JBC -- Table of Contents (Aug 4 2006, 281, (31))

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Classics:

Nicole Kresge, Robert D. Simoni, and Robert L. Hill: 30 Years of Cholesterol Metabolism: the Work of Michael Brown and Joseph Goldstein
Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts. COMPARISON OF CELLS FROM A NORMAL SUBJECT AND FROM A PATIENT WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (Joseph L. Goldstein and Michael S. Brown J. Biol. Chem. 249, 5153-5162)
J. Biol. Chem. 2006 281: e25. [Full Text]

Accelerated Publications:

Debora A. Nicoll, Michael R. Sawaya, Seunghyug Kwon, Duilio Cascio, Kenneth D. Philipson, and Jeff Abramson: The Crystal Structure of the Primary Ca²⁺ Sensor of the Na⁺/Ca²⁺ Exchanger Reveals a Novel Ca²⁺ Binding Motif
J. Biol. Chem. 2006 281: 21577-21581. First Published on June 14, 2006; doi:10.1074/jbc.C600117200 [Abstract] [Full Text] [PDF] [Supplemental Data]

DNA: Replication, Repair, and Recombination:

Shuangli Guo, Yanbin Zhang, Fenghua Yuan, Yin Gao, Liya Gu, Isaac Wong, and Guo-Min Li: Regulation of Replication Protein A Functions in DNA Mismatch Repair by Phosphorylation
J. Biol. Chem. 2006 281: 21607-21616. First Published on May 26, 2006; doi:10.1074/jbc.M603504200 [Abstract] [Full Text] [PDF]

Leonor Oliveira, Adriano O. Henriques, and Paulo Tavares: Modulation of the Viral ATPase Activity by the Portal Protein Correlates with DNA Packaging Efficiency
J. Biol. Chem. 2006 281: 21914-21923. First Published on May 30, 2006; doi:10.1074/jbc.M603314200 [Abstract] [Full Text] [PDF]

Karen Fien and Jerard Hurwitz: Fission Yeast Mcm10p Contains Primase Activity
J. Biol. Chem. 2006 281: 22248-22260. First Published on May 23, 2006; doi:10.1074/jbc.M512997200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Genes: Structure and Regulation:

Chang-Chieh Chen and Shiau-Ting Hu: Two Frameshift Products Involved in the Transposition of Bacterial Insertion Sequence IS629
J. Biol. Chem. 2006 281: 21617-21628. First Published on May 25, 2006; doi:10.1074/jbc.M602437200 [Abstract] [Full Text] [PDF]

Yoshitaka Sato, Katsuhide Miyake, Hidenori Kaneoka, and Shinji Iijima: Sumoylation of CCAAT/Enhancer-binding Protein ${alpha}$ and Its Functional Roles in Hepatocyte Differentiation
J. Biol. Chem. 2006 281: 21629-21639. First Published on May 30, 2006; doi:10.1074/jbc.M600852200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Sanjit Kumar Dhar, Yong Xu, Yumin Chen, and Daret K. St. Clair: Specificity Protein 1-dependent p53-mediated Suppression of Human Manganese Superoxide Dismutase Gene Expression
J. Biol. Chem. 2006 281: 21698-21709. First Published on June 1, 2006; doi:10.1074/jbc.M601083200 [Abstract] [Full Text] [PDF]

Sarmila Majumder, Kalpana Ghoshal, Jharna Datta, David Spencer Smith, Shoumei Bai, and Samson T. Jacob: Role of DNA Methyltransferases in Regulation of Human Ribosomal RNA Gene Transcription
J. Biol. Chem. 2006 281: 22062-22072. First Published on May 30, 2006; doi:10.1074/jbc.M601155200 [Abstract] [Full Text] [PDF]

Heide Muckenfuss, Matthias Hamdorf, Ulrike Held, Mario Perkovic, Johannes Löwer, Klaus Cichutek, Egbert Flory, Gerald G. Schumann, and Carsten Münk: APOBEC3 Proteins Inhibit Human LINE-1 Retrotransposition
J. Biol. Chem. 2006 281: 22161-22172. First Published on May 30, 2006; doi:10.1074/jbc.M601716200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Di Zhang, Jun Chen, Anita Saraf, Steven Cassar, Ping Han, John C. Rogers, Jorge D. Brioni, James P. Sullivan, and Murali Gopalakrishnan: Association of Catsper1 or -2 with Ca_v3.3 Leads to Suppression of T-type Calcium Channel Activity
J. Biol. Chem. 2006 281: 22332-22341. First Published on June 1, 2006; doi:10.1074/jbc.M511288200 [Abstract] [Full Text] [PDF]

RNA: Structure, Metabolism, and Catalysis:

Jonas Mengel-Jørgensen, Søren Skov Jensen, Anette Rasmussen, Jacob Poehlsgaard, Jens Jørgen Lønsmann Iversen, and Finn Kirpekar: Modifications in Thermus thermophilus 23 S Ribosomal RNA Are Centered in Regions of RNA-RNA Contact
J. Biol. Chem. 2006 281: 22108-22117. First Published on May 26, 2006; doi:10.1074/jbc.M600377200 [Abstract] [Full Text] [PDF]

Protein Synthesis, Post-Translation Modification, and Degradation:

