JBC -- Table of Contents (Jul 28 2006, 281, (30))

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Nicole Kresge, Robert D. Simoni, and Robert L. Hill: The Effects of Insulin on Fat Cells and the Role of Guanyl Nucleotides in Signal Transduction: the Work of Martin Rodbell
Metabolism of Isolated Fat Cells. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS (Martin Rodbell J. Biol. Chem. 239, 375-380)
The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver. V. AN OBLIGATORY ROLE OF GUANYL NUCLEOTIDES IN GLUCAGON ACTION (Martin Rodbell, Lutz Birnbaumer, Stephen L. Pohl, and H. Michiel J. Krans J. Biol. Chem. 246, 1877-1882)
J. Biol. Chem. 2006 281: e24. [Full Text]

Accelerated Publications:

Jonathan Soboloff, Maria A. Spassova, Xiang D. Tang, Thamara Hewavitharana, Wen Xu, and Donald L. Gill: Orai1 and STIM Reconstitute Store-operated Calcium Channel Function
J. Biol. Chem. 2006 281: 20661-20665. First Published on June 9, 2006; doi:10.1074/jbc.C600126200 [Abstract] [Full Text] [PDF]

DNA: Replication, Repair, and Recombination:

Atsuko Gyohda, Shujuan Zhu, Nobuhisa Furuya, and Teruya Komano: Asymmetry of Shufflon-specific Recombination Sites in Plasmid R64 Inhibits Recombination between Direct sfx Sequences
J. Biol. Chem. 2006 281: 20772-20779. First Published on May 23, 2006; doi:10.1074/jbc.M513654200 [Abstract] [Full Text] [PDF]

Wensheng Wang, Laura A. Lindsey-Boltz, Aziz Sancar, and Robert A. Bambara: Mechanism of Stimulation of Human DNA Ligase I by the Rad9-Rad1-Hus1 Checkpoint Complex
J. Biol. Chem. 2006 281: 20865-20872. First Published on May 25, 2006; doi:10.1074/jbc.M602289200 [Abstract] [Full Text] [PDF]

Jeong-Yun Choi, Karen C. Angel, and F. Peter Guengerich: Translesion Synthesis across Bulky N²-Alkyl Guanine DNA Adducts by Human DNA Polymerase ${kappa}$
J. Biol. Chem. 2006 281: 21062-21072. First Published on June 1, 2006; doi:10.1074/jbc.M602246200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Hiroyuki Kitao, Kazuhiko Yamamoto, Nobuko Matsushita, Mioko Ohzeki, Masamichi Ishiai, and Minoru Takata: Functional Interplay between BRCA2/FancD1 and FancC in DNA Repair
J. Biol. Chem. 2006 281: 21312-21320. First Published on May 10, 2006; doi:10.1074/jbc.M603290200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Takashi Seki, Masaki Akita, Yoichiro Kamimura, Sachiko Muramatsu, Hiroyuki Araki, and Akio Sugino: GINS Is a DNA Polymerase ${epsilon}$ Accessory Factor during Chromosomal DNA Replication in Budding Yeast
J. Biol. Chem. 2006 281: 21422-21432. First Published on May 19, 2006; doi:10.1074/jbc.M603482200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Genes: Structure and Regulation:

Xinna Li, Shiyong Wang, Haitao Wang, and Dipika Gupta: Differential Expression of Peptidoglycan Recognition Protein 2 in the Skin and Liver Requires Different Transcription Factors
J. Biol. Chem. 2006 281: 20738-20748. First Published on May 19, 2006; doi:10.1074/jbc.M601017200 [Abstract] [Full Text] [PDF]

Nan Zhong, Christina Y. Kim, Patrizia Rizzu, Changiz Geula, Douglas R. Porter, Emmanuel N. Pothos, Ferdinando Squitieri, Peter Heutink, and Jin Xu: DJ-1 Transcriptionally Up-regulates the Human Tyrosine Hydroxylase by Inhibiting the Sumoylation of Pyrimidine Tract-binding Protein-associated Splicing Factor
J. Biol. Chem. 2006 281: 20940-20948. First Published on May 26, 2006; doi:10.1074/jbc.M601935200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Hanguan Liu, Jing Rong Tang, Young Hun Choi, Maria Napolitano, Steven Hockman, Masato Taira, Eva Degerman, and Vincent C. Manganiello: Importance of cAMP-response Element-binding Protein in Regulation of Expression of the Murine Cyclic Nucleotide Phosphodiesterase 3B (Pde3b) Gene in Differentiating 3T3-L1 Preadipocytes
J. Biol. Chem. 2006 281: 21096-21113. First Published on May 15, 2006; doi:10.1074/jbc.M601307200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Annie Moisan and Luc Gaudreau: The BRCA1 COOH-terminal Region Acts as an RNA Polymerase II Carboxyl-terminal Domain Kinase Inhibitor That Modulates p21^WAF1/CIP1 Expression
J. Biol. Chem. 2006 281: 21119-21130. First Published on May 30, 2006; doi:10.1074/jbc.M600712200 [Abstract] [Full Text] [PDF]

Hiroshi Honda, Michael J. Pazin, Hongxiu Ji, Roman P. Wernyj, and Patrice J. Morin: Crucial Roles of Sp1 and Epigenetic Modifications in the Regulation of the CLDN4 Promoter in Ovarian Cancer Cells
J. Biol. Chem. 2006 281: 21433-21444. First Published on May 19, 2006; doi:10.1074/jbc.M603767200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Xiao-Ming Ou, Kevin Chen, and Jean C. Shih: Glucocorticoid and Androgen Activation of Monoamine Oxidase A Is Regulated Differently by R1 and Sp1
J. Biol. Chem. 2006 281: 21512-21525. First Published on May 25, 2006; doi:10.1074/jbc.M600250200 [Abstract] [Full Text] [PDF]

