Abstract] [Full Text] [PDF]

Zoya Ignatova and Lila M. Gierasch: Extended Polyglutamine Tracts Cause Aggregation and Structural Perturbation of an Adjacent $beta$ Barrel Protein
J. Biol. Chem. 2006 281: 12959-12967. First Published on March 8, 2006; doi:10.1074/jbc.M511523200 [Abstract] [Full Text] [PDF]

Enzyme Catalysis and Regulation:

Avvaru N. Suhasini and Ravi Sirdeshmukh: Transfer RNA Cleavages by Onconase Reveal Unusual Cleavage Sites
J. Biol. Chem. 2006 281: 12201-12209. First Published on February 23, 2006; doi:10.1074/jbc.M504488200 [Abstract] [Full Text] [PDF]

Kuanyu Li, Wing-Hang Tong, Robert M. Hughes, and Tracey A. Rouault: Roles of the Mammalian Cytosolic Cysteine Desulfurase, ISCS, and Scaffold Protein, ISCU, in Iron-Sulfur Cluster Assembly
J. Biol. Chem. 2006 281: 12344-12351. First Published on March 9, 2006; doi:10.1074/jbc.M600582200 [Abstract] [Full Text] [PDF]

Ewa Heyduk, Konstantin Kuznedelov, Konstantin Severinov, and Tomasz Heyduk: A Consensus Adenine at Position –11 of the Nontemplate Strand of Bacterial Promoter Is Important for Nucleation of Promoter Melting
J. Biol. Chem. 2006 281: 12362-12369. First Published on March 9, 2006; doi:10.1074/jbc.M601364200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Kun Zhang, Tian-zhu Zang, Wei Yang, Ye Sun, Ying Mu, Jun-qiu Liu, Jia-cong Shen, and Gui-min Luo: Single Chain Antibody Displays Glutathione S-Transferase Activity
J. Biol. Chem. 2006 281: 12516-12520. First Published on February 28, 2006; doi:10.1074/jbc.M513596200 [Abstract] [Full Text] [PDF]

Alexander Aranovich, Garik Y. Gdalevsky, Rivka Cohen-Luria, Itzhak Fishov, and Abraham H. Parola: Membrane-catalyzed Nucleotide Exchange on DnaA: EFFECT OF SURFACE MOLECULAR CROWDING
J. Biol. Chem. 2006 281: 12526-12534. First Published on March 4, 2006; doi:10.1074/jbc.M510266200 [Abstract] [Full Text] [PDF]

Haitao Li, Xiaoping Liu, Hongmei Cui, Yeong-Renn Chen, Arturo J. Cardounel, and Jay L. Zweier: Characterization of the Mechanism of Cytochrome P450 Reductase-Cytochrome P450-mediated Nitric Oxide and Nitrosothiol Generation from Organic Nitrates
J. Biol. Chem. 2006 281: 12546-12554. First Published on March 9, 2006; doi:10.1074/jbc.M511803200 [Abstract] [Full Text] [PDF]

Can Hekim, Jari Leinonen, Ale Närvänen, Hannu Koistinen, Lei Zhu, Erkki Koivunen, Ville Väisänen, and Ulf-Håkan Stenman: Novel Peptide Inhibitors of Human Kallikrein 2
J. Biol. Chem. 2006 281: 12555-12560. First Published on March 9, 2006; doi:10.1074/jbc.M600014200 [Abstract] [Full Text] [PDF]

Yasuaki Hiromasa, Liangyan Hu, and Thomas E. Roche: Ligand-induced Effects on Pyruvate Dehydrogenase Kinase Isoform 2
J. Biol. Chem. 2006 281: 12568-12579. First Published on March 3, 2006; doi:10.1074/jbc.M513514200 [Abstract] [Full Text] [PDF] [Supplemental Data][Supplemental Data]