Yusuke Takahashi, Ying Chen, Gennadiy Moiseyev, and Jian-xing Ma: Two Point Mutations of RPE65 from Patients with Retinal Dystrophies Decrease the Stability of RPE65 Protein and Abolish Its Isomerohydrolase Activity
J. Biol. Chem. 2006 281: 21820-21826. First Published on June 5, 2006; doi:10.1074/jbc.M603725200 [Abstract] [Full Text] [PDF]

Marisa Conte, Alessia Arcaro, Daniela D'Angelo, Ariele Gnata, Gianfranco Mamone, Pasquale Ferranti, Silvestro Formisano, and Fabrizio Gentile: A Single Chondroitin 6-Sulfate Oligosaccharide Unit at Ser-2730 of Human Thyroglobulin Enhances Hormone Formation and Limits Proteolytic Accessibility at the Carboxyl Terminus: POTENTIAL INSIGHTS INTO THYROID HOMEOSTASIS AND AUTOIMMUNITY
J. Biol. Chem. 2006 281: 22200-22211. First Published on May 5, 2006; doi:10.1074/jbc.M513382200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Genomics, Proteomics, and Bioinformatics:

Sebastian M. B. Nijman, E. Marielle Hijmans, Selma El Messaoudi, Miranda M. W. van Dongen, Claude Sardet, and René Bernards: A Functional Genetic Screen Identifies TFE3 as a Gene That Confers Resistance to the Anti-proliferative Effects of the Retinoblastoma Protein and Transforming Growth Factor- $beta$
J. Biol. Chem. 2006 281: 21582-21587. First Published on May 31, 2006; doi:10.1074/jbc.M602312200 [Abstract] [Full Text] [PDF]

Protein Structure and Folding:

Costin I. Popescu, Alina Mares, Livia Zdrentu, Nicole Zitzmann, Raymond A. Dwek, and Stefana M. Petrescu: Productive Folding of Tyrosinase Ectodomain Is Controlled by the Transmembrane Anchor
J. Biol. Chem. 2006 281: 21682-21689. First Published on May 31, 2006; doi:10.1074/jbc.M603841200 [Abstract] [Full Text] [PDF]

Kelly Sackett, Yael Wexler-Cohen, and Yechiel Shai: Characterization of the HIV N-terminal Fusion Peptide-containing Region in Context of Key gp41 Fusion Conformations
J. Biol. Chem. 2006 281: 21755-21762. First Published on June 2, 2006; doi:10.1074/jbc.M603135200 [Abstract] [Full Text] [PDF]

Bei-Wen Ying, Hideki Taguchi, and Takuya Ueda: Co-translational Binding of GroEL to Nascent Polypeptides Is Followed by Post-translational Encapsulation by GroES to Mediate Protein Folding
J. Biol. Chem. 2006 281: 21813-21819. First Published on June 5, 2006; doi:10.1074/jbc.M603091200 [Abstract] [Full Text] [PDF]

Hwee Ching Ang, Andreas C. Joerger, Sebastian Mayer, and Alan R. Fersht: Effects of Common Cancer Mutations on Stability and DNA Binding of Full-length p53 Compared with Isolated Core Domains
J. Biol. Chem. 2006 281: 21934-21941. First Published on June 5, 2006; doi:10.1074/jbc.M604209200 [Abstract] [Full Text] [PDF]

Kathryn L. Kavanagh, James E. Dunford, Gabor Bunkoczi, R. Graham G. Russell, and Udo Oppermann: The Crystal Structure of Human Geranylgeranyl Pyrophosphate Synthase Reveals a Novel Hexameric Arrangement and Inhibitory Product Binding
J. Biol. Chem. 2006 281: 22004-22012. First Published on May 11, 2006; doi:10.1074/jbc.M602603200 [Abstract] [Full Text] [PDF]

Aqeel Ahmad, Sharada Prasad Yadav, Neeta Asthana, Kalyan Mitra, Swati Prakash Srivastava, and Jimut Kanti Ghosh: Utilization of an Amphipathic Leucine Zipper Sequence to Design Antibacterial Peptides with Simultaneous Modulation of Toxic Activity against Human Red Blood Cells
J. Biol. Chem. 2006 281: 22029-22038. First Published on May 22, 2006; doi:10.1074/jbc.M602378200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Cinzia Verde, Marco Balestrieri, Donatella de Pascale, Daniela Pagnozzi, Guillaume Lecointre, and Guido di Prisco: The Oxygen Transport System in Three Species of the Boreal Fish Family Gadidae: MOLECULAR PHYLOGENY OF HEMOGLOBIN
J. Biol. Chem. 2006 281: 22073-22084. First Published on May 22, 2006; doi:10.1074/jbc.M513080200 [Abstract] [Full Text] [PDF] [Supplemental Data]

J. Shaun Lott, Blake Paget, Jodie M. Johnston, Louis T. J. Delbaere, Jill A. Sigrell-Simon, Mark J. Banfield, and Edward N. Baker: The Structure of an Ancient Conserved Domain Establishes a Structural Basis for Stable Histidine Phosphorylation and Identifies a New Family of Adenosine-specific Kinases
J. Biol. Chem. 2006 281: 22131-22141. First Published on May 30, 2006; doi:10.1074/jbc.M603062200 [Abstract] [Full Text] [PDF]