Protein Synthesis, Post-Translation Modification, and Degradation:

Takayuki Murata and Kunitada Shimotohno: Ubiquitination and Proteasome-dependent Degradation of Human Eukaryotic Translation Initiation Factor 4E
J. Biol. Chem. 2006 281: 20788-20800. First Published on May 23, 2006; doi:10.1074/jbc.M600563200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Nagendra R. Hegde, Mathieu S. Chevalier, Todd W. Wisner, Michael C. Denton, Kathy Shire, Lori Frappier, and David C. Johnson: The Role of BiP in Endoplasmic Reticulum-associated Degradation of Major Histocompatibility Complex Class I Heavy Chain Induced by Cytomegalovirus Proteins
J. Biol. Chem. 2006 281: 20910-20919. First Published on May 25, 2006; doi:10.1074/jbc.M602989200 [Abstract] [Full Text] [PDF]

Nicole M. Samuels and Judith P. Klinman: Investigation of cu(I)-dependent 2,4,5-Trihydroxyphenylalanine Quinone Biogenesis in Hansenula polymorpha Amine Oxidase
J. Biol. Chem. 2006 281: 21114-21118. First Published on May 22, 2006; doi:10.1074/jbc.M601501200 [Abstract] [Full Text] [PDF]

Louise D. Dahl, Hans-Joachim Wieden, Marina V. Rodnina, and Charlotte R. Knudsen: The Importance of P-loop and Domain Movements in EF-Tu for Guanine Nucleotide Exchange
J. Biol. Chem. 2006 281: 21139-21146. First Published on May 22, 2006; doi:10.1074/jbc.M602068200 [Abstract] [Full Text] [PDF]

Anna Jakubiec, Vincent Tournier, Gabrièle Drugeon, Stéphanie Pflieger, Laurent Camborde, Joëlle Vinh, François Héricourt, Virginie Redeker, and Isabelle Jupin: Phosphorylation of Viral RNA-dependent RNA Polymerase and Its Role in Replication of a Plus-strand RNA Virus
J. Biol. Chem. 2006 281: 21236-21249. First Published on May 22, 2006; doi:10.1074/jbc.M600052200 [Abstract] [Full Text] [PDF]

Kaiwen Ma, Shuqiu Zheng, and Zhiyi Zuo: The Transcription Factor Regulatory Factor X1 Increases the Expression of Neuronal Glutamate Transporter Type 3
J. Biol. Chem. 2006 281: 21250-21255. First Published on May 24, 2006; doi:10.1074/jbc.M600521200 [Abstract] [Full Text] [PDF]

Evangelia Tomai, Karin Butz, Claudia Lohrey, Fritz von Weizsäcker, Hanswalter Zentgraf, and Felix Hoppe-Seyler: Peptide Aptamer-mediated Inhibition of Target Proteins by Sequestration into Aggresomes
J. Biol. Chem. 2006 281: 21345-21352. First Published on May 22, 2006; doi:10.1074/jbc.M604258200 [Abstract] [Full Text] [PDF]

Juha Hakulinen and Jorma Keski-Oja: ADAM10-mediated Release of Complement Membrane Cofactor Protein during Apoptosis of Epithelial Cells
J. Biol. Chem. 2006 281: 21369-21376. First Published on May 30, 2006; doi:10.1074/jbc.M602053200 [Abstract] [Full Text] [PDF]

Ray S. Oh, Xinli Bai, and Johanna M. Rommens: Human Homologs of Ubc6p Ubiquitin-conjugating Enzyme and Phosphorylation of HsUbc6e in Response to Endoplasmic Reticulum Stress
J. Biol. Chem. 2006 281: 21480-21490. First Published on May 23, 2006; doi:10.1074/jbc.M601843200 [Abstract] [Full Text] [PDF]

Genomics, Proteomics, and Bioinformatics:

Zhiyou Wang, Virginie M. Aris, Kenyon D. Ogburn, Patricia Soteropoulos, and Maria E. Figueiredo-Pereira: Prostaglandin J2 Alters Pro-survival and Pro-death Gene Expression Patterns and 26 S Proteasome Assembly in Human Neuroblastoma Cells
J. Biol. Chem. 2006 281: 21377-21386. First Published on May 30, 2006; doi:10.1074/jbc.M601201200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Protein Structure and Folding:

Mithu De, Joseph Bell, Ninian J. Blackburn, Richard E. Mains, and Betty A. Eipper: Role for an Essential Tyrosine in Peptide Amidation
J. Biol. Chem. 2006 281: 20873-20882. First Published on May 16, 2006; doi:10.1074/jbc.M513886200 [Abstract] [Full Text] [PDF]

Sergey A. Kozlov, Alexander A. Vassilevski, Alexei V. Feofanov, Andrey Y. Surovoy, Dmitry V. Karpunin, and Eugene V. Grishin: Latarcins, Antimicrobial and Cytolytic Peptides from the Venom of the Spider Lachesana tarabaevi (Zodariidae) That Exemplify Biomolecular Diversity
J. Biol. Chem. 2006 281: 20983-20992. First Published on May 30, 2006; doi:10.1074/jbc.M602168200 [Abstract] [Full Text] [PDF]

