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On The Cover: An active ultrastable insulin analog tethered by a peptide linker (cyan). Top, chain connectivity (left) and ribbon model (right). The stabilizing linker is interposed between A- and B-chains (white and gray); disulfide bridges are bronze. Bottom, stereo models showing packing of linker (cyan) relative to electrostatic surface of analog: negative (red) and positive (blue). For details see the article by Hua et al., pages 14703–14716.

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