Tadashi Suzuki, Izumi Hara, Miyako Nakano, Gang Zhao, William J. Lennarz, Hermann Schindelin, Naoyuki Taniguchi, Kiichiro Totani, Ichiro Matsuo, and Yukishige Ito: Site-specific Labeling of Cytoplasmic Peptide:N-Glycanase by N,N'-Diacetylchitobiose-related Compounds
J. Biol. Chem. 2006 281: 22152-22160. First Published on June 1, 2006; doi:10.1074/jbc.M603236200 [Abstract] [Full Text] [PDF]

Li Zhu, Yoshikazu Imanishi, Slawomir Filipek, Andrei Alekseev, Beata Jastrzebska, Wenyu Sun, David A. Saperstein, and Krzysztof Palczewski: Autosomal Recessive Retinitis Pigmentosa and E150K Mutation in the Opsin Gene
J. Biol. Chem. 2006 281: 22289-22298. First Published on May 31, 2006; doi:10.1074/jbc.M602664200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Natalia Korotkova, Isolde Le Trong, Ram Samudrala, Konstantin Korotkov, Cristina P. Van Loy, Anh-Linh Bui, Steve L. Moseley, and Ronald E. Stenkamp: Crystal Structure and Mutational Analysis of the DaaE Adhesin of Escherichia coli
J. Biol. Chem. 2006 281: 22367-22377. First Published on June 2, 2006; doi:10.1074/jbc.M604646200 [Abstract] [Full Text] [PDF]

Gábor Pál, Jean-Louis K. Kouadio, Dean R. Artis, Anthony A. Kossiakoff, and Sachdev S. Sidhu: Comprehensive and Quantitative Mapping of Energy Landscapes for Protein-Protein Interactions by Rapid Combinatorial Scanning
J. Biol. Chem. 2006 281: 22378-22385. First Published on June 8, 2006; doi:10.1074/jbc.M603826200 [Abstract] [Full Text] [PDF] [Supplemental Data] [Summary]

Satoe H. Nakagawa, Qing-xin Hua, Shi-Quan Hu, Wenhua Jia, Shuhua Wang, Panayotis G. Katsoyannis, and Michael A. Weiss: Chiral Mutagenesis of Insulin: CONTRIBUTION OF THE B20-B23 $beta$ -TURN TO ACTIVITY AND STABILITY
J. Biol. Chem. 2006 281: 22386-22396. First Published on June 2, 2006; doi:10.1074/jbc.M603547200 [Abstract] [Full Text] [PDF] [ Supplemental Data]

Enzyme Catalysis and Regulation:

Ramon A. Riojas, Chintan K. Kikani, Changhua Wang, Xuming Mao, Lijun Zhou, Paul R. Langlais, Derong Hu, James L. Roberts, Lily Q. Dong, and Feng Liu: Fine Tuning PDK1 Activity by Phosphorylation at Ser¹⁶³
J. Biol. Chem. 2006 281: 21588-21593. First Published on June 2, 2006; doi:10.1074/jbc.M600393200 [Abstract] [Full Text] [PDF]

Xinxin Gao and Thomas K. Harris: Steady-state Kinetic Mechanism of PDK1
J. Biol. Chem. 2006 281: 21670-21681. First Published on May 31, 2006; doi:10.1074/jbc.M602448200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Shinsuke Yazawa, Hidemi Tsuchiya, Hiroshi Hori, and Ryu Makino: Functional Characterization of Two Nucleotide-binding Sites in Soluble Guanylate Cyclase
J. Biol. Chem. 2006 281: 21763-21770. First Published on June 5, 2006; doi:10.1074/jbc.M508983200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Xiang-dong Li, Hyun Suk Jung, Katsuhide Mabuchi, Roger Craig, and Mitsuo Ikebe: The Globular Tail Domain of Myosin Va Functions as an Inhibitor of the Myosin Va Motor
J. Biol. Chem. 2006 281: 21789-21798. First Published on June 5, 2006; doi:10.1074/jbc.M602957200 [Abstract] [Full Text] [PDF]

Kei Miyano, Noriko Ueno, Ryu Takeya, and Hideki Sumimoto: Direct Involvement of the Small GTPase Rac in Activation of the Superoxide-producing NADPH Oxidase Nox1
J. Biol. Chem. 2006 281: 21857-21868. First Published on June 8, 2006; doi:10.1074/jbc.M513665200 [Abstract] [Full Text] [PDF]

Elizabeth M. Boon, Joseph H. Davis, Rosalie Tran, David S. Karow, Shirley H. Huang, Duohai Pan, Michael M. Miazgowicz, Richard A. Mathies, and Michael A. Marletta: Nitric Oxide Binding to Prokaryotic Homologs of the Soluble Guanylate Cyclase $beta$ 1 H-NOX Domain
J. Biol. Chem. 2006 281: 21892-21902. First Published on May 25, 2006; doi:10.1074/jbc.M600557200 [Abstract] [Full Text] [PDF]

Metabolism and Bioenergetics:

Miho Yoshioka, Suguru Uchida, Hiroki Mori, Keisuke Komayama, Satoshi Ohira, Noriko Morita, Tohru Nakanishi, and Yasusi Yamamoto: Quality Control of Photosystem II: CLEAVAGE OF REACTION CENTER D1 PROTEIN IN SPINACH THYLAKOIDS BY FtsH PROTEASE UNDER MODERATE HEAT STRESS
J. Biol. Chem. 2006 281: 21660-21669. First Published on May 30, 2006; doi:10.1074/jbc.M602896200 [Abstract] [Full Text] [PDF]

Noriyoshi Masuoka, Hitoshi Sugiyama, Naoki Ishibashi, Da-Hong Wang, Takayoshi Masuoka, Hiroyuki Kodama, and Taku Nakano: Characterization of Acatalasemic Erythrocytes Treated with Low and High Dose Hydrogen Peroxide: HEMOLYSIS AND AGGREGATION
J. Biol. Chem. 2006 281: 21728-21734. First Published on June 2, 2006; doi:10.1074/jbc.M513818200 [Abstract] [Full Text] [PDF]

Weiping Qin, Tianle Yang, Lap Ho, Zhong Zhao, Jun Wang, Linghong Chen, Wei Zhao, Meenakshisundaram Thiyagarajan, Donal MacGrogan, Joseph T. Rodgers, Pere Puigserver, Junichi Sadoshima, Haiteng Deng, Steven Pedrini, Samuel Gandy, Anthony A. Sauve, and Giulio M. Pasinetti: Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction
J. Biol. Chem. 2006 281: 21745-21754. First Published on June 2, 2006; doi:10.1074/jbc.M602909200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Carlos Rodríguez-Caso, Raúl Montañez, Marta Cascante, Francisca Sánchez-Jiménez, and Miguel A. Medina: Mathematical Modeling of Polyamine Metabolism in Mammals
J. Biol. Chem. 2006 281: 21799-21812. First Published on May 18, 2006; doi:10.1074/jbc.M602756200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Antje Wehner, Thomas Grasses, and Peter Jahns: De-epoxidation of Violaxanthin in the Minor Antenna Proteins of Photosystem II, LHCB4, LHCB5, and LHCB6
J. Biol. Chem. 2006 281: 21924-21933. First Published on June 5, 2006; doi:10.1074/jbc.M602915200 [Abstract] [Full Text] [PDF]

Jinghong Wang, Nicole Simonavicius, Xiaosu Wu, Gayathri Swaminath, Jeff Reagan, Hui Tian, and Lei Ling: Kynurenic Acid as a Ligand for Orphan G Protein-coupled Receptor GPR35
J. Biol. Chem. 2006 281: 22021-22028. First Published on June 5, 2006; doi:10.1074/jbc.M603503200 [Abstract] [Full Text] [PDF]

Mette V. Jensen, Jamie W. Joseph, Olga Ilkayeva, Shawn Burgess, Danhong Lu, Sarah M. Ronnebaum, Matthew Odegaard, Thomas C. Becker, A. Dean Sherry, and Christopher B. Newgard: Compensatory Responses to Pyruvate Carboxylase Suppression in Islet $beta$ -Cells: PRESERVATION OF GLUCOSE-STIMULATED INSULIN SECRETION
J. Biol. Chem. 2006 281: 22342-22351. First Published on June 1, 2006; doi:10.1074/jbc.M604350200 [Abstract] [Full Text] [PDF]

Lipids and Lipoproteins:

Marion Binder, Gerhard Liebisch, Thomas Langmann, and Gerd Schmitz: Metabolic Profiling of Glycerophospholipid Synthesis in Fibroblasts Loaded with Free Cholesterol and Modified Low Density Lipoproteins
J. Biol. Chem. 2006 281: 21869-21877. First Published on June 8, 2006; doi:10.1074/jbc.M603025200 [Abstract] [Full Text] [PDF]

C. Michael Reynolds, Anthony A. Ribeiro, Sara C. McGrath, Robert J. Cotter, Christian R. H. Raetz, and M. Stephen Trent: An Outer Membrane Enzyme Encoded by Salmonella typhimurium lpxR That Removes the 3'-Acyloxyacyl Moiety of Lipid A
J. Biol. Chem. 2006 281: 21974-21987. First Published on May 16, 2006; doi:10.1074/jbc.M603527200 [Abstract] [Full Text] [PDF]

Songsri Kaewsuwan, Edgar B. Cahoon, Pierre-François Perroud, Chanpen Wiwat, Nathinee Panvisavas, Ralph S. Quatrano, David J. Cove, and Nuntavan Bunyapraphatsara: Identification and Functional Characterization of the Moss Physcomitrella patens ${Delta}$ ⁵-Desaturase Gene Involved in Arachidonic and Eicosapentaenoic Acid Biosynthesis
J. Biol. Chem. 2006 281: 21988-21997. First Published on May 25, 2006; doi:10.1074/jbc.M603022200 [Abstract] [Full Text] [PDF]

Steeve Boulant, Roland Montserret, R. Graham Hope, Maxime Ratinier, Paul Targett-Adams, Jean-Pierre Lavergne, Francois Penin, and John McLauchlan: Structural Determinants That Target the Hepatitis C Virus Core Protein to Lipid Droplets
J. Biol. Chem. 2006 281: 22236-22247. First Published on May 16, 2006; doi:10.1074/jbc.M601031200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Membrane Transport, Structure, Function, and Biogenesis:

Inês Chen, Roberta Provvedi, and David Dubnau: A Macromolecular Complex Formed by a Pilin-like Protein in Competent Bacillus subtilis
J. Biol. Chem. 2006 281: 21720-21727. First Published on June 1, 2006; doi:10.1074/jbc.M604071200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Megha, Omar Bakht, and Erwin London: Cholesterol Precursors Stabilize Ordinary and Ceramide-rich Ordered Lipid Domains (Lipid Rafts) to Different Degrees: IMPLICATIONS FOR THE BLOCH HYPOTHESIS AND STEROL BIOSYNTHESIS DISORDERS
J. Biol. Chem. 2006 281: 21903-21913. First Published on May 30, 2006; doi:10.1074/jbc.M600395200 [Abstract] [Full Text] [PDF]

Songbai Zhang, Seth Malmersjö, Juan Li, Hideaki Ando, Oleg Aizman, Per Uhlén, Katsuhiko Mikoshiba, and Anita Aperia: Distinct Role of the N-terminal Tail of the Na,K-ATPase Catalytic Subunit as a Signal Transducer
J. Biol. Chem. 2006 281: 21954-21962. First Published on May 24, 2006; doi:10.1074/jbc.M601578200 [Abstract] [Full Text] [PDF]

Shuhong Luo, Jianmin Fang, and Roberto Docampo: Molecular Characterization of Trypanosoma brucei P-type H⁺-ATPases
J. Biol. Chem. 2006 281: 21963-21973. First Published on June 6, 2006; doi:10.1074/jbc.M601057200 [Abstract] [Full Text] [PDF]

Igor Splawski, Dana S. Yoo, Stephanie C. Stotz, Allison Cherry, David E. Clapham, and Mark T. Keating: CACNA1H Mutations in Autism Spectrum Disorders
J. Biol. Chem. 2006 281: 22085-22091. First Published on June 5, 2006; doi:10.1074/jbc.M603316200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Yonggang Zhou, Elia Zomot, and Baruch I. Kanner: Identification of a Lithium Interaction Site in the ${gamma}$ -Aminobutyric Acid (GABA) Transporter GAT-1
J. Biol. Chem. 2006 281: 22092-22099. First Published on June 6, 2006; doi:10.1074/jbc.M602319200 [Abstract] [Full Text] [PDF]

Axel Müller, Emmanuele Severi, Christopher Mulligan, Andrew G. Watts, David J. Kelly, Keith S. Wilson, Anthony J. Wilkinson, and Gavin H. Thomas: Conservation of Structure and Mechanism in Primary and Secondary Transporters Exemplified by SiaP, a Sialic Acid Binding Virulence Factor from Haemophilus influenzae
J. Biol. Chem. 2006 281: 22212-22222. First Published on May 15, 2006; doi:10.1074/jbc.M603463200 [Abstract] [Full Text] [PDF]

William A. Anong, Tahlia L. Weis, and Philip S. Low: Rate of Rupture and Reattachment of the Band 3-Ankyrin Bridge on the Human Erythrocyte Membrane
J. Biol. Chem. 2006 281: 22360-22366. First Published on June 8, 2006; doi:10.1074/jbc.M513839200 [Abstract] [Full Text] [PDF]

Molecular Basis Of Cell and Developmental Biology:

Karina Reiss, Thorsten Maretzky, Ingrid G. Haas, Marc Schulte, Andreas Ludwig, Marcus Frank, and Paul Saftig: Regulated ADAM10-dependent Ectodomain Shedding of ${gamma}$ -Protocadherin C3 Modulates Cell-Cell Adhesion
J. Biol. Chem. 2006 281: 21735-21744. First Published on June 2, 2006; doi:10.1074/jbc.M602663200 [Abstract] [Full Text] [PDF]

Chieko Yamada, Hitomi Sano, Takeyuki Shimizu, Hiroaki Mitsuzawa, Chiaki Nishitani, Tetsuo Himi, and Yoshio Kuroki: Surfactant Protein A Directly Interacts with TLR4 and MD-2 and Regulates Inflammatory Cellular Response: IMPORTANCE OF SUPRATRIMERIC OLIGOMERIZATION
J. Biol. Chem. 2006 281: 21771-21780. First Published on June 5, 2006; doi:10.1074/jbc.M513041200 [Abstract] [Full Text] [PDF]

Kazunori Mori, Masayuki Asakawa, Miki Hayashi, Miwako Imura, Takahiro Ohki, Etsuko Hirao, Joo-ri Kim-Kaneyama, Kiyoshi Nose, and Motoko Shibanuma: Oligomerizing Potential of a Focal Adhesion LIM Protein Hic-5 Organizing a Nuclear-Cytoplasmic Shuttling Complex
J. Biol. Chem. 2006 281: 22048-22061. First Published on May 31, 2006; doi:10.1074/jbc.M513111200 [Abstract] [Full Text] [PDF]

Loredana Moro, Arnaldo A. Arbini, Ersilia Marra, and Margherita Greco: Up-regulation of Skp2 after Prostate Cancer Cell Adhesion to Basement Membranes Results in BRCA2 Degradation and Cell Proliferation
J. Biol. Chem. 2006 281: 22100-22107. First Published on June 5, 2006; doi:10.1074/jbc.M604636200 [Abstract] [Full Text] [PDF]