James D. Fessenden, Wei Feng, Isaac N. Pessah, and Paul D. Allen: Amino Acid Residues Gln⁴⁰²⁰ and Lys⁴⁰²¹ of the Ryanodine Receptor Type 1 Are Required for Activation by 4-Chloro-m-cresol
J. Biol. Chem. 2006 281: 21022-21031. First Published on May 31, 2006; doi:10.1074/jbc.M600670200 [Abstract] [Full Text] [PDF]

Hanna Johansson, Kerstin Nordling, Timothy E. Weaver, and Jan Johansson: The Brichos Domain-containing C-terminal Part of Pro-surfactant Protein C Binds to an Unfolded Poly-Val Transmembrane Segment
J. Biol. Chem. 2006 281: 21032-21039. First Published on May 18, 2006; doi:10.1074/jbc.M603001200 [Abstract] [Full Text] [PDF]

Toshihiko Hoashi, Jacqueline Muller, Wilfred D. Vieira, Francois Rouzaud, Kanako Kikuchi, Kunihiko Tamaki, and Vincent J. Hearing: The Repeat Domain of the Melanosomal Matrix Protein PMEL17/GP100 Is Required for the Formation of Organellar Fibers
J. Biol. Chem. 2006 281: 21198-21208. First Published on May 8, 2006; doi:10.1074/jbc.M601643200 [Abstract] [Full Text] [PDF]

Matthew J. Cliff, Claire Limpkin, Angus Cameron, Steven G. Burston, and Anthony R. Clarke: Elucidation of Steps in the Capture of a Protein Substrate for Efficient Encapsulation by GroE
J. Biol. Chem. 2006 281: 21266-21275. First Published on May 9, 2006; doi:10.1074/jbc.M601605200 [Abstract] [Full Text] [PDF]

Ludovic Pecqueur, Benoît D'Autréaux, Jérome Dupuy, Yvain Nicolet, Lilian Jacquamet, Bernhard Brutscher, Isabelle Michaud-Soret, and Beate Bersch: Structural Changes of Escherichia coli Ferric Uptake Regulator during Metal-dependent Dimerization and Activation Explored by NMR and X-ray Crystallography
J. Biol. Chem. 2006 281: 21286-21295. First Published on May 11, 2006; doi:10.1074/jbc.M601278200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Benjamin G. Bobay, Geoffrey A. Mueller, Richele J. Thompson, Alexey G. Murzin, Ronald A. Venters, Mark A. Strauch, and John Cavanagh: NMR Structure of AbhN and Comparison with AbrBN: FIRST INSIGHTS INTO THE DNA BINDING PROMISCUITY AND SPECIFICITY OF AbrB-LIKE TRANSITION STATE REGULATOR PROTEINS
J. Biol. Chem. 2006 281: 21399-21409. First Published on May 15, 2006; doi:10.1074/jbc.M601963200 [Abstract] [Full Text] [PDF]

Huanchen Wang, Yudong Liu, Qing Huai, Jiwen Cai, Roya Zoraghi, Sharron H. Francis, Jackie D. Corbin, Howard Robinson, Zhongcheng Xin, Guiting Lin, and Hengming Ke: Multiple Conformations of Phosphodiesterase-5: IMPLICATIONS FOR ENZYME FUNCTION AND DRUG DEVELOPMENT
J. Biol. Chem. 2006 281: 21469-21479. First Published on May 30, 2006; doi:10.1074/jbc.M512527200 [Abstract] [Full Text] [PDF]

Enzyme Catalysis and Regulation:

Nathaniel D. Ginder, Daniel J. Binkowski, Herbert J. Fromm, and Richard B. Honzatko: Nucleotide Complexes of Escherichia coli Phosphoribosylaminoimidazole Succinocarboxamide Synthetase
J. Biol. Chem. 2006 281: 20680-20688. First Published on May 9, 2006; doi:10.1074/jbc.M602109200 [Abstract] [Full Text] [PDF]

Ellen E. Quillen, Gale C. Haslam, Hardeep S. Samra, Darius Amani-Taleshi, Jeffrey A. Knight, Diane E. Wyatt, Stephanie C. Bishop, Kim K. Colvert, Mark L. Richter, and Paul A. Kitos: Ectoadenylate Kinase and Plasma Membrane ATP Synthase Activities of Human Vascular Endothelial Cells
J. Biol. Chem. 2006 281: 20728-20737. First Published on May 19, 2006; doi:10.1074/jbc.M513042200 [Abstract] [Full Text] [PDF]

Sambanthamurthy Soundar, Molly O'Hagan, Kenneth S. Fomulu, and Roberta F. Colman: Identification of Mn²⁺-binding Aspartates from ${alpha}$ , $beta$ , and ${gamma}$ Subunits of Human NAD-dependent Isocitrate Dehydrogenase
J. Biol. Chem. 2006 281: 21073-21081. First Published on May 31, 2006; doi:10.1074/jbc.M602956200 [Abstract] [Full Text] [PDF]

Andreas Winkler, Franz Hartner, Toni M. Kutchan, Anton Glieder, and Peter Macheroux: Biochemical Evidence That Berberine Bridge Enzyme Belongs to a Novel Family of Flavoproteins Containing a Bi-covalently Attached FAD Cofactor
J. Biol. Chem. 2006 281: 21276-21285. First Published on May 25, 2006; doi:10.1074/jbc.M603267200 [Abstract] [Full Text] [PDF]

Jun-ichiro Nakajima, Yoshiharu Sato, Tyuji Hoshino, Mami Yamazaki, and Kazuki Saito: Mechanistic Study on the Oxidation of Anthocyanidin Synthase by Quantum Mechanical Calculation
J. Biol. Chem. 2006 281: 21387-21398. First Published on May 15, 2006; doi:10.1074/jbc.M600303200 [Abstract] [Full Text] [PDF]