Júlia Tóth, Linda Gombos, Zoltán Simon, Péter Medveczky, László Szilágyi, László Gráf, and András Málnási-Csizmadia: Thermodynamic Analysis Reveals Structural Rearrangement during the Acylation Step in Human Trypsin 4 on 4-Methylumbelliferyl 4-Guanidinobenzoate Substrate Analogue
J. Biol. Chem. 2006 281: 12596-12602. First Published on February 21, 2006; doi:10.1074/jbc.M512301200 [Abstract] [Full Text] [PDF]

Gillian E. Begg, Sara R. Holman, Philippa H. Stokes, Jacqueline M. Matthews, Robert M. Graham, and Siiri E. Iismaa: Mutation of a Critical Arginine in the GTP-binding Site of Transglutaminase 2 Disinhibits Intracellular Cross-linking Activity
J. Biol. Chem. 2006 281: 12603-12609. First Published on March 7, 2006; doi:10.1074/jbc.M600146200 [Abstract] [Full Text] [PDF]

Takehiko Tosha, Takeshi Uchida, Alan R. Brash, and Teizo Kitagawa: On the Relationship of Coral Allene Oxide Synthase to Catalase: A SINGLE ACTIVE SITE MUTATION THAT INDUCES CATALASE ACTIVITY IN CORAL ALLENE OXIDE SYNTHASE
J. Biol. Chem. 2006 281: 12610-12617. First Published on March 2, 2006; doi:10.1074/jbc.M600061200 [Abstract] [Full Text] [PDF]

Iacovos P. Michael, Georgios Pampalakis, Stephen D. Mikolajczyk, Johan Malm, Georgia Sotiropoulou, and Eleftherios P. Diamandis: Human Tissue Kallikrein 5 Is a Member of a Proteolytic Cascade Pathway Involved in Seminal Clot Liquefaction and Potentially in Prostate Cancer Progression
J. Biol. Chem. 2006 281: 12743-12750. First Published on March 3, 2006; doi:10.1074/jbc.M600326200 [Abstract] [Full Text] [PDF]

Youngchool Choe, Francesco Leonetti, Doron C. Greenbaum, Fabien Lecaille, Matthew Bogyo, Dieter Brömme, Jonathan A. Ellman, and Charles S. Craik: Substrate Profiling of Cysteine Proteases Using a Combinatorial Peptide Library Identifies Functionally Unique Specificities
J. Biol. Chem. 2006 281: 12824-12832. First Published on March 6, 2006; doi:10.1074/jbc.M513331200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Metabolism and Bioenergetics:

Verónica Irazusta, Elisa Cabiscol, Gemma Reverter-Branchat, Joaquim Ros, and Jordi Tamarit: Manganese Is the Link between Frataxin and Iron-Sulfur Deficiency in the Yeast Model of Friedreich Ataxia
J. Biol. Chem. 2006 281: 12227-12232. First Published on March 1, 2006; doi:10.1074/jbc.M511649200 [Abstract] [Full Text] [PDF]

Paul A. Cobine, Fabien Pierrel, Scot C. Leary, Florin Sasarman, Yih-Chern Horng, Eric A. Shoubridge, and Dennis R. Winge: The P174L Mutation in Human Sco1 Severely Compromises Cox17-dependent Metallation but Does Not Impair Copper Binding
J. Biol. Chem. 2006 281: 12270-12276. First Published on March 6, 2006; doi:10.1074/jbc.M600496200 [Abstract] [Full Text] [PDF]

Daniel J. Cipriano, Kristi S. Wood, Yumin Bi, and Stanley D. Dunn: Mutations in the Dimerization Domain of the b Subunit from the Escherichia coli ATP synthase: DELETIONS DISRUPT FUNCTION BUT NOT ENZYME ASSEMBLY
J. Biol. Chem. 2006 281: 12408-12413. First Published on March 10, 2006; doi:10.1074/jbc.M513368200 [Abstract] [Full Text] [PDF]