Konstantin Seleznev, Chunying Zhao, Xu Hannah Zhang, Keying Song, and Zhongmin Alex Ma: Calcium-independent Phospholipase A₂ Localizes in and Protects Mitochondria during Apoptotic Induction by Staurosporine
J. Biol. Chem. 2006 281: 22275-22288. First Published on May 25, 2006; doi:10.1074/jbc.M604330200 [Abstract] [Full Text] [PDF]

Yingnan Zhang, Sherry Yeh, Brent A. Appleton, Heike A. Held, P. Jaya Kausalya, Dominic C. Y. Phua, Wai Lee Wong, Laurence A. Lasky, Christian Wiesmann, Walter Hunziker, and Sachdev S. Sidhu: Convergent and Divergent Ligand Specificity among PDZ Domains of the LAP and Zonula Occludens (ZO) Families
J. Biol. Chem. 2006 281: 22299-22311. First Published on May 31, 2006; doi:10.1074/jbc.M602902200 [Abstract] [Full Text] [PDF]

Brent A. Appleton, Yingnan Zhang, Ping Wu, Jian Ping Yin, Walter Hunziker, Nicholas J. Skelton, Sachdev S. Sidhu, and Christian Wiesmann: Comparative Structural Analysis of the Erbin PDZ Domain and the First PDZ Domain of ZO-1: INSIGHTS INTO DETERMINANTS OF PDZ DOMAIN SPECIFICITY
J. Biol. Chem. 2006 281: 22312-22320. First Published on May 31, 2006; doi:10.1074/jbc.M602901200 [Abstract] [Full Text] [PDF]

Yan Yang, Connie L. Mahaffey, Nathalie Bérubé, and Wayne N. Frankel: Interaction between Fidgetin and Protein Kinase A-anchoring Protein AKAP95 Is Critical for Palatogenesis in the Mouse
J. Biol. Chem. 2006 281: 22352-22359. First Published on June 2, 2006; doi:10.1074/jbc.M603626200 [Abstract] [Full Text] [PDF]

Mechanisms Of Signal Transduction:

Jie Xu, Zhongyu Liu, Thomas L. Clemens, and Joseph L. Messina: Insulin Reverses Growth Hormone-induced Homologous Desensitization
J. Biol. Chem. 2006 281: 21594-21606. First Published on May 22, 2006; doi:10.1074/jbc.M513612200 [Abstract] [Full Text] [PDF]

Shlomo Oved, Yaron Mosesson, Yaara Zwang, Elena Santonico, Keren Shtiegman, Mina D. Marmor, Bose S. Kochupurakkal, Menachem Katz, Sara Lavi, Gianni Cesareni, and Yosef Yarden: Conjugation to Nedd8 Instigates Ubiquitylation and Down-regulation of Activated Receptor Tyrosine Kinases
J. Biol. Chem. 2006 281: 21640-21651. First Published on May 30, 2006; doi:10.1074/jbc.M513034200 [Abstract] [Full Text] [PDF]

Qin Wei and Yong Xia: Proteasome Inhibition Down-regulates Endothelial Nitric-oxide Synthase Phosphorylation and Function
J. Biol. Chem. 2006 281: 21652-21659. First Published on May 30, 2006; doi:10.1074/jbc.M602105200 [Abstract] [Full Text] [PDF]

Carles Cantó, Alexander V. Chibalin, Brian R. Barnes, Stephan Glund, Elisabet Suárez, Jeffrey W. Ryder, Manuel Palacín, Juleen R. Zierath, Antonio Zorzano, and Anna Gumà: Neuregulins Mediate Calcium-induced Glucose Transport during Muscle Contraction
J. Biol. Chem. 2006 281: 21690-21697. First Published on June 1, 2006; doi:10.1074/jbc.M600475200 [Abstract] [Full Text] [PDF]

Serena Germano, Davide Barberis, Massimo M. Santoro, Lorenza Penengo, Ami Citri, Yosef Yarden, and Giovanni Gaudino: Geldanamycins Trigger a Novel Ron Degradative Pathway, Hampering Oncogenic Signaling
J. Biol. Chem. 2006 281: 21710-21719. First Published on June 1, 2006; doi:10.1074/jbc.M602014200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Xiang-Qun Hu, Hui Sun, Robert W. Peoples, Ren Hong, and Li Zhang: An Interaction Involving an Arginine Residue in the Cytoplasmic Domain of the 5-HT_3A Receptor Contributes to Receptor Desensitization Mechanism
J. Biol. Chem. 2006 281: 21781-21788. First Published on June 5, 2006; doi:10.1074/jbc.M600676200 [Abstract] [Full Text] [PDF]

Jonathan P. Brennan, Sonya C. Bardswell, Joseph R. Burgoyne, William Fuller, Ewald Schröder, Robin Wait, Shajna Begum, Jonathan C. Kentish, and Philip Eaton: Oxidant-induced Activation of Type I Protein Kinase A Is Mediated by RI Subunit Interprotein Disulfide Bond Formation
J. Biol. Chem. 2006 281: 21827-21836. First Published on June 5, 2006; doi:10.1074/jbc.M603952200 [Abstract] [Full Text] [PDF]