Marco Marino, Miriam Deuss, Dmitri I. Svergun, Petr V. Konarev, Reinhard Sterner, and Olga Mayans: Structural and Mutational Analysis of Substrate Complexation by Anthranilate Phosphoribosyltransferase from Sulfolobus solfataricus
J. Biol. Chem. 2006 281: 21410-21421. First Published on May 19, 2006; doi:10.1074/jbc.M601403200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Metabolism and Bioenergetics:

Alexandre D. T. Costa, Regina Jakob, Cinthia L. Costa, Ksenia Andrukhiv, Ian C. West, and Keith D. Garlid: The Mechanism by Which the Mitochondrial ATP-sensitive K⁺ Channel Opening and H₂O₂ Inhibit the Mitochondrial Permeability Transition
J. Biol. Chem. 2006 281: 20801-20808. First Published on May 23, 2006; doi:10.1074/jbc.M600959200 [Abstract] [Full Text] [PDF]

Yasuhiro Kashino, Natsuko Inoue-Kashino, Johnna L. Roose, and Himadri B. Pakrasi: Absence of the PsbQ Protein Results in Destabilization of the PsbV Protein and Decreased Oxygen Evolution Activity in Cyanobacterial Photosystem II
J. Biol. Chem. 2006 281: 20834-20841. First Published on May 24, 2006; doi:10.1074/jbc.M603188200 [Abstract] [Full Text] [PDF]

Shunzhong Bao, Haowei Song, Mary Wohltmann, Sasanka Ramanadham, Wu Jin, Alan Bohrer, and John Turk: Insulin Secretory Responses and Phospholipid Composition of Pancreatic Islets from Mice That Do Not Express Group VIA Phospholipase A₂ and Effects of Metabolic Stress on Glucose Homeostasis
J. Biol. Chem. 2006 281: 20958-20973. First Published on May 27, 2006; doi:10.1074/jbc.M600075200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Olga Protchenko, Roberto Rodriguez-Suarez, Rachel Androphy, Howard Bussey, and Caroline C. Philpott: A Screen for Genes of Heme Uptake Identifies the FLC Family Required for Import of FAD into the Endoplasmic Reticulum
J. Biol. Chem. 2006 281: 21445-21457. First Published on May 22, 2006; doi:10.1074/jbc.M512812200 [Abstract] [Full Text] [PDF]

Glycobiology and Extracellular Matrices:

Feng Liu and Martin E. Tanner: PseG of Pseudaminic Acid Biosynthesis: A UDP-SUGAR HYDROLASE AS A MASKED GLYCOSYLTRANSFERASE
J. Biol. Chem. 2006 281: 20902-20909. First Published on May 25, 2006; doi:10.1074/jbc.M602972200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Corina M. Borza, Ambra Pozzi, Dorin-Bogdan Borza, Vadim Pedchenko, Thomas Hellmark, Billy G. Hudson, and Roy Zent: Integrin ${alpha}$ 3 $beta$ 1, a Novel Receptor for ${alpha}$ 3(IV) Noncollagenous Domain and a Trans-dominant Inhibitor for Integrin ${alpha}$ v $beta$ 3
J. Biol. Chem. 2006 281: 20932-20939. First Published on May 26, 2006; doi:10.1074/jbc.M601147200 [Abstract] [Full Text] [PDF]

Heather F. Bigg, Robin Wait, Andrew D. Rowan, and Tim E. Cawston: The Mammalian Chitinase-like Lectin, YKL-40, Binds Specifically to Type I Collagen and Modulates the Rate of Type I Collagen Fibril Formation
J. Biol. Chem. 2006 281: 21082-21095. First Published on May 15, 2006; doi:10.1074/jbc.M601153200 [Abstract] [Full Text] [PDF]

Manuel Koch, Guido Veit, Sigmar Stricker, Pinaki Bhatt, Stefanie Kutsch, Peihong Zhou, Elina Reinders, Rita A. Hahn, Rich Song, Robert E. Burgeson, Donald R. Gerecke, Stefan Mundlos, and Marion K. Gordon: Expression of Type XXIII Collagen mRNA and Protein
J. Biol. Chem. 2006 281: 21546-21557. First Published on May 25, 2006; doi:10.1074/jbc.M604131200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Lipids and Lipoproteins:

Shadab A. Siddiqi, Shahzad Siddiqi, James Mahan, Kiffany Peggs, Fred S. Gorelick, and Charles M. Mansbach, II: The Identification of a Novel Endoplasmic Reticulum to Golgi SNARE Complex Used by the Prechylomicron Transport Vesicle
J. Biol. Chem. 2006 281: 20974-20982. First Published on May 30, 2006; doi:10.1074/jbc.M601401200 [Abstract] [Full Text] [PDF]

Jeremy P. Mauldin, Suseela Srinivasan, Anny Mulya, Abraham Gebre, John S. Parks, Alan Daugherty, and Catherine C. Hedrick: Reduction in ABCG1 in Type 2 Diabetic Mice Increases Macrophage Foam Cell Formation
J. Biol. Chem. 2006 281: 21216-21224. First Published on May 24, 2006; doi:10.1074/jbc.M510952200 [Abstract] [Full Text] [PDF]

William H. Witola, Gabriella Pessi, Kamal El Bissati, Jennifer M. Reynolds, and Choukri Ben Mamoun: Localization of the Phosphoethanolamine Methyltransferase of the Human Malaria Parasite Plasmodium falciparum to the Golgi Apparatus
J. Biol. Chem. 2006 281: 21305-21311. First Published on May 16, 2006; doi:10.1074/jbc.M603260200 [Abstract] [Full Text] [PDF]