Anne Galinier, Audrey Carrière, Yvette Fernandez, Christian Carpéné, Mireille André, Sylvie Caspar-Bauguil, Jean-Paul Thouvenot, Brigitte Périquet, Luc Pénicaud, and Louis Casteilla: Adipose Tissue Proadipogenic Redox Changes in Obesity
J. Biol. Chem. 2006 281: 12682-12687. First Published on December 23, 2005; doi:10.1074/jbc.M506949200 [Abstract] [Full Text] [PDF]

Glycobiology and Extracellular Matrices:

Altan Ercan, Maria Panico, Mark Sutton-Smith, Anne Dell, Howard R. Morris, Khushi L. Matta, Daniel F. Gay, and Christopher M. West: Molecular Characterization of a Novel UDP-galactose:Fucoside ${alpha}$ 3-Galactosyltransferase That Modifies Skp1 in the Cytoplasm of Dictyostelium
J. Biol. Chem. 2006 281: 12713-12721. First Published on February 22, 2006; doi:10.1074/jbc.M513664200 [Abstract] [Full Text] [PDF]

Mohan Sarkar, Peter A. Leventis, Cristina I. Silvescu, Vernon N. Reinhold, Harry Schachter, and Gabrielle L. Boulianne: Null Mutations in Drosophila N-Acetylglucosaminyltransferase I Produce Defects in Locomotion and a Reduced Life Span
J. Biol. Chem. 2006 281: 12776-12785. First Published on March 7, 2006; doi:10.1074/jbc.M512769200 [Abstract] [Full Text] [PDF]

Suparna Kanjilal-Kolar, Shib Sankar Basu, Margaret I. Kanipes, Ziqiang Guan, Teresa A. Garrett, and Christian R. H. Raetz: Expression Cloning of Three Rhizobium leguminosarum Lipopolysaccharide Core Galacturonosyltransferases
J. Biol. Chem. 2006 281: 12865-12878. First Published on February 23, 2006; doi:10.1074/jbc.M513864200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Suparna Kanjilal-Kolar and Christian R. H. Raetz: Dodecaprenyl Phosphate-Galacturonic Acid as a Donor Substrate for Lipopolysaccharide Core Glycosylation in Rhizobium leguminosarum
J. Biol. Chem. 2006 281: 12879-12887. First Published on February 23, 2006; doi:10.1074/jbc.M513865200 [Abstract] [Full Text] [PDF]

Richard J. Wenstrup, Jane B. Florer, Jeffrey M. Davidson, Charlotte L. Phillips, Brent J. Pfeiffer, Diana W. Menezes, Inna Chervoneva, and David E. Birk: Murine Model of the Ehlers-Danlos Syndrome: col5a1 HAPLOINSUFFICIENCY DISRUPTS COLLAGEN FIBRIL ASSEMBLY AT MULTIPLE STAGES
J. Biol. Chem. 2006 281: 12888-12895. First Published on February 20, 2006; doi:10.1074/jbc.M511528200 [Abstract] [Full Text] [PDF]

Lipids and Lipoproteins:

Jun Wang, Yasuo Okamoto, Jun Morishita, Kazuhito Tsuboi, Akira Miyatake, and Natsuo Ueda: Functional Analysis of the Purified Anandamide-generating Phospholipase D as a Member of the Metallo- $beta$ -lactamase Family
J. Biol. Chem. 2006 281: 12325-12335. First Published on March 9, 2006; doi:10.1074/jbc.M512359200 [Abstract] [Full Text] [PDF]

Karlygash Abildayeva, Paula J. Jansen, Veronica Hirsch-Reinshagen, Vincent W. Bloks, Arjen H. F. Bakker, Frans C. S. Ramaekers, Jan de Vente, Albert K. Groen, Cheryl L. Wellington,, Folkert Kuipers, and Monique Mulder: 24(S)-Hydroxycholesterol Participates in a Liver X Receptor-controlled Pathway in Astrocytes That Regulates Apolipoprotein E-mediated Cholesterol Efflux
J. Biol. Chem. 2006 281: 12799-12808. First Published on March 8, 2006; doi:10.1074/jbc.M601019200 [Abstract] [Full Text] [PDF]