Maider López De Jesús, Matthias B. Stope, Paschal A. Oude Weernink, Yvonne Mahlke, Christof Börgermann, Viktoria N. Ananaba, Christian Rimmbach, Dieter Rosskopf, Martin C. Michel, Karl H. Jakobs, and Martina Schmidt: Cyclic AMP-dependent and Epac-mediated Activation of R-Ras by G Protein-coupled Receptors Leads to Phospholipase D Stimulation
J. Biol. Chem. 2006 281: 21837-21847. First Published on June 5, 2006; doi:10.1074/jbc.M604156200 [Abstract] [Full Text] [PDF]

Huijian Wu, Luyang Sun, Ying Zhang, Yupeng Chen, Bin Shi, Ruifang Li, Yan Wang, Jing Liang, Dongwei Fan, Ge Wu, Dan Wang, Shaosi Li, and Yongfeng Shang: Coordinated Regulation of AIB1 Transcriptional Activity by Sumoylation and Phosphorylation
J. Biol. Chem. 2006 281: 21848-21856. First Published on June 7, 2006; doi:10.1074/jbc.M603772200 [Abstract] [Full Text] [PDF]

Ning Wang, Zhe Li, Ronghua Ding, Gerald D. Frank, Takaaki Senbonmatsu, Erwin J. Landon, Tadashi Inagami, and Zhizhuang Joe Zhao: Antagonism or Synergism: ROLE OF TYROSINE PHOSPHATASES SHP-1 AND SHP-2 IN GROWTH FACTOR SIGNALING
J. Biol. Chem. 2006 281: 21878-21883. First Published on June 8, 2006; doi:10.1074/jbc.M605018200 [Abstract] [Full Text] [PDF]

Parth Patwari, Luke J. Higgins, William A. Chutkow, Jun Yoshioka, and Richard T. Lee: The Interaction of Thioredoxin with Txnip: EVIDENCE FOR FORMATION OF A MIXED DISULFIDE BY DISULFIDE EXCHANGE
J. Biol. Chem. 2006 281: 21884-21891. First Published on June 9, 2006; doi:10.1074/jbc.M600427200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Feihan F. Dai, Yi Zhang, Youhou Kang, Qinghua Wang, Herbert Y. Gaisano, Karl-Heinz Braunewell, Catherine B. Chan, and Michael B. Wheeler: The Neuronal Ca²⁺ Sensor Protein Visinin-like Protein-1 Is Expressed in Pancreatic Islets and Regulates Insulin Secretion
J. Biol. Chem. 2006 281: 21942-21953. First Published on May 26, 2006; doi:10.1074/jbc.M512924200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Pedro Filipe Teixeira, Filipe Cerca, Sofia D. Santos, and Maria João Saraiva: Endoplasmic Reticulum Stress Associated with Extracellular Aggregates: EVIDENCE FROM TRANSTHYRETIN DEPOSITION IN FAMILIAL AMYLOID POLYNEUROPATHY
J. Biol. Chem. 2006 281: 21998-22003. First Published on June 2, 2006; doi:10.1074/jbc.M602302200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Koji Sayama, Yasushi Hanakawa, Hiroshi Nagai, Yuji Shirakata, Xiuju Dai, Satoshi Hirakawa, Sho Tokumaru, Mikiko Tohyama, Lujun Yang, Shintaro Sato, Akira Shizuo, and Koji Hashimoto: Transforming Growth Factor- $beta$ -activated Kinase 1 Is Essential for Differentiation and the Prevention of Apoptosis in Epidermis
J. Biol. Chem. 2006 281: 22013-22020. First Published on June 5, 2006; doi:10.1074/jbc.M601065200 [Abstract] [Full Text] [PDF]

Je-Hwang Ryu and Jang-Soo Chun: Opposing Roles of WNT-5A and WNT-11 in Interleukin-1 $beta$ Regulation of Type II Collagen Expression in Articular Chondrocytes
J. Biol. Chem. 2006 281: 22039-22047. First Published on June 5, 2006; doi:10.1074/jbc.M601804200 [Abstract] [Full Text] [PDF]

Xavier Dolcet, David Llobet, Mario Encinas, Judit Pallares, Albert Cabero, Joan Antoni Schoenenberger, Joan X. Comella, and Xavier Matias-Guiu: Proteasome Inhibitors Induce Death but Activate NF- ${kappa}$ B on Endometrial Carcinoma Cell Lines and Primary Culture Explants
J. Biol. Chem. 2006 281: 22118-22130. First Published on May 30, 2006; doi:10.1074/jbc.M601350200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Patrick Stiernet, Yves Guiot, Patrick Gilon, and Jean-Claude Henquin: Glucose Acutely Decreases pH of Secretory Granules in Mouse Pancreatic Islets: MECHANISMS AND INFLUENCE ON INSULIN SECRETION
J. Biol. Chem. 2006 281: 22142-22151. First Published on June 7, 2006; doi:10.1074/jbc.M513224200 [Abstract] [Full Text] [PDF]

Kenichi Amagasaki, Hideaki Kaneto, Carl-Henrik Heldin, and Johan Lennartsson: c-Jun N-terminal Kinase Is Necessary for Platelet-derived Growth Factor-mediated Chemotaxis in Primary Fibroblasts
J. Biol. Chem. 2006 281: 22173-22179. First Published on June 7, 2006; doi:10.1074/jbc.M513307200 [Abstract] [Full Text] [PDF]