Membrane Transport, Structure, Function, and Biogenesis:

Lior Cohen, Nicolas Gilles, Izhar Karbat, Nitza Ilan, Dalia Gordon, and Michael Gurevitz: Direct Evidence That Receptor Site-4 of Sodium Channel Gating Modifiers Is Not Dipped in the Phospholipid Bilayer of Neuronal Membranes
J. Biol. Chem. 2006 281: 20673-20679. First Published on May 23, 2006; doi:10.1074/jbc.M603212200 [Abstract] [Full Text] [PDF]

Tyler K. Nygaard, George C. Blouin, Mengyao Liu, Maki Fukumura, John S. Olson, Marian Fabian, David M. Dooley, and Benfang Lei: The Mechanism of Direct Heme Transfer from the Streptococcal Cell Surface Protein Shp to HtsA of the HtsABC Transporter
J. Biol. Chem. 2006 281: 20761-20771. First Published on May 22, 2006; doi:10.1074/jbc.M601832200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Lyubov V. Parfenova, Brittany M. Crane, and Brad S. Rothberg: Modulation of MthK Potassium Channel Activity at the Intracellular Entrance to the Pore
J. Biol. Chem. 2006 281: 21131-21138. First Published on May 25, 2006; doi:10.1074/jbc.M603109200 [Abstract] [Full Text] [PDF]

Sandrine Cestèle, Vladimir Yarov-Yarovoy, Yusheng Qu, François Sampieri, Todd Scheuer, and William A. Catterall: Structure and Function of the Voltage Sensor of Sodium Channels Probed by a $beta$ -Scorpion Toxin
J. Biol. Chem. 2006 281: 21332-21344. First Published on May 4, 2006; doi:10.1074/jbc.M603814200 [Abstract] [Full Text] [PDF] [Supplemental Data]

J. Patrick Kampf, David Cupp, and Alan M. Kleinfeld: Different Mechanisms of Free Fatty Acid Flip-Flop and Dissociation Revealed by Temperature and Molecular Species Dependence of Transport across Lipid Vesicles
J. Biol. Chem. 2006 281: 21566-21574. First Published on May 31, 2006; doi:10.1074/jbc.M602067200 [Abstract] [Full Text] [PDF]

Molecular Basis Of Cell and Developmental Biology:

Marc Arnold, Annegret Nath, Joachim Hauber, and Ralph H. Kehlenbach: Multiple Importins Function as Nuclear Transport Receptors for the Rev Protein of Human Immunodeficiency Virus Type 1
J. Biol. Chem. 2006 281: 20883-20890. First Published on May 16, 2006; doi:10.1074/jbc.M602189200 [Abstract] [Full Text] [PDF]

Daniel J. Belliveau, Mahmud Bani-Yaghoub, Becky McGirr, Christian C. G. Naus, and Walter J. Rushlow: Enhanced Neurite Outgrowth in PC12 Cells Mediated by Connexin Hemichannels and ATP
J. Biol. Chem. 2006 281: 20920-20931. First Published on May 26, 2006; doi:10.1074/jbc.M600026200 [Abstract] [Full Text] [PDF]

Maria V. Abramova, Tatiana V. Pospelova, Fedor P. Nikulenkov, Christine M. Hollander, Albert J. Fornace, Jr., and Valery A. Pospelov: G₁/S Arrest Induced by Histone Deacetylase Inhibitor Sodium Butyrate in E1A + Ras-transformed Cells Is Mediated through Down-regulation of E2F Activity and Stabilization of $beta$ -Catenin
J. Biol. Chem. 2006 281: 21040-21051. First Published on May 22, 2006; doi:10.1074/jbc.M511059200 [Abstract] [Full Text] [PDF] [Supplemental Data]

DanHong Zhu, Michael L. Paine, Wen Luo, Pablo Bringas, Jr., and Malcolm L. Snead: Altering Biomineralization by Protein Design
J. Biol. Chem. 2006 281: 21173-21182. First Published on May 17, 2006; doi:10.1074/jbc.M510757200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Jean-Pierre Etchegaray, Xiaoming Yang, Jason P. DeBruyne, Antoine H. F. M. Peters, David R. Weaver, Thomas Jenuwein, and Steven M. Reppert: The Polycomb Group Protein EZH2 Is Required for Mammalian Circadian Clock Function
J. Biol. Chem. 2006 281: 21209-21215. First Published on May 22, 2006; doi:10.1074/jbc.M603722200 [Abstract] [Full Text] [PDF] [Supplemental Data] [Summary]

Frances E. Turner, Simon Broad, Farhat L. Khanim, Alexa Jeanes, Sonia Talma, Sharon Hughes, Chris Tselepis, and Neil A. Hotchin: Slug Regulates Integrin Expression and Cell Proliferation in Human Epidermal Keratinocytes
J. Biol. Chem. 2006 281: 21321-21331. First Published on May 17, 2006; doi:10.1074/jbc.M509731200 [Abstract] [Full Text] [PDF]

Hideyuki Takeuchi, Shijie Jin, Jinyan Wang, Guiqin Zhang, Jun Kawanokuchi, Reiko Kuno, Yoshifumi Sonobe, Tetsuya Mizuno, and Akio Suzumura: Tumor Necrosis Factor- ${alpha}$ Induces Neurotoxicity via Glutamate Release from Hemichannels of Activated Microglia in an Autocrine Manner
J. Biol. Chem. 2006 281: 21362-21368. First Published on May 23, 2006; doi:10.1074/jbc.M600504200 [Abstract] [Full Text] [PDF]

