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Receptor Transfer in Inflammation

Cells sometimes use microparticles to transfer receptors to other cells that lack particular receptors. For example, platelet-derived microparticles (PMPs) are generated during inflammation and contain receptors that can be acquired by components of the vessel wall and by blood-borne cells such as neutrophils.

Platelet-derived microparticles (PMPs) can transfer GPIIb/IIIa receptors (CD41/61-PE) to neutrophils.

In this Paper of the Week Birgit Salanova and colleagues tested whether or not functional GPIIb/IIIa receptors could be acquired by neutrophils via PMPs and whether these receptors participate in pro-inflammatory signaling. They found that PMPs do indeed transfer GPIIb/IIIa receptors to isolated and whole blood neutrophils and that these newly acquired receptors cooperate with 2-integrins to activate NF-B signaling. From these results, the authors propose that GPIIb/IIIa receptors could be a new therapeutic target in neutrophil-induced inflammation.

FOOTNOTES

See referenced article, J. Biol. Chem. 2007, 282, 27960-27969

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