Membrane Transport, Structure, Function, and Biogenesis:

David J. F. du Plessis, Nico Nouwen, and Arnold J. M. Driessen: Subunit a of Cytochrome o Oxidase Requires Both YidC and SecYEG for Membrane Insertion
J. Biol. Chem. 2006 281: 12248-12252. First Published on March 2, 2006; doi:10.1074/jbc.M600048200 [Abstract] [Full Text] [PDF]

Stéphanie Klein, Michel Franco, Pierre Chardin, and Frédéric Luton: Role of the Arf6 GDP/GTP Cycle and Arf6 GTPase-activating Proteins in Actin Remodeling and Intracellular Transport
J. Biol. Chem. 2006 281: 12352-12361. First Published on March 9, 2006; doi:10.1074/jbc.M601021200 [Abstract] [Full Text] [PDF]

Paula E. Row, Ian A. Prior, John McCullough, Michael J. Clague, and Sylvie Urbé: The Ubiquitin Isopeptidase UBPY Regulates Endosomal Ubiquitin Dynamics and Is Essential for Receptor Down-regulation
J. Biol. Chem. 2006 281: 12618-12624. First Published on March 6, 2006; doi:10.1074/jbc.M512615200 [Abstract] [Full Text] [PDF]

Masaki Imai, Takafumi Mizuno, and Kazunori Kawasaki: Membrane Fusion by Single Influenza Hemagglutinin Trimers: KINETIC EVIDENCE FROM IMAGE ANALYSIS OF HEMAGGLUTININ-RECONSTITUTED VESICLES
J. Biol. Chem. 2006 281: 12729-12735. First Published on February 27, 2006; doi:10.1074/jbc.M600902200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Mark T. Miedel, Kelly M. Weixel, Jennifer R. Bruns, Linton M. Traub, and Ora A. Weisz: Posttranslational Cleavage and Adaptor Protein Complex-dependent Trafficking of Mucolipin-1
J. Biol. Chem. 2006 281: 12751-12759. First Published on March 3, 2006; doi:10.1074/jbc.M511104200 [Abstract] [Full Text] [PDF]

Bettina Blüschke, Rudolf Volkmer-Engert, and Erwin Schneider: Topography of the Surface of the Signal-transducing Protein EIIA^Glc That Interacts with the MalK Subunits of the Maltose ATP-binding Cassette Transporter (MalFGK₂) of Salmonella typhimurium
J. Biol. Chem. 2006 281: 12833-12840. First Published on March 9, 2006; doi:10.1074/jbc.M512646200 [Abstract] [Full Text] [PDF]

Kazutsune Harada, Tsukasa Okiyoneda, Yasuaki Hashimoto, Keiko Ueno, Kimitoshi Nakamura, Kaori Yamahira, Takuya Sugahara, Tsuyoshi Shuto, Ikuo Wada, Mary Ann Suico, and Hirofumi Kai: Calreticulin Negatively Regulates the Cell Surface Expression of Cystic Fibrosis Transmembrane Conductance Regulator
J. Biol. Chem. 2006 281: 12841-12848. First Published on March 9, 2006; doi:10.1074/jbc.M512975200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Tania Ferrer, Jason Rupp, David R. Piper, and Martin Tristani-Firouzi: The S4-S5 Linker Directly Couples Voltage Sensor Movement to the Activation Gate in the Human Ether-á-go-go-related Gene (hERG) K⁺ Channel
J. Biol. Chem. 2006 281: 12858-12864. First Published on March 8, 2006; doi:10.1074/jbc.M513518200 [Abstract] [Full Text] [PDF]

Hong Song, Moo Yeol Lee, Stephen P. Kinsey, David J. Weber, and Mordecai P. Blaustein: An N-terminal Sequence Targets and Tethers Na⁺ Pump ${alpha}$ 2 Subunits to Specialized Plasma Membrane Microdomains
J. Biol. Chem. 2006 281: 12929-12940. First Published on March 8, 2006; doi:10.1074/jbc.M507450200 [Abstract] [Full Text] [PDF]