Richard T. Richardson, Oleg M. Alekseev, Gail Grossman, Esther E. Widgren, Randy Thresher, Eric J. Wagner, Kelly D. Sullivan, William F. Marzluff, and Michael G. O'Rand: Nuclear Autoantigenic Sperm Protein (NASP), a Linker Histone Chaperone That Is Required for Cell Proliferation
J. Biol. Chem. 2006 281: 21526-21534. First Published on May 25, 2006; doi:10.1074/jbc.M603816200 [Abstract] [Full Text] [PDF]

Mechanisms Of Signal Transduction:

Agnes Kenessey and Kaie Ojamaa: Thyroid Hormone Stimulates Protein Synthesis in the Cardiomyocyte by Activating the Akt-mTOR and p70^S6K Pathways
J. Biol. Chem. 2006 281: 20666-20672. First Published on May 22, 2006; doi:10.1074/jbc.M512671200 [Abstract] [Full Text] [PDF]

Parag Patwardhan, Yongquan Shen, Gary S. Goldberg, and W. Todd Miller: Individual Cas Phosphorylation Sites Are Dispensable for Processive Phosphorylation by Src and Anchorage-independent Cell Growth
J. Biol. Chem. 2006 281: 20689-20697. First Published on May 17, 2006; doi:10.1074/jbc.M602311200 [Abstract] [Full Text] [PDF]

Austin U. Gehret, Anshika Bajaj, Fred Naider, and Mark E. Dumont: Oligomerization of the Yeast ${alpha}$ -Factor Receptor: IMPLICATIONS FOR DOMINANT NEGATIVE EFFECTS OF MUTANT RECEPTORS
J. Biol. Chem. 2006 281: 20698-20714. First Published on May 18, 2006; doi:10.1074/jbc.M513642200 [Abstract] [Full Text] [PDF]

Biman C. Paria, Angela M. Bair, Jiaping Xue, Yanni Yu, Asrar B. Malik, and Chinnaswamy Tiruppathi: Ca²⁺ Influx Induced by Protease-activated Receptor-1 Activates a Feed-forward Mechanism of TRPC1 Expression via Nuclear Factor- ${kappa}$ B Activation in Endothelial Cells
J. Biol. Chem. 2006 281: 20715-20727. First Published on May 18, 2006; doi:10.1074/jbc.M600722200 [Abstract] [Full Text] [PDF]

Misato Yamada, Junji Ohnishi, Bisei Ohkawara, Shunichiro Iemura, Kiyotoshi Satoh, Junko Hyodo-Miura, Kaoru Kawachi, Tohru Natsume, and Hiroshi Shibuya: NARF, an Nemo-like Kinase (NLK)-associated Ring Finger Protein Regulates the Ubiquitylation and Degradation of T Cell Factor/Lymphoid Enhancer Factor (TCF/LEF)
J. Biol. Chem. 2006 281: 20749-20760. First Published on May 19, 2006; doi:10.1074/jbc.M602089200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Raghav Rajgopal, Martin Butcher, Jeffrey I. Weitz, and Stephen G. Shaughnessy: Heparin Synergistically Enhances Interleukin-11 Signaling through Up-regulation of the MAPK Pathway
J. Biol. Chem. 2006 281: 20780-20787. First Published on May 23, 2006; doi:10.1074/jbc.M600169200 [Abstract] [Full Text] [PDF]

Adelheid L. Roth, Erika Marzola, Anna Rizzi, Marika Arduin, Claudio Trapella, Corrado Corti, Raffaella Vergura, Prisca Martinelli, Severo Salvadori, Domenico Regoli, Mauro Corsi, Paolo Cavanni, Girolamo Caló, and Remo Guerrini: Structure-Activity Studies on Neuropeptide S: IDENTIFICATION OF THE AMINO ACID RESIDUES CRUCIAL FOR RECEPTOR ACTIVATION
J. Biol. Chem. 2006 281: 20809-20816. First Published on May 23, 2006; doi:10.1074/jbc.M601846200 [Abstract] [Full Text] [PDF]

Beum-Soo An, David M. Selva, Geoffrey L. Hammond, Adolfo Rivero-Muller, Nafis Rahman, and Peter C. K. Leung: Steroid Receptor Coactivator-3 Is Required for Progesterone Receptor Trans-activation of Target Genes in Response to Gonadotropin-releasing Hormone Treatment of Pituitary Cells
J. Biol. Chem. 2006 281: 20817-20824. First Published on May 24, 2006; doi:10.1074/jbc.M600743200 [Abstract] [Full Text] [PDF]

Carl White, Jun Yang, Mervyn J. Monteiro, and J. Kevin Foskett: CIB1, a Ubiquitously Expressed Ca²⁺-binding Protein Ligand of the InsP₃ Receptor Ca²⁺ Release Channel
J. Biol. Chem. 2006 281: 20825-20833. First Published on May 24, 2006; doi:10.1074/jbc.M602175200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Brandy Wilkinson, Jessica Koenigsknecht-Talboo, Christian Grommes, C. Y. Daniel Lee, and Gary Landreth: Fibrillar $beta$ -Amyloid-stimulated Intracellular Signaling Cascades Require Vav for Induction of Respiratory Burst and Phagocytosis in Monocytes and Microglia
J. Biol. Chem. 2006 281: 20842-20850. First Published on May 25, 2006; doi:10.1074/jbc.M600627200 [Abstract] [Full Text] [PDF]