Takashi Kanematsu, Atsushi Yasunaga, Yoshito Mizoguchi, Akiko Kuratani, Josef T. Kittler, Jasmina N. Jovanovic, Kei Takenaka, Keiichi I. Nakayama, Kiyoko Fukami, Tadaomi Takenawa, Stephen J. Moss, Junichi Nabekura, and Masato Hirata: Modulation of GABA_A Receptor Phosphorylation and Membrane Trafficking by Phospholipase C-related Inactive Protein/Protein Phosphatase 1 and 2A Signaling Complex Underlying Brain-derived Neurotrophic Factor-dependent Regulation of GABAergic Inhibition
J. Biol. Chem. 2006 281: 22180-22189. First Published on June 5, 2006; doi:10.1074/jbc.M603118200 [Abstract] [Full Text] [PDF]

Chandrashekara Mallappa, Vandana Yadav, Prem Negi, and Sudip Chattopadhyay: A Basic Leucine Zipper Transcription Factor, G-box-binding Factor 1, Regulates Blue Light-mediated Photomorphogenic Growth in Arabidopsis
J. Biol. Chem. 2006 281: 22190-22199. First Published on April 25, 2006; doi:10.1074/jbc.M601172200 [Abstract] [Full Text] [PDF]

Edgar Grinstein, Ying Shan, Leonid Karawajew, Peter J. F. Snijders, Chris J. L. M. Meijer, Hans-Dieter Royer, and Peter Wernet: Cell Cycle-controlled Interaction of Nucleolin with the Retinoblastoma Protein and Cancerous Cell Transformation
J. Biol. Chem. 2006 281: 22223-22235. First Published on May 12, 2006; doi:10.1074/jbc.M513335200 [Abstract] [Full Text] [PDF]

Georgi L. Lukov, Christine M. Baker, Paul J. Ludtke, Ting Hu, Michael D. Carter, Ryan A. Hackett, Craig D. Thulin, and Barry M. Willardson: Mechanism of Assembly of G Protein $beta$ ${gamma}$ Subunits by Protein Kinase CK2-phosphorylated Phosducin-like Protein and the Cytosolic Chaperonin Complex
J. Biol. Chem. 2006 281: 22261-22274. First Published on May 22, 2006; doi:10.1074/jbc.M601590200 [Abstract] [Full Text] [PDF]

Jolanta Idkowiak-Baldys, Kevin P. Becker, Kazuyuki Kitatani, and Yusuf A. Hannun: Dynamic Sequestration of the Recycling Compartment by Classical Protein Kinase C
J. Biol. Chem. 2006 281: 22321-22331. First Published on June 2, 2006; doi:10.1074/jbc.M512540200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Fumi Mikami, Jae Hyang Lim, Hajime Ishinaga, Un-Hwan Ha, He Gu, Tomoaki Koga, Hirofumi Jono, Hirofumi Kai, and Jian-Dong Li: The Transforming Growth Factor- $beta$ -Smad3/4 Signaling Pathway Acts as a Positive Regulator for TLR2 Induction by Bacteria via a Dual Mechanism Involving Functional Cooperation with NF- ${kappa}$ B and MAPK Phosphatase 1-dependent Negative Cross-talk with p38 MAPK
J. Biol. Chem. 2006 281: 22397-22408. First Published on June 5, 2006; doi:10.1074/jbc.M602124200 [Abstract] [Full Text] [PDF]

Marcel J. M. Schaaf, Lynsey Willetts, Brian P. Hayes, Barbara Maschera, Eleni Stylianou, and Stuart N. Farrow: The Relationship between Intranuclear Mobility of the NF- ${kappa}$ B Subunit p65 and Its DNA Binding Affinity
J. Biol. Chem. 2006 281: 22409-22420. First Published on June 7, 2006; doi:10.1074/jbc.M511086200 [Abstract] [Full Text] [PDF]

Jian Chen, Juan M. Cárcamo, and David W. Golde: The ${alpha}$ Subunit of the Granulocyte-Macrophage Colony-stimulating Factor Receptor Interacts with c-Kit and Inhibits c-Kit Signaling
J. Biol. Chem. 2006 281: 22421-22426. First Published on June 7, 2006; doi:10.1074/jbc.M604644200 [Abstract] [Full Text] [PDF]

Additions and Corrections:

Yajnavalka Banerjee, Jun Mizuguchi, Sadaaki Iwanaga, and R. Manjunatha Kini: Hemextin AB complex, a unique anticoagulant protein complex from Hemachatus haemachatus (African Ringhals cobra) venom that inhibits clot initiation and factor VIIa activity. VOLUME 280 (2005) 42601-42611
J. Biol. Chem. 2006 281: 22427. [Full Text] [PDF]

Bing Ma, Leon H. Lau, Monica M. Palcic, Bart Hazes, and Diane E. Taylor: A single aromatic amino acid at the carboxyl terminus of Helicobacter pylori ${alpha}$ 1,3/4 fucosyltransferase determines substrate specificity. VOLUME 280 (2005) 36848-36856
J. Biol. Chem. 2006 281: 22428. [Full Text] [PDF]