Xiuwei H. Yang, Oleg V. Kovalenko, Tatiana V. Kolesnikova, Milena M. Andzelm, Eric Rubinstein, Jack L. Strominger, and Martin E. Hemler: Contrasting Effects of EWI Proteins, Integrins, and Protein Palmitoylation on Cell Surface CD9 Organization
J. Biol. Chem. 2006 281: 12976-12985. First Published on March 13, 2006; doi:10.1074/jbc.M510617200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Molecular Basis Of Cell and Developmental Biology:

Hideo Taniura, Noriko Sanada, Nobuyuki Kuramoto, and Yukio Yoneda: A Metabotropic Glutamate Receptor Family Gene in Dictyostelium discoideum
J. Biol. Chem. 2006 281: 12336-12343. First Published on March 9, 2006; doi:10.1074/jbc.M512723200 [Abstract] [Full Text] [PDF]

Yongjun Zhang, Yizeng Tu, Vasiliki Gkretsi, and Chuanyue Wu: Migfilin Interacts with Vasodilator-stimulated Phosphoprotein (VASP) and Regulates VASP Localization to Cell-Matrix Adhesions and Migration
J. Biol. Chem. 2006 281: 12397-12407. First Published on March 10, 2006; doi:10.1074/jbc.M512107200 [Abstract] [Full Text] [PDF]

Mingyao Ying, Rener Xu, Xiaohui Wu, Huaxing Zhu, Yuan Zhuang, Min Han, and Tian Xu: Sodium Butyrate Ameliorates Histone Hypoacetylation and Neurodegenerative Phenotypes in a Mouse Model for DRPLA
J. Biol. Chem. 2006 281: 12580-12586. First Published on December 28, 2005; doi:10.1074/jbc.M511677200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Jianning Mao, Xiaoying Qiao, Hongyu Luo, and Jiangping Wu: Transgenic Drak2 Overexpression in Mice Leads to Increased T Cell Apoptosis and Compromised Memory T Cell Development
J. Biol. Chem. 2006 281: 12587-12595. First Published on March 3, 2006; doi:10.1074/jbc.M600497200 [Abstract] [Full Text] [PDF]

Koichiro Wada, Atsushi Nakajima, Kazufumi Katayama, Chiho Kudo, Atsuhito Shibuya, Naoto Kubota, Yasuo Terauchi, Masashi Tachibana, Hiroyuki Miyoshi, Yoshinori Kamisaki, Tadanori Mayumi, Takashi Kadowaki, and Richard S. Blumberg: Peroxisome Proliferator-activated Receptor ${gamma}$ -mediated Regulation of Neural Stem Cell Proliferation and Differentiation
J. Biol. Chem. 2006 281: 12673-12681. First Published on March 8, 2006; doi:10.1074/jbc.M513786200 [Abstract] [Full Text] [PDF]

Elena Torban, Alison Dziarmaga, Diana Iglesias, Lee Lee Chu, Tatiana Vassilieva, Melissa Little, Michael Eccles, Maria Discenza, Jerry Pelletier, and Paul Goodyer: PAX2 Activates WNT4 Expression during Mammalian Kidney Development
J. Biol. Chem. 2006 281: 12705-12712. First Published on December 19, 2005; doi:10.1074/jbc.M513181200 [Abstract] [Full Text] [PDF]

Yunying Chen, Marko Sankala, Juha R. M. Ojala, Yi Sun, Ari Tuuttila, David E. Isenman, Karl Tryggvason, and Timo Pikkarainen: A Phage Display Screen and Binding Studies with Acetylated Low Density Lipoprotein Provide Evidence for the Importance of the Scavenger Receptor Cysteine-rich (SRCR) Domain in the Ligand-binding Function of MARCO
J. Biol. Chem. 2006 281: 12767-12775. First Published on March 7, 2006; doi:10.1074/jbc.M513628200 [Abstract] [Full Text] [PDF]