Lorena González, María Teresa Agulló-Ortuño, José Manuel García-Martínez, Annarica Calcabrini, Carlos Gamallo, José Palacios, Ana Aranda, and Jorge Martín-Pérez: Role of c-Src in Human MCF7 Breast Cancer Cell Tumorigenesis
J. Biol. Chem. 2006 281: 20851-20864. First Published on May 25, 2006; doi:10.1074/jbc.M601570200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Konduru S. R. Sastry, Adrienne Joy Smith, Yelena Karpova, Sandeep Robert Datta, and George Kulik: Diverse Antiapoptotic Signaling Pathways Activated by Vasoactive Intestinal Polypeptide, Epidermal Growth Factor, and Phosphatidylinositol 3-Kinase in Prostate Cancer Cells Converge on BAD
J. Biol. Chem. 2006 281: 20891-20901. First Published on May 25, 2006; doi:10.1074/jbc.M602928200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Christian M. Udell, Lionel A. Samayawardhena, Yuko Kawakami, Toshiaki Kawakami, and Andrew W. B. Craig: Fer and Fps/Fes Participate in a Lyn-dependent Pathway from Fc ${epsilon}$ RI to Platelet-Endothelial Cell Adhesion Molecule 1 to Limit Mast Cell Activation
J. Biol. Chem. 2006 281: 20949-20957. First Published on May 26, 2006; doi:10.1074/jbc.M604252200 [Abstract] [Full Text] [PDF]

Rebecca E. Schweppe, Tom Hiu Cheung, and Natalie G. Ahn: Global Gene Expression Analysis of ERK5 and ERK1/2 Signaling Reveals a Role for HIF-1 in ERK5-mediated Responses
J. Biol. Chem. 2006 281: 20993-21003. First Published on May 30, 2006; doi:10.1074/jbc.M604208200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Monika Göoz, Pal Göoz, Louis M. Luttrell, and John R. Raymond: 5-HT_2A Receptor Induces ERK Phosphorylation and Proliferation through ADAM-17 Tumor Necrosis Factor- ${alpha}$ -converting Enzyme (TACE) Activation and Heparin-bound Epidermal Growth Factor-like Growth Factor (HB-EGF) Shedding in Mesangial Cells
J. Biol. Chem. 2006 281: 21004-21012. First Published on May 31, 2006; doi:10.1074/jbc.M512096200 [Abstract] [Full Text] [PDF]

Jinzhong Qin, Jianhong Yao, Grace Cui, Hui Xiao, Tae Whan Kim, Jerzy Fraczek, Paul Wightman, Shintaro Sato, Shizuo Akira, Anne Puel, Jean-Laurent Casanova, Bing Su, and Xiaoxia Li: TLR8-mediated NF- ${kappa}$ B and JNK Activation Are TAK1-independent and MEKK3-dependent
J. Biol. Chem. 2006 281: 21013-21021. First Published on May 31, 2006; doi:10.1074/jbc.M512908200 [Abstract] [Full Text] [PDF]

Yongde Luo, Sheng Ye, Mikio Kan, and Wallace L. McKeehan: Control of Fibroblast Growth Factor (FGF) 7- and FGF1-induced Mitogenesis and Downstream Signaling by Distinct Heparin Octasaccharide Motifs
J. Biol. Chem. 2006 281: 21052-21061. First Published on May 25, 2006; doi:10.1074/jbc.M601559200 [Abstract] [Full Text] [PDF]

Goran Jovanovic, Louise J. Lloyd, Michael P. H. Stumpf, Antony J. Mayhew, and Martin Buck: Induction and Function of the Phage Shock Protein Extracytoplasmic Stress Response in Escherichia coli
J. Biol. Chem. 2006 281: 21147-21161. First Published on May 17, 2006; doi:10.1074/jbc.M602323200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Elliot R. Lee, Kevin W. McCool, Fern E. Murdoch, and Michael K. Fritsch: Dynamic Changes in Histone H3 Phosphoacetylation during Early Embryonic Stem Cell Differentiation Are Directly Mediated by Mitogen- and Stress-activated Protein Kinase 1 via Activation of MAPK Pathways
J. Biol. Chem. 2006 281: 21162-21172. First Published on May 25, 2006; doi:10.1074/jbc.M602734200 [Abstract] [Full Text] [PDF]

Shu-Jen Chen, Hongyan Ning, Wataru Ishida, Snezna Sodin-Semrl, Shinsuke Takagawa, Yasuji Mori, and John Varga: The Early-Immediate Gene EGR-1 Is Induced by Transforming Growth Factor- $beta$ and Mediates Stimulation of Collagen Gene Expression
J. Biol. Chem. 2006 281: 21183-21197. First Published on May 15, 2006; doi:10.1074/jbc.M603270200 [Abstract] [Full Text] [PDF]

Christine E. Pullar, Amilcar Rizzo, and R. Rivkah Isseroff: $beta$ -Adrenergic Receptor Antagonists Accelerate Skin Wound Healing: EVIDENCE FOR A CATECHOLAMINE SYNTHESIS NETWORK IN THE EPIDERMIS
J. Biol. Chem. 2006 281: 21225-21235. First Published on May 19, 2006; doi:10.1074/jbc.M601007200 [Abstract] [Full Text] [PDF]

Bong-Jo Kim, Seung-Wook Ryu, and Byoung-Joon Song: JNK- and p38 Kinase-mediated Phosphorylation of Bax Leads to Its Activation and Mitochondrial Translocation and to Apoptosis of Human Hepatoma HepG2 Cells
J. Biol. Chem. 2006 281: 21256-21265. First Published on May 18, 2006; doi:10.1074/jbc.M510644200 [Abstract] [Full Text] [PDF]