Franco J. Vizeacoumar, Wanda N. Vreden, Monica Fagarasanu, Gary A. Eitzen, John D. Aitchison, and Richard A. Rachubinski: The Dynamin-like Protein Vps1p of the Yeast Saccharomyces cerevisiae Associates with Peroxisomes in a Pex19p-dependent Manner
J. Biol. Chem. 2006 281: 12817-12823. First Published on March 6, 2006; doi:10.1074/jbc.M600365200 [Abstract] [Full Text] [PDF]

Yuki Yagasaki, Tadahiro Numakawa, Emi Kumamaru, Teruo Hayashi, Tsung-Ping Su, and Hiroshi Kunugi: Chronic Antidepressants Potentiate via Sigma-1 Receptors the Brain-derived Neurotrophic Factor-induced Signaling for Glutamate Release
J. Biol. Chem. 2006 281: 12941-12949. First Published on March 6, 2006; doi:10.1074/jbc.M508157200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Alessandra Valerio, Valentina Ghisi, Marta Dossena, Cristina Tonello, Antonio Giordano, Andrea Frontini, Marina Ferrario, Marina Pizzi, PierFranco Spano, Michele O. Carruba, and Enzo Nisoli: Leptin Increases Axonal Growth Cone Size in Developing Mouse Cortical Neurons by Convergent Signals Inactivating Glycogen Synthase Kinase-3 $beta$
J. Biol. Chem. 2006 281: 12950-12958. First Published on March 7, 2006; doi:10.1074/jbc.M508691200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Cristina-Maria Cruciat, Christine Hassler, and Christof Niehrs: The MRH Protein Erlectin Is a Member of the Endoplasmic Reticulum Synexpression Group and Functions in N-Glycan Recognition
J. Biol. Chem. 2006 281: 12986-12993. First Published on March 10, 2006; doi:10.1074/jbc.M511872200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Mechanisms Of Signal Transduction:

Gary K. Yiu and Alex Toker: NFAT Induces Breast Cancer Cell Invasion by Promoting the Induction of Cyclooxygenase-2
J. Biol. Chem. 2006 281: 12210-12217. First Published on February 27, 2006; doi:10.1074/jbc.M600184200 [Abstract] [Full Text] [PDF]

Wojciech Swiatek, Heeseog Kang, Benjamin A. Garcia, Jeffery Shabanowitz, Gary S. Coombs, Donald F. Hunt, and David M. Virshup: Negative Regulation of LRP6 Function by Casein Kinase I ${epsilon}$ Phosphorylation
J. Biol. Chem. 2006 281: 12233-12241. First Published on March 2, 2006; doi:10.1074/jbc.M510580200 [Abstract] [Full Text] [PDF]

Jessica G. Moreland, A. Paige Davis, Gail Bailey, William M. Nauseef, and Fred. S. Lamb: Anion Channels, Including ClC-3, Are Required for Normal Neutrophil Oxidative Function, Phagocytosis, and Transendothelial Migration
J. Biol. Chem. 2006 281: 12277-12288. First Published on March 7, 2006; doi:10.1074/jbc.M511030200 [Abstract] [Full Text] [PDF]

Appakkudal R. Anand and Ramesh K. Ganju: HIV-1 gp120-mediated Apoptosis of T Cells Is Regulated by the Membrane Tyrosine Phosphatase CD45
J. Biol. Chem. 2006 281: 12289-12299. First Published on March 7, 2006; doi:10.1074/jbc.M511786200 [Abstract] [Full Text] [PDF]

Axel Niebisch, Armin Kabus, Christian Schultz, Brita Weil, and Michael Bott: Corynebacterial Protein Kinase G Controls 2-Oxoglutarate Dehydrogenase Activity via the Phosphorylation Status of the OdhI Protein
J. Biol. Chem. 2006 281: 12300-12307. First Published on March 7, 2006; doi:10.1074/jbc.M512515200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Heike M. Pirner and Jürgen Stolz: Biotin Sensing in Saccharomyces cerevisiae Is Mediated by a Conserved DNA Element and Requires the Activity of Biotin-Protein Ligase
J. Biol. Chem. 2006 281: 12381-12389. First Published on March 10, 2006; doi:10.1074/jbc.M511075200 [Abstract] [Full Text] [PDF]

Bunzo Matsuura, Maoqing Dong, Shruthi Naik, Laurence J. Miller, and Morikazu Onji: Differential Contributions of Motilin Receptor Extracellular Domains for Peptide and Non-peptidyl Agonist Binding and Activity
J. Biol. Chem. 2006 281: 12390-12396. First Published on March 10, 2006; doi:10.1074/jbc.M511921200 [Abstract] [Full Text] [PDF]

Zhongjian Chen, Chris Hague, Randy A. Hall, and Kenneth P. Minneman: Syntrophins Regulate ${alpha}$ _1D-Adrenergic Receptors through a PDZ Domain-mediated Interaction
J. Biol. Chem. 2006 281: 12414-12420. First Published on March 13, 2006; doi:10.1074/jbc.M508651200 [Abstract] [Full Text] [PDF]

Bruno Gomes, Magali Savignac, Marilena Djata Cabral, Pierre Paulet, Marc Moreau, Catherine Leclerc, Robert Feil, Franz Hofmann, Jean-Charles Guéry, Gilles Dietrich, and Lucette Pelletier: The cGMP/Protein Kinase G Pathway Contributes to Dihydropyridine-sensitive Calcium Response and Cytokine Production in TH2 Lymphocytes
J. Biol. Chem. 2006 281: 12421-12427. First Published on March 13, 2006; doi:10.1074/jbc.M510653200 [Abstract] [Full Text] [PDF]

Yuri K. Peterson, Patrick Kelly, Carolyn A. Weinbaum, and Patrick J. Casey: A Novel Protein Geranylgeranyltransferase-I Inhibitor with High Potency, Selectivity, and Cellular Activity
J. Biol. Chem. 2006 281: 12445-12450. First Published on March 3, 2006; doi:10.1074/jbc.M600168200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Hai Ou Duan and Patricia J. Simpson-Haidaris: Cell Type-specific Differential Induction of the Human ${gamma}$ -Fibrinogen Promoter by Interleukin-6
J. Biol. Chem. 2006 281: 12451-12457. First Published on March 8, 2006; doi:10.1074/jbc.M600294200 [Abstract] [Full Text] [PDF]

Andrew S. Cowburn, Anastasia Sobolewski, Ben J. Reed, John Deighton, Joanna Murray, Karen A. Cadwallader, John R. Bradley, and Edwin R. Chilvers: Aminopeptidase N (CD13) Regulates Tumor Necrosis Factor- ${alpha}$ -induced Apoptosis in Human Neutrophils
J. Biol. Chem. 2006 281: 12458-12467. First Published on March 13, 2006; doi:10.1074/jbc.M511277200 [Abstract] [Full Text] [PDF]

Alvin P. Joselin, Klaus Schulze-Osthoff, and Christian Schwerk: Loss of Acinus Inhibits Oligonucleosomal DNA Fragmentation but Not Chromatin Condensation during Apoptosis
J. Biol. Chem. 2006 281: 12475-12484. First Published on March 14, 2006; doi:10.1074/jbc.M509859200 [Abstract] [Full Text] [PDF]

Clark Q. Pan, Joanne M. Buxton, Stephanie L. Yung, Irene Tom, Ling Yang, Hongxing Chen, Margit MacDougall, Andrea Bell, Thomas H. Claus, Kevin B. Clairmont, and James P. Whelan: Design of a Long Acting Peptide Functioning as Both a Glucagon-like Peptide-1 Receptor Agonist and a Glucagon Receptor Antagonist
J. Biol. Chem. 2006 281: 12506-12515. First Published on February 27, 2006; doi:10.1074/jbc.M600127200 [Abstract] [Full Text] [PDF]

Gudrun Totzke, Frank Essmann, Stephan Pohlmann, Charlotte Lindenblatt, Reiner U. Jänicke, and Klaus Schulze-Osthoff: A Novel Member of the I ${kappa}$ B Family, Human I ${kappa}$ B- ${zeta}$ , Inhibits Transactivation of p65 and Its DNA Binding
J. Biol. Chem. 2006 281: 12645-12654. First Published on March 2, 2006; doi:10.1074/jbc.M511956200 [Abstract] [Full Text] [PDF]

Shinkyu Choi, Jin Hyoung Kim, Eun-Jihn Roh, Moon-Jeong Ko, Ji-Eun Jung, and Hwa-Jung Kim: Nuclear Factor- ${kappa}$ B Activated by Capacitative Ca²⁺ Entry Enhances Muscarinic Receptor-mediated Soluble Amyloid Precursor Protein (sAPP ${alpha}$ ) Release in SH-SY5Y Cells
J. Biol. Chem. 2006 281: 12722-12728. First Published on February 20, 2006; doi:10.1074/jbc.M601018200 [Abstract] [Full Text] [PDF]

Yossan-Var Tan, Alain Couvineau, Samuel Murail, Emilie Ceraudo, Jean-Michel Neumann, Jean-Jacques Lacapère, and Marc Laburthe: Peptide Agonist Docking in the N-terminal Ectodomain of a Class II G Protein-coupled Receptor, the VPAC1 Receptor: PHOTOAFFINITY, NMR, AND MOLECULAR MODELING
J. Biol. Chem. 2006 281: 12792-12798. First Published on March 6, 2006; doi:10.1074/jbc.M513305200 [Abstract] [Full Text] [PDF]

Noel M. Delos Santos, Lidia A. Gardner, Stephen W. White, and Suleiman W. Bahouth: Characterization of the Residues in Helix 8 of the Human $beta$ ₁-Adrenergic Receptor That Are Involved in Coupling the Receptor to G Proteins
J. Biol. Chem. 2006 281: 12896-12907. First Published on February 24, 2006; doi:10.1074/jbc.M508500200 [Abstract] [Full Text] [PDF]

Rina Kurihara, Yumi Tohyama, Satoshi Matsusaka, Hiromu Naruse, Emi Kinoshita, Takayuki Tsujioka, Yoshinao Katsumata, and Hirohei Yamamura: Effects of Peripheral Cannabinoid Receptor Ligands on Motility and Polarization in Neutrophil-like HL60 Cells and Human Neutrophils
J. Biol. Chem. 2006 281: 12908-12918. First Published on March 2, 2006; doi:10.1074/jbc.M510871200 [Abstract] [Full Text] [PDF] [Summary]

Adam J. Ratner, Karen R. Hippe, Jorge L. Aguilar, Matthew H. Bender, Aaron L. Nelson, and Jeffrey N. Weiser: Epithelial Cells Are Sensitive Detectors of Bacterial Pore-forming Toxins
J. Biol. Chem. 2006 281: 12994-12998. First Published on March 6, 2006; doi:10.1074/jbc.M511431200 [Abstract] [Full Text] [PDF]

Additions and Corrections:

Ole E. Sørensen, Lone Gram, Anders H. Johnsen, Emma Andersson, Susanne Bangsbøll, G. Sandra Tjabringa, Pieter S. Hiemstra, Johan Malm, Arne Egesten, and Niels Borregaard: Processing of seminal plasma hCAP-18 to ALL-38 by gastricsin. A NOVEL MECHANISM OF GENERATING ANTIMICROBIAL PEPTIDES IN VAGINA. VOLUME 278 (2003) PAGES 28540-28546
J. Biol. Chem. 2006 281: 12999. [Full Text] [PDF]

Andreas Kern, Birgit Roempp, Kai Prager, Jochen Walter, and Christian Behl: Down-regulation of endogenous amyloid precursor protein processing due to cellular aging. VOLUME 281 (2006) PAGES 2405-2413
J. Biol. Chem. 2006 281: 13000. [Full Text] [PDF]