Tian-Fang Li, Di Chen, Qiuqian Wu, Mo Chen, Tzong-jen Sheu, Edward M. Schwarz, Hicham Drissi, Michael Zuscik, and Regis J. O'Keefe: Transforming Growth Factor- $beta$ Stimulates Cyclin D₁ Expression through Activation of $beta$ -Catenin Signaling in Chondrocytes
J. Biol. Chem. 2006 281: 21296-21304. First Published on May 10, 2006; doi:10.1074/jbc.M600514200 [Abstract] [Full Text] [PDF]

Giovanna De Chiara, Maria Elena Marcocci, Maria Torcia, Maria Lucibello, Paolo Rosini, Paolo Bonini, Yukiro Higashimoto, Gianluca Damonte, Andrea Armirotti, Sarah Amodei, Anna Teresa Palamara, Tommaso Russo, Enrico Garaci, and Federico Cozzolino: Bcl-2 Phosphorylation by p38 MAPK: IDENTIFICATION OF TARGET SITES AND BIOLOGIC CONSEQUENCES
J. Biol. Chem. 2006 281: 21353-21361. First Published on May 19, 2006; doi:10.1074/jbc.M511052200 [Abstract] [Full Text] [PDF]

Donalyn Scheuner, Rupali Patel, Feng Wang, Kuei Lee, Kotlo Kumar, Jun Wu, Anders Nilsson, Michael Karin, and Randal J. Kaufman: Double-stranded RNA-dependent Protein Kinase Phosphorylation of the ${alpha}$ -Subunit of Eukaryotic Translation Initiation Factor 2 Mediates Apoptosis
J. Biol. Chem. 2006 281: 21458-21468. First Published on May 22, 2006; doi:10.1074/jbc.M603784200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Xiufeng Song, Dayanidhi Raman, Eugenia V. Gurevich, Sergey A. Vishnivetskiy, and Vsevolod V. Gurevich: Visual and Both Non-visual Arrestins in Their "Inactive" Conformation Bind JNK3 and Mdm2 and Relocalize Them from the Nucleus to the Cytoplasm
J. Biol. Chem. 2006 281: 21491-21499. First Published on May 31, 2006; doi:10.1074/jbc.M603659200 [Abstract] [Full Text] [PDF]

Khanh Kim Dao, Knut Teigen, Reidun Kopperud, Erlend Hodneland, Frank Schwede, Anne E. Christensen, Aurora Martinez, and Stein Ove Døskeland: Epac1 and cAMP-dependent Protein Kinase Holoenzyme Have Similar cAMP Affinity, but Their cAMP Domains Have Distinct Structural Features and Cyclic Nucleotide Recognition
J. Biol. Chem. 2006 281: 21500-21511. First Published on May 25, 2006; doi:10.1074/jbc.M603116200 [Abstract] [Full Text] [PDF]

Cathrine Rein Carlson, Birgitte Lygren, Torunn Berge, Naoto Hoshi, Wei Wong, Kjetil Taskén, and John D. Scott: Delineation of Type I Protein Kinase A-selective Signaling Events Using an RI Anchoring Disruptor
J. Biol. Chem. 2006 281: 21535-21545. First Published on May 25, 2006; doi:10.1074/jbc.M603223200 [Abstract] [Full Text] [PDF]

Jianxin Hu, Jiankang Jiang, Stefano Costanzi, Craig Thomas, Wu Yang, Jean H. M. Feyen, Kenneth A. Jacobson, and Allen M. Spiegel: A Missense Mutation in the Seven-transmembrane Domain of the Human Ca²⁺ Receptor Converts a Negative Allosteric Modulator into a Positive Allosteric Modulator
J. Biol. Chem. 2006 281: 21558-21565. First Published on May 30, 2006; doi:10.1074/jbc.M603682200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Additions and Corrections:

Mauricio Di Fulvio, Thomas M. Lincoln, Peter K. Lauf, and Norma C. Adragna: Protein kinase G regulates potassium chloride cotransporter-4 expression in primary cultures of rat vascular smooth muscle cells. VOLUME 276 (2001) PAGES 21046-21052
J. Biol. Chem. 2006 281: 21575. [Full Text] [PDF]

Stéphane Mandard, Fokko Zandbergen, Esther van Straten, Walter Wahli, Folkert Kuipers, Michael Müller, and Sander Kersten: The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity. VOLUME 281 (2006) PAGES 934-944
J. Biol. Chem. 2006 281: 21575-a. [Full Text] [PDF]

Sandy D. Westerheide, Tiara L. A. Kawahara, Kai Orton, and Richard I. Morimoto: Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death. VOLUME 281 (2006) PAGES 9616-9622
J. Biol. Chem. 2006 281: 21575-b. [Full Text] [PDF]

Shawn K. Milano, You-Me Kim, Frank P. Stefano, Jeffrey L. Benovic, and Charles Brenner: Nonvisual arrestin oligomerization and cellular localization are regulated by inositol hexakisphosphate binding. VOLUME 281 (2006) PAGES 9812-9823
J. Biol. Chem. 2006 281: 21576. [Full Text] [PDF]

Min-Su Kim, Xanthi Merlo, Catherine Wilson, and John Lough: Co-activation of atrial natriuretic factor promoter by Tip60 and serum response factor. VOLUME 281 (2006) 15082-15089
J. Biol. Chem. 2006 281: 21576-a. [Full Text] [